DK1670444T3 - Anvendelse af IFG-1-serumniveau forhøjende indoleddikesyrederivater til fremstilling af en lægemiddelsammensætning til behandling af forskellige sygdomme - Google Patents
Anvendelse af IFG-1-serumniveau forhøjende indoleddikesyrederivater til fremstilling af en lægemiddelsammensætning til behandling af forskellige sygdommeInfo
- Publication number
- DK1670444T3 DK1670444T3 DK03757934.9T DK03757934T DK1670444T3 DK 1670444 T3 DK1670444 T3 DK 1670444T3 DK 03757934 T DK03757934 T DK 03757934T DK 1670444 T3 DK1670444 T3 DK 1670444T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- serum
- ifg
- elevating
- prepare
- Prior art date
Links
- 210000002966 serum Anatomy 0.000 title abstract 2
- BOIZHGCLUSQNLD-UHFFFAOYSA-N acetic acid;1h-indole Chemical class CC(O)=O.C1=CC=C2NC=CC2=C1 BOIZHGCLUSQNLD-UHFFFAOYSA-N 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000003028 elevating effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 abstract 2
- 102100037852 Insulin-like growth factor I Human genes 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010065369 Burnout syndrome Diseases 0.000 abstract 1
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 230000003712 anti-aging effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000015872 dietary supplement Nutrition 0.000 abstract 1
- 206010016256 fatigue Diseases 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/168—Steroids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/184—Hormones
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Birds (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Marine Sciences & Fisheries (AREA)
- Insects & Arthropods (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2003/011171 WO2005039546A2 (en) | 2003-10-03 | 2003-10-03 | Use of indoleacetic acid derivatives which increase the serum igf-1 level for the preparation of a therapeutical composition for treatment of various diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1670444T3 true DK1670444T3 (da) | 2011-08-22 |
Family
ID=34429223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03757934.9T DK1670444T3 (da) | 2003-10-03 | 2003-10-03 | Anvendelse af IFG-1-serumniveau forhøjende indoleddikesyrederivater til fremstilling af en lægemiddelsammensætning til behandling af forskellige sygdomme |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9408405B2 (da) |
| EP (1) | EP1670444B1 (da) |
| JP (1) | JP4641942B2 (da) |
| CN (1) | CN1938018B (da) |
| AT (1) | ATE506948T1 (da) |
| AU (1) | AU2003273967A1 (da) |
| CA (1) | CA2541090C (da) |
| CY (1) | CY1116665T1 (da) |
| DE (1) | DE60336934D1 (da) |
| DK (1) | DK1670444T3 (da) |
| ES (2) | ES2365847T3 (da) |
| PT (2) | PT1670444E (da) |
| RU (1) | RU2345552C2 (da) |
| SI (1) | SI1670444T1 (da) |
| WO (1) | WO2005039546A2 (da) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9408405B2 (en) | 2003-10-03 | 2016-08-09 | Veijlen N.V. | Use of compounds that are able to increase the serum IGF-1 level for the preparation of a therapeutical composition for treatment of various disease states associated with a reduced IGF-1 serum level in humans and animals |
| CN1870992A (zh) | 2003-10-03 | 2006-11-29 | 维伊林股份有限公司 | 动物饲料组合物 |
| EP1685833A1 (en) * | 2003-11-21 | 2006-08-02 | Ajinomoto Co., Inc. | Remedy for diabetes |
| PL2118123T3 (pl) | 2007-01-31 | 2016-06-30 | Dana Farber Cancer Inst Inc | Stabilizowane peptydy p53 i ich zastosowania |
