DK166278C - Triazinsalt, fremgangsmaade til dets fremstilling og farmaceutisk komposition indeholdende saltet - Google Patents

Triazinsalt, fremgangsmaade til dets fremstilling og farmaceutisk komposition indeholdende saltet

Info

Publication number: DK166278C
Authority: DK; Denmark
Prior art keywords: salt; triazin; procedure; preparation; pharmaceutical composition
Prior art date: 1986-05-30

Application number

DK275987A

Other languages

English (en)

Other versions

DK166278B (da

DK275987D0 (da

DK275987A (da

Inventor

David Alan Sawyer

Frederick Charles Copp

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-30

Filing date

1987-05-29

Publication date

1993-08-23

1987-05-29 Application filed by Wellcome Found filed Critical Wellcome Found

1987-05-29 Publication of DK275987D0 publication Critical patent/DK275987D0/da

1987-12-01 Publication of DK275987A publication Critical patent/DK275987A/da

1993-03-29 Publication of DK166278B publication Critical patent/DK166278B/da

1993-08-23 Application granted granted Critical

1993-08-23 Publication of DK166278C publication Critical patent/DK166278C/da

Links

150000003839 salts Chemical class 0.000 title abstract 2
IMHBYKMAHXWHRP-UHFFFAOYSA-N anilazine Chemical class ClC1=CC=CC=C1NC1=NC(Cl)=NC(Cl)=N1 IMHBYKMAHXWHRP-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
CJIDZLNMKONKAD-UHFFFAOYSA-N 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine;2-hydroxyethanesulfonic acid Chemical compound OCCS(O)(=O)=O.NC1=NC(N)=NN=C1C1=CC=CC(Cl)=C1Cl CJIDZLNMKONKAD-UHFFFAOYSA-N 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
238000007911 parenteral administration Methods 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK275987A 1986-05-30 1987-05-29 Triazinsalt, fremgangsmaade til dets fremstilling og farmaceutisk komposition indeholdende saltet DK166278C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB868613183A GB8613183D0 (en)	1986-05-30	1986-05-30	Triazine salt
GB8613183		1986-05-30

Publications (4)

Publication Number	Publication Date
DK275987D0 DK275987D0 (da)	1987-05-29
DK275987A DK275987A (da)	1987-12-01
DK166278B DK166278B (da)	1993-03-29
DK166278C true DK166278C (da)	1993-08-23

Family

ID=10598692

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK275987A DK166278C (da)	1986-05-30	1987-05-29	Triazinsalt, fremgangsmaade til dets fremstilling og farmaceutisk komposition indeholdende saltet

Country Status (18)

Country	Link
US (1)	US4847249A (da)
EP (1)	EP0247892B1 (da)
JP (1)	JPH0751571B2 (da)
KR (1)	KR910002254B1 (da)
AT (1)	ATE62902T1 (da)
AU (1)	AU597982B2 (da)
CA (1)	CA1286670C (da)
DE (1)	DE3769516D1 (da)
DK (1)	DK166278C (da)
ES (1)	ES2021709B3 (da)
FI (1)	FI90770C (da)
GB (1)	GB8613183D0 (da)
GR (1)	GR3001942T3 (da)
HU (1)	HU196769B (da)
IE (1)	IE60626B1 (da)
IL (1)	IL82710A (da)
NZ (1)	NZ220497A (da)
ZA (1)	ZA873896B (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9012312D0 (en) *	1990-06-01	1990-07-18	Wellcome Found	Pharmacologically active cns compounds
GB9124807D0 (en) *	1991-11-22	1992-01-15	Wellcome Found	Pharmaceutical formulations
US5629016A (en) *	1991-01-30	1997-05-13	Glaxo Wellcome Inc.	Water-dispersible tablets
UA37214C2 (uk) *	1991-01-30	2001-05-15	Дзе Веллкам Фаундейшн Лімітед	Таблетки, що диспергуються у воді, та спосіб їх виготовлення
GB9203483D0 (en) *	1992-02-19	1992-04-08	Wellcome Found	Anti-inflammatory compounds
CA2137782A1 (en) *	1992-06-12	1993-12-23	Meire Nakamura-Craig	Therapeutic triazine compounds and use
GB9215908D0 (en) *	1992-07-27	1992-09-09	Wellcome Found	Water dispersible tablets
FR2699078B1 (fr) *	1992-12-16	1995-01-13	Rhone Poulenc Rorer Sa	Application de la lamotrigine dans le traitement de lésions neurologiques liées à des traumatismes.
FR2699077B1 (fr) *	1992-12-16	1995-01-13	Rhone Poulenc Rorer Sa	Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
FR2700117B1 (fr) *	1993-01-07	1995-02-03	Rhone Poulenc Rorer Sa	Application d'anticonvulsivants dans le traitement de la maladie de Parkinson et des syndromes parkinsoniens.
FR2702148B1 (fr) *	1993-03-05	1995-04-07	Rhone Poulenc Rorer Sa	Application d'anticonvulsivants dans le traitement du neuro-sida.
US5866597A (en) *	1993-03-19	1999-02-02	Glaxo Wellcome Inc.	Use of triazine compounds for the treatment of memory and learning disorders
GB9305693D0 (en) *	1993-03-19	1993-05-05	Wellcome Found	Therapeutic triazine compounds and use
GB9306639D0 (en) *	1993-03-30	1993-05-26	Tocris Neuramin Limited	Organic compounds
FR2702149B1 (fr) *	1993-06-03	1995-04-07	Rhone Poulenc Rorer Sa	Application de la lamotrigine dans le traitement du neuro-sida.
US5698226A (en) *	1993-07-13	1997-12-16	Glaxo Wellcome Inc.	Water-dispersible tablets
GB9426448D0 (en) *	1994-12-30	1995-03-01	Wellcome Found	Process
FI972719L (fi) *	1994-12-30	1997-08-27	Wellcome Found	Menetelmä lamotrigiinin valmistamiseksi
GB9512854D0 (en) *	1995-06-23	1995-08-23	Wellcome Found	Novel formulation
GB9812413D0 (en)	1998-06-10	1998-08-05	Glaxo Group Ltd	Compound and its use
AU1292400A (en) *	1998-12-14	2000-07-03	Sharad Kumar Vyas	An improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
US6639072B1 (en)	2000-01-03	2003-10-28	Rpg Life Sciences Limited	Process for the preparation of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, commonly known as lamotrigine
IL134730A (en) *	2000-02-25	2003-10-31	Chemagis Ltd	Process for preparing substituted benzoyl cyanide amidinohydrazones
CA2439468A1 (en) *	2001-02-27	2002-09-06	Teva Pharmaceutical Industries Ltd.	New crystal forms of lamotrigine and processes for their preparations
WO2003090693A2 (en) *	2002-04-23	2003-11-06	Teva Pharmaceutical Industries Ltd.	Pharmaceutical composition containing lamotrigine particles of defined morphology
HU225667B1 (en)	2002-09-20	2007-05-29	Richter Gedeon Nyrt	Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
ES2209639B1 (es)	2002-10-31	2005-08-01	Vita Cientifica, S.L.	Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio.
GB2395483A (en) *	2003-07-03	2004-05-26	Jubilant Organosys Ltd	Crystalline lamotrigine and its monohydrate
WO2009061513A1 (en)	2007-11-09	2009-05-14	Thar Pharmaceuticals	Crystalline forms of lamotrigine
US12605388B2 (en)	2024-09-25	2026-04-21	Azurity Pharmaceuticals Ireland Limited	Lamotrigine salts, co-crystals, and compositions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL124029B1 (en) *	1979-06-01	1982-12-31	Wellcome Found	Process for preparing novel derivatives of 1,2,4-triazine
US4311701A (en) *	1979-08-16	1982-01-19	Barbara Roth	Treatment of convulsions with triazines
DE3271930D1 (en) *	1982-05-03	1986-08-14	Richardson Vicks Ltd	Pharmaceutical preparation for the topical treatment of acne
GB8328757D0 (en) *	1983-10-27	1983-11-30	Wellcome Found	Chemical compounds

1986
- 1986-05-30 GB GB868613183A patent/GB8613183D0/en active Pending
1987
- 1987-05-29 EP EP87304776A patent/EP0247892B1/en not_active Expired - Lifetime
- 1987-05-29 NZ NZ220497A patent/NZ220497A/xx unknown
- 1987-05-29 ES ES87304776T patent/ES2021709B3/es not_active Expired - Lifetime
- 1987-05-29 DK DK275987A patent/DK166278C/da active
- 1987-05-29 IL IL82710A patent/IL82710A/xx unknown
- 1987-05-29 CA CA000538395A patent/CA1286670C/en not_active Expired - Fee Related
- 1987-05-29 HU HU872487A patent/HU196769B/hu not_active IP Right Cessation
- 1987-05-29 AT AT87304776T patent/ATE62902T1/de not_active IP Right Cessation
- 1987-05-29 FI FI872406A patent/FI90770C/fi not_active IP Right Cessation
- 1987-05-29 ZA ZA873896A patent/ZA873896B/xx unknown
- 1987-05-29 JP JP62134772A patent/JPH0751571B2/ja not_active Expired - Fee Related
- 1987-05-29 DE DE8787304776T patent/DE3769516D1/de not_active Expired - Fee Related
- 1987-05-29 US US07/056,136 patent/US4847249A/en not_active Expired - Lifetime
- 1987-05-29 AU AU73684/87A patent/AU597982B2/en not_active Ceased
- 1987-05-29 KR KR1019870005364A patent/KR910002254B1/ko not_active Expired
- 1987-05-29 IE IE141587A patent/IE60626B1/en not_active IP Right Cessation
1991
- 1991-05-13 GR GR91400613T patent/GR3001942T3/el unknown

