DK190179A - Analogifremgangsmaade til fremstilling af neuroleptisk aktive xanthen-og thioxanthenderivater - Google Patents

Analogifremgangsmaade til fremstilling af neuroleptisk aktive xanthen-og thioxanthenderivater

Info

Publication number: DK190179A
Authority: DK; Denmark
Prior art keywords: group; groups; effects; formula; carbon atoms
Prior art date: 1978-05-12

Application number

DK190179A

Other languages

Danish (da)

English (en)

Inventor

N Larsen

K P Boegesoe

P B Hansen

J L M Buus

A J Bigler

Original Assignee

Kefalas As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-05-12

Filing date

1979-05-09

Publication date

1979-11-13

1979-05-09 Application filed by Kefalas As filed Critical Kefalas As

1979-11-13 Publication of DK190179A publication Critical patent/DK190179A/da

Links

230000000701 neuroleptic effect Effects 0.000 title abstract 2
PQJUJGAVDBINPI-UHFFFAOYSA-N 9H-thioxanthene Chemical class C1=CC=C2CC3=CC=CC=C3SC2=C1 PQJUJGAVDBINPI-UHFFFAOYSA-N 0.000 title 1
GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 title 1
229940054058 antipsychotic thioxanthene derivative Drugs 0.000 title 1
QDLAGTHXVHQKRE-UHFFFAOYSA-N lichenxanthone Natural products COC1=CC(O)=C2C(=O)C3=C(C)C=C(OC)C=C3OC2=C1 QDLAGTHXVHQKRE-UHFFFAOYSA-N 0.000 title 1
239000003176 neuroleptic agent Substances 0.000 title 1
-1 dimethylsulphamoyl group Chemical group 0.000 abstract 4
125000004432 carbon atom Chemical group C* 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
125000004043 oxo group Chemical group O=* 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000007059 acute toxicity Effects 0.000 abstract 1
231100000403 acute toxicity Toxicity 0.000 abstract 1
150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 1
230000001078 anti-cholinergic effect Effects 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000011737 fluorine Chemical group 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
230000005923 long-lasting effect Effects 0.000 abstract 1
125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001624 sedative effect Effects 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
RJFHGQWVDZWRTC-UHFFFAOYSA-N thioxanthen-9-one;xanthen-9-one Chemical class C1=CC=C2C(=O)C3=CC=CC=C3OC2=C1.C1=CC=C2C(=O)C3=CC=CC=C3SC2=C1 RJFHGQWVDZWRTC-UHFFFAOYSA-N 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/10—Dibenzothiopyrans; Hydrogenated dibenzothiopyrans
- C07D335/12—Thioxanthenes
- C07D335/14—Thioxanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
- C07D335/18—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Psychiatry (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Polymerisation Methods In General (AREA)
Inks, Pencil-Leads, Or Crayons (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK190179A 1978-05-12 1979-05-09 Analogifremgangsmaade til fremstilling af neuroleptisk aktive xanthen-og thioxanthenderivater DK190179A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB1931078		1978-05-12

Publications (1)

Publication Number	Publication Date
DK190179A true DK190179A (da)	1979-11-13

Family

ID=10127259

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK190179A DK190179A (da)	1978-05-12	1979-05-09	Analogifremgangsmaade til fremstilling af neuroleptisk aktive xanthen-og thioxanthenderivater

Country Status (14)

