DK179986A - Racemiske og optisk aktive 1,12b-disubstituerede octahydroindolo(2,3-a)quinolizinderivater eller cis- og trans-isomere eller syreadditionssalte deraf, deres fremstilling og anvendelse som farmaceutika, mellemprodukter ved fremstillingen og disses fremstilling - Google Patents

Racemiske og optisk aktive 1,12b-disubstituerede octahydroindolo(2,3-a)quinolizinderivater eller cis- og trans-isomere eller syreadditionssalte deraf, deres fremstilling og anvendelse som farmaceutika, mellemprodukter ved fremstillingen og disses fremstilling Download PDF

Info

Publication number: DK179986A
Authority: DK; Denmark
Prior art keywords: variety; preparation; cis; quinolizin; trans
Prior art date: 1985-04-19

Application number

DK179986A

Other languages

English (en)

Other versions

DK179986D0 (da

Inventor

Csaba Szantay

Ferenc Soti

Maria Incze

Zsuzsanna Balogh

Zsolt Szombatelyi

Egon Karpati

Bela Kiss

Katalin Csomor

Istvan Laszlovszky

Erzsebet Lapis

Lilla Forgacs

Csaba Kuthi

Laszlo Szporny

Original Assignee

Richter Gedeon Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-19

Filing date

1986-04-18

Publication date

1986-10-20

1986-04-18 Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet

1986-04-18 Publication of DK179986D0 publication Critical patent/DK179986D0/da

1986-10-20 Publication of DK179986A publication Critical patent/DK179986A/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

Description

(V) eller med formel (VI)

(VI) ved ringslutning, om ønsket efterfulgt af halogenering, nitrering, alkylering, omdannelse til et salt, frigørelse fra et salt, adskillelse i cis- og trans-isomere og/eller optisk spaltning.

Forbindelserne med formel (V) og (VI) er hidtil ukendte. De fremstilles ved kondensation af et ketonderivat med formel (III)

(HI) ned et tryptaminderivat med formel (II)

(ix) I formlerne betyder: R1 og R2 H, halogen, N02» OH, alkyl eller alkoxy, r3 og R5 H, alkyl eller aralkyl, R4 alkyl, ar^l eller aralkyl, R5 en elektrontiltrækkende substituent, fortrinsvis en alkyl-, alkoxy-, aralkyl- eller arylcarbonylgruppe.

DK179986A 1985-04-19 1986-04-18 Racemiske og optisk aktive 1,12b-disubstituerede octahydroindolo(2,3-a)quinolizinderivater eller cis- og trans-isomere eller syreadditionssalte deraf, deres fremstilling og anvendelse som farmaceutika, mellemprodukter ved fremstillingen og disses fremstilling DK179986A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU851517A HU194220B (en)	1985-04-19	1985-04-19	Process for production of derivatives of 1,12 b disubstituated-octahydro-indolo /2,3-a/ quinolisine and medical compounds containing thereof

Publications (2)

Publication Number	Publication Date
DK179986D0 DK179986D0 (da)	1986-04-18
DK179986A true DK179986A (da)	1986-10-20

Family

ID=10954837

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK179986A DK179986A (da)	1985-04-19	1986-04-18	Racemiske og optisk aktive 1,12b-disubstituerede octahydroindolo(2,3-a)quinolizinderivater eller cis- og trans-isomere eller syreadditionssalte deraf, deres fremstilling og anvendelse som farmaceutika, mellemprodukter ved fremstillingen og disses fremstilling

Country Status (10)

