DK173983A - Fremgangsmaade til fremstilling af imidazo (1,2-alfa)pyridiner - Google Patents

Fremgangsmaade til fremstilling af imidazo (1,2-alfa)pyridiner Download PDF

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Publication number
DK173983A
DK173983A DK173983A DK173983A DK173983A DK 173983 A DK173983 A DK 173983A DK 173983 A DK173983 A DK 173983A DK 173983 A DK173983 A DK 173983A DK 173983 A DK173983 A DK 173983A
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Prior art keywords
pyridines
alfa
preparing imidazo
imidazo
preparing
Prior art date
Application number
DK173983A
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English (en)
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DK173983D0 (da
Inventor
Jean-Pierre Kaplan
Pascal George
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Synthelabo
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Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of DK173983D0 publication Critical patent/DK173983D0/da
Publication of DK173983A publication Critical patent/DK173983A/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03G—ELECTROGRAPHY; ELECTROPHOTOGRAPHY; MAGNETOGRAPHY
    • G03G21/00—Arrangements not provided for by groups G03G13/00 - G03G19/00, e.g. cleaning, elimination of residual charge
    • G03G21/0005—Arrangements not provided for by groups G03G13/00 - G03G19/00, e.g. cleaning, elimination of residual charge for removing solid developer or debris from the electrographic recording medium

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Description

R betegner OH, NR^Rj, hvori R^ og R2 betegner hydrogen, eventuelt substitueret C^_5alkyl, allyl, propargyl, C^.gCycloalkyl, benzyl eller phenyl, eller NR^2 betegner sammen en eventuelt substitueret hetero-cyclisk ring, fremstilles ved omsætning af en 2-amino-pyridin med formlen (II)
Figure DK173983AD00021
(II) med en bromeret keton med formlen (III)
Figure DK173983AD00022
(III)
Forbindelserne har anxiolytiske egenskaber, indvirker på den cerebrale gennemstrømning, virker anticonvulsivt, sedativt og hypnotiskt.
DK173983A 1982-04-21 1983-04-20 Fremgangsmaade til fremstilling af imidazo (1,2-alfa)pyridiner DK173983A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8206840A FR2525601A1 (fr) 1982-04-21 1982-04-21 Derives d'imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
FR8206840 1982-04-21

Publications (2)

Publication Number Publication Date
DK173983D0 DK173983D0 (da) 1983-04-20
DK173983A true DK173983A (da) 1983-10-22

Family

ID=9273215

Family Applications (1)

Application Number Title Priority Date Filing Date
DK173983A DK173983A (da) 1982-04-21 1983-04-20 Fremgangsmaade til fremstilling af imidazo (1,2-alfa)pyridiner

Country Status (14)

Country Link
US (1) US4501745A (da)
EP (1) EP0092458A3 (da)
JP (1) JPS58189179A (da)
AU (1) AU1369983A (da)
DK (1) DK173983A (da)
ES (1) ES8402297A1 (da)
FI (1) FI831350A7 (da)
FR (1) FR2525601A1 (da)
GR (1) GR78576B (da)
IL (1) IL68442A0 (da)
NO (1) NO831389L (da)
NZ (1) NZ203956A (da)
PT (1) PT76573B (da)
ZA (1) ZA832788B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3409440A1 (de) * 1984-03-15 1985-09-26 Bayer Ag, 5090 Leverkusen Imidazo(1,5-a)pyridyl-methan- und imidazo(1,5-b)pyridazinylmethan-derivate, ihre herstellung und sie enthaltende aufzeichnungsmaterialien
US4596872A (en) * 1985-06-05 1986-06-24 Schering A.G. Imidazo[1,2-a]pyridines, and process for their preparation
US4772600A (en) * 1986-06-09 1988-09-20 A. H. Robins Company, Inc. Fused imidazoheterocyclic compounds and pharmaceutical compositions
FR2606409B1 (fr) * 1986-11-07 1989-05-05 Synthelabo Derives d'imidazopyridine, leur preparation et leur application en therapeutique
IE904346A1 (en) * 1989-12-04 1991-06-05 Searle & Co IMIDAZO[1,2-a]PYRIDINYLALKYL COMPOUNDS FOR TREATMENT OF¹NEUROTOXIC INJURY
US5716964A (en) * 1989-12-04 1998-02-10 G.D. Searle & Co. Tetrazolyl substituted imidazo 1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury
KR910011852A (ko) * 1989-12-04 1991-08-07 폴 디. 매튜카이티스 신경독 장해 치료용 이미다조[1,2-a]피리디닐알킬 화합물
US5464843A (en) * 1992-06-23 1995-11-07 G.D. Searle & Co. Imidazo[1,2-a]pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neutrotoxic injury
FR2722500B1 (fr) * 1994-07-13 1996-08-09 Synthelabo Derives d'acide 2-thienylimidazo(1,2-a) benzimidazole-3-acetique, leur preparation et leur application en therapeutique
AUPP278498A0 (en) 1998-04-03 1998-04-30 Australian Nuclear Science & Technology Organisation Peripheral benzodiazepine receptor binding agents
EP1475093B1 (en) 2000-04-24 2006-09-06 Teva Pharmaceutical Industries Ltd. Micronized Zolpidem hemitartrate
IL152411A0 (en) * 2000-04-24 2003-05-29 Teva Pharma Zolpidem hemitartrate
DE10040016A1 (de) * 2000-08-16 2002-02-28 Boehringer Ingelheim Pharma Neue beta-Amyloid Inhibitoren, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US6514969B2 (en) 2000-08-16 2003-02-04 Boehringer Ingelheim Pharma Kg β-amyloid inhibitors, processes for preparing them, and their use in pharmaceutical compositions
US6596731B2 (en) 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
US20040204443A1 (en) * 2003-01-27 2004-10-14 Arthur Zaks Method for inducing pain relief using imidazo[1,2-a]pyridine derivatives
US7723324B2 (en) 2003-10-28 2010-05-25 Sepracor, Inc. Imidazo[1,2-A]pyridine anxiolytics
US20080262025A1 (en) * 2004-07-16 2008-10-23 Yatendra Kumar Processes for the Preparation of Zolpidem and its Hemitartrate
FR2874611B1 (fr) * 2004-08-31 2006-11-17 Servier Lab Nouveaux derives d'imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1076089A (en) * 1965-11-09 1967-07-19 Selvi & C Lab Bioterapico New derivatives of imidazo [1,2-a]-pyridine and a process for the manufacture thereof
FR2492382A1 (fr) * 1980-10-22 1982-04-23 Synthelabo Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
ES521650A0 (es) 1984-01-16
PT76573B (fr) 1986-02-27
EP0092458A3 (fr) 1984-02-01
NO831389L (no) 1983-10-24
GR78576B (da) 1984-09-27
IL68442A0 (en) 1983-07-31
AU1369983A (en) 1983-10-27
ZA832788B (en) 1983-12-28
PT76573A (fr) 1983-05-01
FI831350L (fi) 1983-10-22
FI831350A0 (fi) 1983-04-20
FR2525601A1 (fr) 1983-10-28
DK173983D0 (da) 1983-04-20
FI831350A7 (fi) 1983-10-22
ES8402297A1 (es) 1984-01-16
NZ203956A (en) 1985-11-08
JPS58189179A (ja) 1983-11-04
EP0092458A2 (fr) 1983-10-26
US4501745A (en) 1985-02-26
FR2525601B1 (da) 1984-06-15

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Date Code Title Description
ATS Application withdrawn
B1 Patent granted (law 1993)