DK171329B1 - Pseudodisaccharid betegnet salbostatin, fremgangsmåde til dets fremstilling, plantebeskyttelsesmiddel med indhold deraf og fremgangsmåde til beskyttelse af planter mod insekter og/eller skadelige svampe - Google Patents

Pseudodisaccharid betegnet salbostatin, fremgangsmåde til dets fremstilling, plantebeskyttelsesmiddel med indhold deraf og fremgangsmåde til beskyttelse af planter mod insekter og/eller skadelige svampe Download PDF

Info

Publication number: DK171329B1
Authority: DK; Denmark
Prior art keywords: salbostatin; plant protection; pseudodisaccharide; harmful fungi; against insects
Prior art date: 1988-10-28

Application number

DK537389A

Other languages

Danish (da)

English (en)

Other versions

DK537389A (da

DK537389D0 (da

Inventor

Laszlo Vertesy

Hans-Wolfram Fehlhaber

Arno Schulz

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-10-28

Filing date

1989-10-27

Publication date

1996-09-09

1989-10-27 Application filed by Hoechst Ag filed Critical Hoechst Ag

1989-10-27 Publication of DK537389D0 publication Critical patent/DK537389D0/da

1990-04-29 Publication of DK537389A publication Critical patent/DK537389A/da

1996-09-09 Application granted granted Critical

1996-09-09 Publication of DK171329B1 publication Critical patent/DK171329B1/da

Links

238000000034 method Methods 0.000 title claims description 12
241000233866 Fungi Species 0.000 title claims description 5
241000238631 Hexapoda Species 0.000 title claims description 5
239000004476 plant protection product Substances 0.000 title claims description 3
OCTNNXHKAOLDJL-UHFFFAOYSA-N Salbostatin Natural products OC1C(O)C(CO)OCC1NC1C(O)C(O)C(O)C(CO)=C1 OCTNNXHKAOLDJL-UHFFFAOYSA-N 0.000 title abstract description 27
OCTNNXHKAOLDJL-BMGYQPLYSA-N Salbostatin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)OC[C@@H]1N[C@@H]1[C@H](O)[C@@H](O)[C@H](O)C(CO)=C1 OCTNNXHKAOLDJL-BMGYQPLYSA-N 0.000 title abstract description 27
238000002360 preparation method Methods 0.000 title description 3
150000001875 compounds Chemical class 0.000 claims abstract description 10
239000000706 filtrate Substances 0.000 claims description 5
150000003839 salts Chemical class 0.000 claims description 5
241000187759 Streptomyces albus Species 0.000 claims description 4
239000002253 acid Substances 0.000 claims description 4
244000005700 microbiome Species 0.000 claims description 3
229940122069 Glycosidase inhibitor Drugs 0.000 abstract description 2
239000003316 glycosidase inhibitor Substances 0.000 abstract description 2
108010087472 Trehalase Proteins 0.000 description 12
238000000855 fermentation Methods 0.000 description 12
230000004151 fermentation Effects 0.000 description 12
235000015097 nutrients Nutrition 0.000 description 11
102100029677 Trehalase Human genes 0.000 description 10
239000000243 solution Substances 0.000 description 10
241000196324 Embryophyta Species 0.000 description 7
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
239000008103 glucose Substances 0.000 description 6
HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 5
HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 5
HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 5
239000003112 inhibitor Substances 0.000 description 5
239000002609 medium Substances 0.000 description 5
108090000790 Enzymes Proteins 0.000 description 4
102000004190 Enzymes Human genes 0.000 description 4
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 4
230000015572 biosynthetic process Effects 0.000 description 4
229940088598 enzyme Drugs 0.000 description 4
230000002401 inhibitory effect Effects 0.000 description 4
239000007788 liquid Substances 0.000 description 4
239000012071 phase Substances 0.000 description 4
239000007787 solid Substances 0.000 description 4
230000001954 sterilising effect Effects 0.000 description 4
238000004659 sterilization and disinfection Methods 0.000 description 4
239000000126 substance Substances 0.000 description 4
238000012360 testing method Methods 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
229920001817 Agar Polymers 0.000 description 3
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
235000010469 Glycine max Nutrition 0.000 description 3
240000008042 Zea mays Species 0.000 description 3
235000002017 Zea mays subsp mays Nutrition 0.000 description 3
239000008346 aqueous phase Substances 0.000 description 3
238000005119 centrifugation Methods 0.000 description 3
235000013312 flour Nutrition 0.000 description 3
238000011534 incubation Methods 0.000 description 3
