DK1641780T3 - Fremgangsmåder til fremstilling af 1-[(benzimidazol-1yl)quinolin-8-yl]-piperidin-4-ylamin-derivater - Google Patents
Fremgangsmåder til fremstilling af 1-[(benzimidazol-1yl)quinolin-8-yl]-piperidin-4-ylamin-derivaterInfo
- Publication number
- DK1641780T3 DK1641780T3 DK04736779T DK04736779T DK1641780T3 DK 1641780 T3 DK1641780 T3 DK 1641780T3 DK 04736779 T DK04736779 T DK 04736779T DK 04736779 T DK04736779 T DK 04736779T DK 1641780 T3 DK1641780 T3 DK 1641780T3
- Authority
- DK
- Denmark
- Prior art keywords
- benzimidazol
- quinolin
- piperidin
- preparation
- methods
- Prior art date
Links
- ZPCBPHZWHMRXLJ-UHFFFAOYSA-N 1-[2-(benzimidazol-1-yl)quinolin-8-yl]piperidin-4-amine Chemical class C1CC(N)CCN1C1=CC=CC2=CC=C(N3C4=CC=CC=C4N=C3)N=C12 ZPCBPHZWHMRXLJ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48217603P | 2003-06-24 | 2003-06-24 | |
| PCT/IB2004/001983 WO2004113322A1 (en) | 2003-06-24 | 2004-06-14 | Processes for the preparation of 1-[(benzoimidazole-1yl) quinolin-8-yl] piperidin-4-ylamine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1641780T3 true DK1641780T3 (da) | 2009-02-02 |
Family
ID=33539339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04736779T DK1641780T3 (da) | 2003-06-24 | 2004-06-14 | Fremgangsmåder til fremstilling af 1-[(benzimidazol-1yl)quinolin-8-yl]-piperidin-4-ylamin-derivater |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7183414B2 (da) |
| EP (1) | EP1641780B1 (da) |
| JP (1) | JP2007516168A (da) |
| KR (2) | KR20070092333A (da) |
| CN (1) | CN100404530C (da) |
| AR (1) | AR044849A1 (da) |
| AT (1) | ATE414077T1 (da) |
| AU (1) | AU2004249511B2 (da) |
| BR (1) | BRPI0411794A (da) |
| CA (1) | CA2529032C (da) |
| CL (1) | CL2004001470A1 (da) |
| CO (1) | CO5650165A2 (da) |
| DE (1) | DE602004017731D1 (da) |
| DK (1) | DK1641780T3 (da) |
| ES (1) | ES2315663T3 (da) |
| IL (1) | IL172064A (da) |
| MX (1) | MXPA05014203A (da) |
| NO (1) | NO20060376L (da) |
| NZ (2) | NZ543714A (da) |
| RU (1) | RU2323214C2 (da) |
| SG (1) | SG161745A1 (da) |
| TW (1) | TWI294425B (da) |
| WO (1) | WO2004113322A1 (da) |
| ZA (1) | ZA200509253B (da) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0411421D0 (en) * | 2004-05-21 | 2004-06-23 | Glaxo Group Ltd | Novel compounds |
| CA2582479C (en) * | 2004-10-07 | 2011-07-12 | Pfizer Products Inc. | Benzoimidazole derivatives useful as antiproliferative agents |
| BRPI0610514A2 (pt) * | 2005-04-05 | 2016-11-16 | Pharmacopeia Inc | composto, composição farmacêutica, e, método de tratamento de um distúrbio |
| US7504513B2 (en) | 2006-02-27 | 2009-03-17 | Hoffman-La Roche Inc. | Thiazolyl-benzimidazoles |
| JP5576370B2 (ja) | 2008-08-06 | 2014-08-20 | ファイザー・インク | Ｃｈｋ−１阻害剤としての６置換２−ヘテロシクリルアミノピラジン化合物 |
| JP2012512223A (ja) | 2008-12-18 | 2012-05-31 | エフ．ホフマン−ラ ロシュ アーゲー | チアゾリル−ベンズイミダゾール類 |
| CN101993416B (zh) * | 2009-08-27 | 2013-09-11 | 中国科学院上海药物研究所 | 喹啉类化合物、其制备方法、包含该化合物的药物组合物及该化合物的用途 |
