DK177990D0 - Mono-(2-ammonium-2-hydroxymethyl-1,3-propandiol)(2r,cis)-1,2-epoxypropylphosphonat, fremgangsmaade til fremstilling deraf og faste farmaceutiske praeparater indeholdende forbindelsen - Google Patents

Mono-(2-ammonium-2-hydroxymethyl-1,3-propandiol)(2r,cis)-1,2-epoxypropylphosphonat, fremgangsmaade til fremstilling deraf og faste farmaceutiske praeparater indeholdende forbindelsen

Info

Publication number: DK177990D0
Authority: DK; Denmark
Prior art keywords: epoxypropylphosphonate; propandiol; hydroxymethyl; cis; mono
Prior art date: 1989-07-27

Application number

DK177990A

Other languages

English (en)

Other versions

DK170777B1 (da

DK177990A (da

Inventor

Dario Tentorio

Graziano Castaldi

Claudio Giordano

Franco Pozzi

Original Assignee

Zambon Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-27

Filing date

1990-07-26

Publication date

1990-07-26

1990-07-26 Application filed by Zambon Spa filed Critical Zambon Spa

1990-07-26 Publication of DK177990D0 publication Critical patent/DK177990D0/da

1991-01-28 Publication of DK177990A publication Critical patent/DK177990A/da

1996-01-15 Application granted granted Critical

1996-01-15 Publication of DK170777B1 publication Critical patent/DK170777B1/da

Links

GYDBYATURBDGIF-UHFFFAOYSA-N (2-methyloxiran-2-yl)phosphonic acid Chemical compound OP(=O)(O)C1(C)CO1 GYDBYATURBDGIF-UHFFFAOYSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
239000007787 solid Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
- C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

DK177990A 1989-07-27 1990-07-26 Mono-(2-ammonium-2-hydroxymethyl-1,3-propandiol)(2R,cis)-1,2-epoxypropylphosphonat, fremgangsmåde til dets fremstilling og faste farmaceutiske præpar ater med indhold deraf DK170777B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT8921340A IT1231013B (it)	1989-07-27	1989-07-27	Mono (2 ammonio 2 idrossimetil 1,3 propandiolo)(2r,cis) 1,2 epossipropil fosfonato avente migliorate caratteristiche di stabilita' e lavorabilita'.
IT2134089		1989-07-27

Publications (3)

Publication Number	Publication Date
DK177990D0 true DK177990D0 (da)	1990-07-26
DK177990A DK177990A (da)	1991-01-28
DK170777B1 DK170777B1 (da)	1996-01-15

Family

ID=11180349

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK177990A DK170777B1 (da)	1989-07-27	1990-07-26	Mono-(2-ammonium-2-hydroxymethyl-1,3-propandiol)(2R,cis)-1,2-epoxypropylphosphonat, fremgangsmåde til dets fremstilling og faste farmaceutiske præpar ater med indhold deraf

Country Status (19)

Country	Link
US (1)	US5162309A (da)
JP (1)	JP2821803B2 (da)
AT (1)	AT398204B (da)
BE (1)	BE1002775A3 (da)
CA (1)	CA2021809A1 (da)
CH (1)	CH679669A5 (da)
DE (1)	DE4023775C2 (da)
DK (1)	DK170777B1 (da)
ES (1)	ES2020790A6 (da)
FI (1)	FI97232C (da)
FR (1)	FR2650280B1 (da)
GB (1)	GB2234245B (da)
GR (1)	GR1000714B (da)
IE (1)	IE63984B1 (da)
IT (1)	IT1231013B (da)
LU (1)	LU87774A1 (da)
NL (1)	NL194504C (da)
PT (1)	PT94816B (da)
SE (1)	SE468769B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20021725A1 (it) *	2002-08-01	2002-10-31	Zambon Spa	Composizioni farmaceutiche ad attivita' antibiotica.
ES2244333B1 (es) *	2004-05-18	2006-08-01	Simbec Iberica, Sl	Preparado farmaceutico oral de fosfomicina estable y apto para diabeticos.
EP1762573A1 (en)	2005-09-08	2007-03-14	Interquim, S.A. De C.V.	A process for the preparation of fosfomycin salts
ES2385158B1 (es) *	2010-12-24	2013-05-28	Arafarma Group, S.A.	Composición farmacéutica de fosfomicina
CN102351902A (zh) *	2011-08-12	2012-02-15	山西仟源制药股份有限公司	磷霉素单氨丁三醇的制备方法
CN102807586B (zh) *	2012-08-31	2015-05-13	东北制药集团股份有限公司	磷霉素氨盐的制备方法
ITTO20130839A1 (it) *	2013-10-16	2015-04-17	C & G Farmaceutici S R L	Composizione a base di fosfomicina trometamolo
DE102014218913A1 (de) *	2014-09-19	2016-03-24	Heraeus Medical Gmbh	Verfahren zur Herstellung eines antibiotischen Polymehtylmethacrylat-Knochenzementpulvers und ein antibiotisches Polymethtylmethacrylat-Knochenzementpulver
WO2017111718A1 (en)	2015-12-25	2017-06-29	Yusuf Toktamiş Öğün	The formulation comprising phosphomycine and ascorbic acid for the treatment of bacterial urinary system infections
CN108997425B (zh) *	2017-06-06	2020-11-13	湖南华纳大药厂手性药物有限公司	一种制备高含量磷霉素氨丁三醇的方法
CN108997424B (zh) *	2017-06-06	2020-11-13	湖南华纳大药厂手性药物有限公司	一种简捷制备磷霉素氨丁三醇的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3641063A (en) *	1968-01-22	1972-02-08	Merck & Co Inc	Antibiotic purification process
US3914231A (en) *	1970-09-04	1975-10-21	Merck & Co Inc	({31 )(Cis-1,2-epoxypropyl)-phosphonic acid and salts thereof
IT1112282B (it) *	1978-07-19	1986-01-13	Zambon Spa	Bis-(2-ammonio-2-idrossimetil-1,3-propandiolo)(2r-cis)-(3-metilossiranil)fosfonato
IT1124610B (it) *	1979-10-18	1986-05-07	Zambo Spa	Mono(2-ammonio-2-idrossimetil-1,3-propandiolo) (2r-cis)-(o-metilossiranil)fosfonato

