DK1910538T3 - Fremgangsmåder til syntese af kodede biblioteker - Google Patents

Fremgangsmåder til syntese af kodede biblioteker

Info

Publication number: DK1910538T3
Authority: DK; Denmark
Prior art keywords: methods; encoded libraries; synthesizing; synthesizing encoded; libraries
Prior art date: 2005-06-09

Application number

DK06784718.6T

Other languages

English (en)

Inventor

Barry Morgan

Stephen Hale

Christopher C Arico-Muendel

Matthew Clark

Richard Wagner

Malcolm J Kavarana

Steffen Phillip Creaser

George J Franklin

Paolo A Centrella

David I Israel

Malcolm L Gefter

Dennis Benjamin

Nils Jakob Vest Hansen

Raksha A Acharya

Original Assignee

Praecis Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-09

Filing date

2006-06-09

Publication date

2011-08-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36930432&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1910538(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-06-09 Application filed by Praecis Pharm Inc filed Critical Praecis Pharm Inc

2011-08-08 Application granted granted Critical

2011-08-08 Publication of DK1910538T3 publication Critical patent/DK1910538T3/da

Links

230000002194 synthesizing effect Effects 0.000 title abstract 2
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Crystallography & Structural Chemistry (AREA)
Microbiology (AREA)
Bioinformatics & Computational Biology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Steroid Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Polyurethanes Or Polyureas (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Investigating Or Analysing Biological Materials (AREA)
Compounds Of Unknown Constitution (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Saccharide Compounds (AREA)

DK06784718.6T 2005-06-09 2006-06-09 Fremgangsmåder til syntese af kodede biblioteker DK1910538T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US68946605P	2005-06-09	2005-06-09
US73104105P	2005-10-28	2005-10-28
PCT/US2006/022555 WO2006135786A2 (en)	2005-06-09	2006-06-09	Methods for synthesis of encoded libraries

Publications (1)

Publication Number	Publication Date
DK1910538T3 true DK1910538T3 (da)	2011-08-08

Family

ID=36930432

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
DK06784718.6T DK1910538T3 (da)	2005-06-09	2006-06-09	Fremgangsmåder til syntese af kodede biblioteker
DK10075295.5T DK2258870T3 (da)	2005-06-09	2006-06-09	Fremgangsmåde til at identificere forbindelser der binder til et biologisk target-molekyle
DKPA200800005A DK177345B1 (da)	2005-06-09	2008-01-03	Fremgangsmåder til syntese af kodede biblioteker
DKPA201170734A DK179064B1 (da)	2005-06-09	2011-12-20	Fremgangsmåder til syntese af kodede biblioteker

Family Applications After (3)

Application Number	Title	Priority Date	Filing Date
DK10075295.5T DK2258870T3 (da)	2005-06-09	2006-06-09	Fremgangsmåde til at identificere forbindelser der binder til et biologisk target-molekyle
DKPA200800005A DK177345B1 (da)	2005-06-09	2008-01-03	Fremgangsmåder til syntese af kodede biblioteker
DKPA201170734A DK179064B1 (da)	2005-06-09	2011-12-20	Fremgangsmåder til syntese af kodede biblioteker

Country Status (23)

Country	Link
EP (4)	EP2338990A3 (da)
JP (2)	JP5508711B2 (da)
KR (1)	KR101346432B1 (da)
CN (2)	CN102392014A (da)
AT (1)	ATE507292T1 (da)
AU (1)	AU2006257915B2 (da)
BR (1)	BRPI0613566B1 (da)
CA (1)	CA2611512C (da)
CY (1)	CY1112036T1 (da)
DE (1)	DE602006021580D1 (da)
DK (4)	DK1910538T3 (da)
ES (2)	ES2401485T3 (da)
HR (1)	HRP20110528T1 (da)
IL (1)	IL187977A (da)
NO (1)	NO343698B1 (da)
NZ (1)	NZ564545A (da)
PL (2)	PL2258870T3 (da)
PT (2)	PT1910538E (da)
RS (1)	RS51868B (da)
RU (2)	RU2459869C2 (da)
SI (1)	SI1910538T1 (da)
WO (1)	WO2006135786A2 (da)
ZA (2)	ZA200800190B (da)

