DK175460B1 - Fremgangsmåde til fremstilling af et pattedyrpolypeptid - Google Patents

Fremgangsmåde til fremstilling af et pattedyrpolypeptid Download PDF

Info

Publication number
DK175460B1
DK175460B1 DK414486A DK414486A DK175460B1 DK 175460 B1 DK175460 B1 DK 175460B1 DK 414486 A DK414486 A DK 414486A DK 414486 A DK414486 A DK 414486A DK 175460 B1 DK175460 B1 DK 175460B1
Authority
DK
Denmark
Prior art keywords
dna
sequence
fragment
aspergillus
polypeptide
Prior art date
Application number
DK414486A
Other languages
Danish (da)
English (en)
Other versions
DK414486D0 (da
DK414486A (da
Inventor
Kirk J Hayenga
Randy M Berka
Daniel Cullen
Gregory L Gray
Virgil B Lawlis
Original Assignee
Genencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27118452&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK175460(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genencor Inc filed Critical Genencor Inc
Publication of DK414486D0 publication Critical patent/DK414486D0/da
Publication of DK414486A publication Critical patent/DK414486A/da
Application granted granted Critical
Publication of DK175460B1 publication Critical patent/DK175460B1/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/24Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405Glucanases
    • C12N9/2408Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411Amylases
    • C12N9/2428Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478Aspartic endopeptidases (3.4.23)
    • C12N9/6481Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/50Fusion polypeptide containing protease site
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/61Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
DK414486A 1985-08-29 1986-08-29 Fremgangsmåde til fremstilling af et pattedyrpolypeptid DK175460B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77137485A 1985-08-29 1985-08-29
US77137485 1985-08-29
US88222486A 1986-07-07 1986-07-07
US88222486 1986-07-07

Publications (3)

Publication Number Publication Date
DK414486D0 DK414486D0 (da) 1986-08-29
DK414486A DK414486A (da) 1987-03-01
DK175460B1 true DK175460B1 (da) 2004-11-01

Family

ID=27118452

Family Applications (1)

Application Number Title Priority Date Filing Date
DK414486A DK175460B1 (da) 1985-08-29 1986-08-29 Fremgangsmåde til fremstilling af et pattedyrpolypeptid

Country Status (10)

Country Link
EP (2) EP0625577A1 (de)
JP (1) JPH08280388A (de)
AT (1) ATE117020T1 (de)
AU (1) AU607398B2 (de)
CA (1) CA1341532C (de)
DE (1) DE3650202T3 (de)
DK (1) DK175460B1 (de)
HK (1) HK1003579A1 (de)
IE (2) IE65794B1 (de)
NZ (1) NZ217373A (de)

