DK181385A - Heterocycliske pyranoderivater, fremgangsmaade til fremstilling derafog laegemiddel indeholdende saadanne forbindelser - Google Patents

Heterocycliske pyranoderivater, fremgangsmaade til fremstilling derafog laegemiddel indeholdende saadanne forbindelser Download PDF

Info

Publication number: DK181385A
Authority: DK; Denmark
Prior art keywords: pyranode; heterocyclic; derivatives; compounds; procedure
Prior art date: 1984-04-24

Application number

DK181385A

Other languages

English (en)

Other versions

DK181385D0 (da

DK160833B (da

DK160833C (da

Inventor

Andre Esanu

Original Assignee

Scras

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-04-24

Filing date

1985-04-23

Publication date

1985-10-25

1985-04-23 Application filed by Scras filed Critical Scras

1985-04-23 Publication of DK181385D0 publication Critical patent/DK181385D0/da

1985-10-25 Publication of DK181385A publication Critical patent/DK181385A/da

1991-04-22 Publication of DK160833B publication Critical patent/DK160833B/da

1991-10-07 Application granted granted Critical

1991-10-07 Publication of DK160833C publication Critical patent/DK160833C/da

Links

150000001875 compounds Chemical class 0.000 title description 3
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
IJOOHPMOJXWVHK-UHFFFAOYSA-N chlorotrimethylsilane Chemical compound C[Si](C)(C)Cl IJOOHPMOJXWVHK-UHFFFAOYSA-N 0.000 description 2
FFUAGWLWBBFQJT-UHFFFAOYSA-N hexamethyldisilazane Chemical compound C[Si](C)(C)N[Si](C)(C)C FFUAGWLWBBFQJT-UHFFFAOYSA-N 0.000 description 2
MGADZUXDNSDTHW-UHFFFAOYSA-N 2H-pyran Chemical compound C1OC=CC=C1 MGADZUXDNSDTHW-UHFFFAOYSA-N 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
229910021627 Tin(IV) chloride Inorganic materials 0.000 description 1
241000700605 Viruses Species 0.000 description 1
PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
210000000748 cardiovascular system Anatomy 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000003814 drug Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
238000003756 stirring Methods 0.000 description 1
HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 1
239000005051 trimethylchlorosilane Substances 0.000 description 1
230000003612 virological effect Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- E—FIXED CONSTRUCTIONS
- E04—BUILDING
- E04H—BUILDINGS OR LIKE STRUCTURES FOR PARTICULAR PURPOSES; SWIMMING OR SPLASH BATHS OR POOLS; MASTS; FENCING; TENTS OR CANOPIES, IN GENERAL
- E04H1/00—Buildings or groups of buildings for dwelling or office purposes; General layout, e.g. modular co-ordination or staggered storeys
- E04H1/12—Small buildings or other erections for limited occupation, erected in the open air or arranged in buildings, e.g. kiosks, waiting shelters for bus stops or for filling stations, roofs for railway platforms, watchmen's huts or dressing cubicles
- E04H1/1272—Exhibition stands
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
- F16B2/00—Friction-grip releasable fastenings
- F16B2/20—Clips, i.e. with gripping action effected solely by the inherent resistance to deformation of the material of the fastening

Landscapes

Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Architecture (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Mechanical Engineering (AREA)
Veterinary Medicine (AREA)
Civil Engineering (AREA)
Structural Engineering (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrane Compounds (AREA)

Description

hvori X2 er H, Cl eller Br, T = 0 eller S, og Y er en ara-binose-, xylose- eller riboserest, den acetylerede form af en S-ådan, med enten pyran- eller furankonfiguration og bundet som a- eller il-anomer, fremstilles ved reaktion mellem R - H og ose-forbindelsen i acetyleret form i støkiometrisk forhold i acetonitril under ^ og omrøring ved stuetemperatur i 12-24 timer og i nærvær af 1,1,1,3,3,3-hexamethyl-disilazan, trimethylchlorsilan og tintetrachlorid.

