DK181286A - Mutanter af human vaevplasminogenaktivator (t-pa), dna-sekvenser, som koder for disse, udtrykkelsesvektorer, som kan udtrykke dna-sekvenserne, mikroorganismer og cellekulturer transformeret med vektorerne og farmaceutiske praeparater af t-pa-mutanterne - Google Patents

Mutanter af human vaevplasminogenaktivator (t-pa), dna-sekvenser, som koder for disse, udtrykkelsesvektorer, som kan udtrykke dna-sekvenserne, mikroorganismer og cellekulturer transformeret med vektorerne og farmaceutiske praeparater af t-pa-mutanterne Download PDF

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Publication number
DK181286A
DK181286A DK181286A DK181286A DK181286A DK 181286 A DK181286 A DK 181286A DK 181286 A DK181286 A DK 181286A DK 181286 A DK181286 A DK 181286A DK 181286 A DK181286 A DK 181286A
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dna sequences
expression vectors
microorganisms
express
plasminogen activator
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DK181286A
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DK175380B1 (da
DK181286D0 (da
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Herbert Louis Heyneker
Gordon Allen Vehar
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Description

Figure DK181286AD00031
DK198601812A 1985-04-22 1986-04-21 Mutant af human vævsplasminogenaktivator, DNA-sekvens som koder herfor, replicerbar udtrykkelsesvektor til at udtrykke denne DNA-sekvens, mikroorganisme transformeret med denne vektor, cellekulturer transformeret med denne.... DK175380B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72546885A 1985-04-22 1985-04-22
US72546885 1985-04-22
US84669786A 1986-04-01 1986-04-01
US84669786 1986-04-01

Publications (3)

Publication Number Publication Date
DK181286D0 DK181286D0 (da) 1986-04-21
DK181286A true DK181286A (da) 1986-10-23
DK175380B1 DK175380B1 (da) 2004-09-20

Family

ID=27111150

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198601812A DK175380B1 (da) 1985-04-22 1986-04-21 Mutant af human vævsplasminogenaktivator, DNA-sekvens som koder herfor, replicerbar udtrykkelsesvektor til at udtrykke denne DNA-sekvens, mikroorganisme transformeret med denne vektor, cellekulturer transformeret med denne....

Country Status (21)

Country Link
US (1) US5147643A (da)
EP (1) EP0199574B1 (da)
JP (2) JPH0740940B2 (da)
AT (1) ATE68825T1 (da)
AU (1) AU596356B2 (da)
CA (1) CA1341580C (da)
DD (1) DD258026A5 (da)
DE (2) DE3613390C2 (da)
DK (1) DK175380B1 (da)
ES (2) ES8802184A1 (da)
FI (1) FI98930C (da)
FR (1) FR2581652B1 (da)
GB (1) GB2173804B (da)
GR (1) GR861037B (da)
HU (1) HU206520B (da)
IE (1) IE58574B1 (da)
IL (1) IL78571A (da)
MY (1) MY102550A (da)
NO (1) NO175216C (da)
NZ (1) NZ215920A (da)
PT (1) PT82429B (da)

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Also Published As

Publication number Publication date
GB2173804B (en) 1989-07-05
ES9000011A1 (es) 1990-03-01
FI861673A0 (fi) 1986-04-21
IE58574B1 (en) 1993-10-06
JPH06277071A (ja) 1994-10-04
AU5641686A (en) 1986-10-30
NO175216B (da) 1994-06-06
GR861037B (en) 1986-07-16
FR2581652B1 (fr) 1989-12-22
FR2581652A1 (fr) 1986-11-14
AU596356B2 (en) 1990-05-03
NO175216C (no) 1994-09-14
MY102550A (en) 1992-07-31
NZ215920A (en) 1989-07-27
DE3682104D1 (de) 1991-11-28
GB2173804A (en) 1986-10-22
HUT40703A (en) 1987-01-28
HU206520B (en) 1992-11-30
US5147643A (en) 1992-09-15
ATE68825T1 (de) 1991-11-15
ES554251A0 (es) 1988-04-16
IL78571A (en) 1991-06-30
DE3613390A1 (de) 1986-10-30
NO861559L (no) 1986-10-23
JPS6224A (ja) 1987-01-06
CA1341580C (en) 2008-09-30
IL78571A0 (en) 1986-08-31
EP0199574A2 (en) 1986-10-29
EP0199574A3 (en) 1987-08-05
ES8802184A1 (es) 1988-04-16
FI861673L (fi) 1986-10-23
FI98930C (fi) 1997-09-10
FI98930B (fi) 1997-05-30
DK175380B1 (da) 2004-09-20
EP0199574B1 (en) 1991-10-23
DK181286D0 (da) 1986-04-21
DD258026A5 (de) 1988-07-06
GB8609683D0 (en) 1986-05-29
JPH0740940B2 (ja) 1995-05-10
IE861055L (en) 1986-10-22
DE3613390C2 (de) 2001-10-11
PT82429A (en) 1986-05-01
JP2529816B2 (ja) 1996-09-04
ES557800A0 (es) 1990-03-01
PT82429B (pt) 1988-03-03

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