DK178084A - 1,3-dihydro-6-methyl-7-hydroxyfuro-(3,4-c)-pyridinderivater og fremgangsmaade til fremstilling deraf - Google Patents

1,3-dihydro-6-methyl-7-hydroxyfuro-(3,4-c)-pyridinderivater og fremgangsmaade til fremstilling deraf Download PDF

Info

Publication number
DK178084A
DK178084A DK178084A DK178084A DK178084A DK 178084 A DK178084 A DK 178084A DK 178084 A DK178084 A DK 178084A DK 178084 A DK178084 A DK 178084A DK 178084 A DK178084 A DK 178084A
Authority
DK
Denmark
Prior art keywords
hydroxyfuro
dihydro
procedures
methyl
preparing
Prior art date
Application number
DK178084A
Other languages
English (en)
Other versions
DK157931C (da
DK157931B (da
DK178084D0 (da
Inventor
Andre Esanu
Original Assignee
Scras
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838327815A external-priority patent/GB8327815D0/en
Application filed by Scras filed Critical Scras
Publication of DK178084D0 publication Critical patent/DK178084D0/da
Publication of DK178084A publication Critical patent/DK178084A/da
Publication of DK157931B publication Critical patent/DK157931B/da
Application granted granted Critical
Publication of DK157931C publication Critical patent/DK157931C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)

Description

ling af den derved opnåede tertiære alkohol med en sur forbindelse til brydning af isopropyliden-ringen og 3,4-cyclisering.
Forbindelserne, der har meget lav toxicitet, er anvendelige som diuretica med sænkning af blodtrykket og god beskyttelse af nyrerne, samt som anti-histaminmidler.
DK178084A 1983-04-05 1984-04-04 1,3-dihydro-6-methyl-7-hydroxy-furo-(3,4-c)-pyridinderivater og terapeutisk acceptable syreadditionssalte deraf samt farmaceutiske praeparater indeholdende disse DK157931C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8309165 1983-04-05
GB8309165 1983-04-05
GB8327815 1983-10-18
GB838327815A GB8327815D0 (en) 1983-10-18 1983-10-18 Furo-(3 4-c)-pyridine derivatives

Publications (4)

Publication Number Publication Date
DK178084D0 DK178084D0 (da) 1984-04-04
DK178084A true DK178084A (da) 1984-10-06
DK157931B DK157931B (da) 1990-03-05
DK157931C DK157931C (da) 1990-08-27

Family

ID=26285725

Family Applications (1)

Application Number Title Priority Date Filing Date
DK178084A DK157931C (da) 1983-04-05 1984-04-04 1,3-dihydro-6-methyl-7-hydroxy-furo-(3,4-c)-pyridinderivater og terapeutisk acceptable syreadditionssalte deraf samt farmaceutiske praeparater indeholdende disse

Country Status (29)

