DK159688C - Oploeselig baerer-bundet lever-uricase, fremgangsmaade til dens fremstilling og anvendelse - Google Patents

Oploeselig baerer-bundet lever-uricase, fremgangsmaade til dens fremstilling og anvendelse

Info

Publication number
DK159688C
DK159688C DK296682A DK296682A DK159688C DK 159688 C DK159688 C DK 159688C DK 296682 A DK296682 A DK 296682A DK 296682 A DK296682 A DK 296682A DK 159688 C DK159688 C DK 159688C
Authority
DK
Denmark
Prior art keywords
soluble
uricase
bare
procedure
manufacturing
Prior art date
Application number
DK296682A
Other languages
English (en)
Other versions
DK296682A (da
DK159688B (da
Inventor
Manfred Gloger
Josef Heinle
Helmut Schlumberger
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of DK296682A publication Critical patent/DK296682A/da
Publication of DK159688B publication Critical patent/DK159688B/da
Application granted granted Critical
Publication of DK159688C publication Critical patent/DK159688C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/62—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving uric acid

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicinal Preparation (AREA)
  • Bakery Products And Manufacturing Methods Therefor (AREA)
DK296682A 1981-07-07 1982-07-01 Oploeselig baerer-bundet lever-uricase, fremgangsmaade til dens fremstilling og anvendelse DK159688C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3126759 1981-07-07
DE19813126759 DE3126759A1 (de) 1981-07-07 1981-07-07 Loesliche leber-uricase, verfahren zu ihrer herstellung und verwendung

Publications (3)

Publication Number Publication Date
DK296682A DK296682A (da) 1983-01-08
DK159688B DK159688B (da) 1990-11-19
DK159688C true DK159688C (da) 1991-04-15

Family

ID=6136304

Family Applications (1)

Application Number Title Priority Date Filing Date
DK296682A DK159688C (da) 1981-07-07 1982-07-01 Oploeselig baerer-bundet lever-uricase, fremgangsmaade til dens fremstilling og anvendelse

Country Status (7)

