DK171487A - Spergualinderivater, fremgangsmaade til deres fremstilling og deres anvendelse som laegemidler - Google Patents

Spergualinderivater, fremgangsmaade til deres fremstilling og deres anvendelse som laegemidler

Info

Publication number: DK171487A
Authority: DK; Denmark
Prior art keywords: spergual; medicines; ingredients; procedures; preparation
Prior art date: 1986-04-04

Application number

DK171487A

Other languages

English (en)

Other versions

DK171487D0 (da

Inventor

Hamao Umezawa

Tomio Takeuchi

Tetsushi Saino

Masao Yoshida

Katsutoshi Takahashi

Teruya Nakamura

Original Assignee

Microbial Chem Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-04-04

Filing date

1987-04-03

Publication date

1987-10-05

1987-04-03 Application filed by Microbial Chem Res Found filed Critical Microbial Chem Res Found

1987-04-03 Publication of DK171487D0 publication Critical patent/DK171487D0/da

1987-10-05 Publication of DK171487A publication Critical patent/DK171487A/da

Links

238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
239000003814 drug Substances 0.000 title 1
239000004615 ingredient Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
GDVNLLJNADMLLR-BBRMVZONSA-N Spergualin Chemical compound NCCCNCCCCNC(=O)[C@H](O)NC(=O)C[C@@H](O)CCCCN=C(N)N GDVNLLJNADMLLR-BBRMVZONSA-N 0.000 abstract 2
JBVZQDJNGFOSNX-UHFFFAOYSA-N Spergualin Natural products NCCCNCCCCNC(=O)C(O)NC(=O)CC(O)CCCCNC(=CN)N JBVZQDJNGFOSNX-UHFFFAOYSA-N 0.000 abstract 2
230000002519 immonomodulatory effect Effects 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Immunology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Transplantation (AREA)
Hematology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Train Traffic Observation, Control, And Security (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Electric Propulsion And Braking For Vehicles (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines Containing Plant Substances (AREA)

DK171487A 1986-04-04 1987-04-03 Spergualinderivater, fremgangsmaade til deres fremstilling og deres anvendelse som laegemidler DK171487A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP7774786		1986-04-04

Publications (2)

Publication Number	Publication Date
DK171487D0 DK171487D0 (da)	1987-04-03
DK171487A true DK171487A (da)	1987-10-05

Family

ID=13642505

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK171487A DK171487A (da)	1986-04-04	1987-04-03	Spergualinderivater, fremgangsmaade til deres fremstilling og deres anvendelse som laegemidler
DK921027A DK102792D0 (da)	1986-04-04	1992-08-18	Spergualinderivater, fremgangsmaade til deres fremstilling, farmaceutisk praeparat, hvori de indgaar, og fremgangsmaade til fremstilling af praeparatet

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK921027A DK102792D0 (da)	1986-04-04	1992-08-18	Spergualinderivater, fremgangsmaade til deres fremstilling, farmaceutisk praeparat, hvori de indgaar, og fremgangsmaade til fremstilling af praeparatet

Country Status (17)

Country	Link
US (1)	US4956504A (da)
EP (1)	EP0241797B1 (da)
JP (1)	JPH0745460B2 (da)
KR (2)	KR940006768B1 (da)
CN (1)	CN1016341B (da)
AT (1)	ATE64378T1 (da)
AU (1)	AU599092B2 (da)
CA (1)	CA1305827C (da)
DE (1)	DE3770680D1 (da)
DK (2)	DK171487A (da)
ES (1)	ES2039213T3 (da)
FI (1)	FI86546C (da)
GR (1)	GR3002660T3 (da)
HU (1)	HU204069B (da)
IE (1)	IE60077B1 (da)
PT (1)	PT84620B (da)
ZA (1)	ZA872440B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0794424B2 (ja) *	1987-09-30	1995-10-11	財団法人微生物化学研究会	新スパガリン関連化合物およびその製造法
US5770625A (en) *	1988-02-08	1998-06-23	The Trustees Of Columbia University In The City Of New York	Butyryl-tyrosinyl spermine, analogs thereof and methods of preparing and using same
US4990536A (en) *	1989-04-03	1991-02-05	Nippon Kayaku Kabushiki Kaisha	Immunopotentiator and spergualin-related compound therefor
YU48230B (sh) *	1989-05-29	1997-08-22	Takara Shuzo Co.Ltd.	Kristalni deoksispergvalin i postupak za njegovo pripremanje
US5086069A (en) *	1990-02-05	1992-02-04	Rorer Pharmaceutical Corporation	Anti-thrombotic peptide and pseudopeptide derivatives
EP0467280B1 (en) *	1990-07-20	1994-09-28	Nippon Kayaku Kabushiki Kaisha	Novel spergualin-related compound and use thereof
JPH08503920A (ja) *	1991-04-11	1996-04-30	ローヌ−プーランローラーインターナショナル（ホウルディングス）インコーポレイテッド	抗血栓ペプチドおよび偽ペプチド誘導体
WO1994004140A1 (fr) *	1992-08-19	1994-03-03	Nippon Kayaku Kabushiki Kaisha	Medicament anti-protozoose
FR2698628B1 (fr) *	1992-12-02	1995-02-17	Fournier Ind & Sante	Analogues de 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.
GB9726569D0 (en) *	1997-12-16	1998-02-11	Univ Southampton	Neuroprotective agents
US20020142000A1 (en) *	1999-01-15	2002-10-03	Digan Mary Ellen	Anti-CD3 immunotoxins and therapeutic uses therefor
KR100604206B1 (ko) *	2005-12-01	2006-07-24	박현미	배선용 단자