| RU2339378C1 (ru) * | 2007-02-16 | 2008-11-27 | Российская военно-медицинская академия им. С.М. Кирова | ПРИМЕНЕНИЕ ГИДРОБРОМИДА 2-АМИНО-7-БРОМ-4-АЦЕТИЛТИАЗОЛО[5,4-b]ИНДОЛА ДЛЯ ПОВЫШЕНИЯ РАБОТОСПОСОБНОСТИ |
| JP5631201B2 (ja) | 2007-03-28 | 2014-11-26 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ステッチングされたポリペプチド |
| US9063122B2 (en) * | 2008-10-17 | 2015-06-23 | Alfredo Gallegos | Biomodulators for treatment or prevention of disease |
| JP5910495B2 (ja) | 2009-06-11 | 2016-04-27 | ディーエスエム アイピー アセッツ ビー.ブイ. | 筋肉刺激剤としてのナイアシン及び/又はトリゴネリン |
| US9790186B2 (en) | 2009-07-21 | 2017-10-17 | Trustees Of Dartmouth College | Composition and method for prevention, mitigation or treatment of an enteropathogenic bacterial infection |
| KR102104762B1 (ko) | 2010-08-13 | 2020-04-24 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| EP2768518A4 (en) | 2011-10-18 | 2015-05-27 | Aileron Therapeutics Inc | PEPTIDOMIMETIC MACROCYCLES |
| RU2642299C2 (ru) | 2012-02-15 | 2018-01-24 | Эйлерон Терапьютикс, Инк. | P53 пептидомиметические макроциклы |
| CA2864120A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| BR112015009470A2 (pt) | 2012-11-01 | 2019-12-17 | Aileron Therapeutics Inc | aminoácidos dissubstituídos e seus métodos de preparação e uso |
| CN104936591B (zh) * | 2012-11-26 | 2018-05-29 | 国立大学法人东北大学 | 促红细胞生成素表达增强剂 |
| RU2524634C1 (ru) * | 2013-06-25 | 2014-07-27 | Государственное научное учреждение Северо-Кавказский зональный научно-исследовательский ветеринарный институт (ГНУ СКЗНИВИ) Российской академии сельскохозяйственных наук | Способ стимуляции роста птицы |
| ES2872998T3 (es) * | 2013-12-19 | 2021-11-03 | Puretein Bioscience Llc | Procedimientos de tratamiento de animales |
| KR102265412B1 (ko) * | 2014-08-13 | 2021-06-14 | 주식회사 엘지생활건강 | 그라민 또는 이의 약학적으로 허용가능한 염을 포함하는 피부 미백, 탄력, 주름개선, 보습 또는 항염증용 화장료 또는 약학 조성물 |
| EP3197478A4 (en) | 2014-09-24 | 2018-05-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| BR112017012792A2 (pt) * | 2014-12-16 | 2018-01-02 | Puretein Bioscience Llc | métodos para aumentar a concentração de igf, para tratar uma condição, para melhorar ou manter a saúde e para melhorar uma característica |
| JP2018516844A (ja) | 2015-03-20 | 2018-06-28 | エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics,Inc. | ペプチド模倣大環状分子およびその使用 |
| WO2017035288A1 (en) * | 2015-08-27 | 2017-03-02 | Trustees Of Dartmouth College | Composition and method for prevention, mitigation or treatment of an enteropathogenic bacterial infection |
| US20180021326A1 (en) * | 2016-07-23 | 2018-01-25 | Paul Edward Stamets | Compositions and methods for enhancing neuroregeneration and cognition by combining mushroom extracts containing active ingredients psilocin or psilocybin with erinacines or hericenones enhanced with niacin |
| US11701348B1 (en) | 2016-07-23 | 2023-07-18 | Turtle Bear Holdings, Llc | Psilocybin compositions |
| US20210069170A1 (en) | 2016-07-23 | 2021-03-11 | Paul Edward Stamets | Tryptamine compositions for enhancing neurite outgrowth |
| WO2019032627A1 (en) * | 2017-08-09 | 2019-02-14 | Intervene Immune, Inc. | PHARMACEUTICAL PRODUCTS AND MEANS FOR REVERSE INVERSION OF HUMAN AGING |
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| BR112021011331A2 (pt) * | 2018-12-13 | 2021-08-31 | Aim Immunotech Inc. | Métodos para melhorar a tolerância ao exercício em pacientes com encefalomielite miálgica |
| KR20210134313A (ko) * | 2019-01-30 | 2021-11-09 | 다이아몬드 테라퓨틱스 인크. | 심리적, 인지적, 행동적 및/또는 기분 장애의 치료를 위한 5ht 수용체 아고니스트를 포함하는 조성물 및 방법 |
| JP2022529781A (ja) | 2019-04-17 | 2022-06-24 | コンパス パスファインダー リミテッド | サイロシビンによるうつ病及び他の様々な障害の治療 |