Forbindelsen er aktive over for vira og bakterier, og visse af dem indvirker på hjerte-karsystemet, hvorfor de kan anvendes i lægemidler, især til bekæmpelse af virussygdomme .

DK181385A 1984-04-24 1985-04-23 Heterocycliske pyrano-derivater, fremgangsmaade til fremstilling deraf og laegemidler indeholdende saadanne forbindelser DK160833C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB848410484A GB8410484D0 (en)	1984-04-24	1984-04-24	Antiviral and antibacterial compounds
GB8410484		1984-04-24

Publications (4)

Publication Number	Publication Date
DK181385D0 DK181385D0 (da)	1985-04-23
DK181385A true DK181385A (da)	1985-10-25
DK160833B DK160833B (da)	1991-04-22
DK160833C DK160833C (da)	1991-10-07

Family

ID=10560013

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK181385A DK160833C (da)	1984-04-24	1985-04-23	Heterocycliske pyrano-derivater, fremgangsmaade til fremstilling deraf og laegemidler indeholdende saadanne forbindelser
DK181285A DK160832C (da)	1984-04-24	1985-04-23	Heterocycliske bornan-derivater, fremgangsmaade til fremstilling deraf og laegemiddel indeholdende saadanne forbindelser

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK181285A DK160832C (da)	1984-04-24	1985-04-23	Heterocycliske bornan-derivater, fremgangsmaade til fremstilling deraf og laegemiddel indeholdende saadanne forbindelser

Country Status (26)

Country	Link
US (2)	US4720487A (da)
JP (2)	JPS60233095A (da)
AR (2)	AR241916A1 (da)
AT (2)	AT388557B (da)
BE (2)	BE902231A (da)
CA (2)	CA1241649A (da)
CH (2)	CH665837A5 (da)
DE (2)	DE3514641A1 (da)
DK (2)	DK160833C (da)
DZ (1)	DZ772A1 (da)
ES (2)	ES8606380A1 (da)
FI (2)	FI78302C (da)
FR (3)	FR2563107B1 (da)
GB (3)	GB8410484D0 (da)
HK (2)	HK18788A (da)
IE (2)	IE58322B1 (da)
IT (2)	IT1201415B (da)
LU (2)	LU85865A1 (da)
MA (2)	MA20414A1 (da)
MY (1)	MY102313A (da)
NL (2)	NL193067C (da)
NO (2)	NO161121C (da)
OA (2)	OA08000A (da)
PT (2)	PT80325B (da)
SE (2)	SE462972B (da)
ZA (2)	ZA852367B (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7622492B2 (en)	2005-08-31	2009-11-24	Hoffmann-La Roche Inc.	Pyrazolones as inhibitors of 11β-hydroxysteroid dehydrogenase

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3868361A (en) *	1973-03-12	1975-02-25	Richard L Tolman	s-Triazolo{8 2,3-A{9 {0 pryimidine nucleosides
DE3019322A1 (de) *	1980-05-21	1981-12-03	Merck Patent Gmbh, 6100 Darmstadt	Psychopharmakon sowie verwendung von adenosinderivaten

