NO20080392L - Pyrazolpyridinderivater som inhibitorer av beta-adrenergisk receptorkinase 1 - Google Patents

Pyrazolpyridinderivater som inhibitorer av beta-adrenergisk receptorkinase 1

Info

Publication number
NO20080392L
NO20080392L NO20080392A NO20080392A NO20080392L NO 20080392 L NO20080392 L NO 20080392L NO 20080392 A NO20080392 A NO 20080392A NO 20080392 A NO20080392 A NO 20080392A NO 20080392 L NO20080392 L NO 20080392L
Authority
NO
Norway
Prior art keywords
inhibitors
adrenergic receptor
receptor kinase
beta
pyridine derivatives
Prior art date
Application number
NO20080392A
Other languages
English (en)
Inventor
Marcel Patek
Martin Smrcina
Henning Steinhagen
Jochen Huber
Kurt Ritter
Bernard Pirard
Kirsten Bjergarde
Linli Wei
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of NO20080392L publication Critical patent/NO20080392L/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Addiction (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Foreliggende oppfinnelse angår 6-amidosubstituerte pyrazolopyridinderivater med formelen (I) anvendelige som inhibitorer av ß-adrenergisk reseptorkinase-1 (ß-ARK-1), sammensetninger inneholdende slike forbindelser og deres anvendelse for behandlingen og hindring av kronisk hjertesvikt, hypertensjon, myokardisk iskemi, hepatitt C virus (HCV) infeksjoner og for hindringen av opiatavhengighet.
NO20080392A 2005-06-27 2008-01-21 Pyrazolpyridinderivater som inhibitorer av beta-adrenergisk receptorkinase 1 NO20080392L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05013774 2005-06-27
PCT/EP2006/005649 WO2007000241A1 (en) 2005-06-27 2006-06-13 Pyrazolopyridine derivatives as inhibitors of beta-adrenergic receptor kinase 1

Publications (1)

Publication Number Publication Date
NO20080392L true NO20080392L (no) 2008-02-28

Family

ID=35395578

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080392A NO20080392L (no) 2005-06-27 2008-01-21 Pyrazolpyridinderivater som inhibitorer av beta-adrenergisk receptorkinase 1

Country Status (30)

Country Link
US (1) US7910602B2 (no)
EP (1) EP1899333B1 (no)
JP (1) JP5010594B2 (no)
KR (1) KR20080020638A (no)
CN (1) CN101208340B (no)
AR (1) AR054514A1 (no)
AT (1) ATE423118T1 (no)
AU (1) AU2006264044A1 (no)
BR (1) BRPI0612320A2 (no)
CA (1) CA2611296A1 (no)
CY (1) CY1110464T1 (no)
DE (1) DE602006005242D1 (no)
DK (1) DK1899333T3 (no)
ES (1) ES2322197T3 (no)
HR (1) HRP20090244T2 (no)
IL (1) IL188381A0 (no)
MA (1) MA29498B1 (no)
MX (1) MX2007015829A (no)
MY (1) MY139016A (no)
NO (1) NO20080392L (no)
NZ (1) NZ564757A (no)
PL (1) PL1899333T3 (no)
PT (1) PT1899333E (no)
RS (1) RS50821B (no)
RU (1) RU2415855C2 (no)
SI (1) SI1899333T1 (no)
TW (1) TW200800982A (no)
UY (1) UY29632A1 (no)
WO (1) WO2007000241A1 (no)
ZA (1) ZA200709853B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200815438A (en) 2006-06-13 2008-04-01 Bayer Schering Pharma Ag Substituted pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same
US20110009421A1 (en) * 2008-02-27 2011-01-13 Takeda Pharmaceutical Company Limited Compound having 6-membered aromatic ring
US9321787B2 (en) * 2011-07-07 2016-04-26 Sanofi Carboxylic acid derivatives having an oxazolo[5,4-d]pyrimidine ring
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
EP2970177A1 (en) 2013-03-15 2016-01-20 Pfizer Inc. Indole compounds that activate ampk
GB201410815D0 (en) * 2014-06-17 2014-07-30 Ucb Biopharma Sprl And Katholieke Universiteit Leuven Therapeutic agents
WO2020086503A1 (en) * 2018-10-24 2020-04-30 Bristol-Myers Squibb Company Substituted indole and indazole compounds
US11998537B2 (en) 2018-10-24 2024-06-04 Bristol-Myers Squibb Company Substituted indole dimer compounds
KR102904576B1 (ko) 2019-05-09 2025-12-24 브리스톨-마이어스 스큅 컴퍼니 치환된 벤즈이미다졸론 화합물
WO2021067326A1 (en) 2019-10-01 2021-04-08 Bristol-Myers Squibb Company Substituted bicyclic heteroaryl compounds
ES2965164T3 (es) 2019-10-04 2024-04-11 Bristol Myers Squibb Co Compuestos de carbazol sustituidos
EP4638420A1 (en) * 2022-12-20 2025-10-29 Exelixis, Inc. Compounds that inhibit pkmyt1

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0765327B1 (en) * 1994-06-16 1999-07-21 Pfizer Inc. Pyrazolo and pyrrolopyridines
DE69837282T2 (de) * 1997-12-13 2007-11-08 Bristol-Myers Squibb Co. VERWENDUNG VON PYRAZOLO Ä 3,4-bÜ PYRIDIN ALS CYCLIN-ABHÄNGIGE KINASE HEMMER
JP2002020386A (ja) * 2000-07-07 2002-01-23 Ono Pharmaceut Co Ltd ピラゾロピリジン誘導体
AU2003245700A1 (en) * 2002-02-12 2003-09-04 Glaxo Group Limited Pyrazolopyridine derivatives
BR0313262A (pt) * 2002-08-07 2005-07-12 Mitsubishi Pharma Corp Compostos de dihidropirazolpiridina
NZ541836A (en) * 2003-02-27 2008-12-24 Palau Pharma Sa Pyrazolopyridine derivatives

Also Published As

Publication number Publication date
RS50821B (sr) 2010-08-31
KR20080020638A (ko) 2008-03-05
BRPI0612320A2 (pt) 2010-11-09
US7910602B2 (en) 2011-03-22
RU2008102970A (ru) 2009-08-10
MA29498B1 (fr) 2008-05-02
NZ564757A (en) 2009-12-24
JP5010594B2 (ja) 2012-08-29
PL1899333T3 (pl) 2009-07-31
EP1899333B1 (en) 2009-02-18
CN101208340B (zh) 2010-12-22
HRP20090244T2 (hr) 2009-07-31
DE602006005242D1 (de) 2009-04-02
RU2415855C2 (ru) 2011-04-10
US20080227777A1 (en) 2008-09-18
SI1899333T1 (sl) 2009-08-31
PT1899333E (pt) 2009-04-23
AR054514A1 (es) 2007-06-27
ES2322197T3 (es) 2009-06-17
ZA200709853B (en) 2008-12-31
CN101208340A (zh) 2008-06-25
MX2007015829A (es) 2008-02-22
UY29632A1 (es) 2007-01-31
AU2006264044A1 (en) 2007-01-04
MY139016A (en) 2009-08-28
WO2007000241A1 (en) 2007-01-04
JP2008543957A (ja) 2008-12-04
EP1899333A1 (en) 2008-03-19
TW200800982A (en) 2008-01-01
ATE423118T1 (de) 2009-03-15
DK1899333T3 (da) 2009-06-15
IL188381A0 (en) 2008-04-13
CA2611296A1 (en) 2007-01-04
HRP20090244T1 (en) 2009-06-30
CY1110464T1 (el) 2015-04-29

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