DK1891961T3 - Anvendelse af 5'-methylthioadenosin (MTA) i forebyggelsen og/eller behandling af autoimmune sygdomme og/eller transplantatafstödning - Google Patents

Anvendelse af 5'-methylthioadenosin (MTA) i forebyggelsen og/eller behandling af autoimmune sygdomme og/eller transplantatafstödning

Info

Publication number: DK1891961T3
Authority: DK; Denmark
Prior art keywords: prevention; treatment; methylthioadenosine; mta; autoimmune diseases
Prior art date: 2005-03-17

Application number

DK05728461T

Other languages

English (en)

Inventor

Garcia-Trevijano Elena Ruiz

Diaz Pablo Villoslada

Zaragoza Matyas Avila

Bruna Beatriz Moreno

Izquierdo Fernando Corrales

Lasarte Carmen Berasain

Original Assignee

Proyecto Biomedicina Cima Sl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-03-17

Filing date

2005-03-17

Publication date

2009-12-21

2005-03-17 Application filed by Proyecto Biomedicina Cima Sl filed Critical Proyecto Biomedicina Cima Sl

2009-12-21 Application granted granted Critical

2009-12-21 Publication of DK1891961T3 publication Critical patent/DK1891961T3/da

Links

WUUGFSXJNOTRMR-IOSLPCCCSA-N 5'-S-methyl-5'-thioadenosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CSC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 WUUGFSXJNOTRMR-IOSLPCCCSA-N 0.000 title abstract 4
230000002265 prevention Effects 0.000 title abstract 3
208000023275 Autoimmune disease Diseases 0.000 title abstract 2
206010052779 Transplant rejections Diseases 0.000 title abstract 2
201000006417 multiple sclerosis Diseases 0.000 abstract 2
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Neurology (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

DK05728461T 2005-03-17 2005-03-17 Anvendelse af 5'-methylthioadenosin (MTA) i forebyggelsen og/eller behandling af autoimmune sygdomme og/eller transplantatafstödning DK1891961T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/ES2005/000139 WO2006097547A1 (es)	2005-03-17	2005-03-17	Empleo de 5'-metiltioadenosina (mta) en la prevención y/o tratamiento de enfermedades autoinmunes y/o rechazo de transplantes

Publications (1)

Publication Number	Publication Date
DK1891961T3 true DK1891961T3 (da)	2009-12-21

Family

ID=36991307

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK05728461T DK1891961T3 (da)	2005-03-17	2005-03-17	Anvendelse af 5'-methylthioadenosin (MTA) i forebyggelsen og/eller behandling af autoimmune sygdomme og/eller transplantatafstödning

Country Status (19)