Country Link
US (1) US4581363A (da)
JP (1) JPS59193888A (da)
KR (1) KR900005518B1 (da)
AU (1) AU582113B2 (da)
CA (1) CA1257269A (da)
CH (1) CH660191A5 (da)
DE (1) DE3412885C2 (da)
DK (1) DK157931C (da)
DZ (1) DZ629A1 (da)
EG (1) EG18150A (da)
ES (1) ES8601998A1 (da)
FI (1) FI76804C (da)
FR (2) FR2543956B1 (da)
GR (1) GR79577B (da)
HK (1) HK11187A (da)
IE (1) IE57424B1 (da)
IL (1) IL71243A (da)
IN (1) IN160104B (da)
IT (1) IT1173770B (da)
LU (1) LU85262A1 (da)
MA (1) MA20084A1 (da)
MX (1) MX167397B (da)
MY (1) MY8600664A (da)
NL (1) NL190328C (da)
NO (1) NO161802C (da)
NZ (1) NZ207552A (da)
OA (1) OA07699A (da)
PT (1) PT78361B (da)
SE (1) SE458362B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735950A (en) * 1983-04-05 1988-04-05 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S) Furo-(3,4-C)-pyridine derivatives and therapeutic composition containing the same
GB8427218D0 (en) * 1984-10-27 1984-12-05 Scras Pyridine derivatives
DE3990349T1 (de) * 1988-04-06 1990-04-26 Scras Stereospezifisches verfahren zur herstellung von enantiomeren von furo(3,4-c)pyridin, so erhaltene verbindungen und therapeutische zusammensetzungen auf basis dieser verbindungen
GB8808001D0 (en) * 1988-04-06 1988-05-05 Scras Stereospecific preparative process for furol(3,4-c)pyridine derivatives
GB8917168D0 (en) * 1989-07-27 1989-09-13 Scras Asymmetric synthesis of furo(3,4-c)pyridine derivatives
US5130252A (en) * 1990-05-14 1992-07-14 Synthetech, Inc. Resolution of furopyridine enantiomers and synthetic precursors thereof
US6043259A (en) * 1998-07-09 2000-03-28 Medicure Inc. Treatment of cardiovascular and related pathologies
CA2366602A1 (en) 1999-03-08 2000-09-14 Medicure Inc. Pyridoxal analogues for vitamin b-6 disorders
CA2376029A1 (en) 1999-07-13 2001-01-18 Medicure Inc. Use of pyridoxin derivatives for the treatment of diabetes and related complications
US6677356B1 (en) * 1999-08-24 2004-01-13 Medicure International Inc. Treatment of cardiovascular and related pathologies
WO2001064692A1 (en) 2000-02-29 2001-09-07 Medicure International Inc. Cardioprotective phosphonates and malonates
US7442689B2 (en) * 2000-02-29 2008-10-28 Medicure International Inc. Cardioprotective phosphonates and malonates
CA2404329A1 (en) 2000-03-28 2001-10-04 Medicure International Inc. Treatment of cerebrovascular disease
US6548519B1 (en) 2001-07-06 2003-04-15 Medicure International Inc. Pyridoxine and pyridoxal analogues: novel uses
US6897228B2 (en) * 2000-07-07 2005-05-24 Medicure International Inc. Pyridoxine and pyridoxal analogues: new uses
NZ523815A (en) 2000-07-07 2004-07-30 Medicure Int Inc Pyridoxine and pyridoxal analogues: cardiovascular therapeutics
US20040121988A1 (en) * 2001-03-28 2004-06-24 Medicure International Inc. Treatment of cerebrovascular disease
US20040186077A1 (en) * 2003-03-17 2004-09-23 Medicure International Inc. Novel heteroaryl phosphonates as cardioprotective agents
JP2008505126A (ja) * 2004-07-07 2008-02-21 メディキュア インターナショナル インコーポレイテッド 血小板凝集薬を用いる併用療法
US20070060549A1 (en) * 2004-08-10 2007-03-15 Friesen Albert D Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders
US20060094749A1 (en) * 2004-10-28 2006-05-04 Medicure International Inc. Substituted pyridoxines as anti-platelet agents
US7459468B2 (en) * 2004-10-28 2008-12-02 Medicure International, Inc. Aryl sulfonic pyridoxines as antiplatelet agents
EP1817288A4 (en) * 2004-10-28 2009-08-26 Medicure Int Inc DUAL ANTIPLÄTTCHEN / ANTIKOAGULANS PYRIDOXINANALOGE
JP2009517411A (ja) * 2005-11-28 2009-04-30 メディキュア インターナショナル インコーポレーテッド 心血管及び関連病状の処置のための調剤

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2008582B (en) * 1977-11-25 1982-04-28 Scras Pyridine derivative
ZA786269B (en) * 1977-11-25 1979-10-31 Scras New pyridine derivative,its preparation and use
IN156817B (da) * 1981-02-10 1985-11-09 Scras

Also Published As

Publication number Publication date
NL8401013A (nl) 1984-11-01
IE57424B1 (en) 1992-09-09
EG18150A (en) 1992-08-30
IL71243A0 (en) 1984-06-29
FR2543829A1 (fr) 1984-10-12
FR2543956A1 (fr) 1984-10-12
FI841273A0 (fi) 1984-03-30
NL190328B (nl) 1993-08-16
MA20084A1 (fr) 1984-12-31
JPS59193888A (ja) 1984-11-02
ES531285A0 (es) 1985-11-01
FR2543956B1 (fr) 1986-07-04
PT78361A (en) 1984-05-01
NZ207552A (en) 1986-05-09
SE458362B (sv) 1989-03-20
IT8420396A0 (it) 1984-04-05
CH660191A5 (fr) 1987-03-31
NO161802C (no) 1989-09-27
KR840008651A (ko) 1984-12-17
AU2640184A (en) 1984-10-11
NO161802B (no) 1989-06-19
NL190328C (nl) 1994-01-17
MY8600664A (en) 1986-12-31
CA1257269A (en) 1989-07-11
FI76804C (fi) 1988-12-12
JPH0556353B2 (da) 1993-08-19
HK11187A (en) 1987-02-13
IN160104B (da) 1987-06-27
KR900005518B1 (ko) 1990-07-30
FR2543829B1 (fr) 1986-11-21
MX167397B (es) 1993-03-22
GR79577B (da) 1984-10-30
SE8401841L (sv) 1984-10-06
FI76804B (fi) 1988-08-31
FI841273L (fi) 1984-10-06
DE3412885C2 (de) 1990-10-04
DK157931C (da) 1990-08-27
OA07699A (fr) 1985-08-30
AU582113B2 (en) 1989-03-16
SE8401841D0 (sv) 1984-04-03
DZ629A1 (fr) 2004-09-13
ES8601998A1 (es) 1985-11-01
IT1173770B (it) 1987-06-24
DK157931B (da) 1990-03-05
NO841322L (no) 1984-10-08
IL71243A (en) 1987-12-20
DE3412885A1 (de) 1984-10-11
IE840826L (en) 1984-10-05
PT78361B (en) 1986-05-28
DK178084D0 (da) 1984-04-04
LU85262A1 (fr) 1984-10-24
US4581363A (en) 1986-04-08

