DK165280A - Fremgangsmaade til fremstilling af 2- og 6-substituerede 1-carbadethiapen-2-em-3-carboxylsyrer og mellemprodukter til brug ved udoevelse af fremgangsmaaden - Google Patents
Fremgangsmaade til fremstilling af 2- og 6-substituerede 1-carbadethiapen-2-em-3-carboxylsyrer og mellemprodukter til brug ved udoevelse af fremgangsmaadenInfo
- Publication number
- DK165280A DK165280A DK165280A DK165280A DK165280A DK 165280 A DK165280 A DK 165280A DK 165280 A DK165280 A DK 165280A DK 165280 A DK165280 A DK 165280A DK 165280 A DK165280 A DK 165280A
- Authority
- DK
- Denmark
- Prior art keywords
- procedure
- carbadethiapen
- intermediates
- presentation
- substituted
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
- C07D477/04—Preparation by forming the ring or condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3169479A | 1979-04-19 | 1979-04-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK165280A true DK165280A (da) | 1980-10-20 |
Family
ID=21860896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK165280A DK165280A (da) | 1979-04-19 | 1980-04-18 | Fremgangsmaade til fremstilling af 2- og 6-substituerede 1-carbadethiapen-2-em-3-carboxylsyrer og mellemprodukter til brug ved udoevelse af fremgangsmaaden |
Country Status (3)
| Country | Link |
|---|---|
| EP (2) | EP0082133A3 (da) |
| JP (1) | JPS565478A (da) |
| DK (1) | DK165280A (da) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2965394D1 (en) * | 1978-11-01 | 1983-06-16 | Sanraku Ocean Co | Process for producing antibiotic beta-lactam compounds |
| ATE15039T1 (de) * | 1979-04-27 | 1985-09-15 | Merck & Co Inc | Verfahren zur herstellung von 3-(1-hydroxyaethyl)- azetidinonen. |
| DE3070269D1 (en) * | 1979-08-10 | 1985-04-18 | Beecham Group Plc | Beta-lactam antibiotics, their preparation, pharmaceutical compositions containing them and their preparation |
| EP0043197A1 (en) * | 1980-07-02 | 1982-01-06 | Beecham Group Plc | Beta-Lactam antibiotic, its preparation and use |
| PT73791B (en) * | 1980-10-17 | 1983-10-14 | Merck & Co Inc | Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids |
| EP0059554A3 (en) * | 1981-02-27 | 1982-10-20 | Beecham Group Plc | Beta-lactam antibiotics, a process for their preparation and their use in pharmaceutical compositions |
| AU548727B2 (en) * | 1981-03-12 | 1986-01-02 | Gruppo Lepetit S.P.A. | Beta-lactam acetic acid derivatives |
| JPS57158784A (en) * | 1981-03-26 | 1982-09-30 | Toyama Chem Co Ltd | 3-substituted-6-substituted-7-oxo-1-azabicyclo(3,2,0)hept- 2-ene-carboxylic acid derivative |
| ES8404184A1 (es) * | 1981-08-03 | 1984-04-16 | Merck & Co Inc | Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados. |
| US4552873A (en) * | 1981-08-19 | 1985-11-12 | Sankyo Company Limited | Carbapenem compounds, and compositions containing them |
| JPS58198486A (ja) * | 1982-05-14 | 1983-11-18 | Sankyo Co Ltd | ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法 |
| JPS5865291A (ja) * | 1981-10-14 | 1983-04-18 | Sankyo Co Ltd | カルバペネム−３−カルボン酸誘導体およびその製法 |
| JPS58167566A (ja) * | 1982-03-27 | 1983-10-03 | Kanegafuchi Chem Ind Co Ltd | （４ｒ）−（２−ヒドロキシエチル）−２−アゼチジノン及びその誘導体の製法 |
