DK181983A - 1,8-naphthyridin- og 1,5,8-azanaphthyridin-derivater, fremgangsmaade til deres fremstilling samt deres anvendelse - Google Patents
1,8-naphthyridin- og 1,5,8-azanaphthyridin-derivater, fremgangsmaade til deres fremstilling samt deres anvendelse Download PDFInfo
- Publication number
- DK181983A DK181983A DK181983A DK181983A DK181983A DK 181983 A DK181983 A DK 181983A DK 181983 A DK181983 A DK 181983A DK 181983 A DK181983 A DK 181983A DK 181983 A DK181983 A DK 181983A
- Authority
- DK
- Denmark
- Prior art keywords
- azanaphthyridine
- naphthyridine
- procedures
- derivatives
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
eventuelt substitueret C^-C^g-alkyl, R2 er H, C^-Cg-acyl eller -alkyl, C2-Cg-hydroxyalkyl, -dihydroxyalkyl, -alkenyl eller -alkynyl eller R R^NiCHg)^» hvor n er 2-6, og Ra og Rb er H, C^-Cg-alkyl eller danner sammen med N en piperidin-, morpholin-, piperazin- eller pyrrolidin-ring, eller R2 er en kation, (med den betingelse, at når X er CH, R2 er H eller acyl, Y er H, alkyl, alkoxy, CF3, CH3S02, - SCF3 eller N02, og Z er H, halogen, alkyl eller alkoxy, R^ da ikke er usubstitueret alkyl), og syreadditionssalte, hydrater og solvater deraf fremstilles ved en række forskellige fremgangsmåder.
Forbindelserne er anvendelige ved behandling af allergiske reaktioner hos pattedyr.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/371,623 US4452800A (en) | 1982-04-26 | 1982-04-26 | Salts of 3(n-butyl)-4-hydroxy-1-phenyl-1,8-naphthyridine-2(1H)-one and their use in treating chronic obstructive lung diseases |
| US37162382 | 1982-04-26 | ||
| US43868182A | 1982-11-03 | 1982-11-03 | |
| US43868182 | 1982-11-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK181983D0 DK181983D0 (da) | 1983-04-25 |
| DK181983A true DK181983A (da) | 1983-10-27 |
Family
ID=27005451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK181983A DK181983A (da) | 1982-04-26 | 1983-04-25 | 1,8-naphthyridin- og 1,5,8-azanaphthyridin-derivater, fremgangsmaade til deres fremstilling samt deres anvendelse |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4492702A (da) |
| EP (1) | EP0092786B1 (da) |
| AU (1) | AU553958B2 (da) |
| CA (1) | CA1198109A (da) |
| DE (1) | DE3368929D1 (da) |
| DK (1) | DK181983A (da) |
| HK (1) | HK20590A (da) |
| IE (1) | IE55113B1 (da) |
| IL (1) | IL68487A0 (da) |
| NZ (1) | NZ204004A (da) |
| PH (1) | PH21641A (da) |
| PT (1) | PT76596B (da) |
| SG (1) | SG76889G (da) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4628055A (en) * | 1982-11-03 | 1986-12-09 | Schering Corporation | Method for treating allergic reactions and compositions therefore |
| US4680298A (en) * | 1983-05-31 | 1987-07-14 | Schering Corporation | Tricyclic anti-allergy and use as anti-inflammatory agents |
| EP0144996B1 (en) * | 1983-12-14 | 1990-02-28 | Schering Corporation | Substituted spiro pyridine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions |
| US4632923A (en) * | 1984-08-15 | 1986-12-30 | Schering Corporation | Substituted hetero spiro pyridine derivatives as anti-allergy and anti-inflammatory agents |
| FR2567520B1 (fr) * | 1984-07-11 | 1987-01-02 | Carpibem | Nouvelles phenyl-naphthyridines, leur procede de preparation, medicaments les contenant, notamment anti-ulceres |
| DK127086A (da) * | 1985-03-25 | 1986-09-26 | Schering Corp | Substituerede 1,8-naphthyridoner, fremgangsmaader til deres fremstilling og farmaceutiske kompositioner, der indeholder disse forbindelser |
| CA1261754A (en) * | 1985-06-18 | 1989-09-26 | Sidney R. Smith | Pharmaceutical compositions containing azanaphthalenes |
| US4684727A (en) * | 1985-07-29 | 1987-08-04 | Schering Corporation | Zwitterionic 1,8-naphthyridine and pyrazino[2,3-b]pyridine containing compounds useful as anti-allergic, anti-inflammatory and cycloprotective agents |
| US5011860A (en) * | 1986-04-11 | 1991-04-30 | Schering Corporation | Aryl-substituted naphthyridine and pyridopyrazine derivatives and their use in treating hyperproliferative skin diseases |
| US4760073A (en) * | 1986-04-11 | 1988-07-26 | Schering Corporation | Aryl-substituted naphthyridine and pyridopyrazine derivatives, useful as anti-allergic agents |
| US4917896A (en) * | 1986-08-15 | 1990-04-17 | Nelson Research & Development Co. | Penetration enhancers for transdermal delivery of systemic agents |
