DK182483A - Fremgangsmaade til semi-syntese af humant insulin og alkalisk protease til anvendelse derved - Google Patents

Fremgangsmaade til semi-syntese af humant insulin og alkalisk protease til anvendelse derved Download PDF

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Publication number
DK182483A
DK182483A DK182483A DK182483A DK182483A DK 182483 A DK182483 A DK 182483A DK 182483 A DK182483 A DK 182483A DK 182483 A DK182483 A DK 182483A DK 182483 A DK182483 A DK 182483A
Authority
DK
Denmark
Prior art keywords
protease
alkalic
human insulin
semi synthesis
synthesis
Prior art date
Application number
DK182483A
Other languages
English (en)
Other versions
DK182483D0 (da
Inventor
Masami Soejima
Takeharu Masaki
Hideya Suzuki
Jyoji Nagaoka
Yoshitsugu Sakata
Akinori Shintani
Nobuaki Minamii
Tetsuya Matsuo
Haruhiko Sugiyama
Nobuyuki Tokioka
Original Assignee
Wako Pure Chem Ind Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6823882A external-priority patent/JPS58187186A/ja
Priority claimed from JP12391782A external-priority patent/JPS5914798A/ja
Priority claimed from JP57162976A external-priority patent/JPS5951789A/ja
Priority claimed from JP57169428A external-priority patent/JPS5959189A/ja
Application filed by Wako Pure Chem Ind Ltd filed Critical Wako Pure Chem Ind Ltd
Publication of DK182483D0 publication Critical patent/DK182483D0/da
Publication of DK182483A publication Critical patent/DK182483A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Description

vandopløselig tværbundet polymer.
Endvidere et hidtil ukendt alkalisk protease med specificerede karakteristika.
DK182483A 1982-04-23 1983-04-25 Fremgangsmaade til semi-syntese af humant insulin og alkalisk protease til anvendelse derved DK182483A (da)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP6823882A JPS58187186A (ja) 1982-04-23 1982-04-23 固定化酵素
JP6823882 1982-04-23
JP12391782 1982-07-16
JP12391782A JPS5914798A (ja) 1982-07-16 1982-07-16 ヒトインシユリンの半合成法
JP16297682 1982-09-18
JP57162976A JPS5951789A (ja) 1982-09-18 1982-09-18 安定化酵素
JP16942882 1982-09-28
JP57169428A JPS5959189A (ja) 1982-09-28 1982-09-28 新規なアルカリプロテア−ゼ

Publications (2)

Publication Number Publication Date
DK182483D0 DK182483D0 (da) 1983-04-25
DK182483A true DK182483A (da) 1983-10-24

Family

ID=27464963

Family Applications (2)

Application Number Title Priority Date Filing Date
DK182483A DK182483A (da) 1982-04-23 1983-04-25 Fremgangsmaade til semi-syntese af humant insulin og alkalisk protease til anvendelse derved
DK152791A DK152791D0 (da) 1982-04-23 1991-08-29 Fremgangsmaade til semisyntese af humant insulin og achromobacter protease i til anvendelse derved

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK152791A DK152791D0 (da) 1982-04-23 1991-08-29 Fremgangsmaade til semisyntese af humant insulin og achromobacter protease i til anvendelse derved

Country Status (3)

Country Link
EP (2) EP0092829B1 (da)
DE (1) DE3381980D1 (da)
DK (2) DK182483A (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5801022A (en) * 1990-08-03 1998-09-01 Vertex Pharmaceuticals, Incorporated Method of producing a product with crosslinked crystals of thermolysin
US5618710A (en) * 1990-08-03 1997-04-08 Vertex Pharmaceuticals, Inc. Crosslinked enzyme crystals
SK283185B6 (sk) * 1990-08-03 2003-03-04 Vertex Pharmaceuticals Incorporated Zosietené kryštály proteínov, zariadenie ich obsahujúce a ich použitie
AU2091397A (en) * 1996-03-12 1997-10-01 Novo Nordisk A/S Novel achromobacter lyticus protease variants
US7396903B2 (en) * 2001-11-19 2008-07-08 Novo Nordisk A/S Process for preparing insulin compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH564031A5 (da) * 1968-03-29 1975-07-15 Anvar
US4251631A (en) * 1978-02-23 1981-02-17 Research Products Rehovot Ltd. Cross-linked enzyme membrane
NO153061C (no) * 1979-04-13 1986-01-08 Shionogi & Co Fremgangsmaate for fremstilling av et b30-threonininsulin
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DE3101382A1 (de) * 1981-01-17 1982-09-02 Hoechst Ag, 6000 Frankfurt "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"
AU8457482A (en) * 1981-05-20 1982-12-07 Nordisk Insulinlaboratorium A process for the preparation of insulin derivatives
AU550062B2 (en) * 1981-08-10 1986-02-27 Nordisk Insulinlaboratorium A process for the preparation of an insulin derivative
AU551174B2 (en) * 1981-09-15 1986-04-17 Nordisk Insulinlaboratorium Enzymatic preparation of human insulin or b-30 esters thereof

Also Published As

Publication number Publication date
DK152791A (da) 1991-08-29
DK152791D0 (da) 1991-08-29
DE3381980D1 (de) 1990-12-13
DK182483D0 (da) 1983-04-25
EP0092829B1 (en) 1990-11-07
EP0092829A2 (en) 1983-11-02
EP0367302A3 (en) 1991-06-19
EP0092829A3 (en) 1985-08-21
EP0367302A2 (en) 1990-05-09

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