DK1819331T3 - Kombinationer indeholdende epothiloner og proteintyrosinkinaseinhibitoer og farmaceutiske anvendelser heraf - Google Patents

Kombinationer indeholdende epothiloner og proteintyrosinkinaseinhibitoer og farmaceutiske anvendelser heraf

Info

Publication number
DK1819331T3
DK1819331T3 DK05852316T DK05852316T DK1819331T3 DK 1819331 T3 DK1819331 T3 DK 1819331T3 DK 05852316 T DK05852316 T DK 05852316T DK 05852316 T DK05852316 T DK 05852316T DK 1819331 T3 DK1819331 T3 DK 1819331T3
Authority
DK
Denmark
Prior art keywords
tyrosine kinase
protein tyrosine
kinase inhibitors
pharmaceutical applications
combinations containing
Prior art date
Application number
DK05852316T
Other languages
Danish (da)
English (en)
Inventor
Jerry Min-Jian Huang
Anandhi Ranganathan Johri
Ronald Richard Linnartz
Paul M J Mcsheehy
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36118322&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1819331(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK1819331T3 publication Critical patent/DK1819331T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK05852316T 2004-11-30 2005-11-28 Kombinationer indeholdende epothiloner og proteintyrosinkinaseinhibitoer og farmaceutiske anvendelser heraf DK1819331T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63183704P 2004-11-30 2004-11-30
PCT/US2005/042975 WO2006060331A1 (fr) 2004-11-30 2005-11-28 Produits composes contenant des epothilones et des inhibiteurs des proteines tyrosine kinases, et leurs utilisations pharmaceutiques

Publications (1)

Publication Number Publication Date
DK1819331T3 true DK1819331T3 (da) 2010-01-04

Family

ID=36118322

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05852316T DK1819331T3 (da) 2004-11-30 2005-11-28 Kombinationer indeholdende epothiloner og proteintyrosinkinaseinhibitoer og farmaceutiske anvendelser heraf

Country Status (28)

