DK180086A - 12b-substituerede 1-hydroxymethyl-octahydroindolo(2,3-a)-quinolizinderivater eller isomere eller syreadditionssalte deraf, deres fremstilling og anvendelse som farmaceutika - Google Patents

12b-substituerede 1-hydroxymethyl-octahydroindolo(2,3-a)-quinolizinderivater eller isomere eller syreadditionssalte deraf, deres fremstilling og anvendelse som farmaceutika Download PDF

Info

Publication number: DK180086A
Authority: DK; Denmark
Prior art keywords: isomers; octahydroindolo; quinolizin; pharmaceuticals; hydroxymethyl
Prior art date: 1985-04-19

Application number

DK180086A

Other languages

Danish (da)

English (en)

Other versions

DK180086D0 (da

Inventor

Csaba Szantay

Ferenc Soti

Maria Incze

Zsuzsanna Balogh

Zsolt Szombathelyi

Egon Karpati

Kiss Bela

Katalin Csomor

Istvan Laszlovszky

Erzsebet Lapis

Laszlo Szporny

Lilla Forgacs

Csaba Kuthi

Original Assignee

Richter Gedeon Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-19

Filing date

1986-04-18

Publication date

1986-10-20

1986-04-18 Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet

1986-04-18 Publication of DK180086D0 publication Critical patent/DK180086D0/da

1986-10-20 Publication of DK180086A publication Critical patent/DK180086A/da

Links

150000003839 salts Chemical class 0.000 title description 4
-1 12B-SUBSTITUTED 1-HYDROXYMETHYL-OCTAHYDROINDOLO (2,3-A) -QUINOLIZIN Chemical class 0.000 title description 2
239000002253 acid Substances 0.000 title description 2
239000003814 drug Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 description 5
125000003710 aryl alkyl group Chemical group 0.000 description 4
125000003118 aryl group Chemical group 0.000 description 3
125000003545 alkoxy group Chemical group 0.000 description 2
125000002471 4H-quinolizinyl group Chemical class C=1(C=CCN2C=CC=CC12)* 0.000 description 1
230000005792 cardiovascular activity Effects 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
229910052736 halogen Inorganic materials 0.000 description 1
150000002367 halogens Chemical class 0.000 description 1
239000000543 intermediate Substances 0.000 description 1
UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 description 1
230000007017 scission Effects 0.000 description 1
238000000926 separation method Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK180086A 1985-04-19 1986-04-18 12b-substituerede 1-hydroxymethyl-octahydroindolo(2,3-a)-quinolizinderivater eller isomere eller syreadditionssalte deraf, deres fremstilling og anvendelse som farmaceutika DK180086A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU151885		1985-04-19
HU851518A HU195214B (en)	1985-04-19	1985-04-19	Process for producing 12b-substituted-1-(hydroxymethyl)-octahydro-indolo /2,3-a/ quinolizine derivatives and pharmaceutical preparations comprising these compounds

Publications (2)

Publication Number	Publication Date
DK180086D0 DK180086D0 (da)	1986-04-18
DK180086A true DK180086A (da)	1986-10-20

Family

ID=10954843

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK180086A DK180086A (da)	1985-04-19	1986-04-18	12b-substituerede 1-hydroxymethyl-octahydroindolo(2,3-a)-quinolizinderivater eller isomere eller syreadditionssalte deraf, deres fremstilling og anvendelse som farmaceutika

Country Status (9)

Country	Link
EP (1)	EP0200436A3 (de)
JP (1)	JPS61293981A (de)
AU (1)	AU585340B2 (de)
CA (1)	CA1300146C (de)
DK (1)	DK180086A (de)
FI (1)	FI861640A7 (de)
HU (1)	HU195214B (de)
IL (1)	IL78535A0 (de)
ZA (1)	ZA862943B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU191454B (en) *	1984-10-05	1987-02-27	Richter Gedeon Vegyeszeti Gyar Rt.,Hu	Process for producing amides of oktahydro-indolo/2,3-a/quinolyzin-1-yl-alkanecarboxylic acids and pharmaceutically acceptable acid additional salts thereof
HU194221B (en) *	1985-04-19	1988-01-28	Richter Gedeon Vegyeszet	Process for preparing novel octahydro-indolo/2,3-a/quinoline derivative and pharmaceutical comprising this compound
HU194220B (en) *	1985-04-19	1988-01-28	Richter Gedeon Vegyeszet	Process for production of derivatives of 1,12 b disubstituated-octahydro-indolo /2,3-a/ quinolisine and medical compounds containing thereof
WO2017190038A1 (en) *	2016-04-29	2017-11-02	University Of Florida Research Foundation, Incorporated	Analogs of yohimbine and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU170495B (de) *	1974-05-07	1977-06-28
ZA786426B (en) *	1977-11-25	1979-10-31	Scras	New indulo(2,3-a)quinolizidines,preparation and therapeutic use
HU194221B (en) *	1985-04-19	1988-01-28	Richter Gedeon Vegyeszet	Process for preparing novel octahydro-indolo/2,3-a/quinoline derivative and pharmaceutical comprising this compound
HU194220B (en) *	1985-04-19	1988-01-28	Richter Gedeon Vegyeszet	Process for production of derivatives of 1,12 b disubstituated-octahydro-indolo /2,3-a/ quinolisine and medical compounds containing thereof

1985
- 1985-04-19 HU HU851518A patent/HU195214B/hu not_active IP Right Cessation
1986
- 1986-04-18 CA CA000507054A patent/CA1300146C/en not_active Expired - Lifetime
- 1986-04-18 AU AU56382/86A patent/AU585340B2/en not_active Ceased
- 1986-04-18 JP JP61088397A patent/JPS61293981A/ja active Pending
- 1986-04-18 FI FI861640A patent/FI861640A7/fi not_active Application Discontinuation
- 1986-04-18 DK DK180086A patent/DK180086A/da not_active Application Discontinuation
- 1986-04-18 IL IL78535A patent/IL78535A0/xx not_active IP Right Cessation
- 1986-04-18 EP EP86302933A patent/EP0200436A3/de not_active Withdrawn
- 1986-04-18 ZA ZA862943A patent/ZA862943B/xx unknown

Also Published As

Publication number	Publication date
FI861640A0 (fi)	1986-04-18
HUT40432A (en)	1986-12-28
FI861640A7 (fi)	1986-10-20
ZA862943B (en)	1987-09-30
AU585340B2 (en)	1989-06-15
JPS61293981A (ja)	1986-12-24
EP0200436A2 (de)	1986-11-05
IL78535A0 (en)	1986-08-31
EP0200436A3 (de)	1989-01-18
AU5638286A (en)	1986-10-23
CA1300146C (en)	1992-05-05
DK180086D0 (da)	1986-04-18
HU195214B (en)	1988-04-28

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Legal Events

Date	Code	Title	Description
1991-04-22	AHS	Application shelved for other reasons than non-payment