Country Link
US (1) US4460683A (da)
EP (1) EP0069379B1 (da)
JP (1) JPS5841836B2 (da)
AT (1) ATE27967T1 (da)
DE (2) DE3126759A1 (da)
DK (1) DK159688C (da)
IE (1) IE53578B1 (da)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3515586A1 (de) * 1985-04-30 1986-11-06 Boehringer Mannheim Gmbh, 6800 Mannheim Stabilisiertes sarcosinoxidase-praeparat
DE3541186A1 (de) * 1985-11-21 1987-05-27 Boehringer Mannheim Gmbh Wasserloesliche, stabilisierte peroxidasederivate, verfahren zu ihrer herstellung und verwendung zur bestimmung von wasserstoffperoxid
USD299556S (en) 1986-09-16 1989-01-24 Marshbanks, Inc. Electric candle
JPH0648982B2 (ja) * 1986-10-06 1994-06-29 株式会社日立製作所 アミラーゼの分離精製方法およびそれに用いる吸着剤およびその分離精製装置
JPS6467186A (en) * 1987-09-04 1989-03-13 Kanebo Ltd Modified superoxide dismutase
EP0320483B1 (en) * 1987-12-11 1994-04-06 Monsanto Company Encapsulation method
JPH0269180A (ja) * 1988-09-02 1990-03-08 Daicel Chem Ind Ltd 高分子化酵素及びその製造方法
DE4011084A1 (de) * 1990-04-05 1991-10-10 Boehringer Mannheim Gmbh Saccharid-modifizierte, wasserloesliche proteine
FR2733914B1 (fr) * 1995-05-11 1997-08-01 Sanofi Sa Composition de liquide stable contenant de l'urate oxydase et composition lyophilisee pour sa preparation
US6541606B2 (en) 1997-12-31 2003-04-01 Altus Biologics Inc. Stabilized protein crystals formulations containing them and methods of making them
US6451572B1 (en) * 1998-06-25 2002-09-17 Cornell Research Foundation, Inc. Overexpression of phytase genes in yeast systems
EP2158923B1 (en) 1998-08-06 2013-02-27 Mountain View Pharmaceuticals, Inc. Peg-urate oxidase conjugates and use thereof
US20060188971A1 (en) * 1998-08-06 2006-08-24 Duke University Urate oxidase
CA2337967C (en) 1998-08-06 2011-11-01 Duke University Recombinant uricase protein
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
EP1165806B1 (en) * 1999-03-31 2005-08-03 Cornell Research Foundation, Inc. Phosphatases with improved phytase activity
US6841370B1 (en) 1999-11-18 2005-01-11 Cornell Research Foundation, Inc. Site-directed mutagenesis of Escherichia coli phytase
US6913915B2 (en) * 2001-08-02 2005-07-05 Phoenix Pharmacologics, Inc. PEG-modified uricase
PT2335501T (pt) * 2001-10-31 2016-10-28 Huvepharma Ad Alimento animal contendo fitase e método
DE60335497D1 (de) * 2002-09-13 2011-02-03 Cornell Res Foundation Inc Ergillus-phytasen
US20080159976A1 (en) * 2005-04-11 2008-07-03 Jacob Hartman Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
CN102807973A (zh) 2005-04-11 2012-12-05 萨文特医药公司 尿酸氧化酶的变体形式及其用途
WO2008051178A2 (en) * 2006-04-12 2008-05-02 Savient Pharmaceuticals, Inc. Purification of proteins with cationic surfactant
DK3321359T3 (da) 2005-04-11 2021-03-08 Horizon Pharma Rheumatology Llc Variante former af uratoxidase og anvendelse deraf
US8148123B2 (en) * 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
JP2008545665A (ja) * 2005-05-23 2008-12-18 ユニベルシテ ドゥ ジュネーブ 高体温による処置のための注入可能な超常磁性ナノ粒子および高体温インプラントを形成するための使用
US7919297B2 (en) 2006-02-21 2011-04-05 Cornell Research Foundation, Inc. Mutants of Aspergillus niger PhyA phytase and Aspergillus fumigatus phytase
WO2008017066A2 (en) * 2006-08-03 2008-02-07 Cornell Research Foundation, Inc. Phytases with improved thermal stability
US8192734B2 (en) 2007-07-09 2012-06-05 Cornell University Compositions and methods for bone strengthening
WO2009120707A1 (en) * 2008-03-24 2009-10-01 Altus Pharmaceuticals Inc. Uricase compositions and methods of use
RU2535038C2 (ru) 2009-06-25 2014-12-10 Криэлта Фармасьютикалз ЭлЭлСи Способы и наборы для прогнозирования риска инфузионных реакций и опосредованной антителами потери ответа при терапии пэгилированной уриказой с помощью мониторинга содержания мочевой кислоты в сыворотке крови
EP3538135A4 (en) 2016-11-11 2020-07-29 Horizon Pharma Rheumatology LLC POLYTHERAPIES OF PREDNISONE AND URICASE MOLECULES AND THEIR USES
US20200237881A1 (en) 2019-01-30 2020-07-30 Horizon Pharma Rheumatology Llc Reducing immunogenicity to pegloticase
US12121566B2 (en) 2019-01-30 2024-10-22 Horizon Therapeutics Usa, Inc. Methods for treating gout
CN115011586B (zh) * 2022-07-22 2024-07-23 江苏恰瑞生物科技有限公司 一种提高固定化尿酸酶酶活力的方法
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3625827A (en) * 1968-09-27 1971-12-07 Monsanto Co Water-soluble polymer-enzyme products
JPS6031472B2 (ja) * 1978-12-14 1985-07-22 協和醗酵工業株式会社 酸性ウリカ−ゼ
JPS55135590A (en) * 1979-04-05 1980-10-22 Mihama Hisaharu Modified asparaginase and uricase and their preparation

Also Published As

Publication number Publication date
IE53578B1 (en) 1988-12-21
ATE27967T1 (de) 1987-07-15
DE3276637D1 (en) 1987-07-30
US4460683A (en) 1984-07-17
EP0069379B1 (de) 1987-06-24
DE3126759A1 (de) 1983-01-27
EP0069379A3 (en) 1984-10-17
JPS5816680A (ja) 1983-01-31
IE821510L (en) 1983-01-07
EP0069379A2 (de) 1983-01-12
DK296682A (da) 1983-01-08
JPS5841836B2 (ja) 1983-09-14
DK159688B (da) 1990-11-19

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