DK160488C - Fremgangsmaade til fremstilling af symmetriske 1,4-dihydropyridiner - Google Patents

Fremgangsmaade til fremstilling af symmetriske 1,4-dihydropyridiner

Info

Publication number: DK160488C
Authority: DK; Denmark
Prior art keywords: formula; see diagramm; dihydropyridines; degrees; reaction
Prior art date: 1983-04-05

Application number

DK178584A

Other languages

English (en)

Other versions

DK160488B (da

DK178584D0 (da

DK178584A (da

Inventor

Werner Teller

Wolfgang Koebernick

Arthur Haaf

Paul Naab

Michael Preiss

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-04-05

Filing date

1984-04-04

Publication date

1991-08-26

1984-04-04 Application filed by Bayer Ag filed Critical Bayer Ag

1984-04-04 Publication of DK178584D0 publication Critical patent/DK178584D0/da

1984-10-06 Publication of DK178584A publication Critical patent/DK178584A/da

1991-03-18 Publication of DK160488B publication Critical patent/DK160488B/da

1991-08-26 Application granted granted Critical

1991-08-26 Publication of DK160488C publication Critical patent/DK160488C/da

Links

238000000034 method Methods 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
230000003197 catalytic effect Effects 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
-1 enamine compound Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
RAIYODFGMLZUDF-UHFFFAOYSA-N piperidin-1-ium;acetate Chemical compound CC([O-])=O.C1CC[NH2+]CC1 RAIYODFGMLZUDF-UHFFFAOYSA-N 0.000 abstract 1
230000008569 process Effects 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Manufacture Of Tobacco Products (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Air Supply (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Magnetic Ceramics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK178584A 1983-04-05 1984-04-04 Fremgangsmaade til fremstilling af symmetriske 1,4-dihydropyridiner DK160488C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3312216A DE3312216A1 (de)	1983-04-05	1983-04-05	Verfahren zur herstellung von symmetrischen 1,4-dihydropyridincarbonsaeureestern
DE3312216		1983-04-05

Publications (4)

Publication Number	Publication Date
DK178584D0 DK178584D0 (da)	1984-04-04
DK178584A DK178584A (da)	1984-10-06
DK160488B DK160488B (da)	1991-03-18
DK160488C true DK160488C (da)	1991-08-26

Family

ID=6195495

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK178584A DK160488C (da)	1983-04-05	1984-04-04	Fremgangsmaade til fremstilling af symmetriske 1,4-dihydropyridiner

Country Status (18)

Country	Link
EP (1)	EP0124742B1 (da)
JP (1)	JPH0662564B2 (da)
KR (2)	KR900004038B1 (da)
AT (1)	ATE36849T1 (da)
AU (1)	AU558122B2 (da)
CA (1)	CA1234573A (da)
DE (2)	DE3312216A1 (da)
DK (1)	DK160488C (da)
ES (1)	ES8501752A1 (da)
FI (1)	FI78471C (da)
GR (1)	GR81898B (da)
HU (1)	HU192546B (da)
IE (1)	IE57181B1 (da)
IL (1)	IL71425A (da)
NO (1)	NO166178C (da)
PH (1)	PH20992A (da)
PT (1)	PT78365B (da)
ZA (1)	ZA842510B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3312283A1 (de) *	1983-04-05	1984-10-18	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von unsymmetrischen 1,4-dihydropyridincarbonsaeureestern
DE3508533A1 (de) *	1985-03-09	1986-09-11	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von benzylidenverbindungen
US4771057A (en) *	1986-02-03	1988-09-13	University Of Alberta	Reduced pyridyl derivatives with cardiovascular regulating properties
DE4423445A1 (de) *	1994-07-05	1996-01-11	Bayer Ag	Katalysatorverfahren zur Herstellung von Nifedipin
DE19727350C1 (de) *	1997-06-27	1999-01-21	Bayer Ag	Verfahren zur Herstellung von Nifedipin

