DK18984A - 1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-carboxylsyrer - Google Patents

1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-carboxylsyrer Download PDF

Info

Publication number: DK18984A
Authority: DK; Denmark
Prior art keywords: pyrrolo; pyrrole; dihydro; carboxylic acids; vinyl
Prior art date: 1983-01-17

Application number

DK18984A

Other languages

English (en)

Other versions

DK18984D0 (da

Inventor

Joseph M Muchowski

Stefan H Unger

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-01-17

Filing date

1984-01-16

Publication date

1984-07-18

1984-01-16 Application filed by Syntex Inc filed Critical Syntex Inc

1984-01-16 Publication of DK18984D0 publication Critical patent/DK18984D0/da

1984-07-18 Publication of DK18984A publication Critical patent/DK18984A/da

Links

MAPSJTFQCGOIJY-UHFFFAOYSA-N 2,3-dihydro-1h-pyrrolizine-1-carboxylic acid Chemical class C1=CC=C2C(C(=O)O)CCN21 MAPSJTFQCGOIJY-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract description 3
150000003839 salts Chemical class 0.000 abstract description 3
125000005907 alkyl ester group Chemical group 0.000 abstract 1
HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Chemical group C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
229920002554 vinyl polymer Polymers 0.000 abstract 1
239000002253 acid Substances 0.000 description 1
229940035676 analgesics Drugs 0.000 description 1
239000000730 antalgic agent Substances 0.000 description 1
229940121363 anti-inflammatory agent Drugs 0.000 description 1
239000002260 anti-inflammatory agent Substances 0.000 description 1
229940127218 antiplatelet drug Drugs 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
125000000753 cycloalkyl group Chemical group 0.000 description 1
125000004185 ester group Chemical group 0.000 description 1
230000032050 esterification Effects 0.000 description 1
238000005886 esterification reaction Methods 0.000 description 1
230000003480 fibrinolytic effect Effects 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 1
239000000106 platelet aggregation inhibitor Substances 0.000 description 1
238000009938 salting Methods 0.000 description 1
239000000050 smooth muscle relaxant Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

Description

med forbindelser

2 3 4 hvor R betegner C.j_g-alkyl, og X betegner Cl, Br eller NR R , 3 4 hvor R og R uafhængigt af hinanden betegner lavere alkyl, cyclo-alkyl eller morpholino, hvorefter der fakultativt udføres hydrolyse af en estergruppe, esterificering af en carboxygruppe, saltdannelse, frigørelse af en syre fra et salt eller omsaltning.

De hidtil ukendte forbindelser kan anvendes som anti-inflammatoriske midler, som analgetika, som blodpladeaggregationshæmmere, som fi-brinoiytika eller som relaxanter for glat muskulatur.

DK18984A 1983-01-17 1984-01-16 1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-carboxylsyrer DK18984A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/458,243 US4560699A (en)	1983-01-17	1983-01-17	5-(4-Vinylbenzoyl)-1,2-dihydro-3H-pyrrolo-[1,2-a]-pyrrole-1-carboxylic acids and derivatives thereof and use as analgesics and anti-inflammatories
US45824383		1983-01-17

Publications (2)

Publication Number	Publication Date
DK18984D0 DK18984D0 (da)	1984-01-16
DK18984A true DK18984A (da)	1984-07-18

Family

ID=23819967

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK18984A DK18984A (da)	1983-01-17	1984-01-16	1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-carboxylsyrer

Country Status (15)

