DK1786442T3 - Behandling af neurodegenerative sygdomme under anvendelse af DEGS-inhibitorer - Google Patents
Behandling af neurodegenerative sygdomme under anvendelse af DEGS-inhibitorerInfo
- Publication number
- DK1786442T3 DK1786442T3 DK04798068T DK04798068T DK1786442T3 DK 1786442 T3 DK1786442 T3 DK 1786442T3 DK 04798068 T DK04798068 T DK 04798068T DK 04798068 T DK04798068 T DK 04798068T DK 1786442 T3 DK1786442 T3 DK 1786442T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitors
- treatment
- neurodegenerative diseases
- degs
- scd4
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000004770 neurodegeneration Effects 0.000 title abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
- 101150027068 DEGS1 gene Proteins 0.000 title 1
- 101000639987 Homo sapiens Stearoyl-CoA desaturase 5 Proteins 0.000 abstract 2
- 102100033930 Stearoyl-CoA desaturase 5 Human genes 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
- C12Y114/19001—Stearoyl-CoA 9-desaturase (1.14.19.1), i.e. DELTA9-desaturase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96472—Aspartic endopeptidases (3.4.23)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04018874 | 2004-08-09 | ||
| PCT/EP2004/009771 WO2005023833A2 (en) | 2003-09-05 | 2004-09-02 | Treatment of neurodegenerative diseases |
| PCT/EP2004/013341 WO2006015622A1 (en) | 2004-08-09 | 2004-11-24 | Treatment of neurodegenerative diseases by the use of degs inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1786442T3 true DK1786442T3 (da) | 2008-03-17 |
Family
ID=38873800
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04798068T DK1786442T3 (da) | 2004-08-09 | 2004-11-24 | Behandling af neurodegenerative sygdomme under anvendelse af DEGS-inhibitorer |
| DK04822235T DK1778837T3 (da) | 2004-08-09 | 2004-11-24 | Behandling af neurodegenerative sygdomme ved anvendelse af SCD4-inhibitorer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04822235T DK1778837T3 (da) | 2004-08-09 | 2004-11-24 | Behandling af neurodegenerative sygdomme ved anvendelse af SCD4-inhibitorer |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20090098105A1 (da) |
| EP (2) | EP1778837B1 (da) |
| JP (2) | JP2008509172A (da) |
| AT (1) | ATE392471T1 (da) |
| CA (2) | CA2575300A1 (da) |
| DE (2) | DE602004010314T2 (da) |
| DK (2) | DK1786442T3 (da) |
| ES (2) | ES2295949T3 (da) |
| PT (1) | PT1778837E (da) |
| WO (2) | WO2006015621A1 (da) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| US7678783B2 (en) | 2004-11-17 | 2010-03-16 | Merck Sharp & Dohme Corp. | Macrocyclic tertiary amine beta-secretase inhibitors for the treatment of alzheimer's disease |
| US7951949B2 (en) | 2004-11-23 | 2011-05-31 | Merck, Sharp & Dohme, Corp. | Macrocyclic aminopyridyl beta-secretase inhibitors for the treatment of Alzheimer's disease |
| HRP20140240T4 (hr) | 2005-11-30 | 2017-02-24 | Abbvie Inc. | Monoklonalna antitijela protiv amiloidnih beta proteina i njihova upotreba |
| US8691224B2 (en) | 2005-11-30 | 2014-04-08 | Abbvie Inc. | Anti-Aβ globulomer 5F7 antibodies |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| US8895004B2 (en) | 2007-02-27 | 2014-11-25 | AbbVie Deutschland GmbH & Co. KG | Method for the treatment of amyloidoses |
| US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
| EP3533803B1 (en) | 2010-08-14 | 2021-10-27 | AbbVie Inc. | Anti-amyloid-beta antibodies |
| US9233102B2 (en) | 2012-03-07 | 2016-01-12 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| WO2016022955A1 (en) | 2014-08-07 | 2016-02-11 | Mayo Foundation For Medical Education And Research | Compounds and methods for treating cancer |
| JP2019533022A (ja) | 2016-10-24 | 2019-11-14 | ユマニティ セラピューティクス，インコーポレーテッド | 化合物及びその使用 |
| EP3566055B1 (en) | 2017-01-06 | 2025-03-12 | Janssen Pharmaceutica NV | Scd inhibitor for the treatment of neurological disorders |
| CA3083000A1 (en) | 2017-10-24 | 2019-05-02 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| WO2019183587A1 (en) | 2018-03-23 | 2019-09-26 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| WO2020154571A1 (en) | 2019-01-24 | 2020-07-30 | Yumanity Therapeutics, Inc. | Compounds and uses thereof |
| EA202192047A1 (ru) | 2019-11-13 | 2021-12-08 | Юманити Терапьютикс, Инк. | Соединения и их применение |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4980286A (en) * | 1985-07-05 | 1990-12-25 | Whitehead Institute For Biomedical Research | In vivo introduction and expression of foreign genetic material in epithelial cells |
