ES2021709B3 - Nueva sal de triazina. - Google Patents

Nueva sal de triazina.

Info

Publication number: ES2021709B3
Authority: ES; Spain
Prior art keywords: triazine salt; new triazine; salt; new; dichlorophenyl
Prior art date: 1986-05-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES87304776T

Other languages

English (en)

Inventor

David Alan Sawyer

Frederick Charles Copp

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Wellcome Foundation Ltd

Original Assignee

Wellcome Foundation Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-30

Filing date

1987-05-29

Publication date

1991-11-16

1987-05-29 Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd

1991-11-16 Application granted granted Critical

1991-11-16 Publication of ES2021709B3 publication Critical patent/ES2021709B3/es

2007-05-29 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

150000003918 triazines Chemical class 0.000 title 1
CJIDZLNMKONKAD-UHFFFAOYSA-N 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine;2-hydroxyethanesulfonic acid Chemical compound OCCS(O)(=O)=O.NC1=NC(N)=NN=C1C1=CC=CC(Cl)=C1Cl CJIDZLNMKONKAD-UHFFFAOYSA-N 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
238000007911 parenteral administration Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

ES87304776T 1986-05-30 1987-05-29 Nueva sal de triazina. Expired - Lifetime ES2021709B3 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB868613183A GB8613183D0 (en)	1986-05-30	1986-05-30	Triazine salt

Publications (1)

Publication Number	Publication Date
ES2021709B3 true ES2021709B3 (es)	1991-11-16

Family

ID=10598692

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES87304776T Expired - Lifetime ES2021709B3 (es)	1986-05-30	1987-05-29	Nueva sal de triazina.

Country Status (18)

Country	Link
US (1)	US4847249A (es)
EP (1)	EP0247892B1 (es)
JP (1)	JPH0751571B2 (es)
KR (1)	KR910002254B1 (es)
AT (1)	ATE62902T1 (es)
AU (1)	AU597982B2 (es)
CA (1)	CA1286670C (es)
DE (1)	DE3769516D1 (es)
DK (1)	DK166278C (es)
ES (1)	ES2021709B3 (es)
FI (1)	FI90770C (es)
GB (1)	GB8613183D0 (es)
GR (1)	GR3001942T3 (es)
HU (1)	HU196769B (es)
IE (1)	IE60626B1 (es)
IL (1)	IL82710A (es)
NZ (1)	NZ220497A (es)
ZA (1)	ZA873896B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9012312D0 (en) *	1990-06-01	1990-07-18	Wellcome Found	Pharmacologically active cns compounds
GB9124807D0 (en) *	1991-11-22	1992-01-15	Wellcome Found	Pharmaceutical formulations
MY110880A (en) *	1991-01-30	1999-06-30	The Wellcome Foundation Ltd	Water-dispersible tablets
US5629016A (en) *	1991-01-30	1997-05-13	Glaxo Wellcome Inc.	Water-dispersible tablets
GB9203483D0 (en) *	1992-02-19	1992-04-08	Wellcome Found	Anti-inflammatory compounds
ES2097516T3 (es) *	1992-06-12	1997-04-01	Wellcome Found	Uso de isetionato de 3,5-diamino-6-(2,3-diclorofenil)-1,2,4-triazina para el tratamiento y prevencion de la dependencia, tolerancia y sensibilidad a los farmacos y drogas.
GB9215908D0 (en) *	1992-07-27	1992-09-09	Wellcome Found	Water dispersible tablets
FR2699078B1 (fr) *	1992-12-16	1995-01-13	Rhone Poulenc Rorer Sa	Application de la lamotrigine dans le traitement de lésions neurologiques liées à des traumatismes.
FR2699077B1 (fr) *	1992-12-16	1995-01-13	Rhone Poulenc Rorer Sa	Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
FR2700117B1 (fr) *	1993-01-07	1995-02-03	Rhone Poulenc Rorer Sa	Application d'anticonvulsivants dans le traitement de la maladie de Parkinson et des syndromes parkinsoniens.
FR2702148B1 (fr) *	1993-03-05	1995-04-07	Rhone Poulenc Rorer Sa	Application d'anticonvulsivants dans le traitement du neuro-sida.
GB9305693D0 (en) *	1993-03-19	1993-05-05	Wellcome Found	Therapeutic triazine compounds and use
US5866597A (en) *	1993-03-19	1999-02-02	Glaxo Wellcome Inc.	Use of triazine compounds for the treatment of memory and learning disorders
GB9306639D0 (en) *	1993-03-30	1993-05-26	Tocris Neuramin Limited	Organic compounds
FR2702149B1 (fr) *	1993-06-03	1995-04-07	Rhone Poulenc Rorer Sa	Application de la lamotrigine dans le traitement du neuro-sida.
US5698226A (en) *	1993-07-13	1997-12-16	Glaxo Wellcome Inc.	Water-dispersible tablets
GB9426448D0 (en) *	1994-12-30	1995-03-01	Wellcome Found	Process
EP0800520B1 (en) *	1994-12-30	2002-06-19	The Wellcome Foundation Limited	Process for the preparation of lamotrigine
GB9512854D0 (en) *	1995-06-23	1995-08-23	Wellcome Found	Novel formulation
GB9812413D0 (en)	1998-06-10	1998-08-05	Glaxo Group Ltd	Compound and its use
AU1292400A (en) *	1998-12-14	2000-07-03	Sharad Kumar Vyas	An improved process for the preparation of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
WO2001049669A1 (en) *	2000-01-03	2001-07-12	Rpg Life Sciences Limited	A process for the preparation of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, commonly known as lamotrigine
IL134730A (en) *	2000-02-25	2003-10-31	Chemagis Ltd	Process for preparing substituted benzoyl cyanide amidinohydrazones
IL157608A0 (en) *	2001-02-27	2004-03-28	Teva Pharma	New crystal forms of lamotrigine and processes for their preparations
CA2483103A1 (en) *	2002-04-23	2003-11-06	Teva Pharmaceutical Industries Ltd.	Pharmaceutical composition containing lamotrigine particles of defined morphology
HU225667B1 (en) *	2002-09-20	2007-05-29	Richter Gedeon Nyrt	Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
ES2209639B1 (es)	2002-10-31	2005-08-01	Vita Cientifica, S.L.	Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio.
GB2395483A (en) *	2003-07-03	2004-05-26	Jubilant Organosys Ltd	Crystalline lamotrigine and its monohydrate
US8486927B2 (en)	2007-11-09	2013-07-16	Thar Pharmaceuticals	Crystalline forms of lamotrigine
US12605388B2 (en)	2024-09-25	2026-04-21	Azurity Pharmaceuticals Ireland Limited	Lamotrigine salts, co-crystals, and compositions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK153787C (da) *	1979-06-01	1989-01-16	Wellcome Found	Analogifremgangsmaade til fremstilling af substituerede 3,5-diamino-6-phenyl-1,2,4-triaziner og alfa-cyanobenzyliden-aminoguanidinforbindelser til anvendelse som mellemprodukter herved
DE3069556D1 (en) *	1979-08-16	1984-12-06	Wellcome Found	Solid pharmaceutical formulation containing substitued phenyl-triazines
EP0093186B1 (en) *	1982-05-03	1986-07-09	Richardson Vicks Limited	Pharmaceutical preparation for the topical treatment of acne
GB8328757D0 (en) *	1983-10-27	1983-11-30	Wellcome Found	Chemical compounds