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1792764C3 (de) *	1967-03-20	1981-04-23	Bayer Ag, 5090 Leverkusen	Coronarmittel
DE1670824C3 (de) *	1967-03-20	1978-08-03	Bayer Ag, 5090 Leverkusen	1,4-Dihydropyridin-33-dicarbonsäurealkylester
DE2335466A1 (de) *	1973-07-12	1975-01-30	Bayer Ag	Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4370334A (en) *	1975-07-02	1983-01-25	Fujisawa Pharmaceutical Co., Ltd.	1,4-Dihydro-pyridine derivatives and methods of using same
DE2549568C3 (de) *	1975-11-05	1981-10-29	Bayer Ag, 5090 Leverkusen	2,6-Dimethyl-3-methoxycarbonyl-4- (2'-nitrophenyl)-1,4-dihydropyridin-5- carbonsäureisobutylester, mehrere Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel
JPS5936896B2 (ja) *	1976-10-21	1984-09-06	住友化学工業株式会社	α−アセチル桂皮酸エステル誘導体、その製造法および該化合物よりなる除草剤
CA1117117A (en) *	1978-10-10	1982-01-26	Fujisawa Pharmaceutical Co., Ltd.	2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same
JPS5529990A (en) *	1979-03-19	1980-03-03	Wako Pure Chem Ind Ltd	Activity measurement of monoamine oxidase (mao)

1983
- 1983-04-05 DE DE3312216A patent/DE3312216A1/de not_active Withdrawn
1984
- 1984-03-22 NO NO841142A patent/NO166178C/no not_active IP Right Cessation
- 1984-03-26 AT AT84103304T patent/ATE36849T1/de not_active IP Right Cessation
- 1984-03-26 EP EP84103304A patent/EP0124742B1/de not_active Expired
- 1984-03-26 DE DE8484103304T patent/DE3473756D1/de not_active Expired
- 1984-04-02 IL IL71425A patent/IL71425A/xx not_active IP Right Cessation
- 1984-04-02 JP JP59063438A patent/JPH0662564B2/ja not_active Expired - Lifetime
- 1984-04-03 GR GR74294A patent/GR81898B/el unknown
- 1984-04-03 ES ES531236A patent/ES8501752A1/es not_active Expired
- 1984-04-03 CA CA000451158A patent/CA1234573A/en not_active Expired
- 1984-04-03 PT PT78365A patent/PT78365B/pt unknown
- 1984-04-03 PH PH30491A patent/PH20992A/en unknown
- 1984-04-03 FI FI841336A patent/FI78471C/fi not_active IP Right Cessation
- 1984-04-04 DK DK178584A patent/DK160488C/da not_active IP Right Cessation
- 1984-04-04 AU AU26416/84A patent/AU558122B2/en not_active Expired
- 1984-04-04 IE IE828/84A patent/IE57181B1/en not_active IP Right Cessation
- 1984-04-04 KR KR1019840001767A patent/KR900004038B1/ko not_active Expired
- 1984-04-04 KR KR1019840001767A patent/KR840008647A/ko active Granted
- 1984-04-04 ZA ZA842510A patent/ZA842510B/xx unknown
- 1984-04-05 HU HU841337A patent/HU192546B/hu unknown

Also Published As

Publication number	Publication date
HUT34161A (en)	1985-02-28
DK160488B (da)	1991-03-18
NO166178C (no)	1991-06-19
IE57181B1 (en)	1992-05-20
IL71425A (en)	1988-02-29
AU2641684A (en)	1984-10-11
DK178584D0 (da)	1984-04-04
KR900004038B1 (ko)	1990-06-09
CA1234573A (en)	1988-03-29
FI841336A0 (fi)	1984-04-03
FI78471B (fi)	1989-04-28
PH20992A (en)	1987-06-18
KR850007882A (ko)	1985-12-09
DE3473756D1 (en)	1988-10-06
EP0124742A3 (en)	1987-05-27
DK178584A (da)	1984-10-06
ZA842510B (en)	1984-11-28
KR840008647A (ko)	1984-12-17
IL71425A0 (en)	1984-07-31
HU192546B (en)	1987-06-29
PT78365A (en)	1984-05-01
ES531236A0 (es)	1984-12-01
JPH0662564B2 (ja)	1994-08-17
DE3312216A1 (de)	1984-10-11
ATE36849T1 (de)	1988-09-15
AU558122B2 (en)	1987-01-22
PT78365B (en)	1986-05-28
FI841336A7 (fi)	1984-10-06
FI78471C (fi)	1989-08-10
EP0124742A2 (de)	1984-11-14
GR81898B (da)	1984-12-12
JPS59190968A (ja)	1984-10-29
IE840828L (en)	1984-10-05
NO841142L (no)	1984-10-08
EP0124742B1 (de)	1988-08-31
NO166178B (no)	1991-03-04
ES8501752A1 (es)	1984-12-01

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Legal Events

Date	Code	Title	Description
2004-04-19	PUP	Patent expired