| CN111407884B (zh) * | 2019-06-24 | 2021-12-07 | 浙江大学 | 促生长激素释放激素激动剂ghrh-a在制备抗衰老药物中的用途 |
| EP4027984A4 (en) * | 2019-09-09 | 2023-10-18 | The University of Chicago | Combination therapy for the treatment of migraines |
| CN114787363A (zh) | 2019-10-01 | 2022-07-22 | 恩派瑞安神经科学公司 | 对真菌进行遗传工程化以调节色胺表达 |
| AU2020386445B2 (en) | 2019-11-19 | 2025-12-18 | Paul Edward Stamets | Tryptamine compositions for enhancing neurite outgrowth |
| US12240813B2 (en) | 2020-05-19 | 2025-03-04 | Cybin Irl Limited | Deuterated tryptamine derivatives and methods of use |
| US20220132902A1 (en) * | 2020-08-12 | 2022-05-05 | Pharmavite, Llc | Prebiotic composition of pectin, beta-glucan, xylooligosaccharide and/or ashwagandha and a method of improving mood |
| WO2022047580A1 (en) | 2020-09-01 | 2022-03-10 | Magicmed Industries Inc. | Hydroxylated psilocybin derivatives and methods of using |
| CN112138028A (zh) * | 2020-10-10 | 2020-12-29 | 南京中医药大学 | 蟾蜍色胺类物质在制备抗抑郁药物中的应用 |
| US20220265601A1 (en) * | 2021-02-10 | 2022-08-25 | David Alan Heldreth, JR. | Methods of use and formulations of allosteric modulators of the serotonin, dopamine and other receptor systems for medical, recreational, religious, research and other uses. |
| WO2023130078A2 (en) | 2021-12-31 | 2023-07-06 | Empyrean Neuroscience, Inc. | Genetically modified mycelium for producing psychotropic alkaloids |
| EP4486448A1 (en) | 2022-03-04 | 2025-01-08 | Reset Pharmaceuticals, Inc. | Co-crystals or salts comprising psilocin |
| CN114870018A (zh) * | 2022-05-12 | 2022-08-09 | 江南大学 | 炎症小体nlrp3抑制剂通过抑制神经系统炎症在制备治疗阿尔茨海默症药物中的应用 |
| IL315086A (en) | 2022-06-09 | 2024-10-01 | Diamond Therapeutics Inc | Amorphous (A-polymorphic) psilocybin |
| CN115813918B (zh) * | 2022-09-30 | 2024-04-02 | 中国药科大学 | 吲哚乙酸在制备抑郁症治疗药物中的应用 |
| CN117159528A (zh) * | 2023-01-13 | 2023-12-05 | 再造再生健康科技(杭州)有限公司 | 用于促进提高内源类胰岛素样生长因子1分泌的组合物 |
| CN116124950B (zh) * | 2023-02-22 | 2025-02-21 | 复旦大学 | 用于生长激素注射筛查或检测的血清生物标志物及其应用 |
| WO2026047364A1 (en) * | 2024-08-30 | 2026-03-05 | University Of Miami | Method for treatment of neurodegenerative diseases with growth hormone releasing hormone and synthetic analogs thereof |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA957281A (en) * | 1970-02-03 | 1974-11-05 | Nathan N. Share | Pharmaceutical compositions containing indole-3-acetic acid derivatives as a skeletal muscle stimulant |
| US4025650A (en) | 1975-11-24 | 1977-05-24 | Control Drug, Inc. | Method and composition for preventing nutritional deficiency |
| GB1475861A (en) | 1976-03-19 | 1977-06-10 | Warner Lambert Co | Pharmaceutical composition |
| GB1535778A (en) | 1976-12-06 | 1978-12-13 | Mac Sweeney D | Compounds useful in treatment of unipolar depression |
| JPS60199801A (ja) | 1984-03-24 | 1985-10-09 | Masaki Kamata | 動物に対する植物成長ホルモンの投与方法 |
| US4687763A (en) | 1985-02-25 | 1987-08-18 | Massachusetts Institute Of Technology | Composition and method for increasing levels or release of brain serotonin |
| US4650789A (en) * | 1985-10-15 | 1987-03-17 | Commonwealth Medical Corporation Of America | Method and composition for increasing production of serotonin |
| BE1000990A3 (nl) | 1987-10-09 | 1989-05-30 | Picanol Nv | Inrichting voor het op elkaar aansluiten van onderling verplaatsbare elementen, en transportinrichting die eerstgenoemde inrichting toepast. |
| GB8727099D0 (en) | 1987-11-19 | 1987-12-23 | Cellena Cell Eng A G | Compositions containing melantonin/homologues |
