DK1619191T3 - Fremgangsmåde til fremstilling af optisk aktive 2-[6-hydroxymethyl)-1,3-dioxan-4-yl]-eddikesyre-derivater - Google Patents

Fremgangsmåde til fremstilling af optisk aktive 2-[6-hydroxymethyl)-1,3-dioxan-4-yl]-eddikesyre-derivater

Info

Publication number
DK1619191T3
DK1619191T3 DK05017110.7T DK05017110T DK1619191T3 DK 1619191 T3 DK1619191 T3 DK 1619191T3 DK 05017110 T DK05017110 T DK 05017110T DK 1619191 T3 DK1619191 T3 DK 1619191T3
Authority
DK
Denmark
Prior art keywords
dioxan
hydroxymethyl
optically active
acetic acid
acid derivatives
Prior art date
Application number
DK05017110.7T
Other languages
English (en)
Inventor
Yukio Yamada
Yoshihiko Yasohara
Akira Nishiyama
Makoto Miyazaki
Masaru Mitsuda
Takeshi Kondo
Noboru Ueyama
Kenji Inoue
Noriyuki Kizaki
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Application granted granted Critical
Publication of DK1619191T3 publication Critical patent/DK1619191T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
DK05017110.7T 1998-08-05 1999-08-05 Fremgangsmåde til fremstilling af optisk aktive 2-[6-hydroxymethyl)-1,3-dioxan-4-yl]-eddikesyre-derivater DK1619191T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP22149598 1998-08-05
JP15803399 1999-06-04
EP03025159A EP1394157B1 (en) 1998-08-05 1999-08-05 Process for the preparation of 3,5-dihydroxy substituted esters as intermediates for producing optically active 2-(6-(hydroxymethyl)-1,3-dioxan-4-yl) acetic acid dervatives

Publications (1)

Publication Number Publication Date
DK1619191T3 true DK1619191T3 (da) 2011-01-31

Family

ID=26485288

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05017110.7T DK1619191T3 (da) 1998-08-05 1999-08-05 Fremgangsmåde til fremstilling af optisk aktive 2-[6-hydroxymethyl)-1,3-dioxan-4-yl]-eddikesyre-derivater

Country Status (14)

Country Link
US (2) US6472544B1 (da)
EP (3) EP1024139B1 (da)
JP (1) JP3803551B2 (da)
KR (1) KR100654115B1 (da)
CN (2) CN100376682C (da)
AT (3) ATE375989T1 (da)
CA (1) CA2305564C (da)
DE (3) DE69917204T2 (da)
DK (1) DK1619191T3 (da)
ES (2) ES2221406T3 (da)
HU (1) HUP0101122A3 (da)
NO (1) NO325591B1 (da)
PT (1) PT1619191E (da)
WO (1) WO2000008011A1 (da)