Country	Link
US (3)	US4285956A (de)
EP (1)	EP0005607B1 (de)
JP (1)	JPS54154772A (de)
AT (1)	ATE5141T1 (de)
AU (1)	AU522926B2 (de)
CA (1)	CA1127648A (de)
DE (1)	DE2966344D1 (de)
DK (1)	DK190179A (de)
ES (1)	ES480468A1 (de)
FI (1)	FI791503A7 (de)
IE (1)	IE48261B1 (de)
NO (1)	NO150837C (de)
NZ (1)	NZ190373A (de)
ZA (1)	ZA792250B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4356184A (en) *	1980-06-04	1982-10-26	G. D. Searle & Co.	Anti-allergic or antihypertensive 1-piperidinylmethyl benzenamines
US4501749A (en) *	1983-10-31	1985-02-26	Merck & Co., Inc.	Peripherally selective dopamine antagonists in the treatment of ocular hypertension
US4777177A (en) *	1984-10-19	1988-10-11	Ciba-Geigy Corporation	Pesticidal thioxanthen-9-ylidenepiperidines
US5393890A (en) *	1988-06-02	1995-02-28	Ajinomoto Co., Inc.	Piperidine derivatives and hypotensives containing the same
US5250681A (en) *	1988-06-02	1993-10-05	Ajinomoto Co., Inc.	Piperidine derivatives and hypotensives containing the same
CA2004211A1 (en) *	1988-11-30	1990-05-31	Masataka Syoji	Piperidine derivatives and hyportensives containing the same
EP1306376A1 (de) *	2001-10-25	2003-05-02	Biofrontera Pharmaceuticals AG	Derivaten von 4-(Thio- oder Selenoxanthen-9-yliden)-Piperidin oder Acridine und ihre Verwendung als selektieven 5-HT2B antagonisten
US7060711B2 (en) *	2001-10-25	2006-06-13	Biofrontera Bioscience Gmbh	Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT2B receptor antagonist
NZ572901A (en) *	2003-06-27	2010-06-25	Janssen Pharmaceutica Nv	Tricyclic delta opioid modulators
US7553850B2 (en) *	2004-08-05	2009-06-30	Janssen Pharmaceutica Nv	Tricyclic-bridged piperidinylidene derivatives as δ-opioid modulators
WO2006069277A1 (en)	2004-12-22	2006-06-29	Janssen Pharmaceutica N.V.	TRICYCLIC δ-OPIOID MODULATORS
CA2592462A1 (en) *	2004-12-22	2006-06-29	Janssen Pharmaceutica N.V.	Tricyclic delta-opioid modulators
EP1833826B1 (de)	2004-12-22	2009-05-27	Janssen Pharmaceutica N.V.	Tricyclische delta-opioid-modulatoren
KR20070104380A (ko) *	2005-01-06	2007-10-25	얀센 파마슈티카 엔.브이.	트리사이클릭 δ-오피오이드 조절제
RU2008101667A (ru) *	2005-06-16	2009-07-27	Янссен Фармацевтика Н.В. (Be)	Трициклические модуляторы опиоидов

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3470188A (en) *	1967-01-05	1969-09-30	Smithkline Corp	9-cycloalkyl-lower alkyl-piperidylidene derivatives of xanthenes and thioxanthenes
US3974285A (en) *	1974-04-10	1976-08-10	Merck & Co., Inc.	10,11-Furo-derivatives of cyproheptadine
US4086350A (en) *	1974-11-06	1978-04-25	Smithkline Corporation	Pharmaceutical compositions and method of producing anti-psychotic activity without extrapyramidal symptoms
US4031222A (en) *	1975-12-22	1977-06-21	Merck & Co., Inc.	Trifluoromethylthio (and sulfonyl) derivatives of cyproheptadine analogs
US4073912A (en) *	1976-10-12	1978-02-14	Smithkline Corporation	Piperidylidene derivatives of benzo-fused xanthenes, thioxanthenes and dibenzoxepins and antipsychotic use thereof

