DK1638551T3 - Immunosuppressive forbindelser og sammensætninger - Google Patents
Immunosuppressive forbindelser og sammensætningerInfo
- Publication number
- DK1638551T3 DK1638551T3 DK04752678.5T DK04752678T DK1638551T3 DK 1638551 T3 DK1638551 T3 DK 1638551T3 DK 04752678 T DK04752678 T DK 04752678T DK 1638551 T3 DK1638551 T3 DK 1638551T3
- Authority
- DK
- Denmark
- Prior art keywords
- compositions
- immunosuppressive compounds
- diseases
- immunosuppressant
- prevention
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000001506 immunosuppresive effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 102000036530 EDG receptors Human genes 0.000 abstract 1
- 108091007263 EDG receptors Proteins 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229960003444 immunosuppressant agent Drugs 0.000 abstract 1
- 230000001861 immunosuppressant effect Effects 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47193103P | 2003-05-19 | 2003-05-19 | |
| PCT/US2004/015701 WO2004103309A2 (en) | 2003-05-19 | 2004-05-19 | Immunosuppressant compounds and compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1638551T3 true DK1638551T3 (da) | 2012-04-02 |
Family
ID=33476902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04752678.5T DK1638551T3 (da) | 2003-05-19 | 2004-05-19 | Immunosuppressive forbindelser og sammensætninger |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7462629B2 (da) |
| EP (1) | EP1638551B1 (da) |
| JP (1) | JP4575920B2 (da) |
| CN (4) | CN1791592B (da) |
| AT (1) | ATE537825T1 (da) |
| AU (2) | AU2004240649A1 (da) |
| BR (1) | BRPI0410454A (da) |
| CA (1) | CA2524054C (da) |
| CY (1) | CY1112505T1 (da) |
| DK (1) | DK1638551T3 (da) |
| ES (1) | ES2379169T3 (da) |
| MX (1) | MXPA05012459A (da) |
| PL (1) | PL1638551T3 (da) |
| PT (1) | PT1638551E (da) |
| SI (1) | SI1638551T1 (da) |
| WO (1) | WO2004103309A2 (da) |
| ZA (1) | ZA200508203B (da) |
Families Citing this family (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2533587A1 (en) * | 2002-07-30 | 2004-02-05 | University Of Virginia Patent Foundation | Compounds active in sphingosine 1-phosphate signaling |
| EP1661881B1 (en) * | 2003-08-29 | 2014-12-17 | Ono Pharmaceutical Co., Ltd. | Compound capable of binding s1p receptor and pharmaceutical use thereof |
| WO2005041899A2 (en) * | 2003-11-03 | 2005-05-12 | University Of Virginia Patent Foundation | Orally available sphingosine 1-phosphate receptor agonists and antagonists |
| JP4740884B2 (ja) * | 2004-02-24 | 2011-08-03 | アイアールエム・リミテッド・ライアビリティ・カンパニー | 免疫抑制性化合物および組成物 |
| TW200538433A (en) | 2004-02-24 | 2005-12-01 | Irm Llc | Immunosuppressant compounds and compositiions |
| CN101014329B (zh) | 2004-07-16 | 2010-09-08 | 杏林制药株式会社 | 用于对器官或组织的移植的排异反应或骨髓移植的移植物抗宿主反应预防或治疗的药物组合物 |
| EP1806338B1 (en) | 2004-10-12 | 2016-01-20 | Kyorin Pharmaceutical Co., Ltd. | Process for producing 2-amino-2-[2-[4-(3-benzyloxy-phenylthio)-2-chlorophenyl[ethyl]-1,3-propanediol hydrochloride and hydrates thereof. and intermediates the production thereof |
| JP2008522977A (ja) * | 2004-12-06 | 2008-07-03 | ユニバーシティ オブ バージニア パテント ファンデーション | スフィンゴシン=1−リン酸のアリールアミドアナログ |
| EP2592066B1 (en) * | 2004-12-13 | 2014-12-03 | Ono Pharmaceutical Co., Ltd. | Aminocarboxylic acid derivative and medical use thereof |
| US20080206240A1 (en) * | 2005-02-08 | 2008-08-28 | Shreeram Aradhye | Antilymphocyte Antibody Induction |
