DK1879862T3 - Magnesiumsalte af HMG-COA reduktaseinhibitorer - Google Patents
Magnesiumsalte af HMG-COA reduktaseinhibitorerInfo
- Publication number
- DK1879862T3 DK1879862T3 DK06765662.9T DK06765662T DK1879862T3 DK 1879862 T3 DK1879862 T3 DK 1879862T3 DK 06765662 T DK06765662 T DK 06765662T DK 1879862 T3 DK1879862 T3 DK 1879862T3
- Authority
- DK
- Denmark
- Prior art keywords
- magnesium salts
- hmg
- coa reductase
- reductase inhibitors
- compositions
- Prior art date
Links
- 159000000003 magnesium salts Chemical class 0.000 title abstract 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 title 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 title 1
- 229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 title 1
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical class C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 abstract 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 229960005370 atorvastatin Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1108DE2005 | 2005-05-03 | ||
| PCT/IB2006/051396 WO2006117761A2 (en) | 2005-05-03 | 2006-05-03 | Magnesium salts of hmg-coa reductase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1879862T3 true DK1879862T3 (da) | 2011-05-16 |
Family
ID=37308379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06765662.9T DK1879862T3 (da) | 2005-05-03 | 2006-05-03 | Magnesiumsalte af HMG-COA reduktaseinhibitorer |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20100222405A1 (da) |
| EP (2) | EP1879862B1 (da) |
| AT (1) | ATE496025T1 (da) |
| DE (1) | DE602006019710D1 (da) |
| DK (1) | DK1879862T3 (da) |
| ES (1) | ES2304911T3 (da) |
| NO (1) | NO20076191L (da) |
| PT (1) | PT1879862E (da) |
| WO (1) | WO2006117761A2 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE466840T1 (de) | 2005-11-21 | 2010-05-15 | Warner Lambert Co | Neue formen von är-(r*,r*)ü-2-(4-fluorphenyl)-b,d-dihydroxy-5-( -methylethyl)-3-phenyl-4- ä(phenylamino)carbonylü-1h-pyrrol-1-heptansäure magnesium |
| US20100168201A1 (en) * | 2005-11-29 | 2010-07-01 | Biocan Limited | Polymorphs of [R-(R*, R*) ]-2-(4-Fluorophenyl)-Beta, Delta-Dihydroxy-5-(1-Methylethyl)-3-Phenyl-4-[(Phenylamino)Carbonyl]-1H-Pyrrole-1-Heptanoic Acid Magnesium Salt (2:1) |
| WO2007099552A2 (en) * | 2006-03-02 | 2007-09-07 | Matrix Labaratories Ltd | Novel crystalline form of atovastatin hemi-magnesium |
| SI22255A (sl) * | 2006-04-14 | 2007-10-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Novi polimorfi statinovih soli in njihova uporabav farmacevtskih formulacijah |
| IS8587A (is) * | 2006-12-27 | 2008-06-28 | Actavis Group Hf. | Atorvastatin lyfjasamsetning |
| WO2009063476A1 (en) * | 2007-11-16 | 2009-05-22 | Biocon Limited | A crystalline form of atorvastatin hemi magnesium salt and a process thereof |
| EP2130819A3 (en) | 2008-04-10 | 2009-12-23 | Ranbaxy Laboratories Limited | Crystalline forms of atorvastatin magnesium |
| WO2009157005A1 (en) * | 2008-06-26 | 2009-12-30 | Biocon Limited | Crystalline forms of atorvastatin hemi-magnesium salt and a process thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI94339C (fi) * | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| JP2004501191A (ja) * | 2000-06-28 | 2004-01-15 | テバ ファーマシューティカル インダストリーズ リミティド | カルベジロール |
| WO2003068191A1 (en) * | 2002-02-14 | 2003-08-21 | Ranbaxy Laboratories Limited | Formulations of atorvastatin stabilized with alkali metal additions |
| WO2006054308A2 (en) * | 2004-11-22 | 2006-05-26 | Dexcel Pharma Technologies Ltd. | Stable atorvastatin formulations |
| EP1833466A1 (en) * | 2004-12-28 | 2007-09-19 | Ranbaxy Laboratories Limited | Methods for the preparation of stable pharmaceutical solid dosage forms of atorvastatin and amlodipine |
| RU2007133601A (ru) * | 2005-02-10 | 2009-03-20 | Лайфсайкл Фарма А/С (Dk) | УСТОЙЧИВАЯ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ФИКСИРОВАННУЮ ДОЗУ КОМБИНАЦИИ ФЕНОФИБРАТА И ИНГИБИТОРА HMG-CoA-РЕДУКТАЗЫ |
| ATE466840T1 (de) * | 2005-11-21 | 2010-05-15 | Warner Lambert Co | Neue formen von är-(r*,r*)ü-2-(4-fluorphenyl)-b,d-dihydroxy-5-( -methylethyl)-3-phenyl-4- ä(phenylamino)carbonylü-1h-pyrrol-1-heptansäure magnesium |
| US20100168201A1 (en) * | 2005-11-29 | 2010-07-01 | Biocan Limited | Polymorphs of [R-(R*, R*) ]-2-(4-Fluorophenyl)-Beta, Delta-Dihydroxy-5-(1-Methylethyl)-3-Phenyl-4-[(Phenylamino)Carbonyl]-1H-Pyrrole-1-Heptanoic Acid Magnesium Salt (2:1) |