1986
- 1986-05-30 GB GB868613183A patent/GB8613183D0/en active Pending
1987
- 1987-05-29 IE IE141587A patent/IE60626B1/en not_active IP Right Cessation
- 1987-05-29 HU HU872487A patent/HU196769B/hu not_active IP Right Cessation
- 1987-05-29 CA CA000538395A patent/CA1286670C/en not_active Expired - Fee Related
- 1987-05-29 JP JP62134772A patent/JPH0751571B2/ja not_active Expired - Fee Related
- 1987-05-29 AU AU73684/87A patent/AU597982B2/en not_active Ceased
- 1987-05-29 KR KR1019870005364A patent/KR910002254B1/ko not_active Expired
- 1987-05-29 US US07/056,136 patent/US4847249A/en not_active Expired - Lifetime
- 1987-05-29 NZ NZ220497A patent/NZ220497A/xx unknown
- 1987-05-29 DE DE8787304776T patent/DE3769516D1/de not_active Expired - Fee Related
- 1987-05-29 FI FI872406A patent/FI90770C/fi not_active IP Right Cessation
- 1987-05-29 ZA ZA873896A patent/ZA873896B/xx unknown
- 1987-05-29 EP EP87304776A patent/EP0247892B1/en not_active Expired - Lifetime
- 1987-05-29 DK DK275987A patent/DK166278C/da active
- 1987-05-29 IL IL82710A patent/IL82710A/xx unknown
- 1987-05-29 AT AT87304776T patent/ATE62902T1/de not_active IP Right Cessation
- 1987-05-29 ES ES87304776T patent/ES2021709B3/es not_active Expired - Lifetime
1991
- 1991-05-13 GR GR91400613T patent/GR3001942T3/el unknown