Families Citing this family (127)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885249A (en) * 1984-12-05 1989-12-05 Allelix, Inc. Aspergillus niger transformation system
GB8508800D0 (en) * 1985-04-04 1985-05-09 Glaxo Group Ltd Microbiological process
US5198345A (en) 1985-04-15 1993-03-30 Gist-Brocades N.V. Vectors in use in filamentous fungi
DE3650783T2 (de) * 1985-04-15 2004-07-15 Dsm Ip Assets B.V. Verwendung des Glucoamylasepromotors aus Apergillus
DK122686D0 (da) * 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
US5536661A (en) * 1987-03-10 1996-07-16 Novo Nordisk A/S Process for the production of protein products in aspergillus
US5766912A (en) 1986-03-17 1998-06-16 Novo Nordisk A/S Humicola lipase produced in aspergillus
GB8610600D0 (en) * 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
US5780292A (en) * 1987-04-29 1998-07-14 Alko Group Ltd. Production of phytate degrading enzymes in trichoderma
US5610034A (en) * 1987-04-29 1997-03-11 Alko Group Ltd. Immunoglobulin production by trichoderma
DE3854249T2 (de) * 1987-08-28 1996-02-29 Novonordisk As Rekombinante Humicola-Lipase und Verfahren zur Herstellung von rekombinanten Humicola-Lipasen.
EP0383779B2 (de) * 1987-09-04 2000-05-31 Novo Nordisk A/S VERFAHREN ZUR HERSTELLUNG VON PROTEINPRODUKTEN IN $i(ASPERGILLUS) UND PROMOTOREN ZUR VERWENDUNG IN $i(ASPERGILLUS)
CA1333777C (en) 1988-07-01 1995-01-03 Randy M. Berka Aspartic proteinase deficient filamentous fungi
DE69032616T2 (de) * 1989-06-16 1999-03-11 Genencor International, Inc., Rochester, N.Y. Dna-sequenzen, vektoren und fusionspolypeptide zur erhöhung der sekretion gewünschter polypeptide von filamentösen fungi
FR2649120B1 (fr) * 1989-06-30 1994-01-28 Cayla Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede
AU7493491A (en) * 1990-03-13 1991-10-10 Hawaii Biotechnology Group, Inc. (neurospora) expression system
CA2084189A1 (en) * 1990-07-16 1992-01-17 Alko Group Limited Immunoglobulin production by trichoderma
CA2106485A1 (en) * 1991-03-22 1992-09-23 Henrik Dalboge Process for producing heme proteins
WO1992016633A1 (en) * 1991-03-22 1992-10-01 Novo Nordisk A/S A process for producing chymosin
DK36592D0 (da) * 1992-03-20 1992-03-20 Novo Nordisk As Fremgangsmaade til fremstilling af proteiner
JPH09505201A (ja) * 1992-07-31 1997-05-27 パンラブス インコーポレイテッド 組換え細胞、dna構造、ベクター及びフィチン酸塩分解酵素を任意の比率で発現する方法
DE69432543T2 (de) * 1993-07-23 2003-12-24 Dsm N.V., Te Heerlen Selektionmarker-genfreie rekombinante Stämme: Verfahren zur ihrer Herstellung und die Verwendung dieser Stämme
US6300114B1 (en) * 1994-07-29 2001-10-09 Rohm Enzyme Finland Oy Sequences of xylanase and xylanase expression vectors
US5935836A (en) * 1994-07-29 1999-08-10 Rohm Enzyme Finland Oy Actinomadura xylanase sequences and methods of use
US7816129B2 (en) 1994-07-29 2010-10-19 Ab Enzymes Gmbh Production and secretion of proteins of bacterial origin in filamentous fungi
US5700686A (en) * 1995-06-06 1997-12-23 Iogen Corporation Protease-treated and purified cellulase compositions and methods for reducing backstaining during enzymatic stonewashing
US7883872B2 (en) 1996-10-10 2011-02-08 Dyadic International (Usa), Inc. Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose
US6265204B1 (en) 1997-01-17 2001-07-24 Genencor International, Inc. DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi
ES2237159T3 (es) 1998-10-06 2005-07-16 Mark Aaron Emalfarb Sistema de transformacion en el campo de los hongos micoticos filamentosos en chrysosporium.
US7189538B2 (en) * 1999-03-24 2007-03-13 Genencor International, Inc. Hyphal growth in fungi
WO2001020007A1 (en) * 1999-09-13 2001-03-22 Concordia University A multifunctional system for the efficient manipulation of protein expression in filamentous fungi and method using same