| WO2007099552A2 (en) * | 2006-03-02 | 2007-09-07 | Matrix Labaratories Ltd | Novel crystalline form of atovastatin hemi-magnesium |
| SI22255A (sl) * | 2006-04-14 | 2007-10-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Novi polimorfi statinovih soli in njihova uporabav farmacevtskih formulacijah |
| JP2009536638A (ja) * | 2006-05-11 | 2009-10-15 | バイオコン リミテッド | アトルバスタチンマグネシウムの結晶性形状b4及びその方法 |
| EP2130819A3 (en) * | 2008-04-10 | 2009-12-23 | Ranbaxy Laboratories Limited | Crystalline forms of atorvastatin magnesium |
-
2006
- 2006-05-03 ES ES06765662T patent/ES2304911T3/es not_active Expired - Lifetime
- 2006-05-03 DK DK06765662.9T patent/DK1879862T3/da active
- 2006-05-03 EP EP06765662A patent/EP1879862B1/en not_active Revoked
- 2006-05-03 PT PT06765662T patent/PT1879862E/pt unknown
- 2006-05-03 DE DE602006019710T patent/DE602006019710D1/de not_active Expired - Lifetime
- 2006-05-03 WO PCT/IB2006/051396 patent/WO2006117761A2/en not_active Ceased
- 2006-05-03 EP EP08161846A patent/EP2172452A1/en not_active Withdrawn
- 2006-05-03 US US11/913,582 patent/US20100222405A1/en not_active Abandoned
- 2006-05-03 AT AT06765662T patent/ATE496025T1/de active
-
2007
- 2007-11-30 NO NO20076191A patent/NO20076191L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006117761A2 (en) | 2006-11-09 |
| EP1879862A2 (en) | 2008-01-23 |
| NO20076191L (no) | 2008-01-30 |
| DE602006019710D1 (de) | 2011-03-03 |
| ES2304911T3 (es) | 2011-05-30 |
| ATE496025T1 (de) | 2011-02-15 |
| PT1879862E (pt) | 2011-04-19 |
| WO2006117761A3 (en) | 2007-03-29 |
| US20100222405A1 (en) | 2010-09-02 |
| EP1879862B1 (en) | 2011-01-19 |
| EP2172452A1 (en) | 2010-04-07 |
| ES2304911T1 (es) | 2008-11-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE602006010243D1 (de) | 4-(Phenylamino)-6-oxo-1,6-dihydropyridazine-3-carboxamid Derivate als MEK Inhibitoren zur Behandlung von hyperproliferativen Erkrankungen | |
| WO2007138282A3 (en) | Bi-aryl or aryl-heteroaryl substituted indoles | |
| WO2012002741A3 (en) | Process for the preparation of hmg-coa reductase inhibitors and intermediates thereof | |
| WO2007079199A3 (en) | Substituted bis-amide metalloprotease inhibitors | |
| WO2008011557A3 (en) | Heteroaryl inhibitors of rho kinase | |
| EA201100311A1 (ru) | Амидные производные гетероарилов и их применение в качестве активаторов глюкокиназы | |
| CY1112402T1 (el) | Ενισχυτες υποδοχεων γλουταμικου | |
| BRPI0711889B8 (pt) | método para produção de sinvastatina, composição de matéria, método para fabricação de huvastatina, método para fabricação de sinvastatina, e método para fabricação de uma composição de matéria de sinvastatina ou huvastatina | |
| WO2006123113A3 (en) | Pyrazolylaminopyrimidine derivatives useful as tyrosine kinase inhibitors | |
| DK1578733T3 (da) | Fremgangsmåde til fremstilling af rosuvastatin | |
| EA200801025A1 (ru) | Композиция и синтез новых реагентов для ингибирования репликации вич | |
| SG166829A1 (en) | Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt | |
| WO2007079214A3 (en) | Prokineticin 2 receptor antagonists | |
| DK2363130T3 (da) | Kombination af HMG-CoA reduktaseinhibitorer atorvastatin eller simvastatin med en phosphodiesterase 4-inhibitor, såsom roflumilast til behandlingen af inflammatorisk pulmonære sygdomme | |
| NO20043919L (no) | Fremgangsmate for fremstilling av HMG-COA reduktaseinhiberende mevalonsyrederivater | |
| NO20076191L (no) | Magnesiumsalter av HMG-COA reduktaseinhibitorer | |
| NO20081617L (no) | Metoder for fremstilling av Glutaminsyrederivater | |
| EA200601678A1 (ru) | Новые имидазолы | |
| WO2008010087A3 (en) | Polymorphic forms of an hmg-coa reductase inhibitor and uses thereof | |
| EA201170822A1 (ru) | Стереоселективный синтез производных пиперидина | |
| UY28653A1 (es) | N-alquil pirroles como inhibidores de la hmg-coa reductasa | |
| IL186499A (en) | Processes for the preparation of a crystalline form of atorostatin mycelium | |
| DK1723140T3 (da) | Fremgangsmåde til fremstilling af tryptase-inhibitorer | |
| EA200801666A1 (ru) | КОМБИНАЦИЯ ПРОИЗВОДНЫХ ТРИАЗИНА И ИНГИБИТОРОВ HMG-CoA РЕДУКТАЗЫ | |
| ZA200804664B (en) | Process for (3R, 5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt |