DK182483D0 - Fremgangsmade til semi-syntese af humant insulin og alkalisk protease til anvendelse derved - Google Patents

Fremgangsmade til semi-syntese af humant insulin og alkalisk protease til anvendelse derved

Info

Publication number: DK182483D0
Authority: DK; Denmark
Prior art keywords: alkalic; protease; human insulin; semi synthesis; synthesis
Prior art date: 1982-04-23

Application number

DK182483A

Other languages

English (en)

Other versions

DK182483A (da

Inventor

Masami Soejima

Takeharu Masaki

Hideya Suzuki

Jyoji Nagaoka

Yoshitsugu Sakata

Akinori Shintani

Nobuaki Minamii

Tetsuya Matsuo

Haruhiko Sugiyama

Nobuyuki Tokioka

Original Assignee

Wako Pure Chem Ind Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-04-23

Filing date

1983-04-25

Publication date

1983-04-25

1982-04-23 Priority claimed from JP6823882A external-priority patent/JPS58187186A/ja

1982-07-16 Priority claimed from JP12391782A external-priority patent/JPS5914798A/ja

1982-09-18 Priority claimed from JP57162976A external-priority patent/JPS5951789A/ja

1982-09-28 Priority claimed from JP57169428A external-priority patent/JPS5959189A/ja

1983-04-25 Application filed by Wako Pure Chem Ind Ltd filed Critical Wako Pure Chem Ind Ltd

1983-04-25 Publication of DK182483D0 publication Critical patent/DK182483D0/da

1983-10-24 Publication of DK182483A publication Critical patent/DK182483A/da

Links

101000976075 Homo sapiens Insulin Proteins 0.000 title 1
108091005804 Peptidases Proteins 0.000 title 1
239000004365 Protease Substances 0.000 title 1
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)

DK182483A 1982-04-23 1983-04-25 Fremgangsmaade til semi-syntese af humant insulin og alkalisk protease til anvendelse derved DK182483A (da)

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date	Title
JP6823882		1982-04-23
JP6823882A JPS58187186A (ja)	1982-04-23	1982-04-23	固定化酵素
JP12391782A JPS5914798A (ja)	1982-07-16	1982-07-16	ヒトインシユリンの半合成法
JP12391782		1982-07-16
JP57162976A JPS5951789A (ja)	1982-09-18	1982-09-18	安定化酵素
JP16297682		1982-09-18
JP57169428A JPS5959189A (ja)	1982-09-28	1982-09-28	新規なアルカリプロテア−ゼ
JP16942882		1982-09-28

Publications (2)

Publication Number	Publication Date
DK182483D0 true DK182483D0 (da)	1983-04-25
DK182483A DK182483A (da)	1983-10-24

Family

ID=27464963

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK182483A DK182483A (da)	1982-04-23	1983-04-25	Fremgangsmaade til semi-syntese af humant insulin og alkalisk protease til anvendelse derved
DK152791A DK152791D0 (da)	1982-04-23	1991-08-29	Fremgangsmaade til semisyntese af humant insulin og achromobacter protease i til anvendelse derved

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK152791A DK152791D0 (da)	1982-04-23	1991-08-29	Fremgangsmaade til semisyntese af humant insulin og achromobacter protease i til anvendelse derved

Country Status (3)

Country	Link
EP (2)	EP0092829B1 (da)
DE (1)	DE3381980D1 (da)
DK (2)	DK182483A (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69133258T2 (de) *	1990-08-03	2004-03-18	Vertex Pharmaceuticals Inc., Cambridge	Verwendung von vernetzten kristallen als neuem verfahren zur immobilisierung von enzymen
US5618710A (en) *	1990-08-03	1997-04-08	Vertex Pharmaceuticals, Inc.	Crosslinked enzyme crystals
US5801022A (en) *	1990-08-03	1998-09-01	Vertex Pharmaceuticals, Incorporated	Method of producing a product with crosslinked crystals of thermolysin
AU2091397A (en) *	1996-03-12	1997-10-01	Novo Nordisk A/S	Novel achromobacter lyticus protease variants
US7396903B2 (en) *	2001-11-19	2008-07-08	Novo Nordisk A/S	Process for preparing insulin compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH453269A4 (da) *	1968-03-29	1973-01-31
US4251631A (en) *	1978-02-23	1981-02-17	Research Products Rehovot Ltd.	Cross-linked enzyme membrane
NO153061C (no) *	1979-04-13	1986-01-08	Shionogi & Co	Fremgangsmaate for fremstilling av et b30-threonininsulin
DK147437A (en) *	1980-02-11	1900-01-01		Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DE3101382A1 (de) *	1981-01-17	1982-09-02	Hoechst Ag, 6000 Frankfurt	"verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"
EP0079362A1 (en) *	1981-05-20	1983-05-25	Nordisk Insulinlaboratorium	A process for the preparation of insulin derivatives
EP0088117B1 (en) *	1981-09-15	1986-09-24	Nordisk Insulinlaboratorium	Process for preparing human insulin or b-30 esters thereof
DE3262052D1 (en) *	1981-08-10	1985-03-07	Nordisk Insulinlab	Process for the enzymatic preparation of human insulin