1984
- 1984-04-24 GB GB848410484A patent/GB8410484D0/en active Pending
1985
- 1985-03-28 ZA ZA852367A patent/ZA852367B/xx unknown
- 1985-03-28 ZA ZA852366A patent/ZA852366B/xx unknown
- 1985-04-01 US US06/718,065 patent/US4720487A/en not_active Expired - Fee Related
- 1985-04-01 US US06/718,064 patent/US4704454A/en not_active Expired - Fee Related
- 1985-04-10 AR AR85300028A patent/AR241916A1/es active
- 1985-04-10 AR AR85300029A patent/AR241917A1/es active
- 1985-04-17 SE SE8501884A patent/SE462972B/sv not_active IP Right Cessation
- 1985-04-17 SE SE8501885A patent/SE462973B/sv not_active IP Right Cessation
- 1985-04-18 BE BE0/214871A patent/BE902231A/fr not_active IP Right Cessation
- 1985-04-18 CH CH1665/85A patent/CH665837A5/fr not_active IP Right Cessation
- 1985-04-18 CH CH1666/85A patent/CH664572A5/fr not_active IP Right Cessation
- 1985-04-18 BE BE0/214872A patent/BE902232A/fr not_active IP Right Cessation
- 1985-04-19 MA MA20638A patent/MA20414A1/fr unknown
- 1985-04-19 MA MA20639A patent/MA20415A1/fr unknown
- 1985-04-22 PT PT80325A patent/PT80325B/pt not_active IP Right Cessation
- 1985-04-22 FI FI851577A patent/FI78302C/fi not_active IP Right Cessation
- 1985-04-22 IT IT20440/85A patent/IT1201415B/it active
- 1985-04-22 LU LU85865A patent/LU85865A1/fr unknown
- 1985-04-22 PT PT80324A patent/PT80324B/pt not_active IP Right Cessation
- 1985-04-22 FI FI851576A patent/FI78301C/fi not_active IP Right Cessation
- 1985-04-22 IT IT8520439A patent/IT1215265B/it active
- 1985-04-22 LU LU85864A patent/LU85864A1/fr unknown
- 1985-04-23 IE IE102985A patent/IE58322B1/en not_active IP Right Cessation
- 1985-04-23 IE IE103085A patent/IE58323B1/en not_active IP Right Cessation
- 1985-04-23 ES ES542486A patent/ES8606380A1/es not_active Expired
- 1985-04-23 CA CA000479844A patent/CA1241649A/en not_active Expired
- 1985-04-23 DZ DZ850084A patent/DZ772A1/fr active
- 1985-04-23 GB GB08510328A patent/GB2157690B/en not_active Expired
- 1985-04-23 DE DE19853514641 patent/DE3514641A1/de active Granted
- 1985-04-23 ES ES542485A patent/ES8606379A1/es not_active Expired
- 1985-04-23 NL NL8501171A patent/NL193067C/nl not_active IP Right Cessation
- 1985-04-23 GB GB08510329A patent/GB2158436B/en not_active Expired
- 1985-04-23 NL NL8501170A patent/NL193109B/xx not_active Application Discontinuation
- 1985-04-23 DK DK181385A patent/DK160833C/da not_active IP Right Cessation
- 1985-04-23 NO NO851619A patent/NO161121C/no unknown
- 1985-04-23 NO NO851620A patent/NO161122C/no unknown
- 1985-04-23 DK DK181285A patent/DK160832C/da not_active IP Right Cessation
- 1985-04-23 CA CA000479845A patent/CA1265129A/en not_active Expired - Lifetime
- 1985-04-23 DE DE19853514637 patent/DE3514637A1/de active Granted
- 1985-04-24 JP JP60086616A patent/JPS60233095A/ja active Granted
- 1985-04-24 AT AT0122585A patent/AT388557B/de not_active IP Right Cessation
- 1985-04-24 OA OA58577A patent/OA08000A/xx unknown
- 1985-04-24 FR FR8506206A patent/FR2563107B1/fr not_active Expired
- 1985-04-24 JP JP60086617A patent/JPS60233096A/ja active Granted
