DK172787B1 - 4-Phenyl-4-(N-phenylamido)-piperidinderivater, optisk aktive isomere og farmaceutisk acceptable syreadditionssalte deraf sa - Google Patents

4-Phenyl-4-(N-phenylamido)-piperidinderivater, optisk aktive isomere og farmaceutisk acceptable syreadditionssalte deraf sa Download PDF

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Publication number
DK172787B1
DK172787B1 DK198806079A DK607988A DK172787B1 DK 172787 B1 DK172787 B1 DK 172787B1 DK 198806079 A DK198806079 A DK 198806079A DK 607988 A DK607988 A DK 607988A DK 172787 B1 DK172787 B1 DK 172787B1
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DK
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Prior art keywords
phenyl
ethyl
pharmaceutically acceptable
acid addition
compounds
Prior art date
Application number
DK198806079A
Other languages
Danish (da)
English (en)
Other versions
DK607988D0 (da
DK607988A (da
Inventor
H Kenneth Spencer
Linas V Kudzma
Sherry A Severnak
Original Assignee
Baxter Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int filed Critical Baxter Int
Publication of DK607988D0 publication Critical patent/DK607988D0/da
Publication of DK607988A publication Critical patent/DK607988A/da
Application granted granted Critical
Publication of DK172787B1 publication Critical patent/DK172787B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DK198806079A 1987-11-02 1988-11-01 4-Phenyl-4-(N-phenylamido)-piperidinderivater, optisk aktive isomere og farmaceutisk acceptable syreadditionssalte deraf sa DK172787B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/115,284 US4791121A (en) 1987-11-02 1987-11-02 4-phenyl-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
US11528487 1987-11-02

Publications (3)

Publication Number Publication Date
DK607988D0 DK607988D0 (da) 1988-11-01
DK607988A DK607988A (da) 1989-05-03
DK172787B1 true DK172787B1 (da) 1999-07-19

Family

ID=22360366

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198806079A DK172787B1 (da) 1987-11-02 1988-11-01 4-Phenyl-4-(N-phenylamido)-piperidinderivater, optisk aktive isomere og farmaceutisk acceptable syreadditionssalte deraf sa

Country Status (16)

Country Link
US (1) US4791121A (mo)
EP (1) EP0315405B1 (mo)
JP (2) JPH02152963A (mo)
KR (1) KR970008313B1 (mo)
CN (1) CN1020723C (mo)
AU (1) AU611728B2 (mo)
CA (1) CA1334416C (mo)
DE (1) DE3854938T2 (mo)
DK (1) DK172787B1 (mo)
ES (1) ES2081810T3 (mo)
FI (1) FI885035A7 (mo)
GR (1) GR3019342T3 (mo)
IL (1) IL88140A0 (mo)
MX (1) MX9203140A (mo)
NO (1) NO172691C (mo)
NZ (1) NZ226634A (mo)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4871749A (en) * 1987-12-31 1989-10-03 Boc, Inc. 4-heteropentacyclic-4-(N-(phenyl)amido) piperidine derivatives and pharamaceutical compositions and method employing such compounds
US4868194A (en) * 1988-09-23 1989-09-19 Merrell Dow Pharmaceuticals Inc. Imidazole antiarrhythmics
KR900016129A (ko) * 1989-04-20 1990-11-12 테리 아아르 커세트 4-알콕시알킬-4-아미노페닐피페리딘 및 그들의 유도체의 제조 방법
US4939161A (en) * 1989-05-12 1990-07-03 Boc, Inc. Analgesic N-aryl-N-[1-substituted-3,5-dimethyl-4-piperidinyl]amides
FR2678267B1 (fr) * 1991-06-25 1994-02-04 Elf Sanofi Arylalkylamines, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2725986B1 (fr) * 1994-10-21 1996-11-29 Adir Nouveaux derives de piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7361666B2 (en) 1999-05-25 2008-04-22 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US6635661B2 (en) 2000-05-25 2003-10-21 Sepracor Inc. Heterocyclic analgesic compounds and methods of use thereof
US6677332B1 (en) * 1999-05-25 2004-01-13 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
AR028948A1 (es) * 2000-06-20 2003-05-28 Astrazeneca Ab Compuestos novedosos
EP1966140A1 (en) * 2005-11-17 2008-09-10 Mallinckrodt, Inc. Process for synthesizing remifentanil

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3161637A (en) * 1961-10-10 1964-12-15 Res Lab Dr C Janssen N V 1-(gamma-aroyl-propyl)-4-(nu-arylcarbonyl amino) piperidines and related compounds
NL135583C (mo) * 1961-10-10
US3998834A (en) * 1975-03-14 1976-12-21 Janssen Pharmaceutica N.V. N-(4-piperidinyl)-n-phenylamides and -carbamates
US4196210A (en) * 1975-09-23 1980-04-01 Janssen Pharmaceutica N.V. N-Aryl-N-(1-L-4-piperidinyl)-arylacetamides
US4584303A (en) * 1984-04-09 1986-04-22 The Boc Group, Inc. N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne

Also Published As

Publication number Publication date
JPH0215061A (ja) 1990-01-18
AU2455888A (en) 1989-05-04
DK607988D0 (da) 1988-11-01
JPH02152963A (ja) 1990-06-12
DE3854938T2 (de) 1996-05-30
FI885035A0 (fi) 1988-11-01
KR970008313B1 (ko) 1997-05-23
NO172691C (no) 1993-08-25
CN1020723C (zh) 1993-05-19
US4791121A (en) 1988-12-13
FI885035L (fi) 1989-05-03
DE3854938D1 (de) 1996-03-07
NZ226634A (en) 1990-07-26
EP0315405B1 (en) 1996-01-24
NO884842L (no) 1989-05-03
CA1334416C (en) 1995-02-14
AU611728B2 (en) 1991-06-20
JPH0552834B2 (mo) 1993-08-06
CN1041585A (zh) 1990-04-25
NO172691B (no) 1993-05-18
KR890008094A (ko) 1989-07-08
MX9203140A (es) 1992-07-01
GR3019342T3 (en) 1996-06-30
NO884842D0 (no) 1988-10-31
IL88140A0 (en) 1989-06-30
EP0315405A1 (en) 1989-05-10
DK607988A (da) 1989-05-03
ES2081810T3 (es) 1996-03-16
FI885035A7 (fi) 1989-05-03

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