| JP6407504B2 (ja) | 2012-09-21 | 2018-10-17 | アログ・ファーマシューティカルズ・インコーポレイテッドＡｒｏｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 恒常的に活性であるリン酸化型ｆｌｔ３キナーゼの阻害方法 |
| US10835525B2 (en) | 2012-09-26 | 2020-11-17 | Arog Pharmaceuticals, Inc. | Method of inhibiting mutant C-KIT |
| US11642340B2 (en) | 2012-09-26 | 2023-05-09 | Arog Pharmaceuticals, Inc. | Method of inhibiting mutant C-KIT |
| TWI599356B (zh) | 2012-09-26 | 2017-09-21 | 安羅格製藥有限責任公司 | 抑制突變型ｃ－ｋｉｔ的方法 |
| BR112015016282A2 (en) | 2013-01-07 | 2017-07-11 | Arog Pharmaceuticals, Inc. | crenolanib for treatment of mutated flt3 proliferative disorders |
| US10463658B2 (en) | 2013-10-25 | 2019-11-05 | Videra Pharmaceuticals, Llc | Method of inhibiting FLT3 kinase |
| US12534764B2 (en) | 2016-11-02 | 2026-01-27 | Arog Pharmaceuticals, Inc. | Crenolanib for treating FLT3 mutated proliferative disorders associated mutations |
| US12662706B2 (en) | 2016-11-02 | 2026-06-23 | Arog Pharmaceuticals, Inc. | Crenolanib for treating FLT3 mutated proliferative disorders associated mutations |
| KR20180074792A (ko) | 2016-11-02 | 2018-07-03 | 아로그 파마슈티칼스, 인코퍼레이티드 | 돌연변이 연관된 flt3 돌연변이된 증식성 장애를 치료하기 위한 크레노라닙 |
| CN107382984B (zh) * | 2017-08-24 | 2020-07-10 | 扬州市三药制药有限公司 | 一种治疗白血病药物的制备方法 |
| CN107382983B (zh) * | 2017-08-24 | 2020-08-07 | 扬州市三药制药有限公司 | 一种治疗白血病药物的合成方法 |
| CN110840893A (zh) | 2018-12-13 | 2020-02-28 | 安罗格制药有限责任公司 | 含克莱拉尼的药物组合物及其用途 |
| CN109678849A (zh) * | 2019-01-16 | 2019-04-26 | 北京悦康科创医药科技股份有限公司 | 一种抗癌药物的制备方法 |
| US11471451B2 (en) | 2019-08-19 | 2022-10-18 | Arog Pharmaceuticals, Inc. | Uses of crenolanib |
| CN117447376B (zh) * | 2019-12-09 | 2026-06-09 | 苏州恩华生物医药科技有限公司 | 连双环结构sigma-1受体抑制剂 |
| CN114981298B (zh) | 2019-12-12 | 2024-08-20 | 听治疗有限责任公司 | 用于预防和治疗听力损失的组合物和方法 |
| WO2022019998A1 (en) | 2020-07-20 | 2022-01-27 | Arog Pharmaceuticals, Inc. | Crystal forms of crenolanib and methods of use thereof |
| AU2021320860A1 (en) | 2020-08-05 | 2023-02-23 | The General Hospital Corporation | Salt inducible kinase inhibitors |
| US20220079934A1 (en) * | 2020-09-17 | 2022-03-17 | Arog Pharmaceuticals, Inc. | Crenolanib for treating pain |
| US11524006B2 (en) | 2020-09-17 | 2022-12-13 | Arog Pharmaceuticals, Inc. | Crenolanib for treating TRK kinase associated proliferative disorders |
| WO2022090547A1 (en) | 2020-10-30 | 2022-05-05 | Dsm Ip Assets B.V. | Production of carotenoids by fermentation |
| US11969420B2 (en) | 2020-10-30 | 2024-04-30 | Arog Pharmaceuticals, Inc. | Combination therapy of crenolanib and apoptosis pathway agents for the treatment of proliferative disorders |
| CN113683594B (zh) * | 2021-09-07 | 2022-12-27 | 曲靖师范学院 | 一种喹啉-苯并咪唑盐类化合物及其合成方法和应用 |
| JP2023063189A (ja) | 2021-10-22 | 2023-05-09 | アログ・ファーマシューティカルズ・インコーポレイテッド | 以前の治療に対して再発性／不応性のｆｌｔ３突然変異増殖性障害を治療するためのクレノラニブ |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4897401A (en) * | 1987-06-19 | 1990-01-30 | Janssen Pharmaceutical N.V. | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases |
| US5478832A (en) * | 1992-05-08 | 1995-12-26 | The Green Cross Corporation | Quinoline compounds |
| WO1998038156A1 (en) * | 1997-02-27 | 1998-09-03 | Takeda Chemical Industries, Ltd. | Amine compounds, their production and use as amyloid-beta production inhibitors |
| UA75055C2 (uk) * | 1999-11-30 | 2006-03-15 | Пфайзер Продактс Інк. | Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі |
| JP4554135B2 (ja) * | 1999-12-10 | 2010-09-29 | 富士フイルム株式会社 | インクジェットヘッドおよび印刷装置 |
| US6515179B2 (en) * | 2000-09-14 | 2003-02-04 | Kaneka Corporation | Process for the removal of nitrobenzenesulfonyl |
| PA8580301A1 (es) * | 2002-08-28 | 2005-05-24 | Pfizer Prod Inc | Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos |
-
2004
- 2004-06-14 DK DK04736779T patent/DK1641780T3/da active
- 2004-06-14 NZ NZ543714A patent/NZ543714A/en not_active IP Right Cessation
- 2004-06-14 SG SG200700254-6A patent/SG161745A1/en unknown
- 2004-06-14 CN CNB2004800175706A patent/CN100404530C/zh not_active Expired - Lifetime
- 2004-06-14 NZ NZ571898A patent/NZ571898A/en not_active IP Right Cessation
- 2004-06-14 CL CL200401470A patent/CL2004001470A1/es unknown
- 2004-06-14 AT AT04736779T patent/ATE414077T1/de not_active IP Right Cessation
- 2004-06-14 EP EP04736779A patent/EP1641780B1/en not_active Expired - Lifetime
- 2004-06-14 WO PCT/IB2004/001983 patent/WO2004113322A1/en not_active Ceased
- 2004-06-14 MX MXPA05014203A patent/MXPA05014203A/es active IP Right Grant
- 2004-06-14 RU RU2005138367/04A patent/RU2323214C2/ru active
- 2004-06-14 KR KR1020077019713A patent/KR20070092333A/ko not_active Withdrawn
- 2004-06-14 KR KR1020057024593A patent/KR100787649B1/ko not_active Expired - Fee Related
- 2004-06-14 BR BRPI0411794-8A patent/BRPI0411794A/pt not_active IP Right Cessation
- 2004-06-14 DE DE602004017731T patent/DE602004017731D1/de not_active Expired - Lifetime
- 2004-06-14 ES ES04736779T patent/ES2315663T3/es not_active Expired - Lifetime
- 2004-06-14 CA CA002529032A patent/CA2529032C/en not_active Expired - Lifetime
- 2004-06-14 AU AU2004249511A patent/AU2004249511B2/en not_active Ceased
- 2004-06-14 JP JP2006516552A patent/JP2007516168A/ja active Pending
- 2004-06-22 AR ARP040102160A patent/AR044849A1/es unknown
- 2004-06-23 TW TW093118112A patent/TWI294425B/zh not_active IP Right Cessation
- 2004-06-23 US US10/875,030 patent/US7183414B2/en not_active Expired - Lifetime
-
2005
- 2005-11-15 ZA ZA200509253A patent/ZA200509253B/en unknown
- 2005-11-20 IL IL172064A patent/IL172064A/en active IP Right Grant
- 2005-12-20 CO CO05127734A patent/CO5650165A2/es active IP Right Grant
-
2006
- 2006-01-24 NO NO20060376A patent/NO20060376L/no not_active Application Discontinuation
- 2006-12-05 US US11/567,071 patent/US20070088032A1/en not_active Abandoned
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