ATE542823T1 - 4,5-dihydro-ä1,2,4ütriazoloä4,3-füpteridine als plk1-proteinkinasehemmer zur behandlung proliferativer erkrankungen - Google Patents

4,5-dihydro-ä1,2,4ütriazoloä4,3-füpteridine als plk1-proteinkinasehemmer zur behandlung proliferativer erkrankungen

Info

Publication number: ATE542823T1
Authority: AT; Austria
Prior art keywords: füpteridine; dihydro; treatment; protein kinase; kinase inhibitor
Prior art date: 2006-04-12

Application number

AT07755318T

Other languages

English (en)

Inventor

Jean-Damien Charrier

David Kay

Ronald Knegtel

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-04-12

Filing date

2007-04-12

Publication date

2012-02-15

2007-04-12 Application filed by Vertex Pharma filed Critical Vertex Pharma

2012-02-15 Application granted granted Critical

2012-02-15 Publication of ATE542823T1 publication Critical patent/ATE542823T1/de

Links

102100031463 Serine/threonine-protein kinase PLK1 Human genes 0.000 title 1
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
229940043355 kinase inhibitor Drugs 0.000 title 1
108010056274 polo-like kinase 1 Proteins 0.000 title 1
230000002062 proliferating effect Effects 0.000 title 1
239000003909 protein kinase inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Immunology (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pulmonology (AREA)
Neurosurgery (AREA)
Oncology (AREA)
Physical Education & Sports Medicine (AREA)
Endocrinology (AREA)
Obesity (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Virology (AREA)
Emergency Medicine (AREA)
Cardiology (AREA)
Transplantation (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Communicable Diseases (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT07755318T 2006-04-12 2007-04-12 4,5-dihydro-ä1,2,4ütriazoloä4,3-füpteridine als plk1-proteinkinasehemmer zur behandlung proliferativer erkrankungen ATE542823T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US79132706P	2006-04-12	2006-04-12
US83872006P	2006-08-18	2006-08-18
PCT/US2007/009006 WO2007120752A2 (en)	2006-04-12	2007-04-12	4, 5-dihydro- [1, 2, 4] triazolo [4, 3-f] pteridines as protein kinase plk1 inhibitors for the treatment of proliferative disorders

Publications (1)

Publication Number	Publication Date
ATE542823T1 true ATE542823T1 (de)	2012-02-15

Family

ID=38544378

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07755318T ATE542823T1 (de)	2006-04-12	2007-04-12	4,5-dihydro-ä1,2,4ütriazoloä4,3-füpteridine als plk1-proteinkinasehemmer zur behandlung proliferativer erkrankungen

Country Status (16)

