DK1644485T3 - Udskilte proteiner som markører for celledifferentiering - Google Patents

Udskilte proteiner som markører for celledifferentiering

Info

Publication number
DK1644485T3
DK1644485T3 DK04740821.6T DK04740821T DK1644485T3 DK 1644485 T3 DK1644485 T3 DK 1644485T3 DK 04740821 T DK04740821 T DK 04740821T DK 1644485 T3 DK1644485 T3 DK 1644485T3
Authority
DK
Denmark
Prior art keywords
cells
differentiation
markers
cell differentiation
secreted proteins
Prior art date
Application number
DK04740821.6T
Other languages
English (en)
Inventor
Andreas Ehlich
Heribert Bohlen
Silke Schwengberg
Original Assignee
Axiogenesis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axiogenesis Ag filed Critical Axiogenesis Ag
Application granted granted Critical
Publication of DK1644485T3 publication Critical patent/DK1644485T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK04740821.6T 2003-07-08 2004-07-08 Udskilte proteiner som markører for celledifferentiering DK1644485T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48546203P 2003-07-08 2003-07-08
EP03015400 2003-07-08
PCT/EP2004/007529 WO2005005662A2 (en) 2003-07-08 2004-07-08 Secreted proteins as markers for cell differentiation

Publications (1)

Publication Number Publication Date
DK1644485T3 true DK1644485T3 (da) 2011-08-15

Family

ID=34923783

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04740821.6T DK1644485T3 (da) 2003-07-08 2004-07-08 Udskilte proteiner som markører for celledifferentiering

Country Status (9)

Country Link
US (1) US20090328243A1 (da)
EP (1) EP1644485B9 (da)
JP (1) JP2009513106A (da)
AT (1) ATE508183T1 (da)
AU (1) AU2004256208B2 (da)
CA (1) CA2559791A1 (da)
DK (1) DK1644485T3 (da)
ES (1) ES2365786T3 (da)
WO (1) WO2005005662A2 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1740945T3 (da) * 2004-04-07 2019-01-21 Ncardia Ag Kke-invasive, in-vitro funktionele vævspøvesystemer
JP4814875B2 (ja) 2004-05-11 2011-11-16 アキシオジェネシス エージー ｉｎｖｉｔｒｏ分化細胞に基づく薬物発見のための検定
JP5421767B2 (ja) * 2006-04-10 2014-02-19 ウィスコンシン・アルムニ・リサーチ・ファウンデーション ヒト胚性幹細胞を使用して薬学的化合物および他の化学物質の毒性を評価するための試薬および方法
JP5428527B2 (ja) * 2008-06-03 2014-02-26 住友化学株式会社 化学物質が有する発生毒性の予測方法
EP2460006A2 (en) * 2009-07-31 2012-06-06 Chromocell Corporation Methods and compositions for identifying and validating modulators of cell fate
JP5814337B2 (ja) 2010-03-22 2015-11-17 ステミナ バイオマーカー ディスカバリー， インコーポレイテッド ヒト幹細胞様細胞及びメタボロミクスを使用した医薬のヒト発生毒性の予測
GB201007197D0 (en) * 2010-04-30 2010-06-16 Ge Healthcare Uk Ltd Methods and kits for determining the toxicity of an agent
EP3999660A1 (en) * 2019-07-19 2022-05-25 Toxys B.V. Methods to determine the effect of an agent on mammalian embryonic development

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06189770A (ja) * 1992-06-01 1994-07-12 Takeda Chem Ind Ltd 発現用プロモーターおよびその用途
US5602301A (en) * 1993-11-16 1997-02-11 Indiana University Foundation Non-human mammal having a graft and methods of delivering protein to myocardial tissue
AU3409295A (en) * 1994-08-18 1996-03-14 Ariad Gene Therapeutics, Inc. Regulatable elimination of gene expression, gene product function and engineered host cells
CA2203613C (en) * 1997-04-24 2008-01-15 Navneet K. Ahluwalia Secreted .alpha.-amylase as a reporter gene
GB9708526D0 (en) * 1997-04-25 1997-06-18 Royal Free Hosp School Med Eukaryotic gene expression cassette and uses thereof
DE19727962A1 (de) * 1997-07-02 1999-01-14 Juergen Hescheler Fluoreszierende Proteine als zelltypspezifische Reporter
CA2300390A1 (en) 1997-08-12 1999-02-25 Human Genome Sciences, Inc. Human frezzled-like protein
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
EP1192168A4 (en) 1999-04-21 2003-04-16 Human Genome Sciences Inc galectin
US20020042386A1 (en) * 2000-01-31 2002-04-11 Rosen Craig A. Nucleic acids, proteins, and antibodies
JP2002051782A (ja) 2000-08-09 2002-02-19 Sankyo Co Ltd 骨粗鬆症もしくは関節リウマチの治療または予防剤の試験方法
CN100557016C (zh) * 2000-12-27 2009-11-04 爱克西欧詹妮西斯公开股份有限公司 用于细胞特异和发育特异性选择分化的胚干细胞、成人干细胞和胚种系细胞的系统
WO2002086073A2 (en) 2001-04-20 2002-10-31 Memorial Sloan-Kettering Cancer Center Generation of differentiated tissue from nuclear transfer embryonic stem cells and methods of use
CA2458575C (en) 2001-08-24 2014-07-08 Advanced Cell Technology, Inc. Screening assays for identifying differentiation-inducing agents and production of differentiated cells for cell therapy
WO2003048345A1 (en) * 2001-12-07 2003-06-12 Toolgen, Inc. Phenotypic screen of chimeric proteins
US9321997B2 (en) * 2003-06-20 2016-04-26 Axiogenesis Ag Tissue modeling in embryonic stem (ES) cell system
AU2004256209B2 (en) 2003-07-08 2010-04-08 Axiogenesis Ag Novel method for the preparation of embryoid bodies (EBs) and uses thereof

Also Published As

Publication number Publication date
ES2365786T3 (es) 2011-10-11
EP1644485B1 (en) 2011-05-04
AU2004256208A1 (en) 2005-01-20
ES2365786T9 (es) 2012-02-20
CA2559791A1 (en) 2005-01-20
EP1644485A2 (en) 2006-04-12
AU2004256208B2 (en) 2010-05-20
EP1644485B9 (en) 2012-01-04
US20090328243A1 (en) 2009-12-31
WO2005005662A2 (en) 2005-01-20
JP2009513106A (ja) 2009-04-02
WO2005005662A3 (en) 2005-05-12
ATE508183T1 (de) 2011-05-15

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