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EP1401850A1 (en)	2001-06-20	2004-03-31	Nuevolution A/S	Nucleoside derivatives for library preparation
EP1487978B1 (en)	2002-03-15	2008-11-19	Nuevolution A/S	An improved method for synthesising templated molecules
WO2004013070A2 (en)	2002-08-01	2004-02-12	Nuevolution A/S	Multi-step synthesis of templated molecules
PT2348125T (pt)	2002-10-30	2017-08-29	Nuevolution As	Método para a síntese de um complexo bifuncional
AU2003291964A1 (en)	2002-12-19	2004-07-14	Nuevolution A/S	Quasirandom structure and function guided synthesis methods
US20070026397A1 (en)	2003-02-21	2007-02-01	Nuevolution A/S	Method for producing second-generation library
EP1670939B1 (en)	2003-09-18	2009-11-04	Nuevolution A/S	A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
CA2611512C (en)	2005-06-09	2018-05-22	Praecis Pharmaceuticals, Inc.	Methods for synthesis of encoded libraries
HUE056836T2 (hu) *	2005-12-01	2022-03-28	Nuevolution As	Enzimatikus kódolási eljárások nagy könyvtárak hatékony szintéziséhez
DK2396459T3 (da)	2009-02-13	2017-08-28	X-Chem Inc	Fremgangsmåde til fremstilling og screening af DNA-kodede biblioteker
WO2011127933A1 (en)	2010-04-16	2011-10-20	Nuevolution A/S	Bi-functional complexes and methods for making and using such complexes
DK2748357T3 (da) *	2011-09-07	2018-07-16	X Chem Inc	Fremgangsmåder til mærkning af DNA-kodede biblioteker
EA201992285A1 (ru)	2012-07-13	2020-05-31	Икс-Чем, Инк.	Днк-кодированные библиотеки, содержащие связи кодирующих олигонуклеотидов, не доступные для считывания полимеразами
JP6911248B2 (ja)	2017-03-17	2021-07-28	成都先導薬物開発股▲フン▼有限公司ＨｉｔｇｅｎＩｎｃ．	エンコードライブラリの合成方法及び組成物
WO2019149198A1 (zh) *	2018-01-31	2019-08-08	成都先导药物开发股份有限公司	一种dna编码化合物库及化合物筛选方法
GB201821109D0 (en) *	2018-12-21	2019-02-06	Philochem Ag	Nucleic acid encoded chemical libraries
CN110041390B (zh) *	2019-04-26	2022-05-27	上海药明康德新药开发有限公司	DNA编码化合物库中On-DNA的1,2,3-三氮唑化合物的合成方法
CN112779606A (zh) *	2019-11-06	2021-05-11	成都先导药物开发股份有限公司	一种On-DNA曼尼希反应的方法
CN113089104B (zh) *	2019-12-23	2023-03-28	成都先导药物开发股份有限公司	一种On-DNA二胺化合物关环反应的合成方法
CN115506036B (zh) *	2021-06-22	2024-07-02	中国科学院上海药物研究所	Dna编码化合物文库起始片段及其制备和应用
DK4201951T3 (da) *	2021-12-21	2024-01-15	Bachem Holding Ag	Fremgangsmåde til syntese af et peptid
CN114920791B (zh) *	2022-04-28	2024-06-18	康龙化成(宁波)科技发展有限公司	一种寡聚核酸-琥珀酰亚胺化合物的合成方法

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EP1670939B1 (en) *	2003-09-18	2009-11-04	Nuevolution A/S	A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
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CA2611512C (en)	2005-06-09	2018-05-22	Praecis Pharmaceuticals, Inc.	Methods for synthesis of encoded libraries