Country	Link
US (1)	US4560699A (da)
EP (1)	EP0114632B1 (da)
JP (1)	JPS59137483A (da)
KR (1)	KR840007413A (da)
AT (1)	ATE29721T1 (da)
AU (1)	AU558271B2 (da)
CA (1)	CA1229088A (da)
DE (1)	DE3466219D1 (da)
DK (1)	DK18984A (da)
FI (1)	FI78698C (da)
HU (1)	HU190543B (da)
IL (1)	IL70691A (da)
NO (1)	NO161675C (da)
NZ (1)	NZ206839A (da)
ZA (1)	ZA84326B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4849526A (en) *	1987-01-14	1989-07-18	Syntex (U.S.A.) Inc.	Process for preparing (±)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
US4874872A (en) *	1987-01-14	1989-10-17	Syntex (U.S.A.) Inc.	Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-A]pyrrole-1,7-dicarboxylates
HU198927B (en) *	1987-01-14	1989-12-28	Richter Gedeon Vegyeszet	Process for producing 1-/substituted aminomethyl/-octa-hydroindolo-(2,3-a)quinolizine derivatives, pharmaceutically applicable acid addition salts thereof, as well as pharmaceutical compositions comprising same
US4835288A (en) *	1987-01-14	1989-05-30	Syntex Inc.	Process for preparing (+)-2,3-dihydro-1H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylates
US5260451A (en) *	1989-05-11	1993-11-09	Merckle Gmbh	Substituted pyrrole compounds and use thereof in pharmaceutical compositions
DE4338770A1 (de) *	1993-11-12	1995-05-18	Matthias Dr Lehr	Indol-2-alkansäuren und ihre Derivate als Hemmstoffe der Phospholipase A¶2¶
KR0140134B1 (ko) *	1994-11-16	1998-06-01	강재헌	피롤리진 유도체의 제조방법
ES2449194T3 (es) *	2000-01-19	2014-03-18	Cadila Healthcare Limited	Compuestos que tienen actividades hipolipidémica e hipocolesterolémica, procedimiento para su preparación y composiciones farmacéuticas que los contienen
DE10004157A1 (de)	2000-02-01	2001-08-02	Merckle Gmbh Chem Pharm Fabrik	4-Pyridyl-und 2,4-Pyrimidinyl-substituierte Pyrrolderivate und ihre Anwendung in der Pharmazie

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4089969A (en) *	1976-07-14	1978-05-16	Syntex (U.S.A.) Inc.	5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof
JPS584711B2 (ja) *	1978-08-02	1983-01-27	参天製薬株式会社	ピロリジン誘導体
US4347186A (en) *	1980-10-20	1982-08-31	Syntex (U.S.A.) Inc.	Process for preparing 5-aroyl 1,2-dihydro-3-H pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein
US4347185A (en) *	1980-10-20	1982-08-31	Syntex (U.S.A.) Inc.	Processes for preparing 5-benzoyl-7-halo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids
US4353829A (en) *	1980-11-21	1982-10-12	Syntex (U.S.A.) Inc.	Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
US4612325A (en) *	1982-06-08	1986-09-16	Syntex (U.S.A) Inc.	5-Aroyl-6-alkylthio-1,2-dihydro-3H-pyrrolo(1,2-A)pyrrole-1-carboxylic acids and use thereof as analgesics and anti-inflammatories

1983
- 1983-01-17 US US06/458,243 patent/US4560699A/en not_active Expired - Fee Related
1984
- 1984-01-14 JP JP59005500A patent/JPS59137483A/ja active Pending
- 1984-01-16 DE DE8484100393T patent/DE3466219D1/de not_active Expired
- 1984-01-16 NO NO840145A patent/NO161675C/no unknown
- 1984-01-16 AT AT84100393T patent/ATE29721T1/de not_active IP Right Cessation
- 1984-01-16 ZA ZA84326A patent/ZA84326B/xx unknown
- 1984-01-16 DK DK18984A patent/DK18984A/da not_active Application Discontinuation
- 1984-01-16 NZ NZ206839A patent/NZ206839A/en unknown
- 1984-01-16 KR KR1019840000149A patent/KR840007413A/ko not_active Ceased
- 1984-01-16 FI FI840153A patent/FI78698C/fi not_active IP Right Cessation
- 1984-01-16 CA CA000445355A patent/CA1229088A/en not_active Expired
- 1984-01-16 HU HU84151A patent/HU190543B/hu unknown
- 1984-01-16 IL IL70691A patent/IL70691A/xx not_active IP Right Cessation
- 1984-01-16 EP EP84100393A patent/EP0114632B1/en not_active Expired
- 1984-01-16 AU AU23518/84A patent/AU558271B2/en not_active Ceased

