DK1910538T3 - Fremgangsmåder til syntese af kodede biblioteker - Google Patents

Fremgangsmåder til syntese af kodede biblioteker

Info

Publication number: DK1910538T3
Authority: DK; Denmark
Prior art keywords: methods; encoded libraries; synthesizing; synthesizing encoded; libraries
Prior art date: 2005-06-09

Application number

DK06784718.6T

Other languages

English (en)

Inventor

Barry Morgan

Stephen Hale

Christopher C Arico-Muendel

Matthew Clark

Richard Wagner

Malcolm J Kavarana

Steffen Phillip Creaser

George J Franklin

Paolo A Centrella

David I Israel

Malcolm L Gefter

Dennis Benjamin

Nils Jakob Vest Hansen

Raksha A Acharya

Original Assignee

Praecis Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-06-09

Filing date

2006-06-09

Publication date

2011-08-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36930432&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1910538(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2006-06-09 Application filed by Praecis Pharm Inc filed Critical Praecis Pharm Inc

2011-08-08 Application granted granted Critical

2011-08-08 Publication of DK1910538T3 publication Critical patent/DK1910538T3/da

Links

230000002194 synthesizing effect Effects 0.000 title abstract 2
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Crystallography & Structural Chemistry (AREA)
Microbiology (AREA)
Bioinformatics & Computational Biology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Steroid Compounds (AREA)
Investigating Or Analysing Biological Materials (AREA)
Compounds Of Unknown Constitution (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Polyurethanes Or Polyureas (AREA)
Saccharide Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK06784718.6T 2005-06-09 2006-06-09 Fremgangsmåder til syntese af kodede biblioteker DK1910538T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US68946605P	2005-06-09	2005-06-09
US73104105P	2005-10-28	2005-10-28
PCT/US2006/022555 WO2006135786A2 (en)	2005-06-09	2006-06-09	Methods for synthesis of encoded libraries

Publications (1)

Publication Number	Publication Date
DK1910538T3 true DK1910538T3 (da)	2011-08-08

Family

ID=36930432

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
DK06784718.6T DK1910538T3 (da)	2005-06-09	2006-06-09	Fremgangsmåder til syntese af kodede biblioteker
DK10075295.5T DK2258870T3 (da)	2005-06-09	2006-06-09	Fremgangsmåde til at identificere forbindelser der binder til et biologisk target-molekyle
DKPA200800005A DK177345B1 (da)	2005-06-09	2008-01-03	Fremgangsmåder til syntese af kodede biblioteker
DKPA201170734A DK179064B1 (da)	2005-06-09	2011-12-20	Fremgangsmåder til syntese af kodede biblioteker

Family Applications After (3)

Application Number	Title	Priority Date	Filing Date
DK10075295.5T DK2258870T3 (da)	2005-06-09	2006-06-09	Fremgangsmåde til at identificere forbindelser der binder til et biologisk target-molekyle
DKPA200800005A DK177345B1 (da)	2005-06-09	2008-01-03	Fremgangsmåder til syntese af kodede biblioteker
DKPA201170734A DK179064B1 (da)	2005-06-09	2011-12-20	Fremgangsmåder til syntese af kodede biblioteker

Country Status (23)