| US4945103A (en) | 1989-01-17 | 1990-07-31 | Michael Cohen | Method of treating pre-menstrual syndrome |
| IT1237472B (it) * | 1989-10-04 | 1993-06-07 | Polifarma Spa | Derivati di acido 3-indolpiruvico, loro procedimento di produzione ed impiego terapeutico. |
| US5132113A (en) | 1990-10-26 | 1992-07-21 | Maurizio Luca | Nutritional composition containing essential amino acids |
| US5192753A (en) * | 1991-04-23 | 1993-03-09 | Mcgeer Patrick L | Anti-rheumatoid arthritic drugs in the treatment of dementia |
| PT100973A (pt) | 1991-10-18 | 1994-06-30 | Alza Corp | Dispositivo e composicoes farmaceuticas para a administracao de melatonina por via transdermica |
| GB9214419D0 (en) * | 1992-07-07 | 1992-08-19 | Concannon Peter | Biocidal agents |
| JPH0725838A (ja) * | 1993-05-13 | 1995-01-27 | Yotsuba Yuka Kk | 疲労の予防または回復のための経口投与剤 |
| JP3541969B2 (ja) | 1994-09-29 | 2004-07-14 | 東洋紡績株式会社 | ベットマット |
| JP3617102B2 (ja) * | 1995-01-27 | 2005-02-02 | 味の素株式会社 | ヒト筋肉疲労の早期回復効果を有するアミノ酸栄養組成物 |
| JPH08308580A (ja) * | 1995-05-17 | 1996-11-26 | Takeda Chem Ind Ltd | 組換え型ヒトghrhレセプター蛋白質、その製造法および用途 |
| EP0766966A3 (en) | 1995-09-08 | 2001-02-28 | Eli Lilly And Company | Method of treating insulin resistance |
| FR2741799B1 (fr) * | 1995-12-04 | 1998-01-02 | Oreal | Utilisation de melatonine dans une composition pour traiter les signes cutanes des etats de fatigue |
| DE69723812D1 (de) * | 1996-01-09 | 2003-09-04 | Riken Wako | Aminosäurezusammensetzungen |
| FR2746313B1 (fr) | 1996-03-22 | 1998-04-17 | Adir | Utilisation de la melatonine et des ligands melatoninergiques pour l'obtention de compositions pharmaceutiques destinees a la prevention et au traitement du diabete et des complications diabetiques |
| US5958964A (en) | 1997-02-18 | 1999-09-28 | South Alabama Medical Science Foundation | Use of melatonin to prevent cytotoxic effects of amyloid beta protein |
| DE19739763A1 (de) | 1997-09-10 | 1999-09-23 | Franz Uhl | Vitamin B3/Niacin zur Behandlung von Krankheiten |
| US6017946A (en) * | 1997-10-08 | 2000-01-25 | Posner; Robert | Serotonin containing formulation for oral administration and method of use |
| EP1159292A2 (en) | 1998-08-14 | 2001-12-05 | Administrators of The Tulane Educational Fund | Compounds having growth hormone releasing activity |
| CN1261158C (zh) * | 1998-09-03 | 2006-06-28 | 诺兰兹公司 | 生长激素在制备用于诱导神经保护作用的药剂中的应用 |
| IL132366A0 (en) | 1998-10-15 | 2001-03-19 | Cell Pathways Inc | Methods for identifying compounds for inhibition of neoplastic lesions and pharmaceutical compositions containing such compounds |
| CN1069050C (zh) | 1998-12-01 | 2001-08-01 | 周旭生 | 一种治疗糖尿病的中药复方制剂 |
| WO2000033834A1 (en) * | 1998-12-04 | 2000-06-15 | Neurosearch A/S | Use of isatin derivatives as ion channel activating agents |
| FR2795323B1 (fr) * | 1999-06-23 | 2001-11-16 | Adir | Utilisation de ligands melatoninergiques pour l'obtention de compositions pharmaceutiques destinees a la prevention ou au traitement des pathologies du systeme gastrointestinal |
| JP2001026579A (ja) * | 1999-07-13 | 2001-01-30 | Kobe Tennenbutsu Kagaku Kk | インドール酢酸類の製造方法 |
| CN1088597C (zh) * | 1999-10-26 | 2002-08-07 | 合肥永生制药有限公司 | 尿多酸肽组合物及其用途 |
| US20020155163A1 (en) * | 1999-12-27 | 2002-10-24 | Samuel D. Benjamin | Integrated multi-vitamin and mineral combination |
| AU2001238718A1 (en) | 2000-03-02 | 2001-09-12 | The Institutes For Pharmaceutical Discovery, Llc | Compositions containing a substituted indolealkanoic acid and an angiotensin converting enzyme inhibitor |