Also Published As

Publication number	Publication date
FI840153L (fi)	1984-07-18
ZA84326B (en)	1985-09-25
AU2351884A (en)	1984-07-19
DE3466219D1 (en)	1987-10-22
NO161675C (no)	1989-09-13
IL70691A (en)	1986-08-31
ATE29721T1 (de)	1987-10-15
AU558271B2 (en)	1987-01-22
EP0114632B1 (en)	1987-09-16
CA1229088A (en)	1987-11-10
EP0114632A1 (en)	1984-08-01
JPS59137483A (ja)	1984-08-07
FI78698B (fi)	1989-05-31
KR840007413A (ko)	1984-12-07
NO840145L (no)	1984-07-18
FI840153A0 (fi)	1984-01-16
HU190543B (en)	1986-09-29
IL70691A0 (en)	1984-04-30
US4560699A (en)	1985-12-24
NO161675B (no)	1989-06-05
NZ206839A (en)	1987-09-30
DK18984D0 (da)	1984-01-16
FI78698C (fi)	1989-09-11

Legal Events

Date	Code	Title	Description
1989-09-11	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
RU2217431C2 (ru)	2003-11-27	Тиенопиримидины, способ их получения, фармацевтическая композиция, обладающая действием ингибиторов фосфодиэстеразы v
DK18984A (da)	1984-07-18	1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-carboxylsyrer
DE3369972D1 (en)	1987-04-09	Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids, their preparation and use
KR930000514A (ko)	1993-01-15	7-아자이소인돌리닐-퀴놀론- 및 -나프티리돈카르복실산 유도체
ATE36517T1 (de)	1988-09-15	Optisch aktive alpha-substituierte arylketone, verfahren zu ihrer herstellung und ihre anwendung in der herstellung von alphaarylalkancarbons\|uren.
YU43235B (en)	1989-06-30	Process for preparing 6-chloro-or 6-bromo-1,2-dihydro-3h-pyrrolo(1,2-a)pyrrol-1-carboxylic acid and alkyl esthers thereoff
DE3165209D1 (en)	1984-09-06	2-substituted-4-hydroxy-3-quinolinecarboxylic acids, their preparation, their use as medicaments, compositions containing them and intermediates
SE7903976L (sv)	1979-11-10	Nya purinderivat anvendbara sasom icke-adrenenergiska bronkodilatorer
YU45810B (sh)	1992-07-20	Postupak za dobijanje hinolin karboksilnih kiselina
JPS57109754A (en)	1982-07-08	N-benzoyl-omega-anilinoalkane carboxylic acid compound
JPS5758668A (en)	1982-04-08	Manufacture of quinoline, naphthyridine and other nitrogen-bi-heterocyclic compound
ATE29141T1 (de)	1987-09-15	Epoxidharz-diammoniumsalz-emulsion und verfahren zu ihrer herstellung.
ATE15040T1 (de)	1985-09-15	Verbessertes verfahren zur herstellung von 1hpyrrol-2-essigsaeureestern.
JPS5289695A (en)	1977-07-27	Novel 7alpha-methoxycephalosporins and preparation thereof
GR80358B (en)	1985-01-11	Substituted pyrido (1,2-c) imidazo (1,2-a) benzimidazole, method for the preparation thereof, the use thereof, pharmaceutical preparations based on said compounds
ES8704971A1 (es)	1987-04-16	Procedimiento para preparar triesteres de acido corticosteroidefosforico
SE7710933L (sv)	1978-03-31	5-alkoxi-pikolinsyror
YU42307B (en)	1988-08-31	Process for preparing imidazo (1,2-a)imidazoles
FI803887L (fi)	1981-06-15	Nya substituerade 2-fenylamino-imidazoliner-(2) deras syraadditionssalter dessa innehaollande laekemedel och deras framstaellningsfoerfarande
FI803969L (fi)	1981-06-22	Nya substituerade 2-fenylamino-imidazoliner-(2) deras syraadditionssalter dessa innehaollande laekemedel och foerfarande foer deras framstaellning
IE42992L (en)	1977-01-10	PYRIMIDO [1,2-a] QUINOLINE DERIVATIVES
SE7707418L (sv)	1977-12-29	Nya svavelhaltiga n-bensylaminosyror och forfarande for framstellning derav
JPS6432254A (en)	1989-02-02	Recording material
JPS5474845A (en)	1979-06-15	Halogen-containing resin composition having improved processability
JPS5373566A (en)	1978-06-30	7,8,9,10,-tetrahydrophenanthridone-3-acetic acids