Country	Link
EP (4)	EP1910538B1 (da)
JP (2)	JP5508711B2 (da)
KR (1)	KR101346432B1 (da)
CN (2)	CN102392014A (da)
AT (1)	ATE507292T1 (da)
AU (1)	AU2006257915B2 (da)
BR (1)	BRPI0613566B1 (da)
CA (1)	CA2611512C (da)
CY (1)	CY1112036T1 (da)
DE (1)	DE602006021580D1 (da)
DK (4)	DK1910538T3 (da)
ES (2)	ES2401485T3 (da)
HR (1)	HRP20110528T1 (da)
IL (1)	IL187977A (da)
NO (1)	NO343698B1 (da)
NZ (1)	NZ564545A (da)
PL (2)	PL1910538T3 (da)
PT (2)	PT2258870E (da)
RS (1)	RS51868B (da)
RU (2)	RU2459869C2 (da)
SI (1)	SI1910538T1 (da)
WO (1)	WO2006135786A2 (da)
ZA (2)	ZA200800190B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1401850A1 (en)	2001-06-20	2004-03-31	Nuevolution A/S	Nucleoside derivatives for library preparation
US10731151B2 (en)	2002-03-15	2020-08-04	Nuevolution A/S	Method for synthesising templated molecules
WO2004013070A2 (en)	2002-08-01	2004-02-12	Nuevolution A/S	Multi-step synthesis of templated molecules
DK3299463T3 (da)	2002-10-30	2020-12-07	Nuevolution As	Enzymatisk kodning
ATE450609T1 (de)	2002-12-19	2009-12-15	Nuevolution As	Durch quasizufallsstrukturen und funktionen geführte synthesemethode
US20070026397A1 (en)	2003-02-21	2007-02-01	Nuevolution A/S	Method for producing second-generation library
WO2005026387A1 (en)	2003-09-18	2005-03-24	Nuevolution A/S	A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
NZ564545A (en)	2005-06-09	2011-03-31	Praecis Pharm Inc	Methods for synthesis of encoded libraries
LT2336315T (lt)	2005-12-01	2017-11-10	Nuevolution A/S	Fermentiniai kodavimo būdai, skirti efektyviai didelių bibliotekų sintezei
KR102231531B1 (ko) *	2009-02-13	2021-03-23	엑스-켐, 인크.	Ｄｎａ―코딩된 라이브러리의 생성 및 스크리닝 방법
CA2832672A1 (en)	2010-04-16	2011-10-20	Nuevolution A/S	Bi-functional complexes and methods for making and using such complexes
ES2675111T3 (es) *	2011-09-07	2018-07-06	X-Chem, Inc.	Métodos para etiquetar bibliotecas con codificación de ADN
CN104685115A (zh)	2012-07-13	2015-06-03	X-化学有限公司	具有聚合酶不可读的编码性寡核苷酸连接的dna编码文库
CN110325491B (zh)	2017-03-17	2022-04-19	成都先导药物开发股份有限公司	编码库的合成方法及组合物
WO2019149198A1 (zh) *	2018-01-31	2019-08-08	成都先导药物开发股份有限公司	一种dna编码化合物库及化合物筛选方法
GB201821109D0 (en) *	2018-12-21	2019-02-06	Philochem Ag	Nucleic acid encoded chemical libraries
CN110041390B (zh) *	2019-04-26	2022-05-27	上海药明康德新药开发有限公司	DNA编码化合物库中On-DNA的1,2,3-三氮唑化合物的合成方法
CN112779606A (zh) *	2019-11-06	2021-05-11	成都先导药物开发股份有限公司	一种On-DNA曼尼希反应的方法
CN113089104B (zh) *	2019-12-23	2023-03-28	成都先导药物开发股份有限公司	一种On-DNA二胺化合物关环反应的合成方法
CN115506036B (zh) *	2021-06-22	2024-07-02	中国科学院上海药物研究所	Dna编码化合物文库起始片段及其制备和应用
DK4201951T3 (da) *	2021-12-21	2024-01-15	Bachem Holding Ag	Fremgangsmåde til syntese af et peptid
CN114920791B (zh) *	2022-04-28	2024-06-18	康龙化成(宁波)科技发展有限公司	一种寡聚核酸-琥珀酰亚胺化合物的合成方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1545804A (en)	1924-12-26	1925-07-14	Warmerdam Nicholas	Sash fastener
US4356270A (en)	1977-11-08	1982-10-26	Genentech, Inc.	Recombinant DNA cloning vehicle
US4293652A (en)	1979-05-25	1981-10-06	Cetus Corporation	Method for synthesizing DNA sequentially
US4458066A (en)	1980-02-29	1984-07-03	University Patents, Inc.	Process for preparing polynucleotides
US4416988A (en)	1980-12-23	1983-11-22	Harvey Rubin	Detection and isolation of enkephalin mRNA using a synthetic oligodeoxynucleotide
JPS60222842A (ja)	1984-04-19	1985-11-07	Fuji Photo Film Co Ltd	ハロゲン化銀写真乳剤およびその製造方法
US4683202A (en)	1985-03-28	1987-07-28	Cetus Corporation	Process for amplifying nucleic acid sequences
US4965188A (en)	1986-08-22	1990-10-23	Cetus Corporation	Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4800159A (en)	1986-02-07	1989-01-24	Cetus Corporation	Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5360928A (en)	1989-10-23	1994-11-01	Research Corporation Technologies, Inc.	Synthesis and use of amino acid fluorides as peptide coupling reagents
DK0604552T3 (da)	1991-09-18	1997-08-04	Affymax Tech Nv	Fremgangsmåde til syntese af forskellige samlinger af oligomerer
US5573905A (en)	1992-03-30	1996-11-12	The Scripps Research Institute	Encoded combinatorial chemical libraries
US5565324A (en) *	1992-10-01	1996-10-15	The Trustees Of Columbia University In The City Of New York	Complex combinatorial chemical libraries encoded with tags
EP0675873A4 (en)	1992-12-11	2000-03-29	Chiron Corp	PRODUCTION OF CODED POLYMERS
US6537776B1 (en) *	1999-06-14	2003-03-25	Diversa Corporation	Synthetic ligation reassembly in directed evolution
AU1318400A (en)	1998-10-19	2000-05-08	Board Of Trustees Of The Leland Stanford Junior University	Dna-templated combinatorial library chemistry
US7070928B2 (en)	2001-03-19	2006-07-04	President And Fellows Of Harvard College	Evolving new molecular function
CN1539014A (zh)	2001-06-20	2004-10-20	ŦΤ¬ɭ��˾	模控分子和使用这种分子的方法
WO2003101972A1 (en)	2002-05-30	2003-12-11	The Scripps Research Institute	Copper-catalysed ligation of azides and acetylenes
WO2004016767A2 (en) *	2002-08-19	2004-02-26	The President And Fellows Of Harvard College	Evolving new molecular function
DK3299463T3 (da) *	2002-10-30	2020-12-07	Nuevolution As	Enzymatisk kodning
CA2513889A1 (en)	2003-01-29	2004-08-19	454 Corporation	Double ended sequencing
GB0304433D0 (en) *	2003-02-27	2003-04-02	Xceleron Ltd	Improvements relating to chemical libraries
US7915201B2 (en) *	2003-03-20	2011-03-29	Nuevolution A/S	Ligational encoding of small molecules
WO2005026387A1 (en) *	2003-09-18	2005-03-24	Nuevolution A/S	A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
RU2470077C2 (ru) *	2003-12-17	2012-12-20	ГЛЭКСОСМИТКЛАЙН ЭлЭлСи	Биологически активное соединение, содержащее кодирующий олигонуклеотид (варианты), способ его синтеза, библиотека соединений (варианты), способ ее синтеза и способ поиска соединения, связывающегося с биологической мишенью (варианты)
US7116036B2 (en)	2004-08-02	2006-10-03	General Electric Company	Energy harvesting system, apparatus and method
EP1828381B1 (en) *	2004-11-22	2009-01-07	Peter Birk Rasmussen	Template directed split and mix systhesis of small molecule libraries
NZ564545A (en)	2005-06-09	2011-03-31	Praecis Pharm Inc	Methods for synthesis of encoded libraries

