DK192189D0 - Polypeptid, fremgangsmaade til inhibering af fibrinogen, fremgangsmaade til rensning af et polypeptid, gen indeholdende rekombinante dna kodende for et polypeptid, vektor, cellekultur og fremgangsmaade til fremstilling af et cysteinrigt polypeptid - Google Patents

Polypeptid, fremgangsmaade til inhibering af fibrinogen, fremgangsmaade til rensning af et polypeptid, gen indeholdende rekombinante dna kodende for et polypeptid, vektor, cellekultur og fremgangsmaade til fremstilling af et cysteinrigt polypeptid

Info

Publication number: DK192189D0
Authority: DK; Denmark
Prior art keywords: polypeptide; procedure; vector; fibrinogen; purifying
Prior art date: 1988-04-22

Application number

DK192189A

Other languages

English (en)

Other versions

DK192189A (da

Inventor

Paul A Friedman

Zhong-Ru Gan

Robert J Gould

John W Jacobs

Mark A Polokoff

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-22

Filing date

1989-04-20

Publication date

1989-04-20

1989-04-20 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1989-04-20 Publication of DK192189D0 publication Critical patent/DK192189D0/da

1989-10-23 Publication of DK192189A publication Critical patent/DK192189A/da

Links

229920001184 polypeptide Polymers 0.000 title abstract 6
102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
238000000034 method Methods 0.000 title abstract 4
230000002401 inhibitory effect Effects 0.000 title abstract 2
108090000623 proteins and genes Proteins 0.000 title abstract 2
FBPFZTCFMRRESA-ZXXMMSQZSA-N D-iditol Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-ZXXMMSQZSA-N 0.000 title 1
108010049003 Fibrinogen Proteins 0.000 title 1
102000008946 Fibrinogen Human genes 0.000 title 1
108020004511 Recombinant DNA Proteins 0.000 title 1
238000004113 cell culture Methods 0.000 title 1
229940012952 fibrinogen Drugs 0.000 title 1
150000001413 amino acids Chemical class 0.000 abstract 3
241000588724 Escherichia coli Species 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
239000013604 expression vector Substances 0.000 abstract 1
108020001507 fusion proteins Proteins 0.000 abstract 1
102000037865 fusion proteins Human genes 0.000 abstract 1
208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Hematology (AREA)
Zoology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK192189A 1988-04-22 1989-04-20 Polypeptid, fremgangsmaade til inhibering af fibrinogen, fremgangsmaade til rensning af et polypeptid, gen indeholdende rekombinante dna kodende for et polypeptid, vektor, cellekultur og fremgangsmaade til fremstilling af et cysteinrigt polypeptid DK192189A (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date
US18464988A	1988-04-22	1988-04-22
US18465388A	1988-04-22	1988-04-22
US30375789A	1989-02-01	1989-02-01

Publications (2)

Publication Number	Publication Date
DK192189D0 true DK192189D0 (da)	1989-04-20
DK192189A DK192189A (da)	1989-10-23

Family

ID=27391870

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK192189A DK192189A (da)	1988-04-22	1989-04-20	Polypeptid, fremgangsmaade til inhibering af fibrinogen, fremgangsmaade til rensning af et polypeptid, gen indeholdende rekombinante dna kodende for et polypeptid, vektor, cellekultur og fremgangsmaade til fremstilling af et cysteinrigt polypeptid

Country Status (14)