239000002054 inoculum Substances 0.000 description 3
235000013372 meat Nutrition 0.000 description 3
238000001228 spectrum Methods 0.000 description 3
238000003756 stirring Methods 0.000 description 3
239000000758 substrate Substances 0.000 description 3
JRBJSXQPQWSCCF-UHFFFAOYSA-N 3,3'-Dimethoxybenzidine Chemical compound C1=C(N)C(OC)=CC(C=2C=C(OC)C(N)=CC=2)=C1 JRBJSXQPQWSCCF-UHFFFAOYSA-N 0.000 description 2
USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 2
239000005695 Ammonium acetate Substances 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
IAZDPXIOMUYVGZ-UHFFFAOYSA-N DMSO Substances CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
229920001353 Dextrin Polymers 0.000 description 2
239000004375 Dextrin Substances 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
PLUBXMRUUVWRLT-UHFFFAOYSA-N Ethyl methanesulfonate Chemical compound CCOS(C)(=O)=O PLUBXMRUUVWRLT-UHFFFAOYSA-N 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
229920005654 Sephadex Polymers 0.000 description 2
239000012507 Sephadex™ Substances 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
238000005273 aeration Methods 0.000 description 2
235000010419 agar Nutrition 0.000 description 2
239000008272 agar Substances 0.000 description 2
229910052784 alkaline earth metal Inorganic materials 0.000 description 2
229940043376 ammonium acetate Drugs 0.000 description 2
235000019257 ammonium acetate Nutrition 0.000 description 2
150000001450 anions Chemical class 0.000 description 2
150000001720 carbohydrates Chemical class 0.000 description 2
235000014633 carbohydrates Nutrition 0.000 description 2
229910052799 carbon Inorganic materials 0.000 description 2
150000001768 cations Chemical class 0.000 description 2
229920001429 chelating resin Polymers 0.000 description 2
239000012141 concentrate Substances 0.000 description 2
239000000470 constituent Substances 0.000 description 2
235000005822 corn Nutrition 0.000 description 2
235000019425 dextrin Nutrition 0.000 description 2
239000000284 extract Substances 0.000 description 2
238000000605 extraction Methods 0.000 description 2
238000004108 freeze drying Methods 0.000 description 2
150000002500 ions Chemical class 0.000 description 2
238000002955 isolation Methods 0.000 description 2
-1 malt extract Natural products 0.000 description 2
235000010355 mannitol Nutrition 0.000 description 2
239000000203 mixture Substances 0.000 description 2
239000002808 molecular sieve Substances 0.000 description 2
DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 2
230000002093 peripheral effect Effects 0.000 description 2
229920001467 poly(styrenesulfonates) Polymers 0.000 description 2
239000000047 product Substances 0.000 description 2
239000011814 protection agent Substances 0.000 description 2
URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 2
239000012138 yeast extract Substances 0.000 description 2
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
235000017060 Arachis glabrata Nutrition 0.000 description 1
244000105624 Arachis hypogaea Species 0.000 description 1
235000010777 Arachis hypogaea Nutrition 0.000 description 1
235000018262 Arachis monticola Nutrition 0.000 description 1
229920002261 Corn starch Polymers 0.000 description 1
241000206672 Gelidium Species 0.000 description 1
108010015776 Glucose oxidase Proteins 0.000 description 1
239000004366 Glucose oxidase Substances 0.000 description 1
108010056771 Glucosidases Proteins 0.000 description 1
102000004366 Glucosidases Human genes 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
240000002024 Gossypium herbaceum Species 0.000 description 1
235000004341 Gossypium herbaceum Nutrition 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
229910004861 K2 HPO4 Inorganic materials 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
239000001888 Peptone Substances 0.000 description 1
108010080698 Peptones Proteins 0.000 description 1
244000046052 Phaseolus vulgaris Species 0.000 description 1
235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
108091000080 Phosphotransferase Proteins 0.000 description 1
241000220317 Rosa Species 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
101710110901 Trehalase inhibitor Proteins 0.000 description 1
235000021307 Triticum Nutrition 0.000 description 1
244000098338 Triticum aestivum Species 0.000 description 1
235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
239000011149 active material Substances 0.000 description 1
238000010564 aerobic fermentation Methods 0.000 description 1