WO2002053758A2 (de) * 2000-12-29 2002-07-11 Rhein Biotech Gesellschaft für neue Biotechnologische Prozesse und Produkte mbH Verfahren zum herstellen von heterologen proteinen in einem homothallischen pilz der familie sordariaceae
MXPA03008590A (es) 2001-03-22 2003-12-08 Novo Nordisk Healthcare Ag Derivados del factor vii de coagulacion.
BR0212818A (pt) 2001-09-27 2004-10-05 Novo Nordisk Healthcare Ag Polipeptìdeo de fator vii, construção de polionucletìdeo, célula hospedeira, animal transgênico, planta transgênica, método para produzir o polipeptìdeo de fator vii composição farmacêutica, uso de um polipeptìdeo de fator vii, e, método para o tratamento de distúrbios do sangramento em um sujeito ou para o aprimoramento do sistema hemostático normal
DK1495055T3 (da) 2002-04-18 2013-11-11 Genencor Int Produktion af funktionelle antistoffer i filamentøse svampe
CA2498213C (en) 2002-09-10 2013-07-16 Genencor International, Inc. Induction of gene expression using a high concentration sugar mixture
WO2004072225A2 (en) 2003-02-12 2004-08-26 Ramot At Tel Aviv University Ltd. Transgenic fungi expressing bcl-2 and methods of using bcl-2 or portions thereof for improving biomass production, survival, longevity, stress resistance and pathogenicity of fungi
ES2381110T3 (es) 2003-09-09 2012-05-23 Novo Nordisk Health Care Ag Polipéptidos de factor VII de coagulación
KR101348530B1 (ko) 2003-11-06 2014-02-14 다니스코 유에스 인크. 프로테아제 저해자 및 그 변이체의 사상균 내에서의 발현
CN102174490B (zh) * 2003-11-21 2016-09-28 丹尼斯科美国公司 颗粒淀粉水解酶在木霉菌中的表达和从颗粒淀粉底物产生葡萄糖的方法
CN1981037B (zh) 2004-05-27 2011-08-31 金克克国际有限公司 白曲霉酸稳定性α淀粉酶的异源表达和在颗粒淀粉水解中的应用
AU2005249422B2 (en) 2004-05-27 2011-03-17 Genencor International, Inc. Acid-stable alpha amylases having granular starch hydrolyzing activity and enzyme compositions
US7332319B2 (en) 2004-05-27 2008-02-19 Genencor International, Inc. Heterologous alpha amylase expression in Aspergillus
US7413887B2 (en) 2004-05-27 2008-08-19 Genecor International, Inc. Trichoderma reesei glucoamylase and homologs thereof
ATE530643T1 (de) 2004-12-30 2011-11-15 Genencor Int Säureaktive fungale protease
ZA200706858B (en) 2005-02-18 2008-10-29 Genencor Int Polypeptides having alpha-amylase and granular starch hydrolyzing activity
EP2314668B1 (de) 2005-04-12 2016-11-09 Danisco US Inc. Gen-inaktivierte Mutanten mit geänderter Proteinproduktion
JP5690047B2 (ja) 2005-09-14 2015-03-25 ノボ ノルディスク ヘルス ケア アーゲー ヒト凝固第vii因子ポリペプチド
US8198046B2 (en) 2006-07-11 2012-06-12 Danisco Us Inc. KEX2 cleavage regions of recombinant fusion proteins
US20080026376A1 (en) 2006-07-11 2008-01-31 Huaming Wang KEX2 cleavage regions of recombinant fusion proteins
US7968691B2 (en) 2006-08-23 2011-06-28 Danisco Us Inc. Pullulanase variants with increased productivity
US8216844B2 (en) 2006-08-29 2012-07-10 Danisco Us Inc. Compositions and methods for improved protein production
CN101522893B (zh) 2006-10-10 2014-07-09 丹尼斯科美国公司 具有改变性质的葡糖淀粉酶变体
EP2505651A3 (de) 2006-12-10 2013-01-09 Dyadic International, Inc. Pilzisolate mit reduzierter Proteaseaktivität
US20080220498A1 (en) 2007-03-06 2008-09-11 Cervin Marguerite A Variant Buttiauxella sp. phytases having altered properties
US8143046B2 (en) 2007-02-07 2012-03-27 Danisco Us Inc., Genencor Division Variant Buttiauxella sp. phytases having altered properties
JP5167286B2 (ja) 2007-03-14 2013-03-21 ダニスコ・ユーエス・インク、ジェネンコー・ディビジョン トリコデルマ・レセイ(TRICHODERMAREESEI)α−アミラーゼはマルトース産生酵素である。
DK2152892T3 (da) 2007-05-21 2013-07-22 Danisco Us Inc Genencor Div Fremgangsmåde til indføring af nukleinsyrer i fungale celler
DK2147104T3 (en) 2007-05-21 2015-12-14 Danisco Us Inc USING A ASPARAGINPROTEASE- (NSP24) SIGNAL SEQUENCE FOR heterologous protein EXPRESSION
CA2736661A1 (en) 2007-09-07 2009-03-12 Dyadic International, Inc. Novel fungal enzymes
WO2009035500A1 (en) 2007-09-12 2009-03-19 Danisco Us Inc., Genencor Division Trichoderma promoter
