DK1656351T3 - Fremgangsmåde til fremstilling af 4-aryl-nicotinamidderivater - Google Patents
Fremgangsmåde til fremstilling af 4-aryl-nicotinamidderivaterInfo
- Publication number
- DK1656351T3 DK1656351T3 DK04763155T DK04763155T DK1656351T3 DK 1656351 T3 DK1656351 T3 DK 1656351T3 DK 04763155 T DK04763155 T DK 04763155T DK 04763155 T DK04763155 T DK 04763155T DK 1656351 T3 DK1656351 T3 DK 1656351T3
- Authority
- DK
- Denmark
- Prior art keywords
- sub
- formula
- compound
- sup
- compounds
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- AGJSNMGHAVDLRQ-HUUJSLGLSA-N methyl (2s)-2-[[(2r)-2-[[(2s)-2-[[(2r)-2-amino-3-sulfanylpropanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxy-2,3-dimethylphenyl)propanoyl]amino]-4-methylsulfanylbutanoate Chemical compound SC[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(=O)N[C@@H](CCSC)C(=O)OC)CC1=CC=C(O)C(C)=C1C AGJSNMGHAVDLRQ-HUUJSLGLSA-N 0.000 abstract 1
- 239000002742 neurokinin 1 receptor antagonist Substances 0.000 abstract 1
- 150000002825 nitriles Chemical group 0.000 abstract 1
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 abstract 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03015599 | 2003-07-15 | ||
| PCT/EP2004/007618 WO2005014549A1 (en) | 2003-07-15 | 2004-07-10 | Process for preparation of 4-aryl-nicotinamide derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1656351T3 true DK1656351T3 (da) | 2008-04-21 |
Family
ID=34042828
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04763155T DK1656351T3 (da) | 2003-07-15 | 2004-07-10 | Fremgangsmåde til fremstilling af 4-aryl-nicotinamidderivater |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7288658B2 (da) |
| EP (1) | EP1656351B1 (da) |
| JP (1) | JP4575918B2 (da) |
| KR (1) | KR100742013B1 (da) |
| CN (1) | CN1835922B (da) |
| AT (1) | ATE381543T1 (da) |
| CA (1) | CA2532355C (da) |
| DE (1) | DE602004010820T2 (da) |
| DK (1) | DK1656351T3 (da) |
| ES (1) | ES2297457T3 (da) |
| IL (1) | IL173000A0 (da) |
| MX (1) | MXPA06000405A (da) |
| TW (1) | TWI280239B (da) |
| WO (1) | WO2005014549A1 (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1984891B (zh) * | 2004-07-06 | 2012-08-08 | 弗·哈夫曼-拉罗切有限公司 | 用作合成nk-1受体拮抗剂的中间体的甲酰胺吡啶衍生物的制备方法 |
| US8597947B2 (en) | 2004-12-29 | 2013-12-03 | Hadasit Medical Research Services & Development Limited | Undifferentiated stem cell culture systems |
| WO2006070370A2 (en) | 2004-12-29 | 2006-07-06 | Hadasit Medical Research Services & Development Limited | Stem cells culture systems |
| CA2684460C (en) | 2007-04-18 | 2017-01-03 | Hadasit Medical Research Services & Development Limited | Stem cell-derived retinal pigment epithelial cells |
| US20180011092A1 (en) | 2014-12-30 | 2018-01-11 | Cell Cure Neurosciences Ltd. | Assessing retinal pigment epithelial cell populations |
| AU2015373050B2 (en) | 2014-12-30 | 2022-09-29 | Cell Cure Neurosciences Ltd. | RPE cell populations and methods of generating same |
| EP3328995B1 (en) | 2015-07-29 | 2021-03-31 | Hadasit Medical Research Services And Development | Large scale production of retinal pigment epithelial cells |
| EP3331995A1 (en) | 2015-08-05 | 2018-06-13 | Cell Cure Neurosciences Ltd. | Preparation of photoreceptors for the treatment of retinal diseases |
| CN108138144A (zh) | 2015-08-05 | 2018-06-08 | 细胞治疗神经科学有限公司 | 视网膜色素上皮细胞的制备 |
| HUE070900T2 (hu) | 2015-10-26 | 2025-07-28 | Cell Cure Neurosciences Ltd | Eljárás retinális pigmentepitélium-sejtek elõállítására |
| CN106892864A (zh) * | 2015-12-21 | 2017-06-27 | 上海科胜药物研发有限公司 | 一种奈妥皮坦游离碱的晶型a及其制备方法 |
| WO2018146679A2 (en) | 2017-02-08 | 2018-08-16 | Hadasit Medical Research Services And Development Ltd. | Photoreceptor cells for the treatment of retinal diseases |
