IS8117A - 3-Flúr-píperidín sem NMDA/NR2B mótlyf - Google Patents

3-Flúr-píperidín sem NMDA/NR2B mótlyf

Info

Publication number: IS8117A
Authority: IS; Iceland
Prior art keywords: nmda; piperidine; fluoro; nr2b antagonist; nr2b
Prior art date: 2003-06-04

Application number

IS8117A

Other languages

English (en)

Inventor

L. Liverton Nigel

F. Claiborne Christopher

A. Claremon David

A. Mccauley John

Original Assignee

Merck & Co., Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-04

Filing date

2005-11-07

Publication date

2005-11-07

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33511734&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IS8117(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-11-07 Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.

2005-11-07 Publication of IS8117A publication Critical patent/IS8117A/is

Links

YUKQZLBLVRAJSW-UHFFFAOYSA-N 3-fluoropiperidine Chemical compound FC1CCCNC1 YUKQZLBLVRAJSW-UHFFFAOYSA-N 0.000 title 1
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title 1
102000034527 Retinoid X Receptors Human genes 0.000 title 1
108010038912 Retinoid X Receptors Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Virology (AREA)
Immunology (AREA)
Addiction (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Psychology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Biotechnology (AREA)
Diabetes (AREA)

IS8117A 2003-06-04 2005-11-07 3-Flúr-píperidín sem NMDA/NR2B mótlyf IS8117A (is)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US47593803P	2003-06-04	2003-06-04
PCT/US2004/017175 WO2004108705A1 (en)	2003-06-04	2004-05-28	3-fluoro-piperidines as nmda/nr2b antagonists

Publications (1)

Publication Number	Publication Date
IS8117A true IS8117A (is)	2005-11-07

Family

ID=33511734

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IS8117A IS8117A (is)	2003-06-04	2005-11-07	3-Flúr-píperidín sem NMDA/NR2B mótlyf

Country Status (30)

Country	Link
EP (1)	EP1648882B1 (is)
JP (1)	JP3927228B2 (is)
KR (1)	KR20060017839A (is)
CN (1)	CN1798744A (is)
AR (1)	AR044579A1 (is)
AT (1)	ATE403651T1 (is)
AU (1)	AU2004245522B2 (is)
BR (1)	BRPI0410837A (is)
CA (1)	CA2527093C (is)
CL (1)	CL2004001365A1 (is)
CO (1)	CO5700762A2 (is)
DE (1)	DE602004015610D1 (is)
DK (1)	DK1648882T3 (is)
EC (1)	ECSP056192A (is)
ES (1)	ES2309540T3 (is)
HR (1)	HRP20080490T3 (is)
IS (1)	IS8117A (is)
MA (1)	MA27781A1 (is)
MX (1)	MXPA05013151A (is)
MY (1)	MY138547A (is)
NO (1)	NO20060020L (is)
PE (1)	PE20050245A1 (is)
PL (1)	PL1648882T3 (is)
PT (1)	PT1648882E (is)
RU (1)	RU2339630C2 (is)
SI (1)	SI1648882T1 (is)
TW (1)	TW200510378A (is)
UA (1)	UA81319C2 (is)
WO (1)	WO2004108705A1 (is)
ZA (1)	ZA200509000B (is)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007128056A1 (en) *	2006-05-03	2007-11-15	Cnsbio Pty Ltd	Methods and composition for treatment of inflammatory pain
MX2009011416A (es) *	2007-04-23	2009-11-05	Janssen Pharmaceutica Nv	Tia(di)azoles como antagonistas del receptor de dopamina 2 de disociacion rapida.
EP2175886A1 (en) *	2007-06-28	2010-04-21	CNSBio Pty Ltd	Combination methods and compositions for treatment of neuropathic pain
JP2013519722A (ja)	2010-02-16	2013-05-30	ファイザー・インク	（ｒ）−４−（（４−（（４−（テトラヒドロフラン−３−イルオキシ）ベンゾ［ｄ］イソオキサゾール−３−イルオキシ）メチル）ピペリジン−１−イル）メチル）テトラヒドロ−２ｈ−ピラン−４−オール、５−ｈｔ４受容体の部分アゴニスト
AU2013251079B2 (en)	2012-04-20	2017-03-23	Ucb Pharma S.A.	Methods for treating Parkinson's disease
CN103936663B (zh) *	2013-01-23	2016-12-28	艾琪康医药科技（上海）有限公司	一种1-r1-3,3-二氟(或3-氟)-4-r2-4-氨甲基哌啶及其衍生物的制备方法
US9187506B2 (en)	2014-01-09	2015-11-17	Bristol-Myers Squibb Company	(R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one and its prodrugs for the treatment of psychiatric disorders
US9221796B2 (en)	2014-01-09	2015-12-29	Bristol-Myers Squibb Company	Selective NR2B antagonists
TW201609741A (zh)	2014-06-04	2016-03-16	盧郡控股（開曼）有限公司	作為ｎｒ２ｂｎｍｄａ受體拮抗劑之二氟乙基吡啶衍生物
WO2016044323A1 (en)	2014-09-15	2016-03-24	Rugen Holdings (Cayman) Limited	Pyrrolopyrimidine derivatives as nr2b nmda receptor antagonists
WO2016049048A1 (en) *	2014-09-22	2016-03-31	Rugen Holdings (Cayman) Limited	Treatment of anxiety disorders and autism spectrum disorders
WO2016106135A1 (en)	2014-12-23	2016-06-30	Cerecor, Inc.	Compounds, compositions and methods
EP3253761A4 (en)	2015-02-04	2018-06-20	Rugen Holdings (Cayman) Limited	3,3-difluoro-piperidine derivatives as nr2b nmda receptor antagonists
MX380424B (es) *	2015-06-01	2025-03-12	Rugen Holdings Cayman Ltd	Compuestos heterociclicos de 3,3-difluorpiperidina carbamato como antagonistas del receptor de n-metil-d-aspartato (nmda) nr2b.
WO2017066368A1 (en)	2015-10-14	2017-04-20	Bristol-Myers Squibb Company	Selective nr2b antagonists
CA3001890A1 (en)	2015-10-14	2017-04-20	Bristol-Myers Squibb Company	Selective nr2b antagonists
CA3021675C (en)	2016-08-31	2024-06-25	Eisai R&D Management Co., Ltd.	Pyrazolo[1,5-a]pyrimidine compound
WO2018098128A1 (en)	2016-11-22	2018-05-31	Rugen Holdings (Cayman) Limited	Treatment of autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EA005974B1 (ru) *	2001-02-23	2005-08-25	Мерк Энд Ко., Инк.	N-замещенные неарильные гетероциклические антагонисты nmda/nr2b

