JPS565478A - 22substitutedd66substituteddcarbadethiapenee 22emm33carboxylic acid - Google Patents

22substitutedd66substituteddcarbadethiapenee 22emm33carboxylic acid

Info

Publication number
JPS565478A
JPS565478A JP5222180A JP5222180A JPS565478A JP S565478 A JPS565478 A JP S565478A JP 5222180 A JP5222180 A JP 5222180A JP 5222180 A JP5222180 A JP 5222180A JP S565478 A JPS565478 A JP S565478A
Authority
JP
Japan
Prior art keywords
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5222180A
Other languages
English (en)
Inventor
Jii Kurisutensen Baaton
Bii Aaru Jiyonsuto Deibuitsudo
Emu Shiyumitsuto Suuzan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS565478A publication Critical patent/JPS565478A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP5222180A 1979-04-19 1980-04-19 22substitutedd66substituteddcarbadethiapenee 22emm33carboxylic acid Pending JPS565478A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3169479A 1979-04-19 1979-04-19

Publications (1)

Publication Number Publication Date
JPS565478A true JPS565478A (en) 1981-01-20

Family

ID=21860896

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5222180A Pending JPS565478A (en) 1979-04-19 1980-04-19 22substitutedd66substituteddcarbadethiapenee 22emm33carboxylic acid

Country Status (3)

Country Link
EP (2) EP0082133A3 (ja)
JP (1) JPS565478A (ja)
DK (1) DK165280A (ja)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5795989A (en) * 1980-10-17 1982-06-15 Merck & Co Inc 2-carbamimidoyl-6-substituted-1-carbadethiapene- 2-em-3-carboxylic acids
JPS57158784A (en) * 1981-03-26 1982-09-30 Toyama Chem Co Ltd 3-substituted-6-substituted-7-oxo-1-azabicyclo(3,2,0)hept- 2-ene-carboxylic acid derivative
JPS5826887A (ja) * 1981-08-03 1983-02-17 メルク・エンド・カムパニ−・インコ−ポレ−テツド １−，及び１，１−ジ置換−６−置換−２−カルバムイミドイル−１−カルバデチアペン−２−エム−３−カルボン酸類
JPS5865291A (ja) * 1981-10-14 1983-04-18 Sankyo Co Ltd カルバペネム−３−カルボン酸誘導体およびその製法
JPS58198486A (ja) * 1982-05-14 1983-11-18 Sankyo Co Ltd ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法
JPS58198487A (ja) * 1982-04-09 1983-11-18 ブリストル―マイヤーズ　スクイズ　カンパニー カルバペネム抗生物質
JPS5910588A (ja) * 1982-06-18 1984-01-20 ブリストル―マイヤーズ　スクイブ　カンパニー カルバペネム抗生物質
JPS5916892A (ja) * 1982-07-19 1984-01-28 Sankyo Co Ltd カルバペネム−３−カルボン酸誘導体およびその製法
JPS59210087A (ja) * 1983-03-08 1984-11-28 ブリストル―マイヤーズ　スクイブ　カンパニー カルバペネムの製造方法
JPS60260580A (ja) * 1985-04-05 1985-12-23 Sankyo Co Ltd カルバペネム−３−カルボン酸誘導体およびその製造法
JP2019512547A (ja) * 2016-03-16 2019-05-16 オーキッド ファーマ リミテッド カルバペネム化合物

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2965394D1 (en) * 1978-11-01 1983-06-16 Sanraku Ocean Co Process for producing antibiotic beta-lactam compounds
ATE15039T1 (de) * 1979-04-27 1985-09-15 Merck & Co Inc Verfahren zur herstellung von 3-(1-hydroxyaethyl)- azetidinonen.
DE3070269D1 (en) * 1979-08-10 1985-04-18 Beecham Group Plc Beta-lactam antibiotics, their preparation, pharmaceutical compositions containing them and their preparation
EP0043197A1 (en) * 1980-07-02 1982-01-06 Beecham Group Plc Beta-Lactam antibiotic, its preparation and use
EP0059554A3 (en) * 1981-02-27 1982-10-20 Beecham Group Plc Beta-lactam antibiotics, a process for their preparation and their use in pharmaceutical compositions
AU548727B2 (en) * 1981-03-12 1986-01-02 Gruppo Lepetit S.P.A. Beta-lactam acetic acid derivatives
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
JPS58167566A (ja) * 1982-03-27 1983-10-03 Kanegafuchi Chem Ind Co Ltd （４ｒ）−（２−ヒドロキシエチル）−２−アゼチジノン及びその誘導体の製法
US4431654A (en) * 1982-04-05 1984-02-14 Schering Corporation 6-(Hydroxyethyl)-2-[(heterocyclyl or aryl)thioalkylthio]-penem-3-carboxylates
CA1198440A (en) * 1982-04-08 1985-12-24 Choung U. Kim Carbapenem antibiotics
US4683301A (en) * 1982-04-08 1987-07-28 Bristol-Myers Company Carbapenem antibiotics
US4642341A (en) * 1982-04-09 1987-02-10 Bristol-Myers Company Carbapenem antibiotics
US4710568A (en) * 1982-04-09 1987-12-01 Bristol-Myers Company Carbapenem antibiotics
US4552696A (en) * 1982-04-09 1985-11-12 Bristol-Myers Company Carbapenem antibiotics
US4665170A (en) * 1982-06-18 1987-05-12 Bristol-Myers Company Carbapenem antibiotics
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics
US4640799A (en) * 1982-06-18 1987-02-03 Bristol-Myers Company Carbapenem antibiotics
FI832619A7 (fi) * 1982-07-26 1984-01-27 Sandoz Ag Fluoralkylerade karbapenemderivat
CA1269978A (en) * 1982-09-28 1990-06-05 Choung U. Kim Carbapenem antibiotics
US4746736A (en) * 1982-09-28 1988-05-24 Bristol-Myers Company Carbapenem antibiotics
US4732977A (en) * 1982-09-28 1988-03-22 Bristol Myers Company Carbapenem antibiotics
IL70782A (en) * 1983-02-02 1991-03-10 Univ Notre Dame Du Lac N-dicarboxymethyl azetidin-2-ones
US4595532A (en) * 1983-02-02 1986-06-17 University Of Notre Dame Du Lac N-(substituted-methyl)-azetidin-2-ones
EP0126780A1 (en) * 1983-04-12 1984-12-05 Schering Corporation Carbapenem compound
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
EP0171064B1 (en) * 1984-08-06 1995-07-12 Fujisawa Pharmaceutical Co., Ltd. Azetidinone derivative and processes for production thereof
NZ215957A (en) * 1985-04-27 1988-04-29 Sankyo Co Carbapenem derivatives and pharmaceutical compositions
US4665169A (en) * 1985-09-11 1987-05-12 Bristol-Myers Company Carbapenem antibiotics
DE3617626A1 (de) * 1986-05-26 1987-12-03 Bayer Ag Substituierte 6-hydroxymethyl-carbapenem-antibiotika, verfahren zu ihrer herstellung und ihre verwendung
EP0597821A1 (en) * 1988-04-01 1994-05-18 Sankyo Company Limited 2-(Heterocyclylthio)carbapenem derivatives their preparation and their use as antibiotics
US5242914A (en) * 1988-04-01 1993-09-07 Sankyo Company, Limited 2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics
CA2004798A1 (en) * 1988-12-09 1990-06-09 Jacques Banville 6-aminoalkyl carbapenems
GB9107341D0 (en) * 1991-04-08 1991-05-22 Ici Plc Antibiotic compounds
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
GB9304156D0 (en) * 1992-03-26 1993-04-21 Zeneca Ltd Antibiotic compounds
CA2091309A1 (en) * 1992-03-26 1993-09-27 Frederic H. Jung Antibiotic compounds
CA2099817A1 (en) * 1992-07-21 1994-01-22 Frederic H. Jung Antibiotic compounds
CA2099811A1 (en) * 1992-07-21 1994-01-22 Frederic H. Jung Antibiotic compounds
CA2106141A1 (en) * 1992-09-28 1994-03-29 Michael J. Betts Antibiotic compounds
US5750686A (en) * 1993-06-16 1998-05-12 Sumitomo Pharmaceuticals Company, Limited Carbapenem compounds and process for producing the same
US5496816A (en) * 1994-03-14 1996-03-05 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
JPH1077285A (ja) 1996-09-04 1998-03-24 Sumitomo Pharmaceut Co Ltd 新規なβ−ラクタム化合物およびその製造法
EP2127650B1 (en) 2004-06-10 2018-12-05 FOB Synthesis, Inc. Carbapenem antibacterials with gram-negative activity and processes for their preparation
ES2653837T3 (es) 2010-06-18 2018-02-09 Fob Synthesis, Inc. Antibacterianos carbapenem con actividad gramo-negativa
WO2014070774A1 (en) * 2012-10-29 2014-05-08 Southern Methodist University Methods of generating beta-lactamase resistant carbapenem compounds