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5748957A (en) *	1980-09-08	1982-03-20	Microbial Chem Res Found	Novel antibiotic bmg 162-af2, its preparation and carcinostatic agent comprising it as active ingredient
JPS57185254A (en) *	1981-05-11	1982-11-15	Microbial Chem Res Found	Novel carcinostatic substances and their preparation
JPS5862152A (ja) *	1981-10-08	1983-04-13	Microbial Chem Res Found	Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS5942356A (ja) *	1982-09-02	1984-03-08	Microbial Chem Res Found	スパガリン関連化合物およびその製造法
US4525299A (en) *	1983-05-10	1985-06-25	Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai	(-)-15-Deoxyspergualin, process for the preparation thereof, and intermediate of the same
JPS60104099A (ja) *	1983-11-09	1985-06-08	Nippon Kayaku Co Ltd	スパガリン関連化合物の新規製造法
JPS60181056A (ja) *	1984-02-29	1985-09-14	Takara Shuzo Co Ltd	Ν−〔４−（３−アミノプロピル）アミノブチル〕−２，２−ジヒドロキシエタンアミドの製造法
JPS60185758A (ja) *	1984-03-02	1985-09-21	Microbial Chem Res Found	フエニレン基を有するスパガリン関連化合物およびその製造法
JPS61165322A (ja) *	1985-01-14	1986-07-26	Microbial Chem Res Found	スパガリン類の注射用凍結乾燥製剤
AU587691B2 (en) *	1987-03-30	1989-08-24	Shosuke Okamoto	Phenylalanine derivative and proteinase inhibitor

1987
- 1987-03-30 DE DE8787104659T patent/DE3770680D1/de not_active Expired - Lifetime
- 1987-03-30 AT AT87104659T patent/ATE64378T1/de not_active IP Right Cessation
- 1987-03-30 ES ES198787104659T patent/ES2039213T3/es not_active Expired - Lifetime
- 1987-03-30 EP EP87104659A patent/EP0241797B1/en not_active Expired - Lifetime
- 1987-03-31 JP JP62075925A patent/JPH0745460B2/ja not_active Expired - Lifetime
- 1987-04-01 US US07/032,811 patent/US4956504A/en not_active Expired - Fee Related
- 1987-04-02 FI FI871445A patent/FI86546C/fi not_active IP Right Cessation
- 1987-04-03 PT PT84620A patent/PT84620B/pt not_active IP Right Cessation
- 1987-04-03 ZA ZA872440A patent/ZA872440B/xx unknown
- 1987-04-03 DK DK171487A patent/DK171487A/da not_active Application Discontinuation
- 1987-04-03 HU HU871442A patent/HU204069B/hu not_active IP Right Cessation
- 1987-04-03 AU AU71075/87A patent/AU599092B2/en not_active Ceased
- 1987-04-03 CN CN87102538A patent/CN1016341B/zh not_active Expired
- 1987-04-03 IE IE86487A patent/IE60077B1/en not_active IP Right Cessation
- 1987-04-03 CA CA000533809A patent/CA1305827C/en not_active Expired - Lifetime
- 1987-04-04 KR KR1019870003206A patent/KR940006768B1/ko not_active Expired - Fee Related
- 1987-07-01 KR KR1019870006966A patent/KR940007743B1/ko not_active Expired - Fee Related
1991
- 1991-09-06 GR GR91400905T patent/GR3002660T3/el unknown
1992
- 1992-08-18 DK DK921027A patent/DK102792D0/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN87102538A (zh)	1987-11-18
IE60077B1 (en)	1994-06-01
AU7107587A (en)	1987-10-08
DK171487D0 (da)	1987-04-03
CA1305827C (en)	1992-07-28
PT84620B (pt)	1989-11-30
HUT44577A (en)	1988-03-28
ATE64378T1 (de)	1991-06-15
ES2039213T3 (es)	1993-09-16
GR3002660T3 (en)	1993-01-25
KR870009989A (ko)	1987-11-30
PT84620A (en)	1987-05-01
FI86546C (fi)	1992-09-10
KR940007743B1 (ko)	1994-08-24
KR940006768B1 (ko)	1994-07-27
CN1016341B (zh)	1992-04-22
IE870864L (en)	1987-10-04
DK102792A (da)	1992-08-18
EP0241797A2 (en)	1987-10-21
FI86546B (fi)	1992-05-29
KR890001965A (ko)	1989-04-06
ZA872440B (en)	1987-12-30
HU204069B (en)	1991-11-28
EP0241797B1 (en)	1991-06-12
DK102792D0 (da)	1992-08-18
DE3770680D1 (de)	1991-07-18
AU599092B2 (en)	1990-07-12
JPH0745460B2 (ja)	1995-05-17
EP0241797A3 (en)	1988-07-20
FI871445A0 (fi)	1987-04-02
JPS6345247A (ja)	1988-02-26
US4956504A (en)	1990-09-11
FI871445A7 (fi)	1987-10-05

