DK178584A - Fremgangsmaade til fremstilling af symmetriske 1,4-dihydropyridiner - Google Patents

Fremgangsmaade til fremstilling af symmetriske 1,4-dihydropyridiner Download PDF

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Publication number
DK178584A
DK178584A DK178584A DK178584A DK178584A DK 178584 A DK178584 A DK 178584A DK 178584 A DK178584 A DK 178584A DK 178584 A DK178584 A DK 178584A DK 178584 A DK178584 A DK 178584A
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DK
Denmark
Prior art keywords
formula
see diagramm
dihydropyridines
degrees
compound
Prior art date
Application number
DK178584A
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English (en)
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DK178584D0 (da
DK160488C (da
DK160488B (da
Inventor
Werner Teller
Wolfgang Koebernick
Arthur Haaf
Paul Naab
Michael Preiss
Original Assignee
Bayer Ag
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Application filed by Bayer Ag filed Critical Bayer Ag
Publication of DK178584D0 publication Critical patent/DK178584D0/da
Publication of DK178584A publication Critical patent/DK178584A/da
Publication of DK160488B publication Critical patent/DK160488B/da
Application granted granted Critical
Publication of DK160488C publication Critical patent/DK160488C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Air Supply (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Magnetic Ceramics (AREA)

Description

med en enaminforbindeIse med formlen
Figure DK178584AD00021
(III) idet ylidenforbindelsen (II) fremstilles ved omsætning af en ketocarboxylsyreester med formlen
Figure DK178584AD00022
(IV) med et aldehyd RCHO i et opløsningsmiddel i nærværelse af katalytiske mængder af acetatsalte af aminer ved temperaturer fra -10°C til 100°C.
Forbindelserne (I) fås herved i stort udbytte og med høj renhedsgrad.
DK178584A 1983-04-05 1984-04-04 Fremgangsmaade til fremstilling af symmetriske 1,4-dihydropyridiner DK160488C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3312216A DE3312216A1 (de) 1983-04-05 1983-04-05 Verfahren zur herstellung von symmetrischen 1,4-dihydropyridincarbonsaeureestern
DE3312216 1983-04-05

Publications (4)

Publication Number Publication Date
DK178584D0 DK178584D0 (da) 1984-04-04
DK178584A true DK178584A (da) 1984-10-06
DK160488B DK160488B (da) 1991-03-18
DK160488C DK160488C (da) 1991-08-26

Family

ID=6195495

Family Applications (1)

Application Number Title Priority Date Filing Date
DK178584A DK160488C (da) 1983-04-05 1984-04-04 Fremgangsmaade til fremstilling af symmetriske 1,4-dihydropyridiner

Country Status (18)

Country Link
EP (1) EP0124742B1 (da)
JP (1) JPH0662564B2 (da)
KR (2) KR840008647A (da)
AT (1) ATE36849T1 (da)
AU (1) AU558122B2 (da)
CA (1) CA1234573A (da)
DE (2) DE3312216A1 (da)
DK (1) DK160488C (da)
ES (1) ES8501752A1 (da)
FI (1) FI78471C (da)
GR (1) GR81898B (da)
HU (1) HU192546B (da)
IE (1) IE57181B1 (da)
IL (1) IL71425A (da)
NO (1) NO166178C (da)
PH (1) PH20992A (da)
PT (1) PT78365B (da)
ZA (1) ZA842510B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3312283A1 (de) * 1983-04-05 1984-10-18 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von unsymmetrischen 1,4-dihydropyridincarbonsaeureestern
DE3508533A1 (de) * 1985-03-09 1986-09-11 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von benzylidenverbindungen
US4771057A (en) * 1986-02-03 1988-09-13 University Of Alberta Reduced pyridyl derivatives with cardiovascular regulating properties
DE4423445A1 (de) * 1994-07-05 1996-01-11 Bayer Ag Katalysatorverfahren zur Herstellung von Nifedipin
DE19727350C1 (de) * 1997-06-27 1999-01-21 Bayer Ag Verfahren zur Herstellung von Nifedipin

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670824C3 (de) * 1967-03-20 1978-08-03 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-33-dicarbonsäurealkylester
DE1792764C3 (de) * 1967-03-20 1981-04-23 Bayer Ag, 5090 Leverkusen Coronarmittel
DE2335466A1 (de) * 1973-07-12 1975-01-30 Bayer Ag Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US4370334A (en) * 1975-07-02 1983-01-25 Fujisawa Pharmaceutical Co., Ltd. 1,4-Dihydro-pyridine derivatives and methods of using same
DE2549568C3 (de) * 1975-11-05 1981-10-29 Bayer Ag, 5090 Leverkusen 2,6-Dimethyl-3-methoxycarbonyl-4- (2'-nitrophenyl)-1,4-dihydropyridin-5- carbonsäureisobutylester, mehrere Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel
JPS5936896B2 (ja) * 1976-10-21 1984-09-06 住友化学工業株式会社 α−アセチル桂皮酸エステル誘導体、その製造法および該化合物よりなる除草剤
CA1117117A (en) * 1978-10-10 1982-01-26 Fujisawa Pharmaceutical Co., Ltd. 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same
JPS5529990A (en) * 1979-03-19 1980-03-03 Wako Pure Chem Ind Ltd Activity measurement of monoamine oxidase (mao)

Also Published As

Publication number Publication date
KR840008647A (ko) 1984-12-17
DK178584D0 (da) 1984-04-04
ATE36849T1 (de) 1988-09-15
EP0124742A3 (en) 1987-05-27
IL71425A0 (en) 1984-07-31
JPS59190968A (ja) 1984-10-29
HU192546B (en) 1987-06-29
ZA842510B (en) 1984-11-28
DK160488C (da) 1991-08-26
CA1234573A (en) 1988-03-29
NO166178C (no) 1991-06-19
HUT34161A (en) 1985-02-28
IE840828L (en) 1984-10-05
PH20992A (en) 1987-06-18
NO166178B (no) 1991-03-04
FI78471B (fi) 1989-04-28
IL71425A (en) 1988-02-29
EP0124742A2 (de) 1984-11-14
KR850007882A (ko) 1985-12-09
ES531236A0 (es) 1984-12-01
FI841336A7 (fi) 1984-10-06
KR900004038B1 (ko) 1990-06-09
DK160488B (da) 1991-03-18
IE57181B1 (en) 1992-05-20
AU2641684A (en) 1984-10-11
DE3473756D1 (en) 1988-10-06
EP0124742B1 (de) 1988-08-31
DE3312216A1 (de) 1984-10-11
PT78365A (en) 1984-05-01
PT78365B (en) 1986-05-28
FI841336A0 (fi) 1984-04-03
ES8501752A1 (es) 1984-12-01
NO841142L (no) 1984-10-08
GR81898B (da) 1984-12-12
FI78471C (fi) 1989-08-10
AU558122B2 (en) 1987-01-22
JPH0662564B2 (ja) 1994-08-17

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