- 1985-04-24 FR FR8506204A patent/FR2563106B1/fr not_active Expired
- 1985-04-24 OA OA58576A patent/OA07999A/xx unknown
- 1985-04-24 FR FR8506207A patent/FR2563224B1/fr not_active Expired
- 1985-04-24 AT AT0122685A patent/AT388558B/de not_active IP Right Cessation
1988
- 1988-01-26 MY MYPI88000060A patent/MY102313A/en unknown
- 1988-03-10 HK HK187/88A patent/HK18788A/xx not_active IP Right Cessation
1989
- 1989-02-02 HK HK102/89A patent/HK10289A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT80325A (en)	1985-05-01
NO161122B (no)	1989-03-28
DE3514637A1 (de)	1985-10-24
IE58323B1 (en)	1993-09-08
GB2157690B (en)	1988-01-27
SE462973B (sv)	1990-09-24
ATA122585A (de)	1988-12-15
BE902231A (fr)	1985-08-16
NL8501170A (nl)	1985-11-18
NO851620L (no)	1985-10-25
FI851576A0 (fi)	1985-04-22
CH664572A5 (fr)	1988-03-15
DE3514637C2 (da)	1989-04-13
NO851619L (no)	1985-10-25
FI851577L (fi)	1985-10-25
MY102313A (en)	1992-05-28
ES8606379A1 (es)	1986-04-01
ES542486A0 (es)	1986-04-01
IE851029L (en)	1985-10-24
NO161122C (no)	1989-07-05
IE58322B1 (en)	1993-09-08
FI78302C (fi)	1989-07-10
ES542485A0 (es)	1986-04-01
GB2158436B (en)	1987-08-05
PT80324A (en)	1985-05-01
MA20415A1 (fr)	1985-12-31
ZA852367B (en)	1985-11-27
CA1265129A (en)	1990-01-30
ZA852366B (en)	1985-11-27
US4720487A (en)	1988-01-19
DK181285D0 (da)	1985-04-23
GB8410484D0 (en)	1984-05-31
IT1215265B (it)	1990-01-31
JPS60233095A (ja)	1985-11-19
SE8501885L (sv)	1985-10-25
LU85864A1 (fr)	1985-12-16
FR2563106B1 (fr)	1986-12-19
GB8510329D0 (en)	1985-05-30
DK181385D0 (da)	1985-04-23
AT388557B (de)	1989-07-25
JPH0129198B2 (da)	1989-06-08
IT8520439A0 (it)	1985-04-22
NO161121C (no)	1989-07-05
DK160832C (da)	1991-10-07
SE8501884L (sv)	1985-10-25
LU85865A1 (fr)	1985-12-16
FI851576L (fi)	1985-10-25
FI78301B (fi)	1989-03-31
AR241917A1 (es)	1993-01-29
SE462972B (sv)	1990-09-24
FR2563106A1 (fr)	1985-10-25
DK160833B (da)	1991-04-22
SE8501884D0 (sv)	1985-04-17
ES8606380A1 (es)	1986-04-01
NL193067C (nl)	1998-09-08
JPS60233096A (ja)	1985-11-19
SE8501885D0 (sv)	1985-04-17
OA08000A (fr)	1987-01-31
JPH0129197B2 (da)	1989-06-08
FR2563224A1 (fr)	1985-10-25
ATA122685A (de)	1988-12-15
FR2563224B1 (fr)	1986-12-19
HK10289A (en)	1989-02-10
IT8520440A0 (it)	1985-04-22
GB2157690A (en)	1985-10-30
BE902232A (fr)	1985-08-16
FI78302B (fi)	1989-03-31
DE3514641A1 (de)	1985-10-24
MA20414A1 (fr)	1985-12-31
FI78301C (fi)	1989-07-10
PT80325B (pt)	1987-11-11
GB2158436A (en)	1985-11-13
US4704454A (en)	1987-11-03
NL193109B (nl)	1998-07-01
NL193067B (nl)	1998-05-06
IT1201415B (it)	1989-02-02
DK181285A (da)	1985-10-25
PT80324B (pt)	1987-11-11
HK18788A (en)	1988-03-18
DK160833C (da)	1991-10-07
FR2563107A1 (fr)	1985-10-25
DK160832B (da)	1991-04-22
DE3514641C2 (da)	1989-02-23
AT388558B (de)	1989-07-25
CH665837A5 (fr)	1988-06-15
GB8510328D0 (en)	1985-05-30
IE851030L (en)	1985-10-24
NO161121B (no)	1989-03-28
CA1241649A (en)	1988-09-06
OA07999A (fr)	1987-01-31
FR2563107B1 (fr)	1986-12-19
AR241916A1 (es)	1993-01-29
NL8501171A (nl)	1985-11-18
FI851577A0 (fi)	1985-04-22
DZ772A1 (fr)	2004-09-13