1989
- 1989-07-27 IT IT8921340A patent/IT1231013B/it active
1990
- 1990-07-18 IE IE262890A patent/IE63984B1/en not_active IP Right Cessation
- 1990-07-20 CH CH2423/90A patent/CH679669A5/it not_active IP Right Cessation
- 1990-07-24 CA CA002021809A patent/CA2021809A1/en not_active Abandoned
- 1990-07-25 GB GB9016253A patent/GB2234245B/en not_active Expired - Fee Related
- 1990-07-25 US US07/557,030 patent/US5162309A/en not_active Expired - Lifetime
- 1990-07-25 GR GR900100570A patent/GR1000714B/el not_active IP Right Cessation
- 1990-07-25 PT PT94816A patent/PT94816B/pt not_active IP Right Cessation
- 1990-07-25 LU LU87774A patent/LU87774A1/fr unknown
- 1990-07-25 FR FR909009494A patent/FR2650280B1/fr not_active Expired - Fee Related
- 1990-07-26 DE DE4023775A patent/DE4023775C2/de not_active Expired - Fee Related
- 1990-07-26 JP JP2201021A patent/JP2821803B2/ja not_active Expired - Lifetime
- 1990-07-26 DK DK177990A patent/DK170777B1/da not_active IP Right Cessation
- 1990-07-26 BE BE9000747A patent/BE1002775A3/fr not_active IP Right Cessation
- 1990-07-26 ES ES9002011A patent/ES2020790A6/es not_active Expired - Fee Related
- 1990-07-26 SE SE9002501A patent/SE468769B/sv not_active IP Right Cessation
- 1990-07-26 AT AT0156590A patent/AT398204B/de not_active IP Right Cessation
- 1990-07-27 NL NL9001712A patent/NL194504C/nl not_active IP Right Cessation
- 1990-07-27 FI FI903760A patent/FI97232C/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE4023775C2 (de)	1999-07-22
GB2234245A (en)	1991-01-30
CA2021809A1 (en)	1991-01-28
SE9002501L (sv)	1991-01-28
FI97232C (fi)	1996-11-11
IE63984B1 (en)	1995-06-28
NL9001712A (nl)	1991-02-18
GR1000714B (el)	1992-11-23
JP2821803B2 (ja)	1998-11-05
IT1231013B (it)	1991-11-08
FR2650280A1 (fr)	1991-02-01
BE1002775A3 (fr)	1991-06-04
LU87774A1 (fr)	1990-12-11
DE4023775A1 (de)	1991-01-31
ATA156590A (de)	1994-02-15
AT398204B (de)	1994-10-25
NL194504C (nl)	2002-06-04
PT94816B (pt)	1997-03-31
SE9002501D0 (sv)	1990-07-26
GB2234245B (en)	1992-10-14
GB9016253D0 (en)	1990-09-12
NL194504B (nl)	2002-02-01
JPH03101683A (ja)	1991-04-26
SE468769B (sv)	1993-03-15
DK170777B1 (da)	1996-01-15
ES2020790A6 (es)	1991-09-16
CH679669A5 (da)	1992-03-31
PT94816A (pt)	1991-04-18
FI903760A0 (fi)	1990-07-27
DK177990A (da)	1991-01-28
GR900100570A (en)	1991-12-10
FR2650280B1 (fr)	1992-02-07
IT8921340A0 (it)	1989-07-27
US5162309A (en)	1992-11-10
IE902628A1 (en)	1991-02-27
FI97232B (fi)	1996-07-31

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Legal Events

Date	Code	Title	Description
2006-04-18	PBP	Patent lapsed	Country of ref document: DK