DK1651612T5 - 3,4-Disubstituerede 1H-pyrazolforbindelser og deres anvendelse som cyclinafhængige kinaser (CDK) og glykogensynthasekinase-3-(GSK)-modulatorer - Google Patents

3,4-Disubstituerede 1H-pyrazolforbindelser og deres anvendelse som cyclinafhængige kinaser (CDK) og glykogensynthasekinase-3-(GSK)-modulatorer

Info

Publication number: DK1651612T5
Authority: DK; Denmark
Prior art keywords: hydrogen; alkoxy; halogen; optionally substituted; carbocyclic
Prior art date: 2003-07-22

Application number

DK04743512.8T

Other languages

English (en)

Other versions

DK1651612T3 (da

Inventor

Valerio Berdini

Michael Alistair O'brien

Maria Carr

Theresa Rachel Early

Adrian L Gill

Gary Trewartha

Alison Jo-Anne Woolford

Andrew James Woodhead

Paul Wyatt

Original Assignee

Astex Therapeutics Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-22

Filing date

2004-07-22

Publication date

2012-10-22

2004-07-22 Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd

2004-07-22 Priority claimed from PCT/GB2004/003179 external-priority patent/WO2005012256A1/en

2012-07-23 Application granted granted Critical

2012-07-23 Publication of DK1651612T3 publication Critical patent/DK1651612T3/da

2012-10-22 Publication of DK1651612T5 publication Critical patent/DK1651612T5/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Manufacturing & Machinery (AREA)
Ceramic Engineering (AREA)
Inorganic Chemistry (AREA)
Materials Engineering (AREA)
Structural Engineering (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK04743512.8T 2003-07-22 2004-07-22 3,4-Disubstituerede 1H-pyrazolforbindelser og deres anvendelse som cyclinafhængige kinaser (CDK) og glykogensynthasekinase-3-(GSK)-modulatorer DK1651612T5 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US48904603P	2003-07-22	2003-07-22
GBGB0317127.9A GB0317127D0 (en)	2003-07-22	2003-07-22	Pharmaceutical compounds
US56976304P	2004-05-10	2004-05-10
PCT/GB2004/003179 WO2005012256A1 (en)	2003-07-22	2004-07-22	3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators

Publications (2)

Publication Number	Publication Date
DK1651612T3 DK1651612T3 (da)	2012-07-23
DK1651612T5 true DK1651612T5 (da)	2012-10-22

Family

ID=27772442

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK10175329.1T DK2256106T3 (da)	2003-07-22	2004-07-22	3,4-disubstituterede 1 H-pyrazolforbindelser og anvendelse heraf som cyclin-afhængige kinaser (CDK) og glycogensyntase kinase-3- (GSK-3) modulatorer
DK04743512.8T DK1651612T5 (da)	2003-07-22	2004-07-22	3,4-Disubstituerede 1H-pyrazolforbindelser og deres anvendelse som cyclinafhængige kinaser (CDK) og glykogensynthasekinase-3-(GSK)-modulatorer

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK10175329.1T DK2256106T3 (da)	2003-07-22	2004-07-22	3,4-disubstituterede 1 H-pyrazolforbindelser og anvendelse heraf som cyclin-afhængige kinaser (CDK) og glycogensyntase kinase-3- (GSK-3) modulatorer

Country Status (11)