2004
- 2004-05-28 CA CA002527093A patent/CA2527093C/en not_active Expired - Lifetime
- 2004-05-28 MX MXPA05013151A patent/MXPA05013151A/es active IP Right Grant
- 2004-05-28 AT AT04753896T patent/ATE403651T1/de not_active IP Right Cessation
- 2004-05-28 RU RU2005137704/04A patent/RU2339630C2/ru not_active IP Right Cessation
- 2004-05-28 HR HR20080490T patent/HRP20080490T3/xx unknown
- 2004-05-28 SI SI200430845T patent/SI1648882T1/sl unknown
- 2004-05-28 DK DK04753896T patent/DK1648882T3/da active
- 2004-05-28 KR KR1020057023218A patent/KR20060017839A/ko not_active Ceased
- 2004-05-28 EP EP04753896A patent/EP1648882B1/en not_active Expired - Lifetime
- 2004-05-28 DE DE602004015610T patent/DE602004015610D1/de not_active Expired - Lifetime
- 2004-05-28 PL PL04753896T patent/PL1648882T3/pl unknown
- 2004-05-28 UA UAA200511411A patent/UA81319C2/uk unknown
- 2004-05-28 BR BRPI0410837-0A patent/BRPI0410837A/pt not_active IP Right Cessation
- 2004-05-28 CN CNA2004800153228A patent/CN1798744A/zh active Pending
- 2004-05-28 ES ES04753896T patent/ES2309540T3/es not_active Expired - Lifetime
- 2004-05-28 WO PCT/US2004/017175 patent/WO2004108705A1/en not_active Ceased
- 2004-05-28 JP JP2006515051A patent/JP3927228B2/ja not_active Expired - Lifetime
- 2004-05-28 AU AU2004245522A patent/AU2004245522B2/en not_active Expired
- 2004-05-28 PT PT04753896T patent/PT1648882E/pt unknown
- 2004-05-31 AR ARP040101878A patent/AR044579A1/es unknown
- 2004-05-31 MY MYPI20042091A patent/MY138547A/en unknown
- 2004-06-01 PE PE2004000552A patent/PE20050245A1/es not_active Application Discontinuation
- 2004-06-03 CL CL200401365A patent/CL2004001365A1/es unknown
- 2004-06-03 TW TW093115972A patent/TW200510378A/zh unknown
2005
- 2005-11-07 IS IS8117A patent/IS8117A/is unknown
- 2005-11-07 ZA ZA200509000A patent/ZA200509000B/en unknown
- 2005-11-28 MA MA28626A patent/MA27781A1/fr unknown
- 2005-11-29 EC EC2005006192A patent/ECSP056192A/es unknown
- 2005-11-30 CO CO05121658A patent/CO5700762A2/es not_active Application Discontinuation
2006
- 2006-01-03 NO NO20060020A patent/NO20060020L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HRP20080490T3 (en)	2008-11-30
MY138547A (en)	2009-06-30
ECSP056192A (es)	2006-04-19
EP1648882B1 (en)	2008-08-06
ATE403651T1 (de)	2008-08-15
PT1648882E (pt)	2008-10-20
EP1648882A1 (en)	2006-04-26
AR044579A1 (es)	2005-09-21
MXPA05013151A (es)	2006-03-17
CN1798744A (zh)	2006-07-05
DE602004015610D1 (de)	2008-09-18
JP2006526650A (ja)	2006-11-24
RU2339630C2 (ru)	2008-11-27
PE20050245A1 (es)	2005-04-13
KR20060017839A (ko)	2006-02-27
CO5700762A2 (es)	2006-11-30
UA81319C2 (en)	2007-12-25
PL1648882T3 (pl)	2008-12-31
TW200510378A (en)	2005-03-16
MA27781A1 (fr)	2006-02-01
JP3927228B2 (ja)	2007-06-06
BRPI0410837A (pt)	2006-06-27
SI1648882T1 (sl)	2009-02-28
CL2004001365A1 (es)	2005-05-06
NO20060020L (no)	2006-03-03
DK1648882T3 (da)	2008-11-24
WO2004108705A1 (en)	2004-12-16
RU2005137704A (ru)	2006-05-27
ZA200509000B (en)	2006-12-27
AU2004245522A1 (en)	2004-12-16
CA2527093C (en)	2009-10-20
AU2004245522B2 (en)	2009-10-29
ES2309540T3 (es)	2008-12-16
CA2527093A1 (en)	2004-12-16

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