Legal Events

Date	Code	Title	Description
1999-03-15	PBP	Patent lapsed

Publication	Publication Date	Title
NO170977C (no)	1993-01-06	Analogifremgangsmaate for fremstilling av terapeutisk aktive aryl-piperazinyl-etyl (eller butyl)-heterocykliske forbindelser
PT84549A (pt)	1987-04-01	Process for the preparation of macrolide compounds and of anthelmintic acaricidad and insecticidal compositions containing the same
NO159592C (no)	1989-01-18	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolidinderivater.
NO166083C (no)	1991-05-29	Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyridazodiazepinderivater.
PL272999A1 (en)	1989-03-06	Agent for combating pests such as anthropodas,nematodesattacking plants,worms or protozoas,containing derivatives of 4-nitro-n-phenyl-pyrazole
FI854926A0 (fi)	1985-12-12	Foerfarande foer framstaellning av farmakologiskt aktiva pyrrolobensimidazoler.
HUT44410A (en)	1988-03-28	Insecticidal, acaricidal, nematocidal, fungicidal compositions comprising pyridazinone derivatives as active substance and process for preparing the active substances
NO166863C (no)	1991-09-11	Analogifremgangsmaate for fremstilling av terapeutisk aktive 5-substituert-1,2-dihydro-3h-pyrrolo-(1,2-a)-pyrrol-1-carboxylsyrer ut fra deres tilsvarende nitriler.
NO165400C (no)	1991-02-06	Analogifremgangsmaate ved fremstilling av terapeutisk aktive cefemforbindelser.
ATE66479T1 (de)	1991-09-15	3-methyl-substituierte phenylnaphthyridine und diese enthaltende arzneimittel.
DK181285A (da)	1985-10-25	Heterocycliske bornanderivater, fremgangsmaade til fremstilling deraf og laegemiddel indeholdende saadanne forbindelser
PT84718A (en)	1987-05-01	Process for the preparation of insecticidal compositions containing five-membered heterocyclic derivatives of n:-substituted-n,n:-diacylhydrazines
NO162618C (no)	1990-01-24	Analogifremgangsmaate ved fremstilling av terapeutisk aktive 6-substituerte mitomycinanaloger.
IE821108L (en)	1982-11-12	Pyrazoline derivatives.
NO167573C (no)	1991-11-20	Analogifremgangsmaate for fremstilling av terapeutisk aktive (5r, 6s,)-6-((r)-1-hydroksyetyl)-2-azacykloalkyltio-2-penem-3-karboksyl-syrederivater.
DK360388A (da)	1989-01-02	Laegemiddel til behandling af hjerteinsufficiens
DK0410343T3 (da)	1995-09-18	Anvendelse af bisphenolderivater til behandling af diabetes mellitus
JPS5655397A (en)	1981-05-15	Aminobenzoic acid ester derivative, and physiologically active agent containing said derivative
NO171726C (no)	1993-04-28	Analogifremgangsmaate for fremstilling av terapeutisk aktive 3((1,2,3-tiadiazol-4-yl)tiometyl)-8-okso-5-tia-1-azabicyklo(4.2.0)okt-2-en-2-karboksylsyrederivater
WO1987003880A3 (en)	1988-04-21	Tylosin derivatives, processes for their preparation, and novel processes involving tylosin derivatives
IE56519B1 (en)	1991-08-28	Heterocyclic compounds
IE811951L (en)	1982-03-10	Oxazaphosphorins
NO820509L (no)	1982-08-20	Fremgangsmaate for fremstilling av terapeutisk aktive forbindelser ved dyrking av mikroorganismer
ES2040281T3 (es)	1993-10-16	Derivados mono- y di-epoxido de composiciones delta 22-ll-f28249.
JPS5630993A (en)	1981-03-28	Manufacture of complement third ingredient from human blood plasma