Country	Link
US (1)	US7820637B2 (da)
EP (1)	EP1891961B1 (da)
JP (1)	JP2008533107A (da)
CN (1)	CN101141970A (da)
AT (1)	ATE442854T1 (da)
AU (1)	AU2005329287B2 (da)
BR (1)	BRPI0520129A2 (da)
CA (1)	CA2601557A1 (da)
CY (1)	CY1109539T1 (da)
DE (1)	DE602005016729D1 (da)
DK (1)	DK1891961T3 (da)
ES (1)	ES2334924T3 (da)
HR (1)	HRP20090646T1 (da)
MX (1)	MX2007011327A (da)
PL (1)	PL1891961T3 (da)
PT (1)	PT1891961E (da)
RS (1)	RS51122B (da)
SI (1)	SI1891961T1 (da)
WO (1)	WO2006097547A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2329327B1 (es) *	2008-03-19	2010-09-17	Proyecto De Biomedicina Cima, S.L.	Combinaciones sinergicas de 5'-metiltioadenosina.
EP2441459A1 (en) *	2009-06-11	2012-04-18	Proyecto de Biomedicina Cima, S.L.	5'-methylthioadenosine neuroprotective properties
WO2011054990A2 (es) *	2009-11-05	2011-05-12	Proyecto De Biomedicina Cima, S.L.	Composiciones para la inhibición y/o bloqueo de la transición epitelial-mesenquimal
JP5801572B2 (ja) *	2011-03-03	2015-10-28	シーシーアイ株式会社	ＰＰＡＲγ活性化剤
CN105125571B (zh) *	2015-07-17	2018-11-06	四川大学	Prmt1抑制剂在制备治疗可卡因成瘾的药物中的用途
WO2020206299A1 (en)	2019-04-05	2020-10-08	Prelude Therapeutics, Incorporated	Selective inhibitors of protein arginine methyltransferase 5
WO2020206289A1 (en) *	2019-04-05	2020-10-08	Prelude Therapeutics, Incorporated	Selective inhibitors of protein arginine methyltransferase 5
CN114515294A (zh)	2022-02-25	2022-05-20	浙江中医药大学	5’-甲基硫代腺苷在制备肥胖抑制药物或保健品中的应用
CN117122689A (zh) *	2023-09-12	2023-11-28	四川省医学科学院·四川省人民医院	Mta在制备治疗急性葡萄膜炎药物中的应用
CN118141910B (zh) *	2024-04-03	2025-10-28	河北医科大学	甲基转移酶抑制剂作为呼吸道合胞病毒疫苗及过敏疫苗佐剂的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1193529B (it) *	1980-04-22	1988-07-08	Bioresearch Srl	Derivati adenosinici ad attivita' antinfiammatoria ed analgesica e composizioni terapeutiche che li contengono come principio attivo
IT1227049B (it) *	1988-07-29	1991-03-14	Bioresearch Spa	Impiego di derivati adenosinici per la preparazione di composizioni farmaceutiche aventi attivita' immunostimolante.
DE69729887T2 (de)	1996-10-16	2005-07-28	ICN Pharmaceuticals, Inc., Costa Mesa	Purin-L-Nukleoside, Analoga und deren Verwendung
ES2237850T3 (es) *	1997-10-14	2005-08-01	Mitsubishi Pharma Corporation	Compuestos de piperazina y su uso medicinal.
TW466112B (en)	1998-04-14	2001-12-01	Lilly Co Eli	Novel use of 2'-deoxy-2',2'-difluorocytidine for immunosuppressive therapy and pharmaceutical composition comprising the same
JP2001072660A (ja) *	1999-09-08	2001-03-21	Welfide Corp	ＴＮＦ−α産生抑制剤および／またはＩＬ−１０産生促進剤
AU2700301A (en) *	2000-01-31	2001-08-14	Pfizer Products Inc.	Pyrimidine carboxamides useful as inhibitors of pde4 isozymes
WO2001066518A1 (en) *	2000-03-09	2001-09-13	Ono Pharmaceutical Co., Ltd.	φ-SUBSTITUTED PHENYL-PROSTAGLANDIN E-ALCOHOLS, PROCESS FOR PRODUCING THE SAME AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT
WO2003028712A2 (en) *	2001-09-28	2003-04-10	Universite Libre De Bruxelles	Purinergic and pyrimidinergic receptor agonists for the treatment of activated cd4+ t lymphocyte-mediated immune diseases
DE10207843A1 (de) *	2002-02-15	2003-09-04	Schering Ag	Mikrolia-Inhibitoren zur Unterbrechung von Interleukin 12 und IFN-gamma vermittelten Immunreaktionen
IL148736A0 (en) *	2002-03-18	2002-09-12	Pharmos Corp	Dexanabinol and dexanabinol analogs which regulate inflammation related genes

2005
- 2005-03-17 US US11/908,697 patent/US7820637B2/en not_active Expired - Fee Related
- 2005-03-17 WO PCT/ES2005/000139 patent/WO2006097547A1/es not_active Ceased
- 2005-03-17 DE DE602005016729T patent/DE602005016729D1/de not_active Expired - Lifetime
- 2005-03-17 RS RSP-2009/0549A patent/RS51122B/sr unknown
- 2005-03-17 HR HR20090646T patent/HRP20090646T1/hr unknown
- 2005-03-17 PL PL05728461T patent/PL1891961T3/pl unknown
- 2005-03-17 AU AU2005329287A patent/AU2005329287B2/en not_active Ceased
- 2005-03-17 PT PT05728461T patent/PT1891961E/pt unknown
- 2005-03-17 CA CA002601557A patent/CA2601557A1/en not_active Abandoned
- 2005-03-17 SI SI200530844T patent/SI1891961T1/sl unknown
- 2005-03-17 AT AT05728461T patent/ATE442854T1/de active
- 2005-03-17 MX MX2007011327A patent/MX2007011327A/es active IP Right Grant
- 2005-03-17 EP EP05728461A patent/EP1891961B1/en not_active Expired - Lifetime
- 2005-03-17 ES ES05728461T patent/ES2334924T3/es not_active Expired - Lifetime
- 2005-03-17 CN CNA2005800491430A patent/CN101141970A/zh active Pending
- 2005-03-17 JP JP2008501337A patent/JP2008533107A/ja not_active Ceased
- 2005-03-17 DK DK05728461T patent/DK1891961T3/da active
- 2005-03-17 BR BRPI0520129-2A patent/BRPI0520129A2/pt not_active IP Right Cessation
2009
- 2009-12-02 CY CY20091101268T patent/CY1109539T1/el unknown

Also Published As

Publication number	Publication date
MX2007011327A (es)	2008-01-28
EP1891961A1 (en)	2008-02-27
SI1891961T1 (sl)	2010-01-29
ATE442854T1 (de)	2009-10-15
CY1109539T1 (el)	2014-08-13
PL1891961T3 (pl)	2010-02-26
US20090042831A1 (en)	2009-02-12
RS51122B (sr)	2010-10-31
PT1891961E (pt)	2009-12-17
DE602005016729D1 (de)	2009-10-29
JP2008533107A (ja)	2008-08-21
BRPI0520129A2 (pt)	2009-04-28
ES2334924T3 (es)	2010-03-17
EP1891961B1 (en)	2009-09-16
CN101141970A (zh)	2008-03-12
AU2005329287B2 (en)	2011-01-27
HRP20090646T1 (hr)	2010-01-31
AU2005329287A1 (en)	2006-09-21
US7820637B2 (en)	2010-10-26
CA2601557A1 (en)	2006-09-21
WO2006097547A1 (es)	2006-09-21

Publication	Publication Date	Title
CY1109539T1 (el)	2014-08-13	Χρηση 5'-μεθυλοθειοαδενοσινης (μτα) στην προληψη και/η θεραπεια αυτοανοσων νοσων και/η απορριψης μοσχευματων
BR0311285A (pt)	2007-04-27	composições e processos para revestimento de implantes médicos
NO20064547L (no)	2006-10-06	Fremgangsmater for behandling av HIV infeksjon
CY1116107T1 (el)	2017-02-08	Ενωσεις για χρηση στην αγωγη αυτοανοσων παθησεων, ανοσο-αλλεργικων παθησεων και απορριψης μεταμοσχευσης οργανων ή ιστων
WO2002064096A3 (en)	2003-03-06	Methods of using pyrimidine-based antiviral agents
DK1539166T3 (da)	2008-10-20	Farmaceutiske sammensætninger indeholdende dextromethorphan og quinidin til behandling af neurologiske sygdomme
ATE407967T1 (de)	2008-09-15	Nukleierungsmittel
DK2026803T3 (da)	2012-04-16	Sammensætninger af R(+) og S(-) pramipexol og fremgangsmåder til anvendelse heraf
DK1656372T3 (da)	2013-07-01	2,4-pyrimidindiaminforbindelser til anvendelse til behandling eller forebyggelse af autoimmunsygdomme
WO2007037849A3 (en)	2008-01-24	Compositions and methods for the intraocular transport of therapeutic agents
DK1594833T3 (da)	2008-12-15	1-phenylalkancarboxylsyrederivater til behandling af neurodegenerative sygdomme
HRP20090498T1 (hr)	2009-10-31	Kombinacija r,r-glikopirolata, roliprama i budesonida za liječenje upalnih oboljenja
PT1560812E (pt)	2006-09-29	Compostos de aminociclohexil eter e suas utilizacoes
DK1545537T3 (da)	2007-07-02	Alfa-7-nikotinreceptoragonister og statiner i kombination
IL181909A0 (en)	2007-07-04	Phosphoindoles as hiv inhibitors
DK1855677T3 (da)	2009-02-09	3,11 B-CIS-dihydrotetrabanezin til behandling af skizofreni og andre psykoser
WO2006034001A3 (en)	2006-11-23	Methods of treating hiv infection
CY1111762T1 (el)	2015-10-07	Διενυδρη παμοϊκη ολανζαπiνη
ATE554753T1 (de)	2012-05-15	2,2'-dithio-bis(ethansulfonat) für den einsatz zur hemmung paclitaxel-induzierter abnormer thermoesthesia
DK1372669T3 (da)	2005-10-17	Bisphosphonatholding sammensætning til forebyggelse og/eller behandling af metaboliske knoglesygdomme, fremgangsmåde til fremstilling af sådanne sammensætninger og anvendelse deraf
EA200601855A1 (ru)	2007-04-27	Гербицидоактивные 3-амино-2-тиометилбензоилпиразолы
DE602004013011D1 (de)	2008-05-21	Haarbehandlungszusammensetzungen
DK1606233T3 (da)	2006-09-18	Phospholipidestere af Clofarabin
NO20074313L (no)	2007-10-17	Preparater for kontrollert frigjoring omfattende et antipsykotisk middel
WO2006079121A3 (en)	2006-10-19	Methods of treating disease with glycosylated interferon