ES2545076T3 - Uso del inhibidor de HDAC panobinostat para el tratamiento de mieloma - Google Patents

Uso del inhibidor de HDAC panobinostat para el tratamiento de mieloma Download PDF

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Publication number
ES2545076T3
ES2545076T3 ES06789025.1T ES06789025T ES2545076T3 ES 2545076 T3 ES2545076 T3 ES 2545076T3 ES 06789025 T ES06789025 T ES 06789025T ES 2545076 T3 ES2545076 T3 ES 2545076T3
Authority
ES
Spain
Prior art keywords
myeloma
hdac inhibitor
treatment
panobinostat
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES06789025.1T
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English (en)
Inventor
Peter W. Atadja
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37307336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2545076(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2545076T3 publication Critical patent/ES2545076T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

El uso de un inhibidor de HDAC para la preparación de un medicamento para el tratamiento de mieloma, en el que el inhibidor de HDAC es N-hidroxi-3>=[4-[[[2-(2-metil-1H-indol-3-ilo)-etil]-amino]metil]fenil]-2E-2-propenamida que tiene la fórmula (III)**Fórmula** o una sal farmacéuticamente aceptable del mismo, y en el que el mieloma es resistente a quimioterapia convencional.

Description

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Claims (1)

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    imagen2
ES06789025.1T 2005-08-03 2006-08-01 Uso del inhibidor de HDAC panobinostat para el tratamiento de mieloma Expired - Lifetime ES2545076T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70522605P 2005-08-03 2005-08-03
US705226P 2005-08-03
PCT/US2006/029801 WO2007019116A1 (en) 2005-08-03 2006-08-01 Use of hdac inhibitors for the treatment of myeloma

Publications (1)

Publication Number Publication Date
ES2545076T3 true ES2545076T3 (es) 2015-09-08

Family

ID=37307336

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06789025.1T Expired - Lifetime ES2545076T3 (es) 2005-08-03 2006-08-01 Uso del inhibidor de HDAC panobinostat para el tratamiento de mieloma

Country Status (18)

Country Link
US (2) US20080221126A1 (es)
EP (1) EP1912640B1 (es)
JP (2) JP5665271B2 (es)
KR (1) KR101354237B1 (es)
CN (2) CN104324025A (es)
AU (1) AU2006278718B2 (es)
BR (1) BRPI0614090A2 (es)
CA (1) CA2617274C (es)
DK (1) DK1912640T3 (es)
ES (1) ES2545076T3 (es)
HU (1) HUE028025T2 (es)
LT (1) LTC1912640I2 (es)
MX (1) MX2008001610A (es)
PL (1) PL1912640T3 (es)
PT (1) PT1912640E (es)
RU (1) RU2420279C3 (es)
SI (1) SI1912640T1 (es)
WO (1) WO2007019116A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080221126A1 (en) * 2005-08-03 2008-09-11 Atadja Peter W Use of Hdac Inhibitors for the Treatment of Myeloma
CA2677651A1 (en) * 2007-02-15 2008-08-21 Novartis Ag Combinations of therapeutic agents for treating cancer
AU2008260236A1 (en) * 2007-05-30 2008-12-11 Novartis Ag Use of HDAC inhibitors for the treatment of bone destruction
US20120046242A1 (en) * 2008-12-24 2012-02-23 Massachusetts Institute Of Technology Molecular activators of the wnt/beta-catenin pathway
PL2498610T5 (pl) † 2009-11-13 2024-11-04 Receptos Llc Selektywne modulatory receptora sfingozyno-1-fosforanu i sposoby syntezy chiralnej
CA2808908A1 (en) * 2010-09-01 2012-03-08 Novartis Ag Combination of hdac inhibitors with thrombocytopenia drugs
MA41544A (fr) * 2015-02-19 2017-12-26 Novartis Ag Dosages de panobinostat pour le traitement du myélome multiple
WO2017077008A1 (en) 2015-11-03 2017-05-11 Hochschule Darmstadt Selective hdac8 inhibitors and their uses
CN105348169B (zh) * 2015-11-16 2018-03-30 青岛大学 一种组蛋白去乙酰酶抑制剂(e)‑3‑(2‑(1‑(4‑氯苯甲酰基)‑5‑甲氧基‑2‑甲基‑1氢‑吲哚‑3‑基)乙酰氨基)‑n‑羟基丁‑2‑烯酰胺及其制备方法和应用
CN109705057B (zh) * 2017-10-25 2023-05-30 成都先导药物开发股份有限公司 组蛋白去乙酰化酶抑制剂及其制备方法与用途
US10537585B2 (en) 2017-12-18 2020-01-21 Dexcel Pharma Technologies Ltd. Compositions comprising dexamethasone
KR20210053881A (ko) 2018-07-18 2021-05-12 힐스트림 바이오파마 인크. 살리노마이신을 포함하는 폴리머 나노입자
WO2022251844A1 (en) 2021-05-25 2022-12-01 Hillstream Biopharma, Inc. Polymeric nanoparticles comprising chemotherapeutic compounds and related methods

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20020354A1 (es) * 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
AU2002342335B2 (en) * 2001-05-16 2006-02-02 Novartis Ag Combination comprising N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent
AU2002361022A1 (en) * 2001-12-07 2003-06-17 Novartis Ag Use of alpha-tubulin acetylation levels as a biomarker for protein deacetylase inhibitors
US20040132825A1 (en) * 2002-03-04 2004-07-08 Bacopoulos Nicholas G. Methods of treating cancer with HDAC inhibitors
US20050043233A1 (en) * 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
WO2004103358A2 (en) * 2003-05-21 2004-12-02 Novartis Ag Combination of histone deacetylase inhibitors with chemotherapeutic agents
CN102349927A (zh) 2003-08-29 2012-02-15 Hdac默克研究有限责任公司 联合治疗癌症的方法
SG171690A1 (en) 2005-03-22 2011-06-29 Harvard College Treatment of protein degradation disorders
US20080221126A1 (en) * 2005-08-03 2008-09-11 Atadja Peter W Use of Hdac Inhibitors for the Treatment of Myeloma

Also Published As

Publication number Publication date
CN104324025A (zh) 2015-02-04
AU2006278718A1 (en) 2007-02-15
MX2008001610A (es) 2008-02-19
JP5665271B2 (ja) 2015-02-04
CA2617274C (en) 2017-10-10
PT1912640E (pt) 2015-09-22
RU2420279C3 (ru) 2017-03-14
US20080221126A1 (en) 2008-09-11
SI1912640T1 (sl) 2015-10-30
RU2008107871A (ru) 2009-09-10
WO2007019116A1 (en) 2007-02-15
PL1912640T3 (pl) 2015-11-30
HUE028025T2 (en) 2016-11-28
KR101354237B1 (ko) 2014-01-22
RU2420279C2 (ru) 2011-06-10
DK1912640T3 (en) 2015-09-14
US8883842B2 (en) 2014-11-11
US20100160257A1 (en) 2010-06-24
JP5876435B2 (ja) 2016-03-02
JP2013173757A (ja) 2013-09-05
KR20080031937A (ko) 2008-04-11
CN101232880A (zh) 2008-07-30
AU2006278718B2 (en) 2010-10-07
BRPI0614090A2 (pt) 2011-03-09
EP1912640B1 (en) 2015-06-17
JP2009503087A (ja) 2009-01-29
CA2617274A1 (en) 2007-02-15
LTC1912640I2 (lt) 2017-09-11
EP1912640A1 (en) 2008-04-23

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