Country Link
US (2) US20080139587A1 (fr)
EP (1) EP1819331B1 (fr)
JP (1) JP2008521826A (fr)
KR (1) KR20070088653A (fr)
CN (1) CN101065127A (fr)
AT (1) ATE445398T1 (fr)
AU (1) AU2005312061B2 (fr)
BR (1) BRPI0518733A2 (fr)
CA (1) CA2584163A1 (fr)
CY (1) CY1110559T1 (fr)
DE (1) DE602005017181D1 (fr)
DK (1) DK1819331T3 (fr)
ES (1) ES2333348T3 (fr)
HR (1) HRP20100012T1 (fr)
IL (1) IL183138A (fr)
JO (1) JO2596B1 (fr)
MA (1) MA29032B1 (fr)
MX (1) MX2007006371A (fr)
NO (1) NO20073370L (fr)
NZ (1) NZ554552A (fr)
PL (1) PL1819331T3 (fr)
PT (1) PT1819331E (fr)
RU (1) RU2423980C2 (fr)
SI (1) SI1819331T1 (fr)
TN (1) TNSN07212A1 (fr)
TW (1) TW200630091A (fr)
WO (1) WO2006060331A1 (fr)
ZA (1) ZA200703196B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102781237A (zh) 2009-11-23 2012-11-14 天蓝制药公司 用于传递治疗剂的基于环糊精的聚合物
US20110178287A1 (en) 2010-01-19 2011-07-21 Cerulean Pharma Inc. Cyclodextrin-based polymers for therapeutic delivery
US20110300150A1 (en) 2010-05-18 2011-12-08 Scott Eliasof Compositions and methods for treatment of autoimmune and other disease
CN102134246A (zh) * 2011-01-06 2011-07-27 王文怡 一种埃博霉素衍生物及其制备和药物应用
US20130178520A1 (en) 2011-12-23 2013-07-11 Duke University Methods of treatment using arylcyclopropylamine compounds
WO2014025395A1 (fr) 2012-08-06 2014-02-13 Duke University Composés et procédés pour le ciblage de hsp90
US10000469B2 (en) 2014-03-25 2018-06-19 Duke University Heat shock protein 70 (hsp-70) receptor ligands
US11261187B2 (en) 2016-04-22 2022-03-01 Duke University Compounds and methods for targeting HSP90
US10927083B2 (en) 2016-09-29 2021-02-23 Duke University Substituted benzimidazoles as inhibitors of transforming growth factor-β kinase
US10207998B2 (en) 2016-09-29 2019-02-19 Duke University Substituted benzimidazole and substituted benzothiazole inhibitors of transforming growth factor-β kinase and methods of use thereof
US12220423B2 (en) 2018-07-24 2025-02-11 Hygia Pharmaceuticals, Llc Compounds, derivatives, and analogs for cancer
WO2021185844A1 (fr) 2020-03-16 2021-09-23 Pvac Medical Technologies Ltd Utilisation d'une substance et composition pharmaceutique correspondante et traitements médicaux ou utilisations correspondants
WO2021233534A1 (fr) 2020-05-20 2021-11-25 Pvac Medical Technologies Ltd Utilisation d'une substance et composition pharmaceutique associée, et traitements médicaux ou utilisations associées
CN115768890A (zh) 2020-04-15 2023-03-07 加州理工学院 通过分子和物理启动对t细胞免疫疗法的热控制
EP4192509A1 (fr) 2020-08-05 2023-06-14 Ellipses Pharma Ltd Traitement du cancer à l'aide d'un conjugué polymère contenant de la cyclodextrine-inhibiteur de la topoisomérase et d'un inhibiteur de parp
WO2022047259A1 (fr) 2020-08-28 2022-03-03 California Institute Of Technology Circuits de signalisation de mammifère synthétiques pour la régulation de population cellulaire robuste
GB2617409B (en) 2022-04-27 2024-06-26 Cancertain Ltd Method for predicting responsiveness to therapy
CN119816589A (zh) 2022-08-02 2025-04-11 国立大学法人北海道大学 使用细胞器复合体改善细胞疗法的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2775187B1 (fr) * 1998-02-25 2003-02-21 Novartis Ag Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
EP1169038B9 (fr) * 1999-04-15 2013-07-10 Bristol-Myers Squibb Company Inhibiteurs cycliques de proteine tyrosine kinase
ATE369894T1 (de) * 2000-11-22 2007-09-15 Novartis Pharma Gmbh Kombination enthaltend ein mittel zur verminderung von vegf-aktivität und ein mittel zur verminderung von egf-aktivität
RU2313345C2 (ru) * 2001-02-27 2007-12-27 Новартис Аг Комбинации, содержащие ингибитор трансдукции сигнала и производное эпотилона
GB0119249D0 (en) * 2001-08-07 2001-10-03 Novartis Ag Organic compounds
US20050043409A1 (en) * 2001-10-25 2005-02-24 Chen Ying-Nan Pan Combinations comprising a selective cyclooxygenase-2 inhibitor
CN101816792A (zh) * 2002-06-10 2010-09-01 诺瓦提斯公司 包含埃坡霉素的组合及其药学用途
WO2004004644A2 (fr) * 2002-07-05 2004-01-15 Beth Israel Deaconess Medical Center Association d'un inhibiteur de cible mammalienne de rapamycine (mtor) et d'un inhibiteur de la tyrosine kinase aux fins du de traitement de neoplasmes
GB0215844D0 (en) * 2002-07-09 2002-08-14 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
RU2007124492A (ru) 2009-04-10
DE602005017181D1 (de) 2009-11-26
HK1109059A1 (en) 2008-05-30
EP1819331A1 (fr) 2007-08-22
US20110190312A1 (en) 2011-08-04
AU2005312061A1 (en) 2006-06-08
US20080139587A1 (en) 2008-06-12
RU2423980C2 (ru) 2011-07-20
MA29032B1 (fr) 2007-11-01
WO2006060331A1 (fr) 2006-06-08
KR20070088653A (ko) 2007-08-29
PT1819331E (pt) 2009-11-30
JO2596B1 (en) 2011-02-27
CY1110559T1 (el) 2015-04-29
PL1819331T3 (pl) 2010-03-31
TW200630091A (en) 2006-09-01
MX2007006371A (es) 2007-06-20
IL183138A0 (en) 2008-04-13
AU2005312061B2 (en) 2009-09-03
JP2008521826A (ja) 2008-06-26
ATE445398T1 (de) 2009-10-15
TNSN07212A1 (en) 2008-11-21
CN101065127A (zh) 2007-10-31
ES2333348T3 (es) 2010-02-19
NO20073370L (no) 2007-06-29
CA2584163A1 (fr) 2006-06-08
EP1819331B1 (fr) 2009-10-14
IL183138A (en) 2011-03-31
SI1819331T1 (sl) 2010-02-26
ZA200703196B (en) 2009-08-26
HRP20100012T1 (hr) 2010-02-28
NZ554552A (en) 2011-05-27
BRPI0518733A2 (pt) 2008-12-02

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