1979
- 1979-05-03 US US06/035,735 patent/US4285956A/en not_active Expired - Lifetime
- 1979-05-04 NZ NZ190373A patent/NZ190373A/xx unknown
- 1979-05-04 AT AT79300778T patent/ATE5141T1/de not_active IP Right Cessation
- 1979-05-04 EP EP79300778A patent/EP0005607B1/de not_active Expired
- 1979-05-04 DE DE7979300778T patent/DE2966344D1/de not_active Expired
- 1979-05-09 ZA ZA792250A patent/ZA792250B/xx unknown
- 1979-05-09 DK DK190179A patent/DK190179A/da unknown
- 1979-05-10 AU AU46941/79A patent/AU522926B2/en not_active Ceased
- 1979-05-10 FI FI791503A patent/FI791503A7/fi not_active Application Discontinuation
- 1979-05-11 NO NO791592A patent/NO150837C/no unknown
- 1979-05-11 CA CA327,464A patent/CA1127648A/en not_active Expired
- 1979-05-11 ES ES480468A patent/ES480468A1/es not_active Expired
- 1979-05-12 JP JP5764079A patent/JPS54154772A/ja active Pending
- 1979-08-08 IE IE1105/79A patent/IE48261B1/en unknown
- 1979-12-21 US US06/106,353 patent/US4275209A/en not_active Expired - Lifetime
- 1979-12-21 US US06/105,985 patent/US4309429A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ZA792250B (en)	1980-08-27
US4285956A (en)	1981-08-25
US4309429A (en)	1982-01-05
IE48261B1 (en)	1984-11-14
US4275209A (en)	1981-06-23
EP0005607B1 (de)	1983-10-26
NZ190373A (en)	1981-12-15
CA1127648A (en)	1982-07-13
FI791503A7 (fi)	1981-01-01
EP0005607A1 (de)	1979-11-28
ES480468A1 (es)	1980-07-01
AU522926B2 (en)	1982-07-01
JPS54154772A (en)	1979-12-06
NO150837B (no)	1984-09-17
NO791592L (no)	1979-11-13
DE2966344D1 (en)	1983-12-01
NO150837C (no)	1985-01-09
IE791105L (en)	1979-11-12
AU4694179A (en)	1979-11-15
ATE5141T1 (de)	1983-11-15

Publication	Publication Date	Title
AU522926B2 (en)	1982-07-01	Xanthone and thioxanthone derivatives
FI863564A0 (fi)	1986-09-04	Foerfarande foer framstaellning av heterocykliskt substituerade indoler.
EA200100755A1 (ru)	2001-12-24	4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты
SE8604950L (sv)	1987-05-20	Demensforbettrande och terapeutiska medel
SE8000920L (sv)	1980-08-10	4-(naftylmetyl)piperidinderivat
ES8700857A1 (es)	1986-11-16	Un procedimiento para la produccion de dihidropiridinas
ES450166A1 (es)	1977-11-16	Procedimiento de preparacion de nuevos derivados de amino- benzociclohepteno.
SE7601206L (sv)	1976-09-19	Acetylenderivat
DK5086A (da)	1986-07-11	Aminoalkylsubstituerede urinstofderivater og enantiomere
GB1114335A (en)	1968-05-22	10-substituted-10,11-dihydrodibenzo[b,f]thiepine-5-oxides and-5,5-dioxides and process for the preparation thereof
NO802925L (no)	1981-04-06	Nitrosoureaderivater og fremgangsmaate ved fremstilling derav
DK155883C (da)	1989-10-09	Analogifremgangsmaade til fremstilling af triazoloquinazolinonderivater
SE7714372L (sv)	1978-06-19	Nya foreningar med farmakologisk aktivitet
SE8301785L (sv)	1984-06-04	Sett att framstella 2-tiofen-ettiksyraderivat och mellanprodukter erforderliga for deras framstellning
SE8005493L (sv)	1981-02-07	4-(haftalenyloxi)piperidin-derivat
ES497635A0 (es)	1981-11-01	Procedimiento para la preparacion de compuestos cefemicos
NZ220294A (en)	1990-07-26	Heteropolycyclic aromatic amines and pharmaceutical compositions thereof
DK58380A (da)	1980-08-13	Fremgangsmaade til fremstilling af thiazolderivater