CA3069361C (en) 2007-10-09 2023-11-28 Danisco Us Inc. Glucoamylase variants with altered properties
US8592194B2 (en) 2007-10-09 2013-11-26 Danisco Us Inc. Glucoamylase variants with altered properties
EP3323889B1 (de) 2007-11-20 2020-03-25 Danisco US Inc. Glucoamylasevarianten mit veränderten eigenschaften
CN105368764B (zh) 2007-12-13 2019-03-12 丹尼斯科美国公司 用于生产异戊二烯的组合物和方法
CN101918545A (zh) 2008-01-02 2010-12-15 丹尼斯科美国公司 应用嗜糖假单胞菌g4-淀粉酶和其变体获得乙醇的无葡糖淀粉酶的方法
CN101945996A (zh) 2008-02-11 2011-01-12 丹尼斯科美国公司 来自里氏木霉的具有微生物裂解活性的酶
EP2283124B1 (de) 2008-04-18 2016-05-25 Danisco US Inc. Buttiauxella sp.-phytase-varianten
WO2009132220A2 (en) 2008-04-23 2009-10-29 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
MX318543B (es) 2008-07-02 2014-03-18 Danisco Us Inc Composiciones y metodos para producir isopreno libre de hidrocarburos de c5 bajo condicion de desacoplamiento y/o intervalos de operacion seguros.
CA2737223A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Reduction of carbon dioxide emission during isoprene production by fermentation
EP2344629B1 (de) 2008-09-15 2018-01-24 Danisco US Inc. Systeme mit verwendung von zellkultur zur isoprenherstellung
WO2010031062A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Increased isoprene production using the archaeal lower mevalonate pathway
EP2340312A2 (de) 2008-09-15 2011-07-06 Danisco US Inc. Umwandlung von prenylderivaten in isopren
DK2358873T4 (en) 2008-12-15 2018-05-28 Danisco Us Inc HYBRID ALPHA AMYLASER
MY161071A (en) 2008-12-30 2017-04-14 Danisco Us Inc Methods of producing isoprene and a co-product
AU2010238770A1 (en) 2009-04-23 2011-11-03 Danisco Us Inc. Three-dimensional structure of isoprene synthase and its use thereof for generating variants
EP3473711B1 (de) 2009-05-19 2020-11-04 DuPont Nutrition Biosciences ApS Amylase polypeptide
TW201412988A (zh) 2009-06-17 2014-04-01 Danisco Us Inc 使用dxp及mva途徑之改良之異戊二烯製造
TWI434921B (zh) 2009-06-17 2014-04-21 Danisco Us Inc 從生物異戊二烯組合物製造燃料成分之方法及系統
US20120282285A1 (en) 2009-07-17 2012-11-08 Rigshospitalet Masp isoforms as inhibitors of complement activation
AR077942A1 (es) 2009-08-19 2011-10-05 Danisco Variantes de glucoamilasa
CN102712915B (zh) 2009-08-19 2014-12-10 丹尼斯科美国公司 具有改良比活和/或热稳定性的葡糖淀粉酶的组合变体
ES2583259T3 (es) 2009-12-01 2016-09-20 Novo Nordisk A/S Nuevas liasas alfa-amidantes de peptidil alfa-hidroxiglicina
CA2791841C (en) 2010-03-05 2023-01-03 Rigshospitalet Chimeric inhibitor molecules of complement activation
WO2011120993A1 (en) 2010-03-29 2011-10-06 Danisco A/S Polypeptides having transgalactosylating activity
US8933282B2 (en) 2010-06-17 2015-01-13 Danisco Us Inc. Fuel compositions comprising isoprene derivatives
DK2595488T3 (da) * 2010-07-21 2020-02-24 Novozymes As Fremgangsmåde til fremstilling af et bagt produkt med antiældningsamylase og peptidase
CA2807558A1 (en) 2010-08-06 2012-02-09 Danisco Us Inc. Production of isoprene under neutral ph conditions
BR112013001179A2 (pt) 2010-08-06 2016-05-31 Danisco Us Inc sacrificação e fermentação em ph neutro.
EP2608682B1 (de) 2010-08-24 2017-12-13 Danisco US Inc. Verfahren zur herstellung eines snackriegels mit einem niedrigtemperatur-reisproteinkonzentrat
CA2816306A1 (en) 2010-10-27 2012-05-03 Danisco Us Inc. Isoprene synthase variants for improved production of isoprene
BR112013018316A2 (pt) 2010-12-22 2018-09-11 Danisco Us Inc composições e métodos para produção aprimorada de isopreno usando dois tipos de enzimas ispg
JP2014502844A (ja) 2010-12-22 2014-02-06 ダニスコ・ユーエス・インク 組み換え細胞による五炭糖の生物学的生産
BR112013027170A2 (pt) 2011-04-29 2017-06-20 Danisco Us Inc processo em ph único para liquefação e sacarificação de amido para xaropes de glicose de densidade alta
WO2013022799A1 (en) 2011-08-05 2013-02-14 Danisco Us Inc. PRODUCTION OF ISOPRENOIDS UNDER NEUTRAL pH CONDITIONS
