DK1646608T3 - Tricykliske derivater eller farmaceutisk acceptable salte deraf, deres fremstillinger og farmaceutiske sammensætninger indeholdende dem - Google Patents
Tricykliske derivater eller farmaceutisk acceptable salte deraf, deres fremstillinger og farmaceutiske sammensætninger indeholdende demInfo
- Publication number
- DK1646608T3 DK1646608T3 DK04773996.6T DK04773996T DK1646608T3 DK 1646608 T3 DK1646608 T3 DK 1646608T3 DK 04773996 T DK04773996 T DK 04773996T DK 1646608 T3 DK1646608 T3 DK 1646608T3
- Authority
- DK
- Denmark
- Prior art keywords
- tricyclic derivatives
- preparations
- pharmaceutically acceptable
- pharmaceutical compositions
- acceptable salts
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical class C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 abstract 1
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 239000004037 angiogenesis inhibitor Substances 0.000 abstract 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 229940045695 antineooplastic colchicine derivative Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229960001338 colchicine Drugs 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 231100001231 less toxic Toxicity 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
- 231100000820 toxicity test Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
- C07C321/22—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
- C07C2603/34—Benzoheptalenes; Hydrogenated benzoheptalenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20030041547 | 2003-06-25 | ||
| PCT/KR2004/001518 WO2004113281A1 (en) | 2003-06-25 | 2004-06-23 | Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1646608T3 true DK1646608T3 (da) | 2011-06-14 |
Family
ID=36091400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04773996.6T DK1646608T3 (da) | 2003-06-25 | 2004-06-23 | Tricykliske derivater eller farmaceutisk acceptable salte deraf, deres fremstillinger og farmaceutiske sammensætninger indeholdende dem |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20070179143A1 (da) |
| EP (1) | EP1646608B1 (da) |
| JP (1) | JP4430071B2 (da) |
| KR (1) | KR100667464B1 (da) |
| CN (1) | CN100393698C (da) |
| AT (1) | ATE500216T1 (da) |
| AU (1) | AU2004249639B2 (da) |
| CA (1) | CA2531543C (da) |
| DE (1) | DE602004031621D1 (da) |
| DK (1) | DK1646608T3 (da) |
| ES (1) | ES2358801T3 (da) |
| RU (1) | RU2326864C2 (da) |
| WO (1) | WO2004113281A1 (da) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7622612B2 (en) | 2001-05-28 | 2009-11-24 | Chemtech Research Incorporation | Tricyclic derivatives and their use |
| US20070135380A1 (en) * | 2005-08-12 | 2007-06-14 | Radiorx, Inc. | O-nitro compounds, pharmaceutical compositions thereof and uses thereof |
| US7507842B2 (en) | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
| WO2007097279A1 (ja) | 2006-02-21 | 2007-08-30 | Toyama Chemical Co., Ltd. | ３－｛５－［４－（シクロペンチルオキシ）－２－ヒドロキシベンゾイル］－２－［（３－オキソ－２－置換－２，３－ジヒドロ－１，２－ベンズイソオキサゾール－６－イル）メトキシ］フェニル｝プロピオン酸エステルの製造法およびその中間体 |
| KR101077609B1 (ko) | 2009-07-08 | 2011-10-27 | 제일약품주식회사 | 트리사이클릭 유도체의 제조방법 |
| DK2470499T3 (da) | 2009-08-26 | 2019-09-23 | Alberta Health Services | Nye colchicin-derivativer, fremgangsmåder og anvendelse deraf |
| US8471041B2 (en) | 2010-02-09 | 2013-06-25 | Alliant Techsystems Inc. | Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same |
| KR101130754B1 (ko) * | 2010-06-25 | 2012-03-28 | 제일약품주식회사 | 난용성 트리사이클릭 유도체 화합물의 용해도가 향상된 약학적 조성물 |
| US8664247B2 (en) | 2011-08-26 | 2014-03-04 | Radiorx, Inc. | Acyclic organonitro compounds for use in treating cancer |
| JP6019126B2 (ja) | 2011-10-07 | 2016-11-02 | エピセントアーレックス・インコーポレイテッドＥｐｉｃｅｎｔＲｘ， Ｉｎｃ． | 有機ニトロチオエーテル化合物およびその医療用途 |
| US20140308260A1 (en) | 2011-10-07 | 2014-10-16 | Radiorx, Inc. | Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products |
| KR101494280B1 (ko) * | 2012-12-28 | 2015-02-23 | 한국화학연구원 | 콜치신 유도체를 유효성분으로 포함하는 암의 예방 또는 치료용 조성물 |
| JO3705B1 (ar) | 2014-11-26 | 2021-01-31 | Bayer Pharma AG | إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية |
| CN104649943B (zh) * | 2015-01-28 | 2016-10-05 | 中国科学院上海高等研究院 | 秋水仙碱衍生物及其制备方法和应用 |
| US10342778B1 (en) | 2015-10-20 | 2019-07-09 | Epicentrx, Inc. | Treatment of brain metastases using organonitro compound combination therapy |