| US20200085882A1 (en) | 2017-03-16 | 2020-03-19 | Lineage Cell Therapeutics, Inc. | Methods for measuring therapeutic effects of retinal disease therapies |
| BR112020013238A2 (pt) | 2017-12-29 | 2020-12-01 | Cell Cure Neurosciences Ltd. | composição e método para formular células do epitélio pigmentar da retina bem como uso da dita composição para tratar uma condição retiniana |
| JP7520820B2 (ja) | 2018-09-20 | 2024-07-23 | イェダ リサーチ アンド ディベロップメント カンパニー リミテッド | 筋萎縮性側索硬化症の治療方法 |
| EP3754014A1 (en) | 2019-06-21 | 2020-12-23 | Centre d'Etude des Cellules Souches (CECS) | Automated method for preparing retinal pigment epithelium cells |
| CN110862364B (zh) * | 2019-11-14 | 2022-12-30 | 中国科学技术大学 | 制备呋喃基醛类化合物的方法 |
| JP2024522608A (ja) | 2021-06-09 | 2024-06-21 | リネージ セル セラピューティクス インコーポレイテッド | 網膜の疾患および症状を処置するための方法および組成物 |
| CA3225834A1 (en) | 2021-07-28 | 2023-02-02 | Lineage Cell Therapeutics, Inc. | Expansion of retinal pigment epithelium cells |
| CN114181142B (zh) * | 2021-12-31 | 2023-10-20 | 浙江工业大学 | 一种6-(4-甲基哌嗪-1-基)-4-邻甲苯基烟酰胺的合成方法 |
| IL316305A (en) | 2022-04-25 | 2024-12-01 | Hadasit Med Res Service | Methods and preparations for treating vision loss |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1557420A (en) | 1977-03-10 | 1979-12-12 | Soc D Etudes Prod Chimique | Preparation of isobutyramide derivatives |
| KR810001320B1 (ko) | 1977-03-17 | 1981-10-14 | 삐에르 위브 | 신규한 이소부티라미드류의 제조방법 |
| KR810001697B1 (ko) | 1978-02-06 | 1981-10-27 | 삐에르 위브 | 이소부티라미드 유도체의 신규한 제조방법 |
| DE3366369D1 (en) | 1982-03-17 | 1986-10-30 | Smith Kline French Lab | Pyridine derivatives |
| US4745123A (en) | 1986-02-18 | 1988-05-17 | Warner-Lambert Company | Substituted tetrahydro-3-pyridine-carboxylic acid, ester, and amide cholinergic agents |
| GB8607313D0 (en) | 1986-03-25 | 1986-04-30 | Ici Plc | Pharmaceutical compositions |
| GB8607312D0 (en) | 1986-03-25 | 1986-04-30 | Ici Plc | Therapeutic agents |
| CA1339423C (en) | 1988-09-14 | 1997-09-02 | Yuji Ono | Pyridine compounds and pharmaceutical use thereof |
| US4994456A (en) | 1989-03-01 | 1991-02-19 | Nisshin Flour Milling Co., Ltd. | Pyridinecarboxylic acid amide derivatives and pharmaceutical compositions comprising same |
| US4973597A (en) | 1989-06-30 | 1990-11-27 | Eli Lilly And Company | Anticonvulsant agents |
| HU207047B (en) | 1989-11-07 | 1993-03-01 | Richter Gedeon Vegyeszet | Process for producing new pyridine derivatives and pharmaceutical copositions comprising same |
| US5364943A (en) | 1991-11-27 | 1994-11-15 | Pfizer Inc. | Preparation of substituted piperidines |
| GB9021056D0 (en) | 1990-09-27 | 1990-11-07 | Pfizer Ltd | Antiarrhythmic agents |
| GB9214120D0 (en) | 1991-07-25 | 1992-08-12 | Ici Plc | Therapeutic amides |
| US5719147A (en) * | 1992-06-29 | 1998-02-17 | Merck & Co., Inc. | Morpholine and thiomorpholine tachykinin receptor antagonists |
| AU4718093A (en) * | 1992-07-31 | 1994-03-03 | Merck Sharp & Dohme Limited | Substituted amines as tachykinin receptor antagonists |
| US5387595A (en) * | 1992-08-26 | 1995-02-07 | Merck & Co., Inc. | Alicyclic compounds as tachykinin receptor antagonists |
| GB9305672D0 (en) | 1993-03-19 | 1993-05-05 | Wyeth John & Brother Ltd | Amide derivatives |
| AU6807994A (en) | 1993-05-28 | 1994-12-20 | Taisho Pharmaceutical Co., Ltd. | Medicinal use of pyridine derivative |
| NZ264063A (en) | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
| IL111960A (en) | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
| IL112134A (en) | 1993-12-29 | 1999-12-22 | Merck Sharp & Dohme | Substituted morpholine derivatives their preparation and pharmaceutical compositions containing them |
| IL112778A0 (en) | 1994-03-04 | 1995-05-26 | Merck & Co Inc | Substituted heterocycles, their preparation and pharmaceutical compositions containing them |
| DE69523154T2 (de) | 1994-06-06 | 2002-06-06 | Warner-Lambert Co., Morris Plains | Tachykinin (nk1) rezeptor antagonisten |
| WO1996000213A1 (en) | 1994-06-24 | 1996-01-04 | Taisho Pharmaceutical Co., Ltd. | Pyridine derivative |
| US6294537B1 (en) * | 1995-03-17 | 2001-09-25 | Sanofi-Synthelabo | Compounds which are specific antagonists of the human NK3 receptor and their use as medicinal products and diagnostic tools |
| EP0733632B1 (en) | 1995-03-24 | 2003-06-04 | Takeda Chemical Industries, Ltd. | Cyclic compounds, their production and use as tachykinin receptor antagonists |
| AR004735A1 (es) | 1995-11-24 | 1999-03-10 | Smithkline Beecham Spa | Quinoleina 4-amido sustituida, un procedimiento para su preparacion, una composicion farmaceutica que los contiene y el uso de los mismos para lapreparacion de un medicamento. |
| NZ326874A (en) | 1996-03-29 | 2000-01-28 | Pfizer | 6-phenylpyridyl-2-amine derivatives |
| WO1998021185A1 (en) | 1996-11-08 | 1998-05-22 | Sankyo Company, Limited | Arylureas or arylmethylcarbamoyl derivatives |
| US5972938A (en) * | 1997-12-01 | 1999-10-26 | Merck & Co., Inc. | Method for treating or preventing psychoimmunological disorders |
| IL144717A0 (en) | 1999-02-24 | 2002-06-30 | Hoffmann La Roche | Phenyl-and pyridinyl derivatives |
| EP1035115B1 (en) | 1999-02-24 | 2004-09-29 | F. Hoffmann-La Roche Ag | 4-Phenylpyridine derivatives and their use as NK-1 receptor antagonists |
| DE60006340T2 (de) | 1999-11-29 | 2004-09-09 | F. Hoffmann-La Roche Ag | 2-(3,5-Bis-trifluoromethyl-phenyl)-N-methyl-N-(6-morpholin-4-yl-4-o-tolyl-pyridin-3-yl)-isobutyramid |
| US6303790B1 (en) | 1999-11-29 | 2001-10-16 | Hoffman-La Roche Inc. | Process for the preparation of pyridine derivatives |
| TWI287003B (en) | 2000-07-24 | 2007-09-21 | Hoffmann La Roche | 4-phenyl-pyridine derivatives |
-
2004
- 2004-07-09 US US10/888,912 patent/US7288658B2/en not_active Expired - Lifetime
- 2004-07-09 TW TW093120669A patent/TWI280239B/zh not_active IP Right Cessation
- 2004-07-10 JP JP2006519843A patent/JP4575918B2/ja not_active Expired - Lifetime
- 2004-07-10 MX MXPA06000405A patent/MXPA06000405A/es active IP Right Grant
- 2004-07-10 CA CA2532355A patent/CA2532355C/en not_active Expired - Lifetime
- 2004-07-10 WO PCT/EP2004/007618 patent/WO2005014549A1/en not_active Ceased
- 2004-07-10 DE DE602004010820T patent/DE602004010820T2/de not_active Expired - Lifetime
- 2004-07-10 CN CN2004800232840A patent/CN1835922B/zh not_active Expired - Lifetime
- 2004-07-10 EP EP04763155A patent/EP1656351B1/en not_active Expired - Lifetime
- 2004-07-10 AT AT04763155T patent/ATE381543T1/de active
- 2004-07-10 KR KR1020067000860A patent/KR100742013B1/ko not_active Expired - Lifetime
- 2004-07-10 ES ES04763155T patent/ES2297457T3/es not_active Expired - Lifetime
- 2004-07-10 DK DK04763155T patent/DK1656351T3/da active
-
2006
- 2006-01-05 IL IL173000A patent/IL173000A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005014549A1 (en) | 2005-02-17 |
| TWI280239B (en) | 2007-05-01 |
| JP2009500292A (ja) | 2009-01-08 |
| DE602004010820D1 (de) | 2008-01-31 |
| ES2297457T3 (es) | 2008-05-01 |
| IL173000A0 (en) | 2006-06-11 |
| CN1835922A (zh) | 2006-09-20 |
| ATE381543T1 (de) | 2008-01-15 |
| EP1656351A1 (en) | 2006-05-17 |
| DE602004010820T2 (de) | 2008-12-04 |
| CA2532355A1 (en) | 2005-02-17 |
| CN1835922B (zh) | 2011-08-31 |
| EP1656351B1 (en) | 2007-12-19 |
| KR20060036090A (ko) | 2006-04-27 |
| US7288658B2 (en) | 2007-10-30 |
| TW200524872A (en) | 2005-08-01 |
| KR100742013B1 (ko) | 2007-07-23 |
| MXPA06000405A (es) | 2006-03-17 |
| JP4575918B2 (ja) | 2010-11-04 |
| CA2532355C (en) | 2012-05-15 |
| US20050014792A1 (en) | 2005-01-20 |
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