| AU2006214314B2 (en) | 2005-02-14 | 2012-02-09 | University Of Virginia Patent Foundation | Sphingosine 1- phos phate agonists comprising cycloalkanes and 5 -membered heterocycles substituted by amino and phenyl groups |
| CN101203512A (zh) * | 2005-04-22 | 2008-06-18 | 第一三共株式会社 | 杂环化合物 |
| WO2007024922A1 (en) * | 2005-08-23 | 2007-03-01 | Irm Llc | Immunosuppressant compounds and compositions |
| SI1932522T1 (sl) * | 2005-10-07 | 2012-08-31 | Kyorin Seiyaku Kk | Terapevtsko sredstvo za jetrno bolezen, ki vsebuje 2-amino-1,3- propandiolni derivat kot aktivno sestavino |
| KR20080086546A (ko) * | 2006-01-27 | 2008-09-25 | 유니버시티 오브 버지니아 페이턴트 파운데이션 | 신경병증성 통증의 치료 방법 |
| TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| AU2007212193A1 (en) * | 2006-02-09 | 2007-08-16 | University Of Virginia Patent Foundation | Bicyclic sphingosine 1-phosphate analogs |
| JP5188972B2 (ja) * | 2006-08-08 | 2013-04-24 | 杏林製薬株式会社 | アミノリン酸エステル誘導体及びそれらを有効成分とするs1p受容体調節剤 |
| MX2009001457A (es) | 2006-08-08 | 2009-02-19 | Kyorin Seiyaku Kk | Derivados de aminoalcohol e inmunosupresores que contienen lo mismo como ingrediente activo. |
| CA2669104A1 (en) * | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity |
| CA2669102A1 (en) * | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Tetralin analogs having sphingosine 1-phosphate agonist activity |
| AU2007323557A1 (en) * | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity |
| JP5411141B2 (ja) | 2007-09-10 | 2014-02-12 | カルシメディカ,インク. | 細胞内カルシウムを調節する化合物 |
| WO2009060278A1 (en) * | 2007-11-08 | 2009-05-14 | Pfizer Inc. | Cyclobutyl carboxylic acid derivatives |
| GB0725104D0 (en) * | 2007-12-21 | 2008-01-30 | Glaxo Group Ltd | Compounds |
| GB0725101D0 (en) * | 2007-12-21 | 2008-01-30 | Glaxo Group Ltd | Compounds |
| WO2009099174A1 (ja) | 2008-02-07 | 2009-08-13 | Kyorin Pharmaceutical Co., Ltd. | アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤 |
| US20090298894A1 (en) * | 2008-04-21 | 2009-12-03 | Asahi Kasei Pharma Corporation | Amino acid compounds |
| GB0807910D0 (en) * | 2008-04-30 | 2008-06-04 | Glaxo Group Ltd | Compounds |
| EA019252B1 (ru) | 2008-07-23 | 2014-02-28 | Арена Фармасьютикалз, Инк. | ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ (1,2,3,4-ТЕТРАГИДРОЦИКЛОПЕНТА[b]ИНДОЛ-3-ИЛ)УКСУСНОЙ КИСЛОТЫ, ПРИМЕНИМЫЕ В ЛЕЧЕНИИ АУТОИММУННЫХ И ВОСПАЛИТЕЛЬНЫХ РАССТРОЙСТВ |
| US9149459B2 (en) * | 2008-07-23 | 2015-10-06 | Novartis Ag | Sphingosine 1 phosphate receptor modulators and their use to treat muscle inflammation |
| US7906553B2 (en) | 2008-08-27 | 2011-03-15 | Calcimedica, Inc. | Substituted thiophene modulators of intracellular calcium |
| SI2342205T1 (sl) | 2008-08-27 | 2016-09-30 | Arena Pharmaceuticals, Inc. | Substituirani triciklični kislinski derivati kot agonisti S1P1 receptorja, uporabni v zdravljenju avtoimunskih in vnetnih obolenj |
| NZ592748A (en) * | 2008-10-17 | 2013-01-25 | Akaal Pharma Pty Ltd | 2-Amino-(oxadiazol-3-yl)-benzofuran derivatives and their use as S1P receptor modulators |
| CA2747558A1 (en) * | 2008-12-18 | 2010-07-15 | Novartis Ag | New salts |
| WO2010069949A1 (en) * | 2008-12-18 | 2010-06-24 | Merck Serono S.A. | Oxadiazole fused heterocyclic derivatives useful for the treatment of multiple sclerosis |
| CN102256942B (zh) * | 2008-12-18 | 2013-07-24 | 诺瓦提斯公司 | 1-(4-{1-[(e)-4-环己基-3-三氟甲基-苄氧基亚氨基]-乙基}-2-乙基-苄基)-氮杂环丁烷-3-甲酸的多晶型物 |