235000013334 alcoholic beverage Nutrition 0.000 description 1
239000003513 alkali Substances 0.000 description 1
150000001342 alkaline earth metals Chemical class 0.000 description 1
102000016679 alpha-Glucosidases Human genes 0.000 description 1
108010028144 alpha-Glucosidases Proteins 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
239000000908 ammonium hydroxide Substances 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
108010051210 beta-Fructofuranosidase Proteins 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
238000009835 boiling Methods 0.000 description 1
239000000872 buffer Substances 0.000 description 1
229940041514 candida albicans extract Drugs 0.000 description 1
150000004649 carbonic acid derivatives Chemical class 0.000 description 1
239000000969 carrier Substances 0.000 description 1
238000005266 casting Methods 0.000 description 1
239000002962 chemical mutagen Substances 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
150000001805 chlorine compounds Chemical class 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
239000010941 cobalt Substances 0.000 description 1
229910017052 cobalt Inorganic materials 0.000 description 1
GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
239000008120 corn starch Substances 0.000 description 1
239000012531 culture fluid Substances 0.000 description 1
125000004122 cyclic group Chemical group 0.000 description 1
239000007857 degradation product Substances 0.000 description 1
238000005238 degreasing Methods 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000010612 desalination reaction Methods 0.000 description 1
206010012601 diabetes mellitus Diseases 0.000 description 1
AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical class CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 description 1
238000004821 distillation Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000004146 energy storage Methods 0.000 description 1
238000001914 filtration Methods 0.000 description 1
238000005227 gel permeation chromatography Methods 0.000 description 1
239000011521 glass Substances 0.000 description 1
229940116332 glucose oxidase Drugs 0.000 description 1
235000019420 glucose oxidase Nutrition 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
230000003301 hydrolyzing effect Effects 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
235000011073 invertase Nutrition 0.000 description 1
238000004255 ion exchange chromatography Methods 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
239000008101 lactose Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
235000009973 maize Nutrition 0.000 description 1
229910052748 manganese Inorganic materials 0.000 description 1
239000011572 manganese Substances 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000463 material Substances 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
XELZGAJCZANUQH-UHFFFAOYSA-N methyl 1-acetylthieno[3,2-c]pyrazole-5-carboxylate Chemical compound CC(=O)N1N=CC2=C1C=C(C(=O)OC)S2 XELZGAJCZANUQH-UHFFFAOYSA-N 0.000 description 1
YLJRCXSSKLWCDE-UHFFFAOYSA-N methyl ethanesulfonate Chemical compound CCS(=O)(=O)OC YLJRCXSSKLWCDE-UHFFFAOYSA-N 0.000 description 1
229930014626 natural product Natural products 0.000 description 1
150000002823 nitrates Chemical class 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
235000014593 oils and fats Nutrition 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
235000020232 peanut Nutrition 0.000 description 1
235000019319 peptone Nutrition 0.000 description 1
229940066779 peptones Drugs 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
102000020233 phosphotransferase Human genes 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
239000013587 production medium Substances 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
108010009004 proteose-peptone Proteins 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
238000001223 reverse osmosis Methods 0.000 description 1
238000009938 salting Methods 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000000638 solvent extraction Methods 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
229960004793 sucrose Drugs 0.000 description 1
150000005846 sugar alcohols Chemical class 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
150000003527 tetrahydropyrans Chemical group 0.000 description 1
239000011573 trace mineral Substances 0.000 description 1
235000013619 trace mineral Nutrition 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
- Y10S435/887—Streptomyces albus

