DK1912640T3 - Anvendelse af hdac-hæmmeren panobinostat til behandling af myelom - Google Patents
Anvendelse af hdac-hæmmeren panobinostat til behandling af myelom Download PDFInfo
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- DK1912640T3 DK1912640T3 DK06789025.1T DK06789025T DK1912640T3 DK 1912640 T3 DK1912640 T3 DK 1912640T3 DK 06789025 T DK06789025 T DK 06789025T DK 1912640 T3 DK1912640 T3 DK 1912640T3
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- myeloma
- combination
- hdac inhibitor
- cells
- iii
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (8)
- ANVENDELSE AF HDAC-HÆMMEREN PANOBINOSTAT TIL BEHANDLING AF MYELOM PATENTKRAV1. Anvendelse af en HDAC-hæmmer til fremstilling af et medikament til behandling af myelom, hvor HDAC-hæmmeren er V-hydroxy-3-[4-[[[2-(2-methyl-l//-indol-3-yl)-cthyl]-amino]mcthyl]phcnyl]-2L'-2-propenamid med formlen (III)(Hl) > eller et farmaceutisk acceptabelt salt deraf, og hvor myelomet er resistent over for traditionel kemoterapi.
- 2. Anvendelse ifølge krav 1, hvor sygdommen er multipelt myelom.
- 3. HDAC-inhibitor, der er A-hydroxy-3-[4-[[[2-(2-methyl-l//-indol-3-yl)-ethyl]- amino]methyl]phenyl]-2£'-2-propenamid med formlen (III)(III) i eller et farmaceutisk acceptabelt salt deraf, til anvendelse i behandlingen af myelom, hvor myelomet er resistent over for traditionel kemoterapi.
- 4. HDAC-hæmmer ifølge krav 3 til anvendelse ifølge krav 3, hvor sygdommen er multipelt myelom.
- 5. Kombination til anvendelse i behandlingen af myelom, hvilken kombination omfatter en HDAC-hæmmer og en forbindelse, der bevirker apoptose af myelomceller, hvori de aktive bestanddele er til stede i hvert tilfælde i fri form eller i form af et farmaceutisk acceptabelt salt og eventuelt mindst én farmaceutisk acceptabel bærer, hvor HD AC-hæmmeren er V-hydroxy-3-[4-[[[2-(2-methyl-lF/-indol-3-yl)-ethyl]-amino]methyl]phenyl]-2ii-2-propenamid med formlen (III)(III) * og hvor forbindelsen, der bevirker apoptose af myelomceller, er bortezomib.
- 6. Kombination ifølge krav 5 til anvendelse ifølge krav 5, hvor anvendelsen er en simultan, separat eller sekventiel anvendelse.
- 7. Kombination ifølge krav 5 til anvendelse ifølge krav 5 eller 6, hvor myelomet er multipelt myelom.
- 8. Farmaceutisk sammensætning omfattende en kvantitet, der sammen er terapeutisk effektiv mod myelom, af en kombination ifølge krav 5 og mindst én farmaceutisk acceptabel bærer, til anvendelse i behandlingen af myelom.