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US7081546B2 (en) 2003-01-16 2006-07-25 Lg Life Sciences Ltd. Process for preparing a 5-hydroxy-3-oxo-hexanoic acid derivative
EP1660669A4 (en) 2003-08-11 2008-10-01 Codexis Inc ENZYMATIC PROCEDURES FOR THE PREPARATION OF 4-SUBSTITUTED 3-HYDROXYBUTYLIC ACID DERIVATIVES AND OF VICINAL CYANO, HYDROXY-SUBSTITUTED CARBOXYLIC ACID ESTERS
EP1654356A1 (en) * 2003-08-11 2006-05-10 Codexis, Inc. Improved halohydrin dehalogenases and related polynucleotides
EP1654354A1 (en) * 2003-08-11 2006-05-10 Codexis, Inc. Improved ketoreductase polypeptides and related polynucleotides
JP2007502114A (ja) * 2003-08-11 2007-02-08 コデクシス， インコーポレイテッド 改良されたグルコースデヒドロゲナーゼポリペプチドおよび関連ポリヌクレオチド
US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
US7588928B2 (en) * 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
US7879585B2 (en) 2006-10-02 2011-02-01 Codexis, Inc. Ketoreductase enzymes and uses thereof
KR101130717B1 (ko) * 2008-05-14 2012-03-28 웰이앤씨 주식회사 ＨＭＧ-ＣｏＡ 환원 저해제의 제조를 위한 키랄 중간체의제조방법
WO2010080635A2 (en) * 2008-12-18 2010-07-15 Codexis, Inc. Recombinant halohydrin dehalogenase polypeptides
CN101624390B (zh) * 2009-03-09 2014-06-11 鲁南制药集团股份有限公司 一种瑞舒伐他汀钙侧链关键中间体的制备方法
KR101157314B1 (ko) * 2009-06-05 2012-06-15 주식회사종근당 로수바스타틴의 신규한 제조방법, 이 제조에 유용한 중간체 화합물 및 그의 제조방법
GB2474687A (en) * 2009-10-23 2011-04-27 Phoenix Chemicals Ltd A continuous process for the production of (R)-6-cyano-5-hydroxy-3-oxo-hexanoic acid tert-butyl ester (and derivatives)
GB2482525A (en) * 2010-08-05 2012-02-08 Phoenix Chemicals Ltd A process for the production of acyloxymethyldioxanylacetic derivatives
WO2012098050A1 (en) 2011-01-18 2012-07-26 Dsm Sinochem Pharmaceuticals Netherlands B.V. Methyltetrazole sulfides and sulfones
ES2601479T3 (es) 2011-01-18 2017-02-15 Dsm Sinochem Pharmaceuticals Netherlands B.V. Proceso para la preparación de diolsulfonas
CN103313983B (zh) 2011-01-18 2016-06-29 中化帝斯曼制药有限公司荷兰公司 在碱存在下制备他汀类化合物的方法
CN102180862B (zh) * 2011-03-24 2013-08-28 烟台万润精细化工股份有限公司 一种(4R-cis)-6-取代-2,2-二甲基-1,3-二氧六环-4-乙酸叔丁酯的制备方法
WO2012130920A1 (en) 2011-04-01 2012-10-04 Lonza Ltd Preparation of 3,5-dioxo hexanoate ester
JP2014529336A (ja) 2011-07-19 2014-11-06 スンシネ ルアケ プハルマ カンパニー リミテッド スタチン薬中間体及びその製造
EP2788341B1 (en) 2011-12-09 2017-04-05 DSM Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of a thioprecursor for statins
CN102643757B (zh) * 2011-12-29 2013-09-11 浙江工业大学 生物催化制备6-氰基-(3r,5r)-二羟基己酸叔丁酯及菌株
GB201212777D0 (en) * 2012-07-18 2012-08-29 Bakhu Pharma Ltd Process for crossed claisen condensation reactions promoted by lithium amide in liquid ammonia
CN103435592B (zh) * 2013-08-12 2015-02-04 南京欧信医药技术有限公司 2-((4r,6s)-6-甲醛基-2,2-二甲基-1,3二氧六环-4-基)-乙酸甲酯的制备方法
CN105622566B (zh) * 2014-11-19 2018-07-27 上海弈柯莱生物医药科技有限公司 一种3,5-二取代羟基-6-取代己酸酯衍生物的制备方法
CN105669637A (zh) * 2014-11-21 2016-06-15 南京博优康远生物医药科技有限公司 一种3,5,6-取代己酸酯衍生物的制备方法
CN104789505B (zh) * 2015-04-23 2018-03-06 苏州东和盛昌生物科技有限公司 还原制备顺式3,5‑二羟基己酸酯化合物的方法及菌种
CN106011094B (zh) * 2016-07-27 2020-11-03 苏州汉酶生物技术有限公司 工程化酮还原酶多肽及其用于制备(3r,5s)-6-氯-3,5-二羟基己酸叔丁酯的方法

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Also Published As

Publication number Publication date
US6903225B2 (en) 2005-06-07
ATE486068T1 (de) 2010-11-15
CN1566351A (zh) 2005-01-19
CA2305564C (en) 2008-06-17
CN1162422C (zh) 2004-08-18
EP1394157B1 (en) 2007-10-17
KR100654115B1 (ko) 2006-12-05
US20030040634A1 (en) 2003-02-27
EP1619191A2 (en) 2006-01-25
EP1619191B1 (en) 2010-10-27
CN1274356A (zh) 2000-11-22
EP1394157A3 (en) 2004-03-17
EP1394157A2 (en) 2004-03-03
DE69937374T2 (de) 2008-07-24
PT1619191E (pt) 2010-12-21
DE69942897D1 (de) 2010-12-09
EP1024139A4 (en) 2002-04-17
EP1619191A3 (en) 2006-08-23
DE69917204D1 (de) 2004-06-17
ES2221406T3 (es) 2004-12-16
EP1024139A1 (en) 2000-08-02
CN100376682C (zh) 2008-03-26
ATE375989T1 (de) 2007-11-15
EP1024139B1 (en) 2004-05-12
US6472544B1 (en) 2002-10-29
ES2294236T3 (es) 2008-04-01
NO20001703D0 (no) 2000-04-03
ATE266656T1 (de) 2004-05-15
WO2000008011A1 (fr) 2000-02-17
NO325591B1 (no) 2008-06-23
NO20001703L (no) 2000-04-03
HUP0101122A2 (hu) 2001-08-28
DE69937374D1 (de) 2007-11-29
HUP0101122A3 (en) 2006-02-28
JP3803551B2 (ja) 2006-08-02
KR20010030819A (ko) 2001-04-16
CA2305564A1 (en) 2000-02-17
DE69917204T2 (de) 2005-06-23

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