2006
- 2006-06-09 NZ NZ564545A patent/NZ564545A/en not_active IP Right Cessation
- 2006-06-09 KR KR1020087000511A patent/KR101346432B1/ko active Active
- 2006-06-09 WO PCT/US2006/022555 patent/WO2006135786A2/en not_active Ceased
- 2006-06-09 CA CA2611512A patent/CA2611512C/en active Active
- 2006-06-09 EP EP06784718A patent/EP1910538B1/en active Active
- 2006-06-09 ES ES10075295T patent/ES2401485T3/es active Active
- 2006-06-09 PL PL06784718T patent/PL1910538T3/pl unknown
- 2006-06-09 CN CN2011102198704A patent/CN102392014A/zh active Pending
- 2006-06-09 RS RS20110327A patent/RS51868B/sr unknown
- 2006-06-09 ES ES06784718T patent/ES2365534T3/es active Active
- 2006-06-09 PL PL10075295T patent/PL2258870T3/pl unknown
- 2006-06-09 PT PT100752955T patent/PT2258870E/pt unknown
- 2006-06-09 CN CN2006800276157A patent/CN101233235B/zh active Active
- 2006-06-09 RU RU2008100035/10A patent/RU2459869C2/ru active
- 2006-06-09 EP EP10012326A patent/EP2338990A3/en not_active Withdrawn
- 2006-06-09 PT PT06784718T patent/PT1910538E/pt unknown
- 2006-06-09 DK DK06784718.6T patent/DK1910538T3/da active
- 2006-06-09 BR BRPI0613566-8A patent/BRPI0613566B1/pt not_active IP Right Cessation
- 2006-06-09 EP EP10075296.3A patent/EP2311786A3/en not_active Withdrawn
- 2006-06-09 DK DK10075295.5T patent/DK2258870T3/da active
- 2006-06-09 JP JP2008515983A patent/JP5508711B2/ja not_active Expired - Fee Related
- 2006-06-09 SI SI200631057T patent/SI1910538T1/sl unknown
- 2006-06-09 AT AT06784718T patent/ATE507292T1/de active
- 2006-06-09 AU AU2006257915A patent/AU2006257915B2/en not_active Ceased
- 2006-06-09 HR HR20110528T patent/HRP20110528T1/hr unknown
- 2006-06-09 EP EP10075295A patent/EP2258870B1/en active Active
- 2006-06-09 DE DE602006021580T patent/DE602006021580D1/de active Active
2007
- 2007-12-06 IL IL187977A patent/IL187977A/en active IP Right Grant
- 2007-12-12 NO NO20076362A patent/NO343698B1/no unknown
2008
- 2008-01-03 DK DKPA200800005A patent/DK177345B1/da not_active IP Right Cessation
- 2008-01-08 ZA ZA2008/00190A patent/ZA200800190B/en unknown
2010
- 2010-07-07 ZA ZA2010/04791A patent/ZA201004791B/en unknown
2011
- 2011-01-19 RU RU2011101778/10A patent/RU2011101778A/ru not_active Application Discontinuation
- 2011-07-14 CY CY20111100688T patent/CY1112036T1/el unknown
- 2011-12-20 DK DKPA201170734A patent/DK179064B1/da not_active IP Right Cessation
2013
- 2013-09-19 JP JP2013194319A patent/JP2014039550A/ja active Pending