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| UA107360C2 (en) | 2009-08-05 | 2014-12-25 | Biogen Idec Inc | Bicyclic aryl sphingosine 1-phosphate analogs |
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| JP5939158B2 (ja) * | 2009-11-24 | 2016-06-22 | アラーガン、インコーポレイテッドAllergan,Incorporated | 治療的有用性を有する受容体調節物質としての新規化合物 |
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2004
- 2004-05-19 CN CN2004800139502A patent/CN1791592B/zh not_active Expired - Fee Related
- 2004-05-19 US US10/849,450 patent/US7462629B2/en not_active Expired - Fee Related
- 2004-05-19 AT AT04752678T patent/ATE537825T1/de active
- 2004-05-19 WO PCT/US2004/015701 patent/WO2004103309A2/en not_active Ceased
- 2004-05-19 DK DK04752678.5T patent/DK1638551T3/da active
- 2004-05-19 JP JP2006533219A patent/JP4575920B2/ja not_active Expired - Fee Related
- 2004-05-19 PL PL04752678T patent/PL1638551T3/pl unknown
- 2004-05-19 ES ES04752678T patent/ES2379169T3/es not_active Expired - Lifetime
- 2004-05-19 EP EP04752678A patent/EP1638551B1/en not_active Expired - Lifetime
- 2004-05-19 PT PT04752678T patent/PT1638551E/pt unknown
- 2004-05-19 MX MXPA05012459A patent/MXPA05012459A/es active IP Right Grant
- 2004-05-19 US US10/849,079 patent/US7060697B2/en not_active Expired - Fee Related
- 2004-05-19 AU AU2004240649A patent/AU2004240649A1/en not_active Abandoned
- 2004-05-19 CN CN2004800131943A patent/CN1787817B/zh not_active Expired - Fee Related
- 2004-05-19 CN CN2004800188602A patent/CN1816544B/zh not_active Expired - Fee Related
- 2004-05-19 CA CA2524054A patent/CA2524054C/en not_active Expired - Fee Related
- 2004-05-19 BR BRPI0410454-4A patent/BRPI0410454A/pt not_active IP Right Cessation
- 2004-05-19 CN CN2004800132486A patent/CN1791395B/zh not_active Expired - Lifetime
- 2004-05-19 SI SI200431832T patent/SI1638551T1/sl unknown
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2005
- 2005-10-11 ZA ZA200508203A patent/ZA200508203B/en unknown
-
2008
- 2008-07-11 AU AU2008203088A patent/AU2008203088A1/en not_active Abandoned
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2012
- 2012-03-16 CY CY20121100286T patent/CY1112505T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200508203B (en) | 2007-02-28 |
| MXPA05012459A (es) | 2006-02-22 |
| PL1638551T3 (pl) | 2012-05-31 |
| EP1638551A4 (en) | 2008-12-31 |
| AU2008203088A1 (en) | 2008-08-07 |
| US20050014724A1 (en) | 2005-01-20 |
| EP1638551B1 (en) | 2011-12-21 |
| ES2379169T3 (es) | 2012-04-23 |
| CN1791592A (zh) | 2006-06-21 |
| JP4575920B2 (ja) | 2010-11-04 |
| CN1791395A (zh) | 2006-06-21 |
| WO2004103309A3 (en) | 2005-03-03 |
| SI1638551T1 (sl) | 2012-04-30 |
| CN1787817A (zh) | 2006-06-14 |
| CN1787817B (zh) | 2011-09-07 |
| CN1816544A (zh) | 2006-08-09 |
| ATE537825T1 (de) | 2012-01-15 |
| WO2004103309A2 (en) | 2004-12-02 |
| US7462629B2 (en) | 2008-12-09 |
| EP1638551A2 (en) | 2006-03-29 |
| US7060697B2 (en) | 2006-06-13 |
| CA2524054C (en) | 2012-04-24 |
| PT1638551E (pt) | 2012-03-28 |
| HK1090559A1 (en) | 2006-12-29 |
| BRPI0410454A (pt) | 2006-06-13 |
| JP2006528987A (ja) | 2006-12-28 |
| CN1816544B (zh) | 2011-06-08 |
| CN1791395B (zh) | 2012-09-26 |
| CN1791592B (zh) | 2012-07-04 |
| AU2004240649A1 (en) | 2004-12-02 |
| US20050009786A1 (en) | 2005-01-13 |
| CA2524054A1 (en) | 2004-12-02 |
| CY1112505T1 (el) | 2015-12-09 |
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