ES8501752A1 - Procedimiento para la obtencion de 1,4-dihidropiridinas simetricas - Google Patents
Procedimiento para la obtencion de 1,4-dihidropiridinas simetricasInfo
- Publication number
- ES8501752A1 ES8501752A1 ES531236A ES531236A ES8501752A1 ES 8501752 A1 ES8501752 A1 ES 8501752A1 ES 531236 A ES531236 A ES 531236A ES 531236 A ES531236 A ES 531236A ES 8501752 A1 ES8501752 A1 ES 8501752A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- see diagramm
- preparation
- dihydropyridine
- symmetric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000008569 process Effects 0.000 title abstract 2
- CUNSUQKHHZVKMU-UHFFFAOYSA-N 1,4-dihydropyridine-2-carboxylic acid Chemical class OC(=O)C1=CCC=CN1 CUNSUQKHHZVKMU-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- -1 enamine compound Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- RAIYODFGMLZUDF-UHFFFAOYSA-N piperidin-1-ium;acetate Chemical compound CC([O-])=O.C1CC[NH2+]CC1 RAIYODFGMLZUDF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Manufacture Of Tobacco Products (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Air Supply (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Magnetic Ceramics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 1,4-DIHIDROPIRIDINAS SIMETRICAS, DE FORMULA (I), EN LA QUE R ES FENILO; Y R1 ES ALQUILO C1-4.CONSISTE EN LA REACCION DE UN ESTER, DE FORMULA RCHO, EN LAS QUE R Y R1 SON LOS MISMOS QUE EN LA FORMULA (I), EN UN DISOLVENTE, EN PRESENCIA DE SALES DE ACETAL DE AMIDAS, SEGUIDA DEL TRATAMIENTO CON UN COMPUESTO DE FORMULA (II), EN LA QUE R Y R1 TIENEN EL SIGNIFICADO INDICADO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3312216A DE3312216A1 (de) | 1983-04-05 | 1983-04-05 | Verfahren zur herstellung von symmetrischen 1,4-dihydropyridincarbonsaeureestern |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8501752A1 true ES8501752A1 (es) | 1984-12-01 |
| ES531236A0 ES531236A0 (es) | 1984-12-01 |
Family
ID=6195495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES531236A Granted ES531236A0 (es) | 1983-04-05 | 1984-04-03 | Procedimiento para la obtencion de 1,4-dihidropiridinas simetricas |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0124742B1 (es) |
| JP (1) | JPH0662564B2 (es) |
| KR (2) | KR840008647A (es) |
| AT (1) | ATE36849T1 (es) |
| AU (1) | AU558122B2 (es) |
| CA (1) | CA1234573A (es) |
| DE (2) | DE3312216A1 (es) |
| DK (1) | DK160488C (es) |
| ES (1) | ES531236A0 (es) |
| FI (1) | FI78471C (es) |
| GR (1) | GR81898B (es) |
| HU (1) | HU192546B (es) |
| IE (1) | IE57181B1 (es) |
| IL (1) | IL71425A (es) |
| NO (1) | NO166178C (es) |
| PH (1) | PH20992A (es) |
| PT (1) | PT78365B (es) |
| ZA (1) | ZA842510B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3312283A1 (de) * | 1983-04-05 | 1984-10-18 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von unsymmetrischen 1,4-dihydropyridincarbonsaeureestern |
| DE3508533A1 (de) * | 1985-03-09 | 1986-09-11 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von benzylidenverbindungen |
| US4771057A (en) * | 1986-02-03 | 1988-09-13 | University Of Alberta | Reduced pyridyl derivatives with cardiovascular regulating properties |
| DE4423445A1 (de) * | 1994-07-05 | 1996-01-11 | Bayer Ag | Katalysatorverfahren zur Herstellung von Nifedipin |
| DE19727350C1 (de) * | 1997-06-27 | 1999-01-21 | Bayer Ag | Verfahren zur Herstellung von Nifedipin |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670824C3 (de) * | 1967-03-20 | 1978-08-03 | Bayer Ag, 5090 Leverkusen | 1,4-Dihydropyridin-33-dicarbonsäurealkylester |
| DE1792764C3 (de) * | 1967-03-20 | 1981-04-23 | Bayer Ag, 5090 Leverkusen | Coronarmittel |
| DE2335466A1 (de) * | 1973-07-12 | 1975-01-30 | Bayer Ag | Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| US4370334A (en) * | 1975-07-02 | 1983-01-25 | Fujisawa Pharmaceutical Co., Ltd. | 1,4-Dihydro-pyridine derivatives and methods of using same |
| DE2549568C3 (de) * | 1975-11-05 | 1981-10-29 | Bayer Ag, 5090 Leverkusen | 2,6-Dimethyl-3-methoxycarbonyl-4- (2'-nitrophenyl)-1,4-dihydropyridin-5- carbonsäureisobutylester, mehrere Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel |
| JPS5936896B2 (ja) * | 1976-10-21 | 1984-09-06 | 住友化学工業株式会社 | α−アセチル桂皮酸エステル誘導体、その製造法および該化合物よりなる除草剤 |
| CA1117117A (en) * | 1978-10-10 | 1982-01-26 | Fujisawa Pharmaceutical Co., Ltd. | 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same |
| JPS5529990A (en) * | 1979-03-19 | 1980-03-03 | Wako Pure Chem Ind Ltd | Activity measurement of monoamine oxidase (mao) |
-
1983
- 1983-04-05 DE DE3312216A patent/DE3312216A1/de not_active Withdrawn
-
1984
- 1984-03-22 NO NO841142A patent/NO166178C/no not_active IP Right Cessation
- 1984-03-26 AT AT84103304T patent/ATE36849T1/de not_active IP Right Cessation
- 1984-03-26 DE DE8484103304T patent/DE3473756D1/de not_active Expired
- 1984-03-26 EP EP84103304A patent/EP0124742B1/de not_active Expired
- 1984-04-02 JP JP59063438A patent/JPH0662564B2/ja not_active Expired - Lifetime
- 1984-04-02 IL IL71425A patent/IL71425A/xx not_active IP Right Cessation
- 1984-04-03 FI FI841336A patent/FI78471C/fi not_active IP Right Cessation
- 1984-04-03 GR GR74294A patent/GR81898B/el unknown
- 1984-04-03 CA CA000451158A patent/CA1234573A/en not_active Expired
- 1984-04-03 PH PH30491A patent/PH20992A/en unknown
- 1984-04-03 PT PT78365A patent/PT78365B/pt unknown
- 1984-04-03 ES ES531236A patent/ES531236A0/es active Granted
- 1984-04-04 KR KR1019840001767A patent/KR840008647A/ko active Granted
- 1984-04-04 ZA ZA842510A patent/ZA842510B/xx unknown
- 1984-04-04 AU AU26416/84A patent/AU558122B2/en not_active Expired
- 1984-04-04 KR KR1019840001767A patent/KR900004038B1/ko not_active Expired
- 1984-04-04 DK DK178584A patent/DK160488C/da not_active IP Right Cessation
- 1984-04-04 IE IE828/84A patent/IE57181B1/en not_active IP Right Cessation
- 1984-04-05 HU HU841337A patent/HU192546B/hu unknown
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