Legal Events

Date	Code	Title	Description
1996-11-25	B1	Patent granted (law 1993)
1996-12-16	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
RO91075A (ro)	1987-02-27	Procedeu pentru prepararea unor-heterociclil-biciclic-4-piperidinamine
NO176101C (no)	1995-02-01	Analogifremgangsmåte for fremstilling av terapeutisk aktive N-(3-hydroksy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran eller dihydrobenzodioksin)karboksamidderivater
IE850042L (en)	1985-07-09	Disubstituted piperidines
NO158539C (no)	1988-09-28	Analogifremgangsmaate for fremstilling av en terapeutisk aktiv 2,6-diaminopurinforbindelse.
NO173015C (no)	1993-10-13	Analogifremgangsmaate til fremstilling av pyrido(1,2-a)pyrimidin-3-piperidinyl-1,2-benzisoksazoler
EP0269574A3 (en)	1989-03-22	Novel adenosine derivatives and pharmaceutical compositions containing them as an active ingredient
IE45256L (en)	1977-06-19	Quinazolone derivatives
DK171487A (da)	1987-10-05	Spergualinderivater, fremgangsmaade til deres fremstilling og deres anvendelse som laegemidler
ES8801245A1 (es)	1988-01-01	Un procedimiento para preparar derivados de piperidina
FI884375A0 (fi)	1988-09-23	Menetelmä terapeuttisesti käyttökelpoisten N-(1-alkyyli-3-hydroksi-4-piperidinyyli)bentsamidien valmistamiseksi
DK96786A (da)	1986-09-05	Aminosyrederivater
NO163818C (no)	1990-07-25	Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte n-((4-piperidinyl)alkyl) bicykliske kondenserte oksazol- og tiazolaminer.
ATE48001T1 (de)	1989-12-15	Cephemverbindungen, verfahren zu ihrer herstellung und ihre pharmazeutischen praeparate.
GR3018096T3 (en)	1996-02-29	Polypeptide comprising repeated cell-adhesive core sequences.
SE8601799D0 (sv)	1986-04-18	(-)-1beta-ethyl-1alfa-hydroxymethyl-1,2,3,4,6,7,12,12balfa-octahydroindolo/2,3-a/quinolizine, process for its preparation and pharmaceutical compositions containing same
NZ231485A (en)	1993-03-26	Amino-diol derivatives, preparation and use in pharmaceutical compositions thereof
DK291786D0 (da)	1986-06-20	Neuroleptisk aktivt, farmaceutisk praeparat og fremgangsmaade til dets fremstilling
DK400385D0 (da)	1985-09-02	Arphameninderivater, fremgangsmaade til deres fremstilling samt anvendelse heraf som laegemiddel
ES8801291A1 (es)	1987-12-16	Un procedimiento para la preparacion de nuevos derivados de beta-lactama.