DK171237B1 - Adenosinderivater, deres fremstilling, farmaceutiske midler med indhold deraf og anvendelse deraf til fremstilling af farmaceutiske midler - Google Patents

Adenosinderivater, deres fremstilling, farmaceutiske midler med indhold deraf og anvendelse deraf til fremstilling af farmaceutiske midler Download PDF

Info

Publication number: DK171237B1
Authority: DK; Denmark
Prior art keywords: adenosine; derivative; chloro; compound; methylidene
Prior art date: 1988-09-27

Application number

DK473289A

Other languages

Danish (da)

English (en)

Other versions

DK473289A (da

DK473289D0 (da

Inventor

James R Mccarthy

Michael L Edwards

David M Stemerick

Esa T Jarvi

Nellikunja J Prakash

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-09-27

Filing date

1989-09-26

Publication date

1996-08-05

1989-09-26 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1989-09-26 Publication of DK473289D0 publication Critical patent/DK473289D0/da

1990-03-28 Publication of DK473289A publication Critical patent/DK473289A/da

1996-08-05 Application granted granted Critical

1996-08-05 Publication of DK171237B1 publication Critical patent/DK171237B1/da

Links

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238000006243 chemical reaction Methods 0.000 claims description 13
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK473289A 1988-09-27 1989-09-26 Adenosinderivater, deres fremstilling, farmaceutiske midler med indhold deraf og anvendelse deraf til fremstilling af farmaceutiske midler DK171237B1 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US24991188A	1988-09-27	1988-09-27
US24991188		1988-09-27
US38939189A	1989-08-03	1989-08-03
US38939189		1989-08-03

Publications (3)

Publication Number	Publication Date
DK473289D0 DK473289D0 (da)	1989-09-26
DK473289A DK473289A (da)	1990-03-28
DK171237B1 true DK171237B1 (da)	1996-08-05

Family

ID=26940460

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK473289A DK171237B1 (da)	1988-09-27	1989-09-26	Adenosinderivater, deres fremstilling, farmaceutiske midler med indhold deraf og anvendelse deraf til fremstilling af farmaceutiske midler

Country Status (18)

Country	Link
EP (1)	EP0365849B1 (de)
JP (1)	JP2968002B2 (de)
KR (1)	KR0146333B1 (de)
CN (1)	CN1046334A (de)
AR (1)	AR248283A1 (de)
AT (1)	ATE111477T1 (de)
AU (1)	AU621664B2 (de)
CA (1)	CA1336903C (de)
DE (1)	DE68918215T2 (de)
DK (1)	DK171237B1 (de)
ES (1)	ES2063796T3 (de)
FI (1)	FI94763C (de)
HU (1)	HU204843B (de)
IE (1)	IE63561B1 (de)
IL (1)	IL91773A (de)
NO (1)	NO171857C (de)
NZ (1)	NZ230766A (de)
PT (1)	PT91803B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5206244A (en) *	1990-10-18	1993-04-27	E. R. Squibb & Sons, Inc.	Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
US5340816A (en) *	1990-10-18	1994-08-23	E. R. Squibb & Sons, Inc.	Hydroxymethyl(methylenecyclopentyl) purines and pyrimidines
FR2668153B1 (fr) *	1990-10-22	1995-03-31	Pasteur Merieux Serums Vacc	Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
DK0640092T3 (da) *	1992-05-12	1996-12-30	Merrell Pharma Inc	Fremgangsmåde til fremstilling af ribonucleotid-reduktaseinhibitorer
US5589587A (en) *	1992-05-12	1996-12-31	Merrell Pharmaceuticals Inc.	Process for the preparation of ribonucleotide reductase inhibitors
US5627053A (en) *	1994-03-29	1997-05-06	Ribozyme Pharmaceuticals, Inc.	2'deoxy-2'-alkylnucleotide containing nucleic acid
US5811408A (en) *	1994-07-12	1998-09-22	Yamasa Corporation	2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides
AU784794B2 (en) *	1999-06-09	2006-06-22	Anticancer, Inc.	Modulators of methylation for control of bacterial virulence
US6579857B1 (en)	1999-06-11	2003-06-17	Evanston Northwestern Healthcare Research Institute	Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
WO2003068162A2 (en) *	2002-02-14	2003-08-21	Pharmasset Ltd.	Modified fluorinated nucleoside analogues
SG10201610936RA (en)	2011-12-22	2017-02-27	Alios Biopharma Inc	Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en)	2012-03-21	2020-08-25	Janssen Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en)	2012-03-21	2016-09-13	Alios Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0267878A1 (de) *	1986-11-14	1988-05-18	Ciba-Geigy Ag	N9-Cyclopentylsubstituierte Adeninderivate
WO1988007049A1 (fr) *	1987-03-19	1988-09-22	Yamasa Shoyu Kabushiki Kaisha	Derives de nucleosides de 2'-alkylidene pyrimidine, procede de preparation et utilisation de ces composes
NZ225906A (en) *	1987-08-26	1990-10-26	Merrell Dow Pharma	Aristeromycin/adenosine derivatives and pharmaceutical compositions
ZA894534B (en) *	1988-06-20	1990-03-28	Merrell Dow Pharma	Novel neplanocin derivatives