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| US70522605P | 2005-08-03 | 2005-08-03 | |
| PCT/US2006/029801 WO2007019116A1 (en) | 2005-08-03 | 2006-08-01 | Use of hdac inhibitors for the treatment of myeloma |
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| SI (1) | SI1912640T1 (da) |
| WO (1) | WO2007019116A1 (da) |
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| RU2420279C3 (ru) * | 2005-08-03 | 2017-03-14 | Новартис Аг | Применение ингибиторов hdac для лечения миеломы |
| US20100069458A1 (en) * | 2007-02-15 | 2010-03-18 | Peter Wisdom Atadja | Combination of lbh589 with other therapeutic agents for treating cancer |
| ES2726401T3 (es) * | 2007-05-30 | 2019-10-04 | Novartis Ag | Uso de inhibidores de HDAC para el tratamiento de la destrucción ósea |
| US20120046242A1 (en) * | 2008-12-24 | 2012-02-23 | Massachusetts Institute Of Technology | Molecular activators of the wnt/beta-catenin pathway |
| MX2012005560A (es) † | 2009-11-13 | 2012-10-05 | Receptos Inc | Moduladores selectivos del receptor de esfingosina 1 fosfato y metodos de sintesis quiral. |
| BR112013004714A2 (pt) * | 2010-09-01 | 2016-05-17 | Novartis Ag | "combinações de inibidores de hdac com fármacos de trombocitopenia e seus usos" |
| MA41544A (fr) * | 2015-02-19 | 2017-12-26 | Novartis Ag | Dosages de panobinostat pour le traitement du myélome multiple |
| JP6923219B2 (ja) | 2015-11-03 | 2021-08-18 | ホーホシューレ ダルムシュタット | 選択的ｈｄａｃ８阻害剤およびこれらの使用 |
| CN105348169B (zh) * | 2015-11-16 | 2018-03-30 | 青岛大学 | 一种组蛋白去乙酰酶抑制剂(e)‑3‑(2‑(1‑(4‑氯苯甲酰基)‑5‑甲氧基‑2‑甲基‑1氢‑吲哚‑3‑基)乙酰氨基)‑n‑羟基丁‑2‑烯酰胺及其制备方法和应用 |
| CN109705057B (zh) * | 2017-10-25 | 2023-05-30 | 成都先导药物开发股份有限公司 | 组蛋白去乙酰化酶抑制剂及其制备方法与用途 |
| US10537585B2 (en) | 2017-12-18 | 2020-01-21 | Dexcel Pharma Technologies Ltd. | Compositions comprising dexamethasone |
| JP2021530504A (ja) | 2018-07-18 | 2021-11-11 | ヒルストリーム・バイオファーマ・インコーポレイテッド | サリノマイシンを含む高分子ナノ粒子 |
| WO2022251844A1 (en) | 2021-05-25 | 2022-12-01 | Hillstream Biopharma, Inc. | Polymeric nanoparticles comprising chemotherapeutic compounds and related methods |
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| CA2444867C (en) * | 2001-05-16 | 2010-08-17 | Novartis Ag | Combination comprising n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent |
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| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
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| CN102349927A (zh) | 2003-08-29 | 2012-02-15 | Hdac默克研究有限责任公司 | 联合治疗癌症的方法 |
| US8999289B2 (en) | 2005-03-22 | 2015-04-07 | President And Fellows Of Harvard College | Treatment of protein degradation disorders |
| RU2420279C3 (ru) * | 2005-08-03 | 2017-03-14 | Новартис Аг | Применение ингибиторов hdac для лечения миеломы |
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| US8883842B2 (en) | 2014-11-11 |
| JP5665271B2 (ja) | 2015-02-04 |
| CA2617274A1 (en) | 2007-02-15 |
| LTC1912640I2 (lt) | 2017-09-11 |
| JP2013173757A (ja) | 2013-09-05 |
| EP1912640A1 (en) | 2008-04-23 |
| KR101354237B1 (ko) | 2014-01-22 |
| US20080221126A1 (en) | 2008-09-11 |
| RU2420279C2 (ru) | 2011-06-10 |
| RU2420279C3 (ru) | 2017-03-14 |
| CN101232880A (zh) | 2008-07-30 |
| CA2617274C (en) | 2017-10-10 |
| KR20080031937A (ko) | 2008-04-11 |
| WO2007019116A1 (en) | 2007-02-15 |
| RU2008107871A (ru) | 2009-09-10 |
| MX2008001610A (es) | 2008-02-19 |
| PL1912640T3 (pl) | 2015-11-30 |
| SI1912640T1 (sl) | 2015-10-30 |
| AU2006278718A1 (en) | 2007-02-15 |
| CN104324025A (zh) | 2015-02-04 |
| HUE028025T2 (en) | 2016-11-28 |
| AU2006278718B2 (en) | 2010-10-07 |
| BRPI0614090A2 (pt) | 2011-03-09 |
| ES2545076T3 (es) | 2015-09-08 |
| EP1912640B1 (en) | 2015-06-17 |
| US20100160257A1 (en) | 2010-06-24 |
| JP2009503087A (ja) | 2009-01-29 |
| PT1912640E (pt) | 2015-09-22 |
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