Country	Link
CN (1)	CN1826323B (da)
AT (1)	ATE553091T1 (da)
DK (2)	DK2256106T3 (da)
ES (2)	ES2385328T3 (da)
GB (1)	GB0317127D0 (da)
HU (1)	HUE025425T2 (da)
PT (2)	PT2256106E (da)
RU (1)	RU2408585C2 (da)
SI (2)	SI2256106T1 (da)
TW (1)	TWI356823B (da)
ZA (1)	ZA200600313B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2436575C2 (ru) *	2005-01-21	2011-12-20	Астекс Терапьютикс Лимитед	Соединения для использования в фармацевтике
FR2947546B1 (fr) *	2009-07-03	2011-07-01	Sanofi Aventis	Derives de pyrazoles, leur preparation et leur application en therapeutique
US9200008B2 (en) *	2010-07-02	2015-12-01	Aska Pharmaceutical Co., Ltd.	Heterocyclic compound and p27Kip1 degradation inhibitor
CN103012428A (zh) *	2013-01-08	2013-04-03	中国药科大学	4-(五元杂环并嘧啶/吡啶取代)氨基-1H-3-吡唑甲酰胺类CDK/Aurora双重抑制剂及其用途
CN104592251B (zh) *	2015-01-23	2019-10-01	上海复星医药产业发展有限公司	4-(稠杂环取代氨基)-1h-吡唑-3-甲酰胺类化合物及其用途
EP3786164B1 (en) *	2015-06-18	2024-08-14	Ting Therapeutics LLC	Methods and compositions for the prevention and treatment of hearing loss
CN107245073B (zh) *	2017-07-11	2020-04-17	中国药科大学	4-(芳杂环取代)氨基-1h-3-吡唑甲酰胺类flt3抑制剂及其用途
MD3784664T2 (ro)	2018-04-26	2025-06-30	Pfizer	Derivați de 2-amino-piridină sau de 2-amino-pirimidină utilizați ca inhibitori de kinaze dependente de cicline
CN111848579B (zh) *	2019-04-26	2023-11-14	君实润佳(上海)医药科技有限公司	4-(2,6-二氯苯甲酰氨基)-n-(4-哌啶基)-1h-吡唑-3-甲酰胺的前药
CN116041324B (zh) *	2022-11-20	2025-05-23	药康众拓(北京)医药科技有限公司	一种氘代吡唑二氯苯甲酰胺类化合物、药物组合物和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0674624T3 (da) *	1992-12-17	1999-09-13	Pfizer	Pyrazoler med CRF-antagonistisk aktivitet
US6414013B1 (en) *	2000-06-19	2002-07-02	Pharmacia & Upjohn S.P.A.	Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
IL154016A0 (en) *	2000-08-31	2003-07-31	Pfizer Prod Inc	Pyrazole derivatives and their use as protein kinase inhibitors
EP1317450B1 (en) *	2000-09-15	2006-11-22	Vertex Pharmaceuticals Incorporated	Pyrazole compounds useful as protein kinase inhibitors
GB0102687D0 (en) *	2001-02-02	2001-03-21	Pharmacia & Upjohn Spa	Oxazolyl-pyrazole derivatives active as kinase inhibitors,process for their preparation and pharmaceutical compositions comprising them
MY130778A (en) *	2001-02-09	2007-07-31	Vertex Pharma	Heterocyclic inhibitiors of erk2 and uses thereof

2003
- 2003-07-22 GB GBGB0317127.9A patent/GB0317127D0/en not_active Ceased
2004
- 2004-07-22 PT PT101753291T patent/PT2256106E/pt unknown
- 2004-07-22 ES ES04743512T patent/ES2385328T3/es not_active Expired - Lifetime
- 2004-07-22 SI SI200432244T patent/SI2256106T1/sl unknown
- 2004-07-22 CN CN2004800211596A patent/CN1826323B/zh not_active Expired - Fee Related
- 2004-07-22 TW TW093121972A patent/TWI356823B/zh not_active IP Right Cessation
- 2004-07-22 DK DK10175329.1T patent/DK2256106T3/da active
- 2004-07-22 DK DK04743512.8T patent/DK1651612T5/da active
- 2004-07-22 RU RU2006105338/04A patent/RU2408585C2/ru not_active IP Right Cessation
- 2004-07-22 SI SI200431891T patent/SI1651612T1/sl unknown
- 2004-07-22 AT AT04743512T patent/ATE553091T1/de active
- 2004-07-22 PT PT04743512T patent/PT1651612E/pt unknown
- 2004-07-22 ES ES10175329.1T patent/ES2539480T3/es not_active Expired - Lifetime
- 2004-07-22 HU HUE10175329A patent/HUE025425T2/en unknown
2006
- 2006-01-12 ZA ZA200600313A patent/ZA200600313B/xx unknown