WO2013067028A1 (en) 2011-10-31 2013-05-10 Bp Corporation North America Inc. Use of mammalian promoters in filamentous fungi
US9249418B2 (en) 2011-10-31 2016-02-02 Bp Corporation North America Inc. Use of plant promoters in filamentous fungi
AU2013217986B2 (en) 2012-02-09 2017-04-27 Var2 Pharmaceuticals Aps Targeting of chondroitin sulfate glycans
US9163263B2 (en) 2012-05-02 2015-10-20 The Goodyear Tire & Rubber Company Identification of isoprene synthase variants with improved properties for the production of isoprene
WO2013182686A1 (en) 2012-06-08 2013-12-12 Dupont Nutrition Biosciences Aps Polypeptides having transgalactosylating activity
MX2015002099A (es) 2012-08-22 2015-05-11 Dupont Nutrition Biosci Aps Variantes que tienen actividad glucoamilasa.
CN104704118A (zh) 2012-10-15 2015-06-10 诺和诺德保健Ag(股份有限公司) 凝血因子vii多肽
WO2014145768A2 (en) 2013-03-15 2014-09-18 Bp Corporation North America Inc. Use of non-fungal 5' utrs in filamentous fungi
EP4165999A1 (de) 2013-12-11 2023-04-19 DuPont Nutrition Biosciences ApS Verfahren zur herstellung eines milchprodukts mit einem stabilen gehalt an galacto-oligosaccharid(en)
WO2016071504A1 (en) 2014-11-07 2016-05-12 Dupont Nutrition Biosciences Aps Recombinant host cell expressing beta-galactosidase and/or transgalactosylating activity deficient in mannanase, cellulase and pectinase
BR112017016897A2 (pt) 2015-02-09 2018-03-27 Danisco Us Inc cepas fúngicas e métodos de uso
ES2929531T3 (es) 2015-05-22 2022-11-30 Dupont Nutrition Biosci Aps Acetolactato descarboxilasa
US20180148683A1 (en) 2015-07-07 2018-05-31 Danisco Us Inc. Induction of gene expression using a high concentration sugar mixture
CA2997213C (en) 2015-09-02 2021-01-19 Dupont Nutrition Biosciences Aps Glycoside hydolases and their use in preventing and/or treating a pathogenic infection in an animal
BR112018077458A2 (pt) 2016-06-30 2019-04-02 Danisco Us Inc. proteases aspárticas
CA3037083A1 (en) 2016-09-16 2018-03-22 Dupont Nutrition Biosciences Aps Acetolactate decarboxylase variants having improved specific activity
RU2763378C2 (ru) 2016-09-23 2021-12-28 ДюПон НЬЮТРИШН БАЙОСАЙЕНСИЗ АпС ПРИМЕНЕНИЕ АКТИВНЫХ ПРИ НИЗКОМ ЗНАЧЕНИИ pH АЛЬФА-1,4/1,6-ГЛИКОЗИДГИДРОЛАЗ В КАЧЕСТВЕ КОРМОВОЙ ДОБАВКИ ДЛЯ ЖВАЧНЫХ ЖИВОТНЫХ ДЛЯ УЛУЧШЕНИЯ ПЕРЕВАРИВАНИЯ КРАХМАЛА
EP3523415A1 (de) 2016-10-04 2019-08-14 Danisco US Inc. Herstellung von proteinen in fadenpilzzellen in abwesenheit von induzierenden substraten
WO2018093752A1 (en) 2016-11-15 2018-05-24 Danisco Us Inc. Filamentous fungi with improved protein production
WO2018164876A1 (en) 2017-03-06 2018-09-13 Dupont Nutrition Biosciences Aps Novel fungal fucosidases and their use in preventing and/or treating a pathogenic infection in an animal
US20210278406A1 (en) 2018-07-13 2021-09-09 Varct Diagnostic Aps Isolation of circulating cells of fetal origin using recombinant malaria protein var2csa
EP3935157A2 (de) 2019-03-08 2022-01-12 Danisco US Inc. Fusionspolypeptide
CN113874392B (zh) 2019-03-28 2025-10-21 丹尼斯科美国公司 工程化抗体
JP7793519B2 (ja) 2019-12-19 2026-01-05 ビーエーエスエフ ソシエタス・ヨーロピア ファインケミカルを生成する際の空時収率、炭素変換効率、及び炭素基質適応性の増加
KR20220119408A (ko) 2019-12-20 2022-08-29 바스프 에스이 터펜의 독성 감소 및 미생물에서 생산 잠재성 증가
WO2021202473A2 (en) 2020-03-30 2021-10-07 Danisco Us Inc Engineered antibodies
EP4139332A1 (de) 2020-04-22 2023-03-01 Danisco US Inc. Zusammensetzungen und verfahren zur verbesserten proteinproduktion in filamentösen pilzzellen
CN117716039A (zh) 2021-07-19 2024-03-15 丹尼斯科美国公司 用于增强真菌细胞中的蛋白质产生的组合物和方法
CN116135979B (zh) * 2021-11-16 2025-08-29 中国科学院天津工业生物技术研究所 一种基于流式细胞术的免涂板操作的菌株工程改造的方法及应用
JP2024542623A (ja) 2021-12-01 2024-11-15 ダニスコ・ユーエス・インク 真菌細胞におけるタンパク質生産を増強するための組成物及び方法
WO2024015953A1 (en) 2022-07-15 2024-01-18 Danisco Us Inc. Methods for producing monoclonal antibodies