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Animal Behavior & Ethology (AREA)
Agronomy & Crop Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Environmental Sciences (AREA)
Zoology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Obesity (AREA)
Pest Control & Pesticides (AREA)
Plant Pathology (AREA)
Dentistry (AREA)
Wood Science & Technology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pyrane Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)

DK537389A 1988-10-28 1989-10-27 Pseudodisaccharid betegnet salbostatin, fremgangsmåde til dets fremstilling, plantebeskyttelsesmiddel med indhold deraf og fremgangsmåde til beskyttelse af planter mod insekter og/eller skadelige svampe DK171329B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3836675		1988-10-28
DE3836675A DE3836675A1 (de)	1988-10-28	1988-10-28	Glykosidase-inhibitor salbostatin, verfahren zu seiner herstellung und seine verwendung

Publications (3)

Publication Number	Publication Date
DK537389D0 DK537389D0 (da)	1989-10-27
DK537389A DK537389A (da)	1990-04-29
DK171329B1 true DK171329B1 (da)	1996-09-09

Family

ID=6366058

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK537389A DK171329B1 (da)	1988-10-28	1989-10-27	Pseudodisaccharid betegnet salbostatin, fremgangsmåde til dets fremstilling, plantebeskyttelsesmiddel med indhold deraf og fremgangsmåde til beskyttelse af planter mod insekter og/eller skadelige svampe

Country Status (10)

Country	Link
US (1)	US5091524A (fr)
EP (1)	EP0366060B1 (fr)
JP (1)	JP2942574B2 (fr)
AT (1)	ATE102196T1 (fr)
CA (1)	CA1338185C (fr)
DE (2)	DE3836675A1 (fr)
DK (1)	DK171329B1 (fr)
ES (1)	ES2063097T3 (fr)
IE (1)	IE63272B1 (fr)
PT (1)	PT92146B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5268367A (en) *	1991-12-30	1993-12-07	Kanegafuchi Kagaku Kogyo Kabushiki Kaisha	Composition and method for lowering blood level of LDL-cholesterol
JPH05279374A (ja) *	1992-03-31	1993-10-26	Sawao Murao	スイダトレスチン及びその製造方法
GB2338235B (en) *	1997-04-15	2001-11-14	Csir	Appetite suppressing plant extracts
GB2355657B (en) *	1999-10-27	2004-07-28	Phytopharm Plc	Inhibitors Of Gastric Acid Secretion
GB2363985B (en)	2000-06-30	2004-09-29	Phytopharm Plc	Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
US7262318B2 (en) *	2004-03-10	2007-08-28	Pfizer, Inc.	Substituted heteroaryl- and phenylsulfamoyl compounds
US20050288340A1 (en) *	2004-06-29	2005-12-29	Pfizer Inc	Substituted heteroaryl- and phenylsulfamoyl compounds
AP2007003979A0 (en) *	2004-11-23	2007-06-30	Warner Lambert Co	7-(2h-pyrazol-3-yl)-3,5-dihyroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for thetreatment of lipidemia
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
CN101663262B (zh)	2006-12-01	2014-03-26	百时美施贵宝公司	用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
US8877717B2 (en)	2007-03-12	2014-11-04	Zadec Aps	Anti-diabetic extract of rooibos
US20130072519A1 (en)	2010-05-21	2013-03-21	Edward Lee Conn	2-phenyl benzoylamides
EP2680874A2 (fr)	2011-03-04	2014-01-08	Pfizer Inc	Peptides de type edn3 et utilisations associées
US20150050371A1 (en)	2012-03-09	2015-02-19	Biotropics Malaysia Berhad	Extract Formulations of Rhodamnia Cinerea And Uses Thereof
EP2986599A1 (fr)	2013-04-17	2016-02-24	Pfizer Inc.	Dérivés de n-pipéridin-3-ylbenzamide dans le traitement des maladies cardiovasculaires
CN104208695A (zh) *	2013-05-30	2014-12-17	苏州科景生物医药科技有限公司	一种多功能组合物及其制备方法与应用
KR102431436B1 (ko)	2014-08-29	2022-08-10	테스 파마 에스.알.엘.	α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제
WO2016055901A1 (fr)	2014-10-08	2016-04-14	Pfizer Inc.	Composés d'amide substitué
WO2018069532A1 (fr)	2016-10-14	2018-04-19	Tes Pharma S.R.L.	Inhibiteurs de la semialdéhyde décarboxylase de l'acide alpha-amino-bêta-carboxymuconique
AR117122A1 (es)	2018-11-20	2021-07-14	Tes Pharma S R L	INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA
BR112021013807A2 (pt)	2019-01-18	2021-11-30	Astrazeneca Ab	Inibidores de pcsk9 e seus métodos de uso
ES2970297A1 (es) *	2022-10-24	2024-05-27	Francisco Aragon S L U	Iminoazucares y aminociclitol glucosidos biodegradables inhibidores de alfa-glucosidasa con actividad sinergica insecticida, acaricida o ambas