Also Published As

Publication number	Publication date
IE60626B1 (en)	1994-07-27
HU196769B (en)	1989-01-30
EP0247892B1 (en)	1991-04-24
GB8613183D0 (en)	1986-07-02
JPH0751571B2 (ja)	1995-06-05
AU7368487A (en)	1987-12-03
EP0247892A1 (en)	1987-12-02
DK166278B (da)	1993-03-29
DK275987D0 (da)	1987-05-29
ZA873896B (en)	1989-01-25
KR910002254B1 (ko)	1991-04-08
FI90770C (fi)	1994-03-25
IL82710A (en)	1992-01-15
JPS62289570A (ja)	1987-12-16
AU597982B2 (en)	1990-06-14
ES2021709B3 (es)	1991-11-16
KR870011112A (ko)	1987-12-21
ATE62902T1 (de)	1991-05-15
IE871415L (en)	1987-11-30
CA1286670C (en)	1991-07-23
HUT45978A (en)	1988-09-28
US4847249A (en)	1989-07-11
GR3001942T3 (en)	1992-11-23
FI872406L (fi)	1987-12-01
NZ220497A (en)	1990-05-28
DK275987A (da)	1987-12-01
FI872406A0 (fi)	1987-05-29
FI90770B (fi)	1993-12-15
DE3769516D1 (de)	1991-05-29
IL82710A0 (en)	1987-11-30

Publication	Publication Date	Title
DK275987A (da)	1987-12-01	Triazinsalt, fremgangsmaade til dets fremstilling og farmaceutisk komposition indeholdende saltet
DE3668892D1 (en)	1990-03-15	Hypoglycemische thiazolidinedione.
KR0156747B1 (en)	1998-11-16	Use of 1,3-oxathiolan nucleoside analogues in the treatment of hepatitis-b
ES2032503T3 (es)	1993-02-16	Medicamento para la zona de la cavidad bucal. (reserva del art. 167.2 cpe).
MX23619A (es)	1993-10-01	Derivados de aminoacidos y procedimiento para su preparacion y medicamento que lo contiene.
DK644388D0 (da)	1988-11-18	Farmaceutiske praeparater indeholdende 3-hydroxy-smoeresyrederivater
GR3006091T3 (da)	1993-06-21
PL291080A1 (en)	1992-01-27	Solution of cellulose in water and n-methyl-morpholin n-oxide
IL90551A0 (en)	1990-01-18	Stable,injectable,aqueous pharmaceutical compositions for the treatment of cardiac conditions
HU901085D0 (en)	1991-09-30	Process for producing substituted benzimidazole and pharmaceutical preparatives containing it
NO170330C (no)	1992-10-07	Fremgangsmaate for fremstilling av vesentlig optisk rent monohydrat av s-(-)-propyl-2',6'-pipekoloksylididhydroklorid
IT8767951A0 (it)	1987-11-06	Procedimento per la preparazione del 5 6 diidrossiindolo e del suo derivato 3 alchilato e composti intermedi
IL92799A0 (en)	1990-09-17	Benzimidazole derivatives with gastric acid inhibition and process for its preparation
CY1870A (en)	1996-04-05	Derivatives of penciclovir for the treatment of hepatitis-B infections
IL104775A0 (en)	1993-06-10	Pharmaceutical compositions containing triazine derivatives
SE8704849L (sv)	1988-06-06	Bruksferdiga injektionslosningar innehallande en antitumorantracyklinglykosid
IT1228437B (it)	1991-06-17	"derivati di 2,3,4,5,6,7 esaidro 2,7-metano-1,5 benzossazonina (rispettivamente 1,4 benzossazonina), procedimento per la loro preparazione e prodotti medicinali che contengono questi composti.
IL89401A0 (en)	1989-09-10	Medicaments containing 1,4-dihydropyridine derivatives for the treatment of alcohol addiction
MY104782A (en)	1994-05-31	Glutaric acid derivatives and preparations thereof.
DK417889D0 (da)	1989-08-24	Anvendelse af 2-azabicyklo(2.2.2.)-carboxylsyrederivater til fremstilling af medicinske produkter til behandling af vaskulaere sygdomme
RO94741A2 (ro)	1988-08-15	Procedeu pentru prepararea unor derivati tetrametilpiperidinici
IT8520877A0 (it)	1985-05-24	Procedimento di preparazione di derivati del 9h-xanthen-9-one, derivati cosi' ottenuti e loro impiego terapeutico.
IT8867820A0 (it)	1988-09-15	Procedimento di preparazione di derivati dell'1,4-benzodiazepina-4-one