Country	Link
US (3)	US7763629B2 (de)
EP (1)	EP2010542B1 (de)
JP (1)	JP5313875B2 (de)
KR (1)	KR101432316B1 (de)
AR (1)	AR060432A1 (de)
AT (1)	ATE542823T1 (de)
AU (1)	AU2007238690B2 (de)
CA (1)	CA2649324A1 (de)
ES (1)	ES2381212T3 (de)
IL (1)	IL194699A (de)
MX (1)	MX2008013110A (de)
NO (1)	NO20084747L (de)
NZ (1)	NZ571969A (de)
RU (1)	RU2441006C2 (de)
TW (1)	TW200808805A (de)
WO (1)	WO2007120752A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2695753A1 (en) *	2007-08-15	2009-02-19	Vertex Pharmaceuticals Incorporated	Compounds useful as protein kinases inhibitors
MX2010006457A (es)	2007-12-19	2010-07-05	Amgen Inc	Compuestos fusionados de piridina, pirimidina y triazina como inhibidores de ciclo celular.
MX2010010975A (es)	2008-04-07	2010-11-01	Amgen Inc	Amino piridinas/pirimidinas gem-disustituidas y espirociclicas como inhibidores de ciclo celular.
MX2011000021A (es) *	2008-06-23	2011-02-24	Vertex Pharma	Inhibidores de proteina cinasas.
MX346186B (es) *	2008-06-23	2017-03-10	Vertex Pharma	Inhibidores de proteina cinasas.
SG179206A1 (en)	2009-09-25	2012-04-27	Vertex Pharma	Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
NZ599342A (en) *	2009-09-25	2014-04-30	Vertex Pharma	Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
CA2783258A1 (en)	2009-12-23	2011-06-30	Elan Pharmaceuticals, Inc.	Pteridinones as inhibitors of polo-like kinase
WO2011099502A1 (ja) *	2010-02-10	2011-08-18	公立大学法人横浜市立大学	神経選択的転写抑制因子NRSFに特異的に結合するmSin3B に結合する化合物の利用
WO2012000103A1 (en)	2010-07-02	2012-01-05	University Health Network	Methods of targeting pten mutant diseases and compositions therefor
JP2013539759A (ja)	2010-10-08	2013-10-28	エランファーマシューティカルズ，インコーポレイテッド	ポロ様キナーゼの阻害剤
WO2012061342A2 (en)	2010-11-01	2012-05-10	Arqule, Inc.	Substituted benzo-imidazo-pyrido-diazepine compounds
DK2937349T3 (en)	2011-03-23	2017-02-20	Amgen Inc	CONDENSED TRICYCLIC DUAL INHIBITORS OF CDK 4/6 AND FLT3
MD4300C1 (ro) *	2012-12-28	2015-03-31	Государственный Университет Молд0	Inhibitor al proliferării celulelor HepG2 în cancerul hepatic în bază de cloro-[2-fenil(piridin-2-il)metanon-4-(3-metoxifenil)tiosemicarbazono]nichel
US9840503B2 (en)	2015-05-11	2017-12-12	Incyte Corporation	Heterocyclic compounds and uses thereof
WO2017027717A1 (en)	2015-08-12	2017-02-16	Incyte Corporation	Bicyclic fused pyrimidine compounds as tam inhibitors
US10053465B2 (en)	2015-08-26	2018-08-21	Incyte Corporation	Pyrrolopyrimidine derivatives as TAM inhibitors
CN114456176B (zh)	2016-03-28	2024-08-30	因赛特公司	作为tam抑制剂的吡咯并三嗪化合物
KR102739325B1 (ko)	2017-09-27	2024-12-09	인사이트 코포레이션	Tam 억제제로서 유용한 피롤로트리아진 유도체의 염
US11241438B2 (en)	2018-06-29	2022-02-08	Incyte Corporation	Formulations of an AXL/MER inhibitor
CN109734809A (zh) *	2019-02-27	2019-05-10	南方科技大学	治疗性的人Plk1蛋白单克隆抗体及其制备方法
PH12022552347A1 (en)	2020-03-06	2024-01-29	Incyte Corp	Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors
WO2022166725A1 (zh)	2021-02-08	2022-08-11	南京明德新药研发有限公司	5，6-二氢噻吩并[3，4-h]喹唑啉类化合物
KR102604801B1 (ko) *	2021-08-10	2023-11-22	(주) 업테라	신규 plk1 분해 유도 화합물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA973884B (en) *	1996-05-23	1998-11-06	Du Pont Merck Pharma	Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders
US6184226B1 (en)	1998-08-28	2001-02-06	Scios Inc.	Quinazoline derivatives as inhibitors of P-38 α
KR20020027649A (ko) *	1999-09-15	2002-04-13	로즈 암스트롱, 크리스틴 에이. 트러트웨인	카이나제 억제제로서의 프테리딘온
WO2002076985A1 (en)	2001-03-23	2002-10-03	Smithkline Beecham Corporation	Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases
BR0315053A (pt) *	2002-10-03	2005-08-09	Targegen Inc	Agentes vasculostáticos , composição, artigo e processo de preparação dos mesmos
EP2039683B1 (de) *	2002-10-03	2012-12-19	Targegen, Inc.	Vasculo-statisches Mittel und Anwendungsverfahren dafür
CA2528975A1 (en)	2003-06-10	2004-12-16	Pfizer Inc.	Therapeutic combinations comprising pde inhibitors and vasopressin receptor antagonists for the treatment of dysmenorrhoea
GB0315966D0 (en) *	2003-07-08	2003-08-13	Cyclacel Ltd	Compounds
GB0400700D0 (en)	2004-01-13	2004-02-18	Pfizer Ltd	Compounds useful in therapy
GB0412874D0 (en)	2004-06-09	2004-07-14	Pfizer Ltd	Novel pharmaceuticals
DE102004029784A1 (de)	2004-06-21	2006-01-05	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel

2007
- 2007-04-12 TW TW096112918A patent/TW200808805A/zh unknown
- 2007-04-12 KR KR1020087027593A patent/KR101432316B1/ko not_active Expired - Fee Related
- 2007-04-12 WO PCT/US2007/009006 patent/WO2007120752A2/en not_active Ceased
- 2007-04-12 EP EP07755318A patent/EP2010542B1/de not_active Not-in-force
- 2007-04-12 JP JP2009505472A patent/JP5313875B2/ja not_active Expired - Fee Related
- 2007-04-12 RU RU2008144584/04A patent/RU2441006C2/ru not_active IP Right Cessation
- 2007-04-12 AU AU2007238690A patent/AU2007238690B2/en not_active Ceased
- 2007-04-12 ES ES07755318T patent/ES2381212T3/es active Active
- 2007-04-12 CA CA002649324A patent/CA2649324A1/en not_active Abandoned
- 2007-04-12 MX MX2008013110A patent/MX2008013110A/es active IP Right Grant
- 2007-04-12 NZ NZ571969A patent/NZ571969A/en not_active IP Right Cessation
- 2007-04-12 AR ARP070101560A patent/AR060432A1/es unknown
- 2007-04-12 AT AT07755318T patent/ATE542823T1/de active
- 2007-04-12 US US11/786,578 patent/US7763629B2/en not_active Expired - Fee Related
2008
- 2008-10-12 IL IL194699A patent/IL194699A/en not_active IP Right Cessation
- 2008-11-10 NO NO20084747A patent/NO20084747L/no not_active Application Discontinuation
2010
- 2010-06-08 US US12/796,174 patent/US8067417B2/en not_active Expired - Fee Related
2011
- 2011-10-05 US US13/253,196 patent/US8524902B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP5313875B2 (ja)	2013-10-09
KR20080109919A (ko)	2008-12-17
EP2010542A2 (de)	2009-01-07
ES2381212T3 (es)	2012-05-24
US20090062292A1 (en)	2009-03-05
AU2007238690A1 (en)	2007-10-25
AU2007238690B2 (en)	2013-05-02
AR060432A1 (es)	2008-06-18
US7763629B2 (en)	2010-07-27
WO2007120752A3 (en)	2008-05-08
RU2008144584A (ru)	2010-05-20
IL194699A0 (en)	2009-08-03
NZ571969A (en)	2011-10-28
RU2441006C2 (ru)	2012-01-27
US20110021519A1 (en)	2011-01-27
TW200808805A (en)	2008-02-16
US8067417B2 (en)	2011-11-29
IL194699A (en)	2014-07-31
HK1134486A1 (en)	2010-04-30
US8524902B2 (en)	2013-09-03
WO2007120752A2 (en)	2007-10-25
JP2009536155A (ja)	2009-10-08
CA2649324A1 (en)	2007-10-25
MX2008013110A (es)	2009-03-06
NO20084747L (no)	2008-11-25
KR101432316B1 (ko)	2014-08-29
EP2010542B1 (de)	2012-01-25
US20120277425A1 (en)	2012-11-01

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DE602007004092D1 (de)	2010-02-11	C-met-proteinkinasehemmer zur behandlung proliferativer erkrankungen
IL284991A (en)	2021-08-31	Antibodies against cd38 for treatment of multiple myeloma
ATE434620T1 (de)	2009-07-15	Dihydrothienopyrimidine zur behandlung von entzündlichen erkrankungen
BRPI0716844A2 (pt)	2013-10-22	Inidores de quinase úteis para o tratamento de doenças proliferativas
ATE550338T1 (de)	2012-04-15	Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit
NO20083002L (no)	2008-08-14	Fremgangsmate for anvendelse av CD40-bindende forbindelser
DE602005007717D1 (de)	2008-08-07	Imidazolverbindungen zur behandlung von neurodegenerativen erkrankungen
EP2063897A4 (de)	2010-09-29	Kinasehemmer zur behandlung proliferativer krankheiten
SI2001892T1 (sl)	2013-07-31	Spojine imidazolotiazol za zdravljenje proliferacijskih bolezni
DE602005023172D1 (de)	2010-10-07	Hydantoinderivate zur behandlung von entzündlichen erkrankungen
ATE534633T1 (de)	2011-12-15	Indazolderivate zur behandlung von hsp90- induzierten krankheiten
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ATE527241T1 (de)	2011-10-15	Pyridiazinonderivate zur behandlung von tumoren
ATE476414T1 (de)	2010-08-15	Biphenyloxyessigsäurederivate zur behandlung von atemwegserkrankungen
EP2135858A4 (de)	2012-02-08	Zusammensetzung zur behandlung von infektionserkrankungen
DK1847524T3 (da)	2010-01-11	Terphenylderivater til behandling af Alzheimers sygdom
ATE525355T1 (de)	2011-10-15	1-ä(4-äbenzoyl(methyl)aminoü-3- (phenyl)butylüazetidinderivate zur behandlung von gastrointestinalen erkrankungen 1
DE502006008804D1 (de)	2011-03-10	Neue, langwirksame betamimetika zur behandlung von atemwegserkrankungen
DE602006003094D1 (de)	2008-11-20	4-phenyl-5-oxo-1,4,5,6,7,8-hexahydrochinolin-derivate zur behandlung von unfruchtbarkeit
ITRM20050179A1 (it)	2006-10-14	Composizione impiegabile per il trattamento delle patologie paradontali.
ATE439843T1 (de)	2009-09-15	S-mirtazapin zur behandlung von hitzewallungen
DE602006005640D1 (de)	2009-04-23	4-phenyl-5-oxo-1,4,5,6,7,8-hexahydrochinolin-derivate als arzneimittel zur behandlung von unfruchtbarkeit
DE602006002608D1 (de)	2008-10-16	4-phenyl-5-oxo-l,4,5,6,7,8-hexahydrochinolin-derivate als arzneimittel zur behandlung von unfruchtbarkeit
ATE448228T1 (de)	2009-11-15	Pyrrolopyrimidinderivate zur behandlung proliferativer krankheiten
ATE446757T1 (de)	2009-11-15	1-ä2h-1-benzopyran-2-one-8-ylü- piperazinderivative zur behandlung von bewegungsstörungen