1989
- 1989-09-22 HU HU894982A patent/HU204843B/hu not_active IP Right Cessation
- 1989-09-25 IL IL9177389A patent/IL91773A/en not_active IP Right Cessation
- 1989-09-25 NZ NZ230766A patent/NZ230766A/en unknown
- 1989-09-26 PT PT91803A patent/PT91803B/pt not_active IP Right Cessation
- 1989-09-26 IE IE308089A patent/IE63561B1/en not_active IP Right Cessation
- 1989-09-26 JP JP1250413A patent/JP2968002B2/ja not_active Expired - Fee Related
- 1989-09-26 KR KR1019890013825A patent/KR0146333B1/ko not_active Expired - Fee Related
- 1989-09-26 FI FI894546A patent/FI94763C/fi not_active IP Right Cessation
- 1989-09-26 DK DK473289A patent/DK171237B1/da not_active IP Right Cessation
- 1989-09-26 NO NO893826A patent/NO171857C/no not_active IP Right Cessation
- 1989-09-26 CN CN89108169A patent/CN1046334A/zh active Pending
- 1989-09-26 ES ES89117735T patent/ES2063796T3/es not_active Expired - Lifetime
- 1989-09-26 AT AT89117735T patent/ATE111477T1/de not_active IP Right Cessation
- 1989-09-26 DE DE68918215T patent/DE68918215T2/de not_active Expired - Fee Related
- 1989-09-26 EP EP89117735A patent/EP0365849B1/de not_active Expired - Lifetime
- 1989-09-26 AU AU41760/89A patent/AU621664B2/en not_active Ceased
- 1989-09-26 AR AR89315002A patent/AR248283A1/es active
- 1989-09-27 CA CA000613429A patent/CA1336903C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
FI894546A0 (fi)	1989-09-26
PT91803A (pt)	1990-03-30
IE893080L (en)	1990-03-27
EP0365849A2 (de)	1990-05-02
NZ230766A (en)	1992-07-28
KR0146333B1 (ko)	1998-08-01
HUT50844A (en)	1990-03-28
CA1336903C (en)	1995-09-05
ATE111477T1 (de)	1994-09-15
KR900004736A (ko)	1990-04-12
JPH02160769A (ja)	1990-06-20
FI94763C (fi)	1995-10-25
DE68918215T2 (de)	1995-02-02
HU204843B (en)	1992-02-28
AR248283A1 (es)	1995-07-12
IE63561B1 (en)	1995-05-17
FI94763B (fi)	1995-07-14
DE68918215D1 (de)	1994-10-20
PT91803B (pt)	1995-05-31
IL91773A (en)	1994-02-27
NO171857B (no)	1993-02-01
DK473289A (da)	1990-03-28
IL91773A0 (en)	1990-06-10
CN1046334A (zh)	1990-10-24
AU4176089A (en)	1990-04-05
DK473289D0 (da)	1989-09-26
JP2968002B2 (ja)	1999-10-25
NO893826D0 (no)	1989-09-26
NO171857C (no)	1993-05-12
ES2063796T3 (es)	1995-01-16
NO893826L (no)	1990-03-28
FI894546A7 (fi)	1990-03-28
AU621664B2 (en)	1992-03-19
EP0365849A3 (en)	1990-12-27
EP0365849B1 (de)	1994-09-14

Legal Events

Date	Code	Title	Description
1996-08-05	B1	Patent granted (law 1993)
2005-06-06	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
DK171844B1 (da)	1997-06-30	2'-Halogenmethyliden-cytidin-derivater, deres fremstilling og anvendelse og farmaceutisk præparat indeholdende sådanne derivater samt 2-arylsulfonylhalogenmethyliden-nucleosid
DK171237B1 (da)	1996-08-05	Adenosinderivater, deres fremstilling, farmaceutiske midler med indhold deraf og anvendelse deraf til fremstilling af farmaceutiske midler
NO179710B (no)	1996-08-26	Nye fosfolipidderivater av nukleosider, og legemiddel inneholdende disse
US5792841A (en)	1998-08-11	2'-halomethylidene, 2'-ethenylidene and 2'-ethynl cytidine, uridine and guanosine derivatives
AU606792B2 (en)	1991-02-14	Novel acetylenic, cyano and allenic aristeromycin/adenosine derivatives
DK166355B (da)	1993-04-13	Adenosin-derivater samt farmaceutiske praeparater indeholdende saadanne derivater
US20030109484A1 (en)	2003-06-12	Novel 2'-halomethylidene, 2'-ethenylidene and 2'ethynyl cytidine, uridine and guanosine derivatives
Génu-Dellac et al.	1991	Systematic synthesis and antiviral evaluation of α-L-arabinofuranosyl and 2′-Deoxy-α-L-erythro-pento-furanosyl nucleosides of the five naturally occurring nucleic acid bases
CZ74894A3 (en)	1994-11-16	Thiaxanthene antitumor-active preparations
JPH02189A (ja)	1990-01-05	１‐アミノメチルホスホン酸誘導体、その製造法および医薬組成物
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