Also Published As

Publication number	Publication date
PT1651612E (pt)	2012-07-06
DK2256106T3 (da)	2015-06-01
ES2385328T3 (es)	2012-07-23
DK1651612T3 (da)	2012-07-23
TW200524877A (en)	2005-08-01
CN1826323A (zh)	2006-08-30
RU2408585C2 (ru)	2011-01-10
ATE553091T1 (de)	2012-04-15
ZA200600313B (en)	2007-02-28
SI2256106T1 (sl)	2015-10-30
CN1826323B (zh)	2012-06-27
SI1651612T1 (sl)	2012-09-28
HUE025425T2 (en)	2016-02-29
RU2006105338A (ru)	2007-09-20
TWI356823B (en)	2012-01-21
ES2539480T3 (es)	2015-07-01
PT2256106E (pt)	2015-07-22
GB0317127D0 (en)	2003-08-27

Publication	Publication Date	Title
WO2005012256A8 (en)	2005-04-07	3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
WO2008007113A3 (en)	2008-10-23	Pharmaceutical combinations
MX2007008784A (es)	2007-09-11	Derivados de pirazol para la inhibicion de las cdks y gsks.
NO20063028L (no)	2006-06-28	6-substituerte 2-kinolinoner og 2-kinoksalinoner som poly(adp-ribose)-polymeraseinhibitorer
CO5540316A2 (es)	2005-07-29	Pirimidinas inhibidoras de cdk, su preparacion y uso como medicamento
NZ533310A (en)	2004-12-24	Benzimidazoles useful as protein kinase inhibitors
NO20062892L (no)	2006-08-09	7-fenylalkyl-substituert 2-kinolinoner og 2-kinoksalinoner som poly(adp-ribose)-polymeraseinhibitorer
NO20062726L (no)	2006-06-12	Nye pyridazin-3(2H)-on derivater
MX2009002229A (es)	2009-03-16	Benzotriazoles como moduladores de cinasas.
ECSP088812A (es)	2008-11-27	Derivados de dihidropirazolopirimidinona
ATE373653T1 (de)	2007-10-15	Pyrimidine verbindungen
BR0213899A (pt)	2004-08-31	Aminopirimidinas e aminopiridinas
IL182093A0 (en)	2007-07-24	3,6-substituted 5-arylamino-1h-pyridine-2-one derivatives and related compounds as poly(adp-ribose)polymerase (parp) inhibitors in the treatment of tissue damage or disease caused by necrosis or apoptosis
NO20061047L (no)	2006-04-04	Malonamid-derivater som blokkerer aktiviteten til gama-sekretase
NO20062174L (no)	2006-07-14	Sulfoksiminsubstituerte pyrimidiner for anvendelse som CDK og /eller VEGF-inhibitorer, fremstilling derav og deres anvendelse som legemidler
PE20040808A1 (es)	2004-12-31	Derivados de urea ciclica como inhibidores de quinasas
DK1651612T5 (da)	2012-10-22	3,4-Disubstituerede 1H-pyrazolforbindelser og deres anvendelse som cyclinafhængige kinaser (CDK) og glykogensynthasekinase-3-(GSK)-modulatorer
DK1200426T3 (da)	2004-06-21	Substituerede thien-3-yl-sulfonylamino(thio)carbonyl-tiazolin(thi)oner
ATE433454T1 (de)	2009-06-15	Pyrazoloä1,5-aüpyrimidine als antagonisten des adenosin-a2a-rezeptors
NO20061126L (no)	2006-05-09	Aminopyroner og deres anvendelse som ATM-inhibitorer
NO20054340L (no)	2005-09-26	Nye sammenkoplede heterocykler og deres anvendelse
MXPA05009151A (es)	2005-10-20	Inhibidores de cinasa heterociclica.
NO905368D0 (no)	1990-12-12	Serotonin-antagonister, deres fremstilling og anvendelse.
ATE419242T1 (de)	2009-01-15	Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren
NO20022123L (no)	2002-05-03	Osoksazolderivater for anvendelse som inhibitorer for fosfodiesterase VII