| US4431654A (en) * | 1982-04-05 | 1984-02-14 | Schering Corporation | 6-(Hydroxyethyl)-2-[(heterocyclyl or aryl)thioalkylthio]-penem-3-carboxylates |
| CA1198440A (en) * | 1982-04-08 | 1985-12-24 | Choung U. Kim | Carbapenem antibiotics |
| US4683301A (en) * | 1982-04-08 | 1987-07-28 | Bristol-Myers Company | Carbapenem antibiotics |
| US4642341A (en) * | 1982-04-09 | 1987-02-10 | Bristol-Myers Company | Carbapenem antibiotics |
| ZA832412B (en) * | 1982-04-09 | 1983-12-28 | Bristol Myers Co | Carbapenem antibiotics |
| US4710568A (en) * | 1982-04-09 | 1987-12-01 | Bristol-Myers Company | Carbapenem antibiotics |
| US4552696A (en) * | 1982-04-09 | 1985-11-12 | Bristol-Myers Company | Carbapenem antibiotics |
| US4665170A (en) * | 1982-06-18 | 1987-05-12 | Bristol-Myers Company | Carbapenem antibiotics |
| US4536335A (en) * | 1982-06-18 | 1985-08-20 | Bristol-Myers Company | Carbapenem antibiotics |
| US4640799A (en) * | 1982-06-18 | 1987-02-03 | Bristol-Myers Company | Carbapenem antibiotics |
| BE897086A (fr) * | 1982-06-18 | 1983-12-19 | Bristol Myers Co | Produits nouveaux de la classe des carbapenems et leur application en tant qu'antibiotiques |
| JPS5916892A (ja) * | 1982-07-19 | 1984-01-28 | Sankyo Co Ltd | カルバペネム−３−カルボン酸誘導体およびその製法 |
| FI832619A7 (fi) * | 1982-07-26 | 1984-01-27 | Sandoz Ag | Fluoralkylerade karbapenemderivat |
| CA1269978A (en) * | 1982-09-28 | 1990-06-05 | Choung U. Kim | Carbapenem antibiotics |
| US4746736A (en) * | 1982-09-28 | 1988-05-24 | Bristol-Myers Company | Carbapenem antibiotics |
| US4732977A (en) * | 1982-09-28 | 1988-03-22 | Bristol Myers Company | Carbapenem antibiotics |
| IL70782A (en) * | 1983-02-02 | 1991-03-10 | Univ Notre Dame Du Lac | N-dicarboxymethyl azetidin-2-ones |
| US4595532A (en) * | 1983-02-02 | 1986-06-17 | University Of Notre Dame Du Lac | N-(substituted-methyl)-azetidin-2-ones |
| ZM1484A1 (en) * | 1983-03-08 | 1984-12-21 | Bristol Myers Co | Carbapenem process |
| EP0126780A1 (en) * | 1983-04-12 | 1984-12-05 | Schering Corporation | Carbapenem compound |
| CA1283906C (en) * | 1983-05-09 | 1991-05-07 | Makoto Sunagawa | .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF |
| EP0171064B1 (en) * | 1984-08-06 | 1995-07-12 | Fujisawa Pharmaceutical Co., Ltd. | Azetidinone derivative and processes for production thereof |
| JPS60260580A (ja) * | 1985-04-05 | 1985-12-23 | Sankyo Co Ltd | カルバペネム−３−カルボン酸誘導体およびその製造法 |
| NZ215957A (en) * | 1985-04-27 | 1988-04-29 | Sankyo Co | Carbapenem derivatives and pharmaceutical compositions |
| US4665169A (en) * | 1985-09-11 | 1987-05-12 | Bristol-Myers Company | Carbapenem antibiotics |
| DE3617626A1 (de) * | 1986-05-26 | 1987-12-03 | Bayer Ag | Substituierte 6-hydroxymethyl-carbapenem-antibiotika, verfahren zu ihrer herstellung und ihre verwendung |
| EP0597821A1 (en) * | 1988-04-01 | 1994-05-18 | Sankyo Company Limited | 2-(Heterocyclylthio)carbapenem derivatives their preparation and their use as antibiotics |
| US5242914A (en) * | 1988-04-01 | 1993-09-07 | Sankyo Company, Limited | 2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics |
| CA2004798A1 (en) * | 1988-12-09 | 1990-06-09 | Jacques Banville | 6-aminoalkyl carbapenems |
| GB9107341D0 (en) * | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