Also Published As

Publication number	Publication date
NZ564545A (en)	2011-03-31
CN101233235A (zh)	2008-07-30
AU2006257915B2 (en)	2011-09-08
BRPI0613566A2 (pt)	2011-01-18
PL2258870T3 (pl)	2013-05-31
EP1910538A2 (en)	2008-04-16
PL1910538T3 (pl)	2011-12-30
JP2014039550A (ja)	2014-03-06
CY1112036T1 (el)	2015-11-04
EP2311786A2 (en)	2011-04-20
NO343698B1 (no)	2019-05-13
PT1910538E (pt)	2011-07-28
CA2611512A1 (en)	2006-12-21
SI1910538T1 (sl)	2011-09-30
PT2258870E (pt)	2013-04-01
KR20080036577A (ko)	2008-04-28
CA2611512C (en)	2018-05-22
IL187977A (en)	2013-02-28
JP2008543289A (ja)	2008-12-04
HK1120546A1 (en)	2009-04-03
EP2258870A3 (en)	2011-11-30
DE602006021580D1 (de)	2011-06-09
DK200800005A (da)	2008-03-04
DK177345B1 (da)	2013-01-28
BRPI0613566B1 (pt)	2020-01-07
DK2258870T3 (da)	2013-03-18
JP5508711B2 (ja)	2014-06-04
RU2459869C2 (ru)	2012-08-27
DK201170734A (en)	2011-12-20
ATE507292T1 (de)	2011-05-15
WO2006135786A2 (en)	2006-12-21
DK179064B1 (da)	2017-10-02
RU2008100035A (ru)	2009-07-20
NO20076362L (no)	2008-03-07
HRP20110528T1 (hr)	2011-09-30
EP2258870B1 (en)	2013-01-02
KR101346432B1 (ko)	2014-02-14
RS51868B (sr)	2012-02-29
ZA200800190B (en)	2010-11-24
IL187977A0 (en)	2008-03-20
EP2311786A3 (en)	2014-04-02
EP2258870A2 (en)	2010-12-08
CN102392014A (zh)	2012-03-28
ES2365534T3 (es)	2011-10-06
EP2338990A3 (en)	2011-10-19
ZA201004791B (en)	2012-06-27
ES2401485T3 (es)	2013-04-22
AU2006257915A1 (en)	2006-12-21
WO2006135786A3 (en)	2007-06-21
EP1910538B1 (en)	2011-04-27
CN101233235B (zh)	2012-10-03
EP2338990A2 (en)	2011-06-29
HK1150454A1 (en)	2011-12-30
RU2011101778A (ru)	2012-07-27

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CY1112036T1 (el)	2015-11-04	Μεθοδοι για συνθεση κωδικοποιημενων συλλογων
WO2007053358A3 (en)	2007-11-01	Methods for identifying compounds of interest using encoded libraries
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