1983
- 1983-04-25 EP EP19830104036 patent/EP0092829B1/en not_active Expired
- 1983-04-25 EP EP19890123550 patent/EP0367302A3/en not_active Withdrawn
- 1983-04-25 DE DE8383104036T patent/DE3381980D1/de not_active Expired - Fee Related
- 1983-04-25 DK DK182483A patent/DK182483A/da not_active Application Discontinuation
1991
- 1991-08-29 DK DK152791A patent/DK152791D0/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0092829B1 (en)	1990-11-07
DK182483A (da)	1983-10-24
DK152791A (da)	1991-08-29
DE3381980D1 (de)	1990-12-13
EP0367302A3 (en)	1991-06-19
DK152791D0 (da)	1991-08-29
EP0092829A3 (en)	1985-08-21
EP0367302A2 (en)	1990-05-09
EP0092829A2 (en)	1983-11-02

Similar Documents

Publication	Publication Date	Title
DK554685D0 (da)	1985-11-29	Renininhiberende dipeptider og fremgangsmaade til fremstilling deraf
DK189884A (da)	1984-10-15	Insekticidt halsbaand og fremgangsmaade til dets fremstilling
DK163253C (da)	1992-07-06	Gennemskinnelige saeber og fremgangsmaade til fremstilling deraf
DK100484A (da)	1984-12-09	Gangtoej og fremgangsmaade til at fremstille gangtoej
DK276683D0 (da)	1983-06-15	Carbapenemer og fremgangsmade til fremstilling deraf
DK80184A (da)	1984-09-12	Fremgangsmaade og kredsloeb til behandling af impulser
DK204884D0 (da)	1984-04-24	Gaerudtrykkelsesmedium,gaerorganisme transformeret dermed og fremgangsmaade til fremstilling af et for gaer heterologt protein
DK314081A (da)	1982-01-15	Fremgangsmaade og anlaeg til fremstilling af alfagipssemihydrat
DK617984D0 (da)	1984-12-20	Fremgangsmaade til inhibering af tandplaque og gingivitis
DK517083D0 (da)	1983-11-11	Fremgangsmade og anlaeg til rensning af roeggas
NO860326L (no)	1985-10-07	Kjemisk forbindelse og fremgangsmaate til fremstilling derav
DK331784D0 (da)	1984-07-06	Naturligt humant interleukin-2 og fremgangsmaader til fremstilling deraf
DK114384D0 (da)	1984-02-28	Monocycliske beta-lactam-forbindelser og fremgangsmaade til fremstilling deraf
DK129983A (da)	1983-09-24	2-beta-d-ribofuranosylselenazol-4-carboxamidforbindelser og fremgangsmaader til fremstilling deraf
DK343183A (da)	1984-05-04	Ketoquinoliner og fremgangsmaade til fremstilling deraf
DK413384A (da)	1985-03-01	Thioxanthylmethyloxycarbonyldioxidforbindelser og deres anvendelse til peptidsyntese
DK152791D0 (da)	1991-08-29	Fremgangsmaade til semisyntese af humant insulin og achromobacter protease i til anvendelse derved
DK467984A (da)	1985-03-30	4-alkylmethylendioxy-2-1(h)-quinazolinoner og fremgangsmaade til fremstilling deraf
DK81192A (da)	1992-06-18	Substituerede ethandiimidamider og fremgangsmaade til fremstilling deraf
DK552284D0 (da)	1984-11-21	2-chlor-3-trifluormethylbenzaldehyd og fremgangsmaade til fremstilling deraf
IS2491A7 (is)	1980-01-06	Aðferð og búnaður til þurr-vinnslu mjög verðmæts hreins vikurs úr hrávikri
DK280389D0 (da)	1989-06-08	Fremgangsmaade til syntese af desferrioxamin b og analoger dertil
DK585686D0 (da)	1986-12-05	Form iii krystaller af n-alfa-(((s)-4-oxo-2-azetidinyl)carbonyl)-l-histidyl-l-prolinamid og fremgangsmaade til fremstilling af krystallerne
DK350183D0 (da)	1983-07-29	Alkalisk protease og fremgangsmade til fremstilling deraf
DK84183A (da)	1983-09-12	Benzyletherderivater af pentiter og fremgangsmaade til fremstilling deraf

Legal Events

Date	Code	Title	Description
1992-12-28	AHB	Application shelved due to non-payment