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
NO840200L (no) * 1983-01-28 1984-07-30 Cefus Corp Glukoamylase cdna.
DK601984D0 (da) * 1984-12-14 1984-12-14 Hansens Lab Fremgangsmaade til fremstilling af genprodukter
DE3650783T2 (de) * 1985-04-15 2004-07-15 Dsm Ip Assets B.V. Verwendung des Glucoamylasepromotors aus Apergillus
DK122686D0 (da) * 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
FI872102A7 (fi) * 1986-06-06 1987-12-07 Panlabs Inc Rihmasienten ilmentymisjärjestelmät.

Also Published As

Publication number Publication date
DK414486D0 (da) 1986-08-29
EP0215594A2 (de) 1987-03-25
HK1003579A1 (en) 1998-10-30
DE3650202D1 (de) 1995-02-23
EP0215594A3 (en) 1988-08-31
AU6200886A (en) 1987-03-05
DE3650202T3 (de) 2004-06-03
IE950656L (en) 1987-02-28
NZ217373A (en) 1990-10-26
EP0215594B1 (de) 1995-01-11
DK414486A (da) 1987-03-01
IE862310L (en) 1987-02-28
CA1341532C (en) 2007-06-19
ATE117020T1 (de) 1995-01-15
EP0215594B2 (de) 2003-10-15
IE65794B1 (en) 1995-11-15
JPH08280388A (ja) 1996-10-29
AU607398B2 (en) 1991-03-07
DE3650202T2 (de) 1995-06-01
EP0625577A1 (de) 1994-11-23

Similar Documents

Publication Publication Date Title
DK175460B1 (da) Fremgangsmåde til fremstilling af et pattedyrpolypeptid
US5364770A (en) Heterologous polypeptides expressed in aspergillus
US6509171B1 (en) Aspartic proteinase deficient filamentous fungi
HK1003579B (en) Heterologous polypeptide expressed in filamentous fungi, processes for their preparation, and vectors for their preparation
Jeenes et al. 9 Heterologous Protein Production by Filamentous Fungi
US5863759A (en) Process for the production of protein products in aspergillus
JP3005618B2 (ja) アスペルギルス属酵母のプロモーター
US5766912A (en) Humicola lipase produced in aspergillus
US5874558A (en) Nucleic acid encoding a recombinant humicola sp. lipase
JPH10500024A (ja) 無毒、非毒素原性、非病原性の発現系、並びにその中で利用するためのプロモーター及びターミネーター
HUT51336A (en) Process for construction of aspergillus strains by gene substitution
JP3153234B2 (ja) 糸状菌からの目的とするポリペプチドの分泌を増幅するdna配列、ベクター、及び融合ポリペプチド
DK175534B1 (da) Rekombinant DNA-molekyle, fremgangsmåde til dets fremstilling, transformeret vært, fremgangsmåde til dens fremstilling, fremgangsmåde til fremstilling af et polypeptid samt pectinlyaser
US6004785A (en) Heterologous polypeptides expressed in filamentous fungi, processes for making same, and vectors for making same
Ward Chymosin production in Aspergillus
AU6323800A (en) Novel means of transformation of fungi and their use for heterologous protein production
US7776581B2 (en) Method of producing an aspartic protease in a recombinant host organism
Chiu Construction of a gene expression model in Mucor
JPH0538289A (ja) 蛋白質の製造法

Legal Events

Date Code Title Description
PUP Patent expired