2006
- 2006-06-09 CA CA2611512A patent/CA2611512C/en active Active
- 2006-06-09 RS RS20110327A patent/RS51868B/sr unknown
- 2006-06-09 KR KR1020087000511A patent/KR101346432B1/ko active Active
- 2006-06-09 AU AU2006257915A patent/AU2006257915B2/en not_active Ceased
- 2006-06-09 CN CN2011102198704A patent/CN102392014A/zh active Pending
- 2006-06-09 AT AT06784718T patent/ATE507292T1/de active
- 2006-06-09 EP EP10012326A patent/EP2338990A3/en not_active Withdrawn
- 2006-06-09 NZ NZ564545A patent/NZ564545A/en not_active IP Right Cessation
- 2006-06-09 CN CN2006800276157A patent/CN101233235B/zh active Active
- 2006-06-09 JP JP2008515983A patent/JP5508711B2/ja not_active Expired - Fee Related
- 2006-06-09 ES ES10075295T patent/ES2401485T3/es active Active
- 2006-06-09 ES ES06784718T patent/ES2365534T3/es active Active
- 2006-06-09 PL PL10075295T patent/PL2258870T3/pl unknown
- 2006-06-09 PT PT06784718T patent/PT1910538E/pt unknown
- 2006-06-09 SI SI200631057T patent/SI1910538T1/sl unknown
- 2006-06-09 BR BRPI0613566-8A patent/BRPI0613566B1/pt not_active IP Right Cessation
- 2006-06-09 DK DK06784718.6T patent/DK1910538T3/da active
- 2006-06-09 EP EP10075295A patent/EP2258870B1/en active Active
- 2006-06-09 DK DK10075295.5T patent/DK2258870T3/da active
- 2006-06-09 PL PL06784718T patent/PL1910538T3/pl unknown
- 2006-06-09 EP EP06784718A patent/EP1910538B1/en active Active
- 2006-06-09 DE DE602006021580T patent/DE602006021580D1/de active Active
- 2006-06-09 HR HR20110528T patent/HRP20110528T1/hr unknown
- 2006-06-09 EP EP10075296.3A patent/EP2311786A3/en not_active Withdrawn
- 2006-06-09 WO PCT/US2006/022555 patent/WO2006135786A2/en not_active Ceased
- 2006-06-09 RU RU2008100035/10A patent/RU2459869C2/ru active
- 2006-06-09 PT PT100752955T patent/PT2258870E/pt unknown
2007
- 2007-12-06 IL IL187977A patent/IL187977A/en active IP Right Grant
- 2007-12-12 NO NO20076362A patent/NO343698B1/no unknown
2008
- 2008-01-03 DK DKPA200800005A patent/DK177345B1/da not_active IP Right Cessation
- 2008-01-08 ZA ZA2008/00190A patent/ZA200800190B/en unknown
2010
- 2010-07-07 ZA ZA2010/04791A patent/ZA201004791B/en unknown
2011
- 2011-01-19 RU RU2011101778/10A patent/RU2011101778A/ru not_active Application Discontinuation
- 2011-07-14 CY CY20111100688T patent/CY1112036T1/el unknown
- 2011-12-20 DK DKPA201170734A patent/DK179064B1/da not_active IP Right Cessation
2013
- 2013-09-19 JP JP2013194319A patent/JP2014039550A/ja active Pending

Also Published As

Publication number	Publication date
ES2365534T3 (es)	2011-10-06
EP2338990A3 (en)	2011-10-19
IL187977A0 (en)	2008-03-20
AU2006257915A1 (en)	2006-12-21
PL2258870T3 (pl)	2013-05-31
ZA200800190B (en)	2010-11-24
CN102392014A (zh)	2012-03-28
HRP20110528T1 (hr)	2011-09-30
EP2258870A3 (en)	2011-11-30
NO20076362L (no)	2008-03-07
EP2258870A2 (en)	2010-12-08
EP1910538A2 (en)	2008-04-16
JP5508711B2 (ja)	2014-06-04
HK1150454A1 (en)	2011-12-30
EP2258870B1 (en)	2013-01-02
PT2258870E (pt)	2013-04-01
JP2008543289A (ja)	2008-12-04
EP1910538B1 (en)	2011-04-27
DK200800005A (da)	2008-03-04
KR20080036577A (ko)	2008-04-28
WO2006135786A3 (en)	2007-06-21
RU2459869C2 (ru)	2012-08-27
CA2611512C (en)	2018-05-22
RU2008100035A (ru)	2009-07-20
KR101346432B1 (ko)	2014-02-14
RS51868B (sr)	2012-02-29
CN101233235B (zh)	2012-10-03
BRPI0613566A2 (pt)	2011-01-18
AU2006257915B2 (en)	2011-09-08
ATE507292T1 (de)	2011-05-15
PL1910538T3 (pl)	2011-12-30
DK177345B1 (da)	2013-01-28
RU2011101778A (ru)	2012-07-27
CY1112036T1 (el)	2015-11-04
EP2311786A3 (en)	2014-04-02
EP2311786A2 (en)	2011-04-20
NZ564545A (en)	2011-03-31
ES2401485T3 (es)	2013-04-22
ZA201004791B (en)	2012-06-27
DE602006021580D1 (de)	2011-06-09
DK201170734A (en)	2011-12-20
CN101233235A (zh)	2008-07-30
DK2258870T3 (da)	2013-03-18
SI1910538T1 (sl)	2011-09-30
PT1910538E (pt)	2011-07-28
CA2611512A1 (en)	2006-12-21
WO2006135786A2 (en)	2006-12-21
HK1120546A1 (en)	2009-04-03
NO343698B1 (no)	2019-05-13
DK179064B1 (da)	2017-10-02
BRPI0613566B1 (pt)	2020-01-07
IL187977A (en)	2013-02-28
JP2014039550A (ja)	2014-03-06
EP2338990A2 (en)	2011-06-29

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