| GB9202298D0 (en) * | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
| GB9304156D0 (en) * | 1992-03-26 | 1993-04-21 | Zeneca Ltd | Antibiotic compounds |
| CA2091309A1 (en) * | 1992-03-26 | 1993-09-27 | Frederic H. Jung | Antibiotic compounds |
| CA2099817A1 (en) * | 1992-07-21 | 1994-01-22 | Frederic H. Jung | Antibiotic compounds |
| CA2099811A1 (en) * | 1992-07-21 | 1994-01-22 | Frederic H. Jung | Antibiotic compounds |
| CA2106141A1 (en) * | 1992-09-28 | 1994-03-29 | Michael J. Betts | Antibiotic compounds |
| US5750686A (en) * | 1993-06-16 | 1998-05-12 | Sumitomo Pharmaceuticals Company, Limited | Carbapenem compounds and process for producing the same |
| US5496816A (en) * | 1994-03-14 | 1996-03-05 | Merck & Co., Inc. | Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment |
| JPH1077285A (ja) | 1996-09-04 | 1998-03-24 | Sumitomo Pharmaceut Co Ltd | 新規なβ−ラクタム化合物およびその製造法 |
| EP2127650B1 (en) | 2004-06-10 | 2018-12-05 | FOB Synthesis, Inc. | Carbapenem antibacterials with gram-negative activity and processes for their preparation |
| ES2653837T3 (es) | 2010-06-18 | 2018-02-09 | Fob Synthesis, Inc. | Antibacterianos carbapenem con actividad gramo-negativa |
| WO2014070774A1 (en) * | 2012-10-29 | 2014-05-08 | Southern Methodist University | Methods of generating beta-lactamase resistant carbapenem compounds |
| JP7213173B2 (ja) * | 2016-03-16 | 2023-01-26 | オーキッド ファーマ リミテッド | カルバペネム化合物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS226166B2 (cs) * | 1975-11-21 | 1984-03-19 | Merck & Co Inc | Způsob přípravy derivátů thienamycinu |
| NL7612937A (nl) * | 1975-11-21 | 1977-05-24 | Merck & Co Inc | Thienamycinederivaten en farmaceutische prepa- raten alsmede werkwijze voor het bereiden daarvan. |
| NL7712093A (nl) * | 1976-11-19 | 1978-05-23 | Merck & Co Inc | Werkwijze voor het bereiden van isomere thienamycinen. |
| AU4061378A (en) * | 1977-10-19 | 1980-04-17 | Merck & Co., Inc. | 1-azabicyclo (3.2.0) hept-2-enes |
| AU531084B2 (en) * | 1977-10-19 | 1983-08-11 | Merck & Co., Inc. | Azetidine derivatives |
| US4446146A (en) * | 1978-07-26 | 1984-05-01 | Beecham Group Limited | β-Lactam containing compounds, their preparation and use |
| EP0008888B1 (en) * | 1978-08-23 | 1983-09-21 | Beecham Group Plc | Beta-lactam antibacterial compounds, their preparation and pharmaceutical compositions containing them |
| DE2961882D1 (en) * | 1978-08-25 | 1982-03-04 | Beecham Group Plc | Beta-lactam anti-bacterials, compositions containing them and a process for their preparation |
| DE2965394D1 (en) * | 1978-11-01 | 1983-06-16 | Sanraku Ocean Co | Process for producing antibiotic beta-lactam compounds |
-
1980
- 1980-04-18 DK DK165280A patent/DK165280A/da not_active Application Discontinuation
- 1980-04-18 EP EP83100022A patent/EP0082133A3/en not_active Withdrawn
- 1980-04-18 EP EP80102076A patent/EP0017992A1/en not_active Withdrawn
- 1980-04-19 JP JP5222180A patent/JPS565478A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0082133A3 (en) | 1983-07-20 |
| EP0017992A1 (en) | 1980-10-29 |
| EP0082133A2 (en) | 1983-06-22 |
| JPS565478A (en) | 1981-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed | ||
| AHS | Application shelved for other reasons than non-payment |