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5277085A (en) * 1975-11-21 1977-06-29 Merck & Co Inc Nnalkyl derivative of thienamycine
JPS5285188A (en) * 1975-11-21 1977-07-15 Merck & Co Inc Substituted nnmethylene derivative of thienacmycine
JPS5466697A (en) * 1977-10-19 1979-05-29 Merck & Co Inc 33substitutedd66substitutedd77oxoo11 azabicyclo*3*2*0**heptaa22enee22carboxylic acid
JPS5466696A (en) * 1977-10-19 1979-05-29 Merck & Co Inc 33substitutedd66*1**hydroxyethyl**77oxoo11 azabicyclo*3*2*0**heptoo22enee22carboxylic acid
JPS5533485A (en) * 1978-08-23 1980-03-08 Beecham Group Ltd Betaalactum antibacterial*its composition and manufacture
JPS5533494A (en) * 1978-08-25 1980-03-08 Beecham Group Ltd Betaalactum antibacterial*its manufacture and composition

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7712093A (nl) * 1976-11-19 1978-05-23 Merck & Co Inc Werkwijze voor het bereiden van isomere thienamycinen.
US4446146A (en) * 1978-07-26 1984-05-01 Beecham Group Limited β-Lactam containing compounds, their preparation and use
DE2965394D1 (en) * 1978-11-01 1983-06-16 Sanraku Ocean Co Process for producing antibiotic beta-lactam compounds

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5277085A (en) * 1975-11-21 1977-06-29 Merck & Co Inc Nnalkyl derivative of thienamycine
JPS5285188A (en) * 1975-11-21 1977-07-15 Merck & Co Inc Substituted nnmethylene derivative of thienacmycine
JPS5466697A (en) * 1977-10-19 1979-05-29 Merck & Co Inc 33substitutedd66substitutedd77oxoo11 azabicyclo*3*2*0**heptaa22enee22carboxylic acid
JPS5466696A (en) * 1977-10-19 1979-05-29 Merck & Co Inc 33substitutedd66*1**hydroxyethyl**77oxoo11 azabicyclo*3*2*0**heptoo22enee22carboxylic acid
JPS5533485A (en) * 1978-08-23 1980-03-08 Beecham Group Ltd Betaalactum antibacterial*its composition and manufacture
JPS5533494A (en) * 1978-08-25 1980-03-08 Beecham Group Ltd Betaalactum antibacterial*its manufacture and composition

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5795989A (en) * 1980-10-17 1982-06-15 Merck & Co Inc 2-carbamimidoyl-6-substituted-1-carbadethiapene- 2-em-3-carboxylic acids
JPS57158784A (en) * 1981-03-26 1982-09-30 Toyama Chem Co Ltd 3-substituted-6-substituted-7-oxo-1-azabicyclo(3,2,0)hept- 2-ene-carboxylic acid derivative
JPS5826887A (ja) * 1981-08-03 1983-02-17 メルク・エンド・カムパニ−・インコ−ポレ−テツド １−，及び１，１−ジ置換−６−置換−２−カルバムイミドイル−１−カルバデチアペン−２−エム−３−カルボン酸類
JPS5865291A (ja) * 1981-10-14 1983-04-18 Sankyo Co Ltd カルバペネム−３−カルボン酸誘導体およびその製法
JPS58198487A (ja) * 1982-04-09 1983-11-18 ブリストル―マイヤーズ　スクイズ　カンパニー カルバペネム抗生物質
JPS58198486A (ja) * 1982-05-14 1983-11-18 Sankyo Co Ltd ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法
JPS5910588A (ja) * 1982-06-18 1984-01-20 ブリストル―マイヤーズ　スクイブ　カンパニー カルバペネム抗生物質
JPS5916892A (ja) * 1982-07-19 1984-01-28 Sankyo Co Ltd カルバペネム−３−カルボン酸誘導体およびその製法
JPS59210087A (ja) * 1983-03-08 1984-11-28 ブリストル―マイヤーズ　スクイブ　カンパニー カルバペネムの製造方法
JPS60260580A (ja) * 1985-04-05 1985-12-23 Sankyo Co Ltd カルバペネム−３−カルボン酸誘導体およびその製造法
JP2019512547A (ja) * 2016-03-16 2019-05-16 オーキッド ファーマ リミテッド カルバペネム化合物
US11180504B2 (en) 2016-03-16 2021-11-23 Orchid Pharma Ltd. Substituted carbapenems for the treatment of bacterial infections

Also Published As

Publication number Publication date
DK165280A (da) 1980-10-20
EP0082133A3 (en) 1983-07-20
EP0017992A1 (en) 1980-10-29
EP0082133A2 (en) 1983-06-22

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