| DE10037773C1 (de) * | 2000-08-03 | 2002-08-22 | Hennecke Gmbh | Verfahren und Vorrichtung zum Herstellen von mit Langfasern verstärkten Kunststoff-Formteilen |
| DE10109798A1 (de) | 2001-03-01 | 2002-09-12 | Aventis Pharma Gmbh | Gesundheitsfördernde Zusammensetzung von Verbindungen |
| US20030166554A1 (en) * | 2001-01-16 | 2003-09-04 | Genset, S.A. | Treatment of CNS disorders using D-amino acid oxidase and D-aspartate oxidase antagonists |
| JP2002281914A (ja) | 2001-03-27 | 2002-10-02 | Nishi Nippon Green Kk | 魚類、家畜類の栄養活力促進剤の製造方法 |
| US20020147155A1 (en) * | 2001-04-06 | 2002-10-10 | Foster Warren G. | Prevention and treatment of endometriosis with aryl hydrocarbon receptor binding ligands |
| CN1408397A (zh) | 2001-09-26 | 2003-04-09 | 北京本元青阳生物科技发展有限公司 | 含褪黑素和益智中药的组合物 |
| JP2003137808A (ja) * | 2001-10-26 | 2003-05-14 | Kakunai Juyotai Kenkyusho:Kk | 新規経腸栄養剤の製造法 |
| KR20040091141A (ko) * | 2002-03-18 | 2004-10-27 | 파마시아 코포레이션 | 알도스테론 수용체 길항물질 및 니코틴산 또는 니코틴산유도체의 혼합물 |
| CN1440744A (zh) | 2003-02-15 | 2003-09-10 | 高景曦 | 纳米包覆退黑激素复合保健品 |
| EP1620088A4 (en) | 2003-04-28 | 2007-08-29 | Bayer Pharmaceuticals Corp | ACETIC INDOLE ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS |
| CN1870992A (zh) | 2003-10-03 | 2006-11-29 | 维伊林股份有限公司 | 动物饲料组合物 |
| US9408405B2 (en) | 2003-10-03 | 2016-08-09 | Veijlen N.V. | Use of compounds that are able to increase the serum IGF-1 level for the preparation of a therapeutical composition for treatment of various disease states associated with a reduced IGF-1 serum level in humans and animals |
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- 2003-10-03 CA CA2541090A patent/CA2541090C/en not_active Expired - Lifetime
- 2003-10-03 PT PT03757934T patent/PT1670444E/pt unknown
- 2003-10-03 AU AU2003273967A patent/AU2003273967A1/en not_active Abandoned
- 2003-10-03 ES ES03757934T patent/ES2365847T3/es not_active Expired - Lifetime
- 2003-10-03 SI SI200332019T patent/SI1670444T1/sl unknown
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- 2003-10-03 JP JP2005509805A patent/JP4641942B2/ja not_active Expired - Fee Related
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- 2003-10-03 WO PCT/EP2003/011171 patent/WO2005039546A2/en not_active Ceased
- 2003-10-03 DE DE60336934T patent/DE60336934D1/de not_active Expired - Lifetime
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- 2004-09-28 RU RU2006114743/13A patent/RU2345552C2/ru active
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| Publication number | Publication date |
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| ATE506948T1 (de) | 2011-05-15 |
| RU2345552C2 (ru) | 2009-02-10 |
| CN1938018A (zh) | 2007-03-28 |
| US9408405B2 (en) | 2016-08-09 |
| PT1667678E (pt) | 2009-08-05 |
| WO2005039546A2 (en) | 2005-05-06 |
| EP1670444B1 (en) | 2011-04-27 |
| US20080194553A1 (en) | 2008-08-14 |
| PT1670444E (pt) | 2011-07-29 |
| CY1116665T1 (el) | 2017-03-15 |
| ES2365847T3 (es) | 2011-10-11 |
| ES2326595T3 (es) | 2009-10-15 |
| US10716778B2 (en) | 2020-07-21 |
| EP1670444A2 (en) | 2006-06-21 |
| SI1670444T1 (sl) | 2011-09-30 |
| AU2003273967A8 (en) | 2005-05-11 |
| CA2541090C (en) | 2013-04-16 |
| US20160331725A1 (en) | 2016-11-17 |
| JP2007525405A (ja) | 2007-09-06 |
| DE60336934D1 (de) | 2011-06-09 |
| CN1938018B (zh) | 2010-09-01 |
| RU2006114743A (ru) | 2007-11-10 |
| WO2005039546A3 (en) | 2007-10-04 |
| HK1103963A1 (zh) | 2008-01-04 |
| JP4641942B2 (ja) | 2011-03-02 |
| AU2003273967A1 (en) | 2005-05-11 |
| CA2541090A1 (en) | 2005-05-06 |
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