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4062950A (en) *	1973-09-22	1977-12-13	Bayer Aktiengesellschaft	Amino sugar derivatives
US4065557A (en) *	1974-03-21	1977-12-27	Bayer Aktiengesellschaft	Amino sugars and their use in improving the meat:fat ratio in animals
JPS5953920B2 (ja) *	1977-12-28	1984-12-27	東洋醸造株式会社	新規なアミノ糖化合物およびその製法
EP0224024B1 (fr) *	1985-10-26	1990-06-20	Hoechst Aktiengesellschaft	Dérivés de silanes, leur procédé de préparation, agents les contenant et leur utilisation comme pesticides
DE3611425A1 (de) *	1986-04-05	1987-10-08	Hoechst Ag	2,4-6-tris-tertiaerbutylamino-1,3,5-triazin zur prophylaxe und behandlung von epilepsie und angstzustaenden, verwendung dieser verbindung zur herstellung eines arzneimittels sowie arzneimittel auf basis dieser verbindung

1988
- 1988-10-28 DE DE3836675A patent/DE3836675A1/de not_active Withdrawn
1989
- 1989-09-29 CA CA000614553A patent/CA1338185C/fr not_active Expired - Lifetime
- 1989-10-24 ES ES89119704T patent/ES2063097T3/es not_active Expired - Lifetime
- 1989-10-24 EP EP89119704A patent/EP0366060B1/fr not_active Expired - Lifetime
- 1989-10-24 DE DE89119704T patent/DE58907085D1/de not_active Expired - Lifetime
- 1989-10-24 AT AT89119704T patent/ATE102196T1/de not_active IP Right Cessation
- 1989-10-26 US US07/426,805 patent/US5091524A/en not_active Expired - Lifetime
- 1989-10-27 DK DK537389A patent/DK171329B1/da not_active IP Right Cessation
- 1989-10-27 JP JP1278755A patent/JP2942574B2/ja not_active Expired - Lifetime
- 1989-10-27 IE IE348289A patent/IE63272B1/en not_active IP Right Cessation
- 1989-10-27 PT PT92146A patent/PT92146B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
IE893482L (en)	1990-04-28
CA1338185C (fr)	1996-03-26
EP0366060B1 (fr)	1994-03-02
EP0366060A1 (fr)	1990-05-02
ES2063097T3 (es)	1995-01-01
DK537389A (da)	1990-04-29
IE63272B1 (en)	1995-04-05
DE58907085D1 (de)	1994-04-07
DK537389D0 (da)	1989-10-27
PT92146B (pt)	1995-06-30
PT92146A (pt)	1990-04-30
US5091524A (en)	1992-02-25
JP2942574B2 (ja)	1999-08-30
JPH02196780A (ja)	1990-08-03
DE3836675A1 (de)	1990-05-03
ATE102196T1 (de)	1994-03-15