Country	Link
US (1)	US4843080A (da)
EP (1)	EP0202774A3 (da)
JP (1)	JPS61249985A (da)
AU (1)	AU587025B2 (da)
CA (1)	CA1301171C (da)
DK (1)	DK179986A (da)
FI (1)	FI861642A7 (da)
HU (1)	HU194220B (da)
IL (1)	IL78536A0 (da)
ZA (1)	ZA862942B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU194221B (en) *	1985-04-19	1988-01-28	Richter Gedeon Vegyeszet	Process for preparing novel octahydro-indolo/2,3-a/quinoline derivative and pharmaceutical comprising this compound
HU195214B (en) *	1985-04-19	1988-04-28	Richter Gedeon Vegyeszet	Process for producing 12b-substituted-1-(hydroxymethyl)-octahydro-indolo /2,3-a/ quinolizine derivatives and pharmaceutical preparations comprising these compounds
JPH0368582A (ja) *	1989-06-08	1991-03-25	Duphar Internatl Res Bv	Ｎ―オキソ―テトラヒドロ―β―カルボリンおよびその製造方法
CA2900710C (en)	2013-02-08	2023-08-08	General Mills, Inc.	Reduced sodium food products
EP3830086A4 (en)	2018-07-27	2022-03-30	University of Sharjah	Discovery of novel first in class nature-inspired compounds targeting the mitochondrial function and pharmaceutical composition thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3478051A (en) *	1967-03-17	1969-11-11	Sandoz Ag	Azecino- and azonino(5,4-b)indoles
HU174502B (hu) *	1976-12-30	1980-01-28	Richter Gedeon Vegyeszet	Sposob poluchenija novykh proizvodnykh oktagidro-indolo/2,3-a/-khinolizina
ZA786426B (en) *	1977-11-25	1979-10-31	Scras	New indulo(2,3-a)quinolizidines,preparation and therapeutic use
GB2009749B (en) *	1977-11-25	1982-04-28	Scras	Indolo(1,3-a)quinolizidines
HU178700B (en) *	1978-02-10	1982-06-28	Richter Gedeon Vegyeszet	Process for preparing 1,1-disubstituted octahydro-indolo/2,3-a/-quinolizines
HU178402B (en) *	1978-08-01	1982-04-28	Richter Gedeon Vegyeszet	New process for producing okrahydro-indolo-square bracket-2,3-a-square bracket closed-quinolysines
HU177732B (en) *	1978-12-15	1981-12-28	Richter Gedeon Vegyeszet	Process for producing 10-bromo-vincamine and acid additional salts thereof,and 10-bromo-14-epivincamine
US4353911A (en) *	1979-07-20	1982-10-12	Andre Buzas	Indolo(2,3-a)quinolizidines, useful in increasing femoral and vertebral blood flow
US4358452A (en) *	1980-05-09	1982-11-09	John Wyeth & Brother Limited	N-[1,2,3,4,6,7,12,12 α-octahydro-2H-indolo(2,3α)-quinolizinyl-2β-yl]alkane and benzyl sulfonamides and anti-hypertensive use thereof
HU185305B (en) *	1981-08-23	1985-01-28	Richter Gedeon Vegyeszet	Process for preparing vincine and apovincine
HU182380B (en) *	1981-09-30	1983-12-28	Richter Gedeon Vegyeszet	Process for producing esters of vincaminic acid
EP0079411B1 (fr) *	1981-11-18	1987-02-04	Thal, Claude	Dérivés d'indoloquinolizine, leur procédé de préparation et leur application en thérapeutique
HU194221B (en) *	1985-04-19	1988-01-28	Richter Gedeon Vegyeszet	Process for preparing novel octahydro-indolo/2,3-a/quinoline derivative and pharmaceutical comprising this compound
HU195214B (en) *	1985-04-19	1988-04-28	Richter Gedeon Vegyeszet	Process for producing 12b-substituted-1-(hydroxymethyl)-octahydro-indolo /2,3-a/ quinolizine derivatives and pharmaceutical preparations comprising these compounds

1985
- 1985-04-19 HU HU851517A patent/HU194220B/hu not_active IP Right Cessation
1986
- 1986-04-17 US US06/853,353 patent/US4843080A/en not_active Expired - Fee Related
- 1986-04-18 JP JP61088396A patent/JPS61249985A/ja active Pending
- 1986-04-18 CA CA000507053A patent/CA1301171C/en not_active Expired - Lifetime
- 1986-04-18 AU AU56381/86A patent/AU587025B2/en not_active Ceased
- 1986-04-18 EP EP86302934A patent/EP0202774A3/en not_active Withdrawn
- 1986-04-18 IL IL78536A patent/IL78536A0/xx not_active IP Right Cessation
- 1986-04-18 ZA ZA862942A patent/ZA862942B/xx unknown
- 1986-04-18 DK DK179986A patent/DK179986A/da not_active Application Discontinuation
- 1986-04-18 FI FI861642A patent/FI861642A7/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
JPS61249985A (ja)	1986-11-07
CA1301171C (en)	1992-05-19
US4843080A (en)	1989-06-27
HUT40650A (en)	1987-01-28
ZA862942B (en)	1987-03-25
FI861642A7 (fi)	1986-10-20
HU194220B (en)	1988-01-28
FI861642A0 (fi)	1986-04-18
EP0202774A2 (en)	1986-11-26
AU5638186A (en)	1986-10-23
AU587025B2 (en)	1989-08-03
EP0202774A3 (en)	1989-03-15
DK179986D0 (da)	1986-04-18
IL78536A0 (en)	1986-08-31

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Legal Events

Date	Code	Title	Description
1991-04-22	AHS	Application shelved for other reasons than non-payment