DK189786A - 4-aminoalkylidensubstituerede 3-aryl-5(4h)-isoxazoloner, fremgangsmaader til fremstilling deraf, samt laegemidler indeholdende disse forbindelser og deres anvendelse - Google Patents
4-aminoalkylidensubstituerede 3-aryl-5(4h)-isoxazoloner, fremgangsmaader til fremstilling deraf, samt laegemidler indeholdende disse forbindelser og deres anvendelse Download PDFInfo
- Publication number
- DK189786A DK189786A DK189786A DK189786A DK189786A DK 189786 A DK189786 A DK 189786A DK 189786 A DK189786 A DK 189786A DK 189786 A DK189786 A DK 189786A DK 189786 A DK189786 A DK 189786A
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- substituted
- aminoalkylidene
- isoxazolones
- aryl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title description 3
- 239000003814 drug Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 5
- 229910052736 halogen Inorganic materials 0.000 description 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 4
- 125000003545 alkoxy group Chemical group 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- 125000004433 nitrogen atom Chemical group N* 0.000 description 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 2
- 125000005843 halogen group Chemical group 0.000 description 2
- 150000002367 halogens Chemical class 0.000 description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 description 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 125000002619 bicyclic group Chemical group 0.000 description 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 1
- 125000000490 cinnamyl group Chemical group C(C=CC1=CC=CC=C1)* 0.000 description 1
- 208000010877 cognitive disease Diseases 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Description
g 7
hvor R betyder hydrogen eller Cj^-alkyl, og R
betyder C1-4-alkyl eller phenyl-(Cj^)-alkyl, eller hvor R® og R^ tilsammen danner en alkylenkæde med 3 til 7 methylengrupper, som eventuelt er substitueret med C1_4-alkyl eller phenyl, som eventuelt er substitueret med C^_4-alkyl, C^_4~alkoxy, halogen, nitro eller trifluormethyl, eller hvor en CH2“gruppe eventuelt
Q Q
er erstattet med 0, S eller N-R , hvor R betyder hydrogen, Cj^-alkyl eller phenyl, som eventuelt er substitueret med C^_4-alkyl, C^_4~alkoxy, halogen, nitro eller trifluormethyl, eller R3 og R4 sammen med ' nitrogenatomet danner en mættet eller umættet, monoeller bicyclisk ring med ialt 4 til 10 ringled, der foruden nitrogenatornet som yderligere heteroatom kan indeholde et oxygenatom, et svovlatom eller et nitrogenatom, og som eventuelt er substitueret med C^_4~alkyl,
Cj_4-alkoxycarbonyl, carbamoyl, cinnamyl, phenyl, som eventuelt kan være substitueret med halogen, C1_4-alkyl, C1_4-alkoxy eller trifluormethyl, eller roed gruppen -(CH,) -CH3 R9m, hvor y er 0 til 3, m er A “ 1 eller 2, og R7 er en phenylgruppe, som kan være substitueret med halogen, C^_4-alkyl, C^_4-alkoxy eller trifluormethyl, med undtagelse af forbindelser, hvor R^ 2 3 4 og R betyder hydrogen, og R og R betyder methyl, samt fysiologisk acceptable syreadditionssalte kan fremstilles på flere måder.
Forbindelserne (I) er anvendelige til behandling af cognitive dysfunktioner.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853515093 DE3515093A1 (de) | 1985-04-26 | 1985-04-26 | 4-aminoalkylidensubstituierte 3-aryl-5(4h)-isoxazolone, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
| DE3515093 | 1985-04-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK189786D0 DK189786D0 (da) | 1986-04-24 |
| DK189786A true DK189786A (da) | 1986-10-27 |
Family
ID=6269184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK189786A DK189786A (da) | 1985-04-26 | 1986-04-24 | 4-aminoalkylidensubstituerede 3-aryl-5(4h)-isoxazoloner, fremgangsmaader til fremstilling deraf, samt laegemidler indeholdende disse forbindelser og deres anvendelse |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0199323A3 (da) |
| JP (1) | JPS61251674A (da) |
| KR (1) | KR860008171A (da) |
| AU (1) | AU5671486A (da) |
| DE (1) | DE3515093A1 (da) |
| DK (1) | DK189786A (da) |
| ES (1) | ES8704484A1 (da) |
| FI (1) | FI861729A7 (da) |
| GR (1) | GR861100B (da) |
| HU (1) | HU194193B (da) |
| IL (1) | IL78616A0 (da) |
| PT (1) | PT82454B (da) |
| ZA (1) | ZA863112B (da) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5021439A (en) * | 1988-10-31 | 1991-06-04 | Takeda Chemical Industries, Ltd. | Cerebral function ameliorating agents related to Tan-950 A |
| ATE148462T1 (de) * | 1991-03-28 | 1997-02-15 | Givaudan Roure Int | Isoxazole derivate als lichtschutzmittel |
| GB2274282B (en) * | 1993-01-19 | 1996-08-14 | Erba Carlo Spa | Piperazine-and piperidine-isoxazole derivatives |
-
1985
- 1985-04-26 DE DE19853515093 patent/DE3515093A1/de not_active Withdrawn
-
1986
- 1986-04-21 EP EP86105468A patent/EP0199323A3/de not_active Withdrawn
- 1986-04-24 PT PT82454A patent/PT82454B/pt unknown
- 1986-04-24 AU AU56714/86A patent/AU5671486A/en not_active Abandoned
- 1986-04-24 HU HU861710A patent/HU194193B/hu unknown
- 1986-04-24 ES ES554312A patent/ES8704484A1/es not_active Expired
- 1986-04-24 FI FI861729A patent/FI861729A7/fi not_active Application Discontinuation
- 1986-04-24 DK DK189786A patent/DK189786A/da not_active Application Discontinuation
- 1986-04-25 KR KR1019860003198A patent/KR860008171A/ko not_active Withdrawn
- 1986-04-25 IL IL78616A patent/IL78616A0/xx unknown
- 1986-04-25 JP JP61094974A patent/JPS61251674A/ja active Pending
- 1986-04-25 GR GR861100A patent/GR861100B/el unknown
- 1986-04-25 ZA ZA863112A patent/ZA863112B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU194193B (en) | 1988-01-28 |
| ES8704484A1 (es) | 1987-04-01 |
| DK189786D0 (da) | 1986-04-24 |
| GR861100B (en) | 1986-08-19 |
| PT82454A (de) | 1986-05-01 |
| HUT41749A (en) | 1987-05-28 |
| ES554312A0 (es) | 1987-04-01 |
| FI861729A0 (fi) | 1986-04-24 |
| EP0199323A2 (de) | 1986-10-29 |
| AU5671486A (en) | 1986-10-30 |
| JPS61251674A (ja) | 1986-11-08 |
| IL78616A0 (en) | 1986-08-31 |
| EP0199323A3 (de) | 1987-10-28 |
| KR860008171A (ko) | 1986-11-12 |
| ZA863112B (en) | 1987-06-24 |
| DE3515093A1 (de) | 1986-10-30 |
| PT82454B (de) | 1988-04-29 |
| FI861729A7 (fi) | 1986-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ATS | Application withdrawn |