Similar Documents

Publication Publication Date Title
DK178084A (da) 1,3-dihydro-6-methyl-7-hydroxyfuro-(3,4-c)-pyridinderivater og fremgangsmaade til fremstilling deraf
NO870076D0 (no) Fremgangsmaate til fremstilling av 2-okso-1,3-dioksolaner.
IE810236L (en) Sulfamoyl derivatives.
DK590085A (da) Bicycliske heteroarylpiperazinderivater og fremgangsmaade til deres fremstilling
NO884329D0 (no) Fremgangsmaate for fremstilling av vannfritt, krystallinsk natriumsalt av 5-klor-3-(2-tenoyl)-2-oksindol-1-karboksamid.
DK258078A (da) Fremgangsmaade til fremstilling af 7alfa-methoxy-7beta-(1,3-dithiethan-2-carboxamido) cephalosporansyre-derivater
DK130288A (da) Fremgangsmaade til fremstilling af stiv polyurethan
DK453982A (da) Fremgangsmaade til fremstilling af oligosaccharidderivater
ES500765A0 (es) Procedimiento para preparar derivados de enterotoxina termoestable (st) de e. coli.
AR228011A1 (es) Procedimiento para la preparacion de derivados sustituidos de 2,5,5,8a-tetrametil-1,2,3,4,4a,5,6,7,8,8a-decahidronaftaleno-1-spiro-2'-(4',6',7'-sustituido-2',3'-dihidrobenzofurano)
DK15282A (da) Fremgangsmaade til fremstilling af (+)-enantiomere eller (+)(-)-racemiske 4a,9b-trans-hexahydro-1h-pyridoindol-derivater eller farmaceutisk acceptable syreadditionssalte deraf
DK154974C (da) Analogifremgangsmaade til fremstilling af 6-substituerede 6h-dibenzo(b,d)pyranderivater
AR226869A1 (es) Procedimiento para la preparacion de derivados de 7-(3-ter.butil-e isopropil-amino-2-hidroxi-propoxi)-1-alquilo(c1-c4)o fenil alquilo(c1-c4)sustituido 2,3-indolediona
DK261482A (da) Maettede aminocyclitolderivater og fremgangsmaade til deres fremstilling
ES513974A0 (es) Procedimiento de preparacion de derivados del 3,4-difenil-5-metil pirazol.
NO882030D0 (no) Fremgangsmaate til fremstilling av hydrasinderivater til bruk som antihypertensivt middel.
IT8221254A0 (it) Procedimento per la preparazione di derivati del (7e,9z)-alcadienolo.
IT8422245A0 (it) Procedimento per la preparazione di derivati del lisergolo.
NO154636C (no) Fremgangsmaate til fremstilling av krystallinske aminocyklitolderivater.
DK688087A (da) Imidazolderivater, fremgangsmaade til fremstilling deraf og anvendelse deraf som antimycotiske midler
NO158806C (no) Organosilisiummodifiserte polydiener, fremgangsmaate til deres fremstilling og deres anvendelse som demulgatorer forjordolje.
NO156008C (no) Fremgangsmaate for fremstilling av 1-(3-benzyloksyfenyl)-1,1-dimetylheptan.
ES510302A0 (es) Procedimiento para la preparacion de 4-(3-trifluormetilfenil)-1,2,3,6-tetrahidropiridinas.
IT7827342A0 (it) Valvola di sicurezza per prove di trivellazione di pozzi in particolare petroliferi, effettuate in mare mediante natanti di trivellazione.
AR230994A1 (es) Procedimiento para preparar compuesto de 3'-substituido-5'-(2-amino-4-piridil)-1',2',4'-triazol

Legal Events

Date Code Title Description
PBP Patent lapsed