Also Published As

Publication number	Publication date
IL82710A0 (en)	1987-11-30
KR870011112A (ko)	1987-12-21
DK275987A (da)	1987-12-01
JPH0751571B2 (ja)	1995-06-05
EP0247892A1 (en)	1987-12-02
ATE62902T1 (de)	1991-05-15
HUT45978A (en)	1988-09-28
US4847249A (en)	1989-07-11
NZ220497A (en)	1990-05-28
AU597982B2 (en)	1990-06-14
GB8613183D0 (en)	1986-07-02
FI872406L (fi)	1987-12-01
DE3769516D1 (de)	1991-05-29
DK166278B (da)	1993-03-29
FI90770C (fi)	1994-03-25
FI90770B (fi)	1993-12-15
IE60626B1 (en)	1994-07-27
IL82710A (en)	1992-01-15
EP0247892B1 (en)	1991-04-24
AU7368487A (en)	1987-12-03
DK275987D0 (da)	1987-05-29
CA1286670C (en)	1991-07-23
ZA873896B (en)	1989-01-25
IE871415L (en)	1987-11-30
GR3001942T3 (en)	1992-11-23
HU196769B (en)	1989-01-30
JPS62289570A (ja)	1987-12-16
KR910002254B1 (ko)	1991-04-08
DK166278C (da)	1993-08-23
FI872406A0 (fi)	1987-05-29

Publication	Publication Date	Title
ES2021709B3 (es)	1991-11-16	Nueva sal de triazina.
NO2006018I2 (no)	2008-10-20	Entekavir
DK0509019T3 (da)	1999-04-19	Behandling af humane retrovirale infektioner med 2',3'-dideoxyinosin
TJ249B (en)	1999-12-23	1,3-Oxathiolane nucleoside analogues their use
DE69122646D1 (de)	1996-11-21	Konzentrierte wässrige Tensidlösung
EP0617698A4 (en)	1995-02-01	AQUEOUS AMMONIA INJECTION PROCESS.
FI911763A7 (fi)	1991-10-13	N5-metyyli-5,6,7,8-tetrahydrofoolihapon ammoniumsuolat
SE8600017D0 (sv)	1986-01-03	New compound
NO174232C (no)	1994-04-06	Anvendelse av 1,2,4-triazindioner for fremstilling av midler mot fiskeparasitter
MX9203125A (es)	1992-07-01	Compuestos con actividad similar a la insulina, antidiabeticos.
DE3688776D1 (de)	1993-09-02	Hydroxyoxaalkylmelamine, verfahren zu ihrer herstellung und deren verwendung.
CY1870A (en)	1996-04-05	Derivatives of penciclovir for the treatment of hepatitis-B infections
SE8704849L (sv)	1988-06-06	Bruksferdiga injektionslosningar innehallande en antitumorantracyklinglykosid
GB2277265A (en)	1994-10-26	Use of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine for the treatment of pain and oedema
IT8885584A0 (it)	1988-05-27	Sistema di bloccaggio dell'apertura contemporanea di piu' cassetti in una cassettiera.
ES1006421Y (es)	1989-08-01	Cerradura antipanico perfeccionada.
GR871510B (en)	1987-10-08	Paracetamole stable aqueous solutions for injection
ATE18410T1 (de)	1986-03-15	Kristallines human-leukocyten-interferon.
KR880001379U (ko)	1988-03-15	단파장, 다파장 일체형 레이저 발진기
DE3363560D1 (en)	1986-06-26	Finely pulverized 2,4-diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine and pharmaceutically acceptable acid addition salts thereof
DE3260053D1 (de)	1984-04-12	Herbicidal 4-amino-6-(2-chloro-1-methyl-cyclopropyl)-3-methylthio-1,2,4-triazin-5-one
IT8522214V0 (it)	1985-06-19	Bottone del tipo detto "automatico" avente anche una funzione di gancio per un bloccaggio stabile delle due parti del bottone.
IT8607120V0 (it)	1986-12-03	Serratura tubolare perfezionata.
NO885273D0 (no)	1988-11-25	5,6-dihydro-2-(substituert fenyl)-1,2,4-triazin-3,5(2h,4h)-dioner.
SU1499898A1 (ru)	2016-09-10	СОЛИ 9-ДИАЛКИЛАМИНОЭТИЛ-2-МЕТИЛ-3-ТЕНОИЛИМИДАЗО[1,2-а]БЕНЗИМИДАЗОЛА, ОБЛАДАЮЩИЕ АНТИРАДИОМИМЕТИЧЕСКИМ ДЕЙСТВИЕМ