| US9987270B1 (en) | 2015-10-29 | 2018-06-05 | Epicentrix, Inc. | Treatment of gliomas using organonitro compound combination therapy |
| SG11201805942UA (en) | 2016-01-11 | 2018-08-30 | Epicentrx Inc | Compositions and methods for intravenous administration of 2-bromo-1-(3,3-dinitroazetidin-1-yl)ethanone |
| JP6947743B2 (ja) | 2016-03-03 | 2021-10-13 | バイエル・ファルマ・アクティエンゲゼルシャフト | 新規な２−置換インダゾール、その製造方法、それを含有する医薬製剤、および薬物を製造するためのその使用 |
| WO2017207385A1 (de) | 2016-05-31 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Substituierte 3-methylindazole, verfahren zu ihrer herstellung, pharmazeutische präparate, die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln |
| UA124237C2 (uk) | 2016-06-01 | 2021-08-11 | Байєр Енімал Хелс Гмбх | Заміщені індазоли, придатні для лікування і попередження алергійних і/або запальних захворювань у тварин |
| WO2018060174A1 (de) | 2016-09-29 | 2018-04-05 | Bayer Pharma Aktiengesellschaft | Substituierte benzimidazole, pharmazeutische präparate diese enthaltend, sowie deren verwendung zur herstellung von arzneimitteln |
| EA201990949A1 (ru) | 2016-10-14 | 2019-10-31 | Сульфоксиалкильные органические нитросоединения и родственные соединения и фармацевтические композиции для применения в медицине | |
| US10538503B2 (en) | 2016-10-26 | 2020-01-21 | Ishihara Sangyo Kaisha, Ltd. | Method for producing 3-methyl-2-thiophenecarboxylic acid |
| KR102869384B1 (ko) | 2017-07-07 | 2025-10-15 | 에피센트알엑스, 인코포레이티드 | 치료제의 비경구 투여를 위한 조성물 |
| WO2019164593A2 (en) | 2018-01-08 | 2019-08-29 | Epicentrx, Inc. | Methods and compositions utilizing rrx-001 combination therapy for radioprotection |
| KR20250172901A (ko) | 2018-06-29 | 2025-12-09 | 알버타 헬스 서비시즈 | 콜히친 유도체의 방법 및 용도 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4533675A (en) | 1984-04-17 | 1985-08-06 | The United States Of America As Represented By The Department Of Health And Human Services | Carbamates of colchicine for treatment of gout |
| IT1270124B (it) * | 1994-10-05 | 1997-04-28 | Indena Spa | Derivati della colchicina e loro impiego terapeutico |
| IT1276996B1 (it) * | 1995-06-27 | 1997-11-04 | Indena Spa | Derivati della colchicina, loro uso e formulazioni che li contengono |
| IT1291550B1 (it) | 1997-04-11 | 1999-01-11 | Indena Spa | Derivati della colchicina e della tiocolchicina ad attivita' antinfiammatoria e miorilassante |
| DE60222131D1 (de) * | 2001-05-28 | 2007-10-11 | Chemtech Res Inc | Neues alkaloidderivat und dieses enthaltende pharmazeutische zusammensetzung |
-
2004
- 2004-06-23 EP EP04773996A patent/EP1646608B1/en not_active Expired - Lifetime
- 2004-06-23 AU AU2004249639A patent/AU2004249639B2/en not_active Ceased
- 2004-06-23 US US10/562,615 patent/US20070179143A1/en not_active Abandoned
- 2004-06-23 JP JP2006515341A patent/JP4430071B2/ja not_active Expired - Lifetime
- 2004-06-23 CA CA2531543A patent/CA2531543C/en not_active Expired - Fee Related
- 2004-06-23 RU RU2006101987/04A patent/RU2326864C2/ru not_active IP Right Cessation
- 2004-06-23 WO PCT/KR2004/001518 patent/WO2004113281A1/en not_active Ceased
- 2004-06-23 DE DE602004031621T patent/DE602004031621D1/de not_active Expired - Lifetime
- 2004-06-23 DK DK04773996.6T patent/DK1646608T3/da active
- 2004-06-23 AT AT04773996T patent/ATE500216T1/de active
- 2004-06-23 KR KR1020040047277A patent/KR100667464B1/ko not_active Expired - Lifetime
- 2004-06-23 ES ES04773996T patent/ES2358801T3/es not_active Expired - Lifetime
- 2004-06-23 CN CNB2004800212673A patent/CN100393698C/zh not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR20050001383A (ko) | 2005-01-06 |
| DE602004031621D1 (de) | 2011-04-14 |
| JP4430071B2 (ja) | 2010-03-10 |
| EP1646608A4 (en) | 2006-11-22 |
| EP1646608A1 (en) | 2006-04-19 |
| AU2004249639B2 (en) | 2008-07-17 |
| AU2004249639A1 (en) | 2004-12-29 |
| HK1095133A1 (zh) | 2007-04-27 |
| KR100667464B1 (ko) | 2007-01-10 |
| JP2007520422A (ja) | 2007-07-26 |
| CN100393698C (zh) | 2008-06-11 |
| ATE500216T1 (de) | 2011-03-15 |
| ES2358801T3 (es) | 2011-05-13 |
| CA2531543A1 (en) | 2004-12-29 |
| RU2006101987A (ru) | 2006-07-10 |
| RU2326864C2 (ru) | 2008-06-20 |
| CA2531543C (en) | 2010-10-12 |
| CN1826316A (zh) | 2006-08-30 |
| US20070179143A1 (en) | 2007-08-02 |
| WO2004113281A1 (en) | 2004-12-29 |
| EP1646608B1 (en) | 2011-03-02 |
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