| US5225539A (en) * | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5198346A (en) * | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
| US5096815A (en) * | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| US5498538A (en) * | 1990-02-15 | 1996-03-12 | The University Of North Carolina At Chapel Hill | Totally synthetic affinity reagents |
| US5625126A (en) * | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) * | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) * | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| ATE158021T1 (de) * | 1990-08-29 | 1997-09-15 | Genpharm Int | Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper |
| US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5582981A (en) * | 1991-08-14 | 1996-12-10 | Gilead Sciences, Inc. | Method for identifying an oligonucleotide aptamer specific for a target |
| US20020025508A1 (en) * | 2000-01-06 | 2002-02-28 | Katja Fechteler | Process for finding a protease inhibitor |
| EP1257635A2 (en) * | 2000-01-21 | 2002-11-20 | Incyte Genomics, Inc. | Lipid metabolism enzymes and polynucleotides encoding them |
| EP1257633A1 (en) * | 2000-02-25 | 2002-11-20 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Presenilin deficient multipotent cell lines and screening methods for intramembrane regulated proteolytic activities using these lines |
| US6686185B1 (en) * | 2000-03-07 | 2004-02-03 | Millennium Pharmaceuticals, Inc. | 25934, a novel fatty acid desaturase and uses therefor |
| CA2301158A1 (en) * | 2000-03-24 | 2001-09-24 | Stephen J. Allen | Screening methods for compounds useful for modulating lipid metabolism in disease |
| US20030198953A1 (en) * | 2000-03-30 | 2003-10-23 | Spytek Kimberly A. | Novel proteins and nucleic acids encoding same |
| US20020124273A1 (en) * | 2000-10-17 | 2002-09-05 | Jean-Marc Roch | Protein-protein interactions in neurodegenerative diseases |
| ES2170030B1 (es) * | 2000-12-19 | 2003-11-16 | Consejo Superior Investigacion | Inhibidores de la dihidroceramida desaturasa. |
| WO2002062999A2 (en) * | 2000-12-29 | 2002-08-15 | Curagen Corporation | Proteins and nucleic acids encoding same |
-
2004
- 2004-11-24 AT AT04822235T patent/ATE392471T1/de not_active IP Right Cessation
- 2004-11-24 PT PT04822235T patent/PT1778837E/pt unknown
- 2004-11-24 EP EP04822235A patent/EP1778837B1/en not_active Expired - Lifetime
- 2004-11-24 ES ES04798068T patent/ES2295949T3/es not_active Expired - Lifetime
- 2004-11-24 CA CA002575300A patent/CA2575300A1/en not_active Abandoned
- 2004-11-24 WO PCT/EP2004/013340 patent/WO2006015621A1/en not_active Ceased
- 2004-11-24 CA CA002575190A patent/CA2575190A1/en not_active Abandoned
- 2004-11-24 DK DK04798068T patent/DK1786442T3/da active
- 2004-11-24 WO PCT/EP2004/013341 patent/WO2006015622A1/en not_active Ceased
- 2004-11-24 DK DK04822235T patent/DK1778837T3/da active
- 2004-11-24 DE DE602004010314T patent/DE602004010314T2/de not_active Expired - Lifetime
- 2004-11-24 US US11/659,245 patent/US20090098105A1/en not_active Abandoned
- 2004-11-24 JP JP2007525182A patent/JP2008509172A/ja not_active Withdrawn
- 2004-11-24 ES ES04822235T patent/ES2304642T3/es not_active Expired - Lifetime
- 2004-11-24 JP JP2007525181A patent/JP2008509171A/ja not_active Withdrawn
- 2004-11-24 EP EP04798068A patent/EP1786442B1/en not_active Expired - Lifetime
- 2004-11-24 US US11/659,680 patent/US20070298029A1/en not_active Abandoned
- 2004-11-24 DE DE602004013202T patent/DE602004013202T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006015622A1 (en) | 2006-02-16 |
| EP1778837A1 (en) | 2007-05-02 |
| ES2295949T3 (es) | 2008-04-16 |
| DE602004010314D1 (de) | 2008-01-03 |
| US20090098105A1 (en) | 2009-04-16 |
| CA2575190A1 (en) | 2006-02-16 |
| EP1778837B1 (en) | 2008-04-16 |
| DE602004013202T2 (de) | 2009-05-28 |
| EP1786442B1 (en) | 2007-11-21 |
| JP2008509171A (ja) | 2008-03-27 |
| CA2575300A1 (en) | 2006-02-16 |
| PT1778837E (pt) | 2008-07-11 |
| EP1786442A1 (en) | 2007-05-23 |
| ES2304642T3 (es) | 2008-10-16 |
| WO2006015621A1 (en) | 2006-02-16 |
| DK1778837T3 (da) | 2008-08-04 |
| US20070298029A1 (en) | 2007-12-27 |
| DE602004013202D1 (de) | 2008-05-29 |
| ATE392471T1 (de) | 2008-05-15 |
| DE602004010314T2 (de) | 2009-03-05 |
| JP2008509172A (ja) | 2008-03-27 |
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