| EP0267691A3 (en) * | 1986-10-15 | 1989-08-23 | Schering Corporation | Use of 1-substituted naphthyridine and pyridopyrazine derivatives for the preparation of medicaments with immunosuppressor activity. |
| US5037826A (en) * | 1986-10-15 | 1991-08-06 | Schering Corporation | 1-substituted naphthyridine and pyridopyrazine derivatives |
| US4916131A (en) * | 1986-10-15 | 1990-04-10 | Schering Corporation | Naphthyridine derivatives and method for treating allergic reactions |
| US4775686A (en) * | 1986-10-15 | 1988-10-04 | Schering Corporation | Naphthyridine derivatives and method for treating allergic reactions |
| US5045542A (en) * | 1986-10-20 | 1991-09-03 | Schering Corporation | Immune suppression method employing aryl-substituted naphthyridine and pyridopyrazine derivatives |
| CA1305478C (en) * | 1986-11-06 | 1992-07-21 | Margaret H. Sherlock | Naphthyridine and pyridopyrazine compounds and pharmaceutical usage thereof |
| AU632461B2 (en) * | 1987-07-22 | 1993-01-07 | Schering Corporation | Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation |
| US4897487A (en) * | 1988-04-06 | 1990-01-30 | Schering Corporation | Process for preparing intermediates for pharmaceutically useful bicyclic compounds |
| US4859669A (en) * | 1987-12-23 | 1989-08-22 | Schering Corporation | Antiinflammatory and anti-hyperproliferative naphthyridin-4-ones |
| US5180823A (en) * | 1988-04-06 | 1993-01-19 | Schering Corporation | Processes for preparing bicyclic compounds |
| US5079360A (en) * | 1988-04-06 | 1992-01-07 | Schering Corporation | Processes for preparing bicyclic compounds and intermediates thereof |
| US4996212A (en) * | 1989-12-21 | 1991-02-26 | Schering Corporation | Antiinflammatory and anti-hyperproliferative compounds |
| JP2988739B2 (ja) * | 1990-04-16 | 1999-12-13 | 協和醗酵工業株式会社 | １，８−ナフチリジン−２−オン誘導体 |
| CA2197984A1 (en) * | 1994-08-29 | 1996-03-07 | Kazuhisa Takayama | Novel naphthyridine derivatives and pharmaceutical compositions thereof |
| DE60008917T2 (de) | 1999-12-08 | 2005-03-10 | Grelan Pharmaceutical Co., Ltd., Hamura | Neue 1,8-naphtyridin-2(1h)-on-derivate |
| DE60205899T2 (de) * | 2001-05-24 | 2006-06-29 | Merck Frosst Canada & Co, Kirkland | 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren |
| GB0614471D0 (en) | 2006-07-20 | 2006-08-30 | Syngenta Ltd | Herbicidal Compounds |
| AU2009309837A1 (en) * | 2008-10-29 | 2010-05-06 | Basf Se | Substituted pyridines having a herbicidal effect |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4128649A (en) * | 1977-06-29 | 1978-12-05 | Sandoz, Inc. | 4-Hydroxy-pyrido[2,3-b]pyridine-2(1H)-one-3-carboxylic acids and esters |
| JP3774543B2 (ja) * | 1997-06-17 | 2006-05-17 | 株式会社日立製作所 | 立軸ポンプおよびその駆動装置 |
-
1983
- 1983-04-20 EP EP83103839A patent/EP0092786B1/en not_active Expired
- 1983-04-20 DE DE8383103839T patent/DE3368929D1/de not_active Expired
- 1983-04-25 PH PH28813A patent/PH21641A/en unknown
- 1983-04-25 DK DK181983A patent/DK181983A/da not_active Application Discontinuation
- 1983-04-25 IE IE934/83A patent/IE55113B1/en not_active IP Right Cessation
- 1983-04-25 IL IL68487A patent/IL68487A0/xx not_active IP Right Cessation
- 1983-04-25 CA CA000426661A patent/CA1198109A/en not_active Expired
- 1983-04-26 NZ NZ204004A patent/NZ204004A/en unknown
- 1983-04-26 AU AU13927/83A patent/AU553958B2/en not_active Ceased
- 1983-04-26 PT PT76596A patent/PT76596B/pt unknown
- 1983-09-19 US US06/533,674 patent/US4492702A/en not_active Expired - Lifetime
-
1989
- 1989-11-29 SG SG768/89A patent/SG76889G/en unknown
-
1990
- 1990-03-15 HK HK205/90A patent/HK20590A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT76596A (en) | 1983-05-01 |
| PH21641A (en) | 1988-01-13 |
| AU553958B2 (en) | 1986-07-31 |
| IE830934L (en) | 1983-10-26 |
| EP0092786B1 (en) | 1987-01-07 |
| DE3368929D1 (de) | 1987-02-12 |
| NZ204004A (en) | 1986-03-14 |
| EP0092786A3 (en) | 1984-07-25 |
| AU1392783A (en) | 1983-11-03 |
| HK20590A (en) | 1990-03-23 |
| SG76889G (en) | 1990-04-20 |
| US4492702A (en) | 1985-01-08 |
| CA1198109A (en) | 1985-12-17 |
| IE55113B1 (en) | 1990-06-06 |
| PT76596B (en) | 1986-02-27 |
| DK181983D0 (da) | 1983-04-25 |
| IL68487A0 (en) | 1983-07-31 |
| EP0092786A2 (en) | 1983-11-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment |