BRPI0908508A2 - anticorpo monoclonal nkg2a anti-humano humanizado - Google Patents
anticorpo monoclonal nkg2a anti-humano humanizadoInfo
- Publication number
- BRPI0908508A2 BRPI0908508A2 BRPI0908508A BRPI0908508A BRPI0908508A2 BR PI0908508 A2 BRPI0908508 A2 BR PI0908508A2 BR PI0908508 A BRPI0908508 A BR PI0908508A BR PI0908508 A BRPI0908508 A BR PI0908508A BR PI0908508 A2 BRPI0908508 A2 BR PI0908508A2
- Authority
- BR
- Brazil
- Prior art keywords
- monoclonal antibody
- humanized anti
- human nkg2a
- nkg2a monoclonal
- human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08150601 | 2008-01-24 | ||
| PCT/EP2009/050795 WO2009092805A1 (en) | 2008-01-24 | 2009-01-23 | Humanized anti-human nkg2a monoclonal antibody |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0908508A2 true BRPI0908508A2 (pt) | 2016-03-22 |
Family
ID=40566366
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0908508A BRPI0908508A2 (pt) | 2008-01-24 | 2009-01-23 | anticorpo monoclonal nkg2a anti-humano humanizado |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8796427B2 (pt) |
| EP (2) | EP2628753A1 (pt) |
| JP (1) | JP5774312B2 (pt) |
| KR (1) | KR20100110864A (pt) |
| CN (1) | CN101952317B (pt) |
| AU (1) | AU2009207644A1 (pt) |
| BR (1) | BRPI0908508A2 (pt) |
| CA (1) | CA2712220A1 (pt) |
| IL (1) | IL206639A0 (pt) |
| MX (1) | MX2010007935A (pt) |
| RU (1) | RU2010133892A (pt) |
| WO (1) | WO2009092805A1 (pt) |
| ZA (1) | ZA201004752B (pt) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2481356C2 (ru) | 2004-12-28 | 2013-05-10 | Иннейт Фарма | Моноклональные антитела против nkg2a |
| DK2038306T3 (en) | 2006-06-30 | 2015-03-09 | Novo Nordisk As | ANTI-NKG2A ANTIBODIES AND APPLICATIONS THEREOF |
| MX2010007935A (es) | 2008-01-24 | 2010-08-23 | Novo Nordisk As | Anticuerpo monoclonal humanizado anti-nkg2a humano. |
| SI3409289T1 (sl) | 2010-02-26 | 2020-12-31 | Novo Nordisk A/S | Stabilni sestavki, ki vsebujejo protitelo |
| MX342131B (es) * | 2011-06-17 | 2016-09-14 | Novo Nordisk As | Eliminacion selectiva de celulas erosivas. |
| US9982038B2 (en) | 2014-01-24 | 2018-05-29 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Antibodies against F glycoprotein of Hendra and Nipah viruses |
| RU2017105425A (ru) | 2014-08-28 | 2018-09-28 | Академиш Зикенхёйс Лейден Х.О.Д.Н. Люмк | Комбинации антитела против cd94/nkg2a и/или cd94/nkg2b и вакцины |
| AU2015316993B2 (en) * | 2014-09-16 | 2021-03-18 | Innate Pharma | Treatment regimens using anti-NKG2A antibodies |
| KR20250007689A (ko) * | 2014-09-16 | 2025-01-14 | 이나뜨 파르마 에스.에이. | 림프구에서의 억제 경로의 중화 |
| EP3209687A1 (en) * | 2014-10-23 | 2017-08-30 | Innate Pharma | Treatment of cancers using anti-nkg2a agents |
| HRP20220890T1 (hr) * | 2015-02-06 | 2022-10-14 | National University Of Singapore | Postupci za povećanje učinkovitosti terapijskih imunosnih stanica |
| EP3297672B1 (en) | 2015-05-21 | 2021-09-01 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
| CN115960235A (zh) * | 2015-08-28 | 2023-04-14 | 艾利妥 | 抗siglec-7抗体及其使用方法 |
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| CN118581046A (zh) | 2016-11-22 | 2024-09-03 | 新加坡国立大学 | 用于t细胞恶性肿瘤免疫疗法的cd7表达阻滞剂和嵌合抗原受体 |
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| US11786551B2 (en) | 2017-09-26 | 2023-10-17 | The Trustees Of The University Of Pennsylvania | Methods for treating heart disease via redirected T cell immunotherapies |
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| TWI924623B (zh) | 2018-03-13 | 2026-05-11 | 法商天賜製藥公司 | 頭頸癌之治療 |
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| JP7584299B2 (ja) | 2018-05-23 | 2024-11-15 | ナショナル ユニバーシティ オブ シンガポール | Ｔ細胞悪性腫瘍の免疫療法のためのｃｄ２表面発現の遮断およびキメラ抗原受容体の発現 |
| CN119841953A (zh) | 2018-06-08 | 2025-04-18 | 艾利妥 | 抗siglec-7抗体及其使用方法 |
| WO2020035345A1 (en) | 2018-08-14 | 2020-02-20 | Innate Pharma | Treatment of colorectal cancer by a combination of an anti-mica antibody and an anti-nkg2a antibody |
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| EP3878869A4 (en) | 2018-11-07 | 2023-04-19 | Shanghai Hyamab Biotech Co., Ltd. | NKG2A ANTIBODIES, METHOD OF PRODUCTION THEREOF AND USE THEREOF |
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| WO2025166550A1 (zh) * | 2024-02-06 | 2025-08-14 | 香港北恒生物科技有限公司 | 工程化细胞及其用途 |
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2009
- 2009-01-23 MX MX2010007935A patent/MX2010007935A/es not_active Application Discontinuation
- 2009-01-23 BR BRPI0908508A patent/BRPI0908508A2/pt not_active IP Right Cessation
- 2009-01-23 AU AU2009207644A patent/AU2009207644A1/en not_active Withdrawn
- 2009-01-23 US US12/811,990 patent/US8796427B2/en active Active
- 2009-01-23 EP EP13165207.5A patent/EP2628753A1/en not_active Withdrawn
- 2009-01-23 RU RU2010133892/10A patent/RU2010133892A/ru unknown
- 2009-01-23 EP EP09704675A patent/EP2247619A1/en not_active Ceased
- 2009-01-23 CN CN200980102632.6A patent/CN101952317B/zh active Active
- 2009-01-23 CA CA2712220A patent/CA2712220A1/en not_active Abandoned
- 2009-01-23 WO PCT/EP2009/050795 patent/WO2009092805A1/en not_active Ceased
- 2009-01-23 JP JP2010543510A patent/JP5774312B2/ja active Active
- 2009-01-23 KR KR1020107017547A patent/KR20100110864A/ko not_active Withdrawn
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- 2010-06-27 IL IL206639A patent/IL206639A0/en unknown
- 2010-07-06 ZA ZA2010/04752A patent/ZA201004752B/en unknown
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2014
- 2014-08-01 US US14/449,346 patent/US9422368B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2010133892A (ru) | 2012-02-27 |
| EP2247619A1 (en) | 2010-11-10 |
| JP5774312B2 (ja) | 2015-09-09 |
| IL206639A0 (en) | 2010-12-30 |
| US20140341896A1 (en) | 2014-11-20 |
| KR20100110864A (ko) | 2010-10-13 |
| US20110052606A1 (en) | 2011-03-03 |
| EP2628753A1 (en) | 2013-08-21 |
| US9422368B2 (en) | 2016-08-23 |
| ZA201004752B (en) | 2011-04-28 |
| CN101952317B (zh) | 2015-07-22 |
| JP2011510047A (ja) | 2011-03-31 |
| MX2010007935A (es) | 2010-08-23 |
| WO2009092805A1 (en) | 2009-07-30 |
| CA2712220A1 (en) | 2009-07-30 |
| AU2009207644A1 (en) | 2009-07-30 |
| CN101952317A (zh) | 2011-01-19 |
| US8796427B2 (en) | 2014-08-05 |
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