Legal Events

Date	Code	Title	Description
1996-09-09	B1	Patent granted (law 1993)
2003-06-02	PBP	Patent lapsed	Country of ref document: DK

Publication	Publication Date	Title
DK171329B1 (da)	1996-09-09	Pseudodisaccharid betegnet salbostatin, fremgangsmåde til dets fremstilling, plantebeskyttelsesmiddel med indhold deraf og fremgangsmåde til beskyttelse af planter mod insekter og/eller skadelige svampe
JPH0367073B2 (fr)	1991-10-21
JPH0678757A (ja)	1994-03-22	抗菌性ｃｌ−１５７７を生産できる放線菌
JPH06339390A (ja)	1994-12-13	Ｂｕ−４１６４ｅ−ａ及びｂ、プロリルエンドペプチダーゼインヒビター
US4019960A (en)	1977-04-26	Process for the production of a saccharase inhibitor
US5563054A (en)	1996-10-08	Process for preparation of benzo[B]thiophene glucuronides
NO783545L (no)	1979-04-23	Fremgangsmaate til fremstilling av deoksynarasinantibiotisk kompleks
US3937817A (en)	1976-02-10	Pharmaceutical compositions containing a saccharase inhibitor
EP0414914A1 (fr)	1991-03-06	Nouvelle substance, trehalostatine, et sa production
CA1302927C (fr)	1992-06-09	Efomycine g, sa preparation et son utilisation pour ameliorer le rendement chez les animaux
AU657011B2 (en)	1995-02-23	Antibiotic AB-041 and the process for its production
EP0522715A1 (fr)	1993-01-13	Inhibiteurs de la squalène synthéthase et procédé pour les obtenir
JPH0740950B2 (ja)	1995-05-10	微生物によるニコチアナミンの製造法
US5118882A (en)	1992-06-02	Streptenols from streptomycetes, and the preparation and use thereof
JPH02257887A (ja)	1990-10-18	ストレプトミセス属菌からの新規アングサイクリノンおよびその製造方法
JPS61141889A (ja)	1986-06-28	新抗生物質ｓｆ−２１９７ｂ物質及びその製造法
US3585111A (en)	1971-06-15	Process for making antibiotic sphaeropsidin
JP2849460B2 (ja)	1999-01-20	新規化合物ａ―７０６１５物質及びその製造法
NO760873L (fr)	1976-09-14
RU2051174C1 (ru)	1995-12-27	Способ получения веществ ws 7622 а, в, с и/или d-ингибиторов лейкоцитэластазы человека или их фармацевтически приемлемых солей
EP0524671A1 (fr)	1993-01-27	Culture de exserohilum rostratum et procédés qui en dépendent
US4696794A (en)	1987-09-29	CL-1957D antibiotic compound and its production
JPH0625095B2 (ja)	1994-04-06	抗生物質ｓｆ−２４１５物質およびその製造法
KR790001573B1 (ko)	1979-11-05	항생물질 BM123r의 환원적 알킬화에 의해 유도된 항균제 제조방법
JP3068700B2 (ja)	2000-07-24	新規トレハゾリン誘導体およびその製造法