Country	Link
EP (1)	EP0338634B1 (da)
JP (1)	JPH02138298A (da)
KR (1)	KR900016261A (da)
CN (1)	CN1039441A (da)
AT (1)	ATE103931T1 (da)
AU (1)	AU627724B2 (da)
DE (1)	DE68914316T2 (da)
DK (1)	DK192189A (da)
ES (1)	ES2063113T3 (da)
FI (1)	FI891916A7 (da)
IL (1)	IL89938A0 (da)
NO (1)	NO891662L (da)
NZ (1)	NZ228710A (da)
PT (1)	PT90321B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU639409B2 (en) *	1987-12-10	1993-07-29	La Jolla Cancer Research Foundation	Conformationally stabilized cell adhesion peptides
US5827821A (en)	1987-12-10	1998-10-27	The Burnham Institute	Conformationally stabilized cell adhesion peptides
US5196403A (en) *	1989-01-27	1993-03-23	Biogen, Inc.	Method of inhibiting platelet activation
US5182260A (en) *	1989-01-27	1993-01-26	Biogen, Inc.	Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
EP0382451A3 (en) *	1989-02-07	1991-05-29	Merck & Co. Inc.	Viper venom polypeptides and variants
EP0382538A3 (en) *	1989-02-09	1991-10-23	Merck & Co. Inc.	A process for the preparation of cysteine-rich polypeptides, including echistatin
US5384309A (en) *	1989-07-17	1995-01-24	Genentech, Inc.	Cyclized peptides and their use as platelet aggregation inhibitors
WO1991011458A1 (en) *	1990-02-02	1991-08-08	Genentech, Inc.	CYCLIC PEPTIDES CONTAINING Arg-Gly-Asp FLANKED BY PROLINE
US5227469A (en) *	1990-02-14	1993-07-13	Genentech, Inc.	Platelet aggregation inhibitors from the leech
US5648330A (en) *	1990-04-06	1997-07-15	La Jolla Cancer Research Foundation	Method and composition for treating vascular graft occlusion
DE69126871T2 (de) *	1990-04-06	1998-03-12	Jolla Cancer Res Found	Verfahren und verbindung zur behandlung von thrombose
US6521594B1 (en)	1990-04-06	2003-02-18	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
US5612311A (en) *	1990-04-06	1997-03-18	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
US5780303A (en) *	1990-04-06	1998-07-14	La Jolla Cancer Research Foundation	Method and composition for treating thrombosis
US5179082A (en) *	1990-11-13	1993-01-12	Merck & Co., Inc.	Method for blocking platelet adhesion to collagen
US5342830A (en) *	1990-11-16	1994-08-30	Cor Therapeutics, Inc.	Antithrombosis agents
US5242810A (en) *	1990-12-07	1993-09-07	Biogen, Inc.	Bifunctional inhibitors of thrombin and platelet activation
CA2106314A1 (en) *	1991-04-05	1992-10-06	John P. Burnier	Platelet aggregation inhibitors having high specification for gpiibiiia
US5380646A (en) *	1992-10-19	1995-01-10	Temple University Of The Commonwealth System Of Higher Education	Thrombus detection using radiolabelled disintegrins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4683291A (en) *	1985-10-28	1987-07-28	Scripps Clinic And Research Foundation	Platelet binding inhibitors
DE3886175T2 (de) *	1987-11-18	1994-04-07	Univ Temple	Trigramin, ein Polypeptid, das die Aggregation der Blutplättchen hemmt.

1989
- 1989-04-12 NZ NZ228710A patent/NZ228710A/xx unknown
- 1989-04-13 IL IL89938A patent/IL89938A0/xx unknown
- 1989-04-17 EP EP89200967A patent/EP0338634B1/en not_active Expired - Lifetime
- 1989-04-17 DE DE68914316T patent/DE68914316T2/de not_active Expired - Fee Related
- 1989-04-17 AT AT89200967T patent/ATE103931T1/de not_active IP Right Cessation
- 1989-04-17 ES ES89200967T patent/ES2063113T3/es not_active Expired - Lifetime
- 1989-04-20 DK DK192189A patent/DK192189A/da unknown
- 1989-04-20 PT PT90321A patent/PT90321B/pt not_active IP Right Cessation
- 1989-04-21 NO NO89891662A patent/NO891662L/no unknown
- 1989-04-21 KR KR1019890005261A patent/KR900016261A/ko not_active Withdrawn
- 1989-04-21 FI FI891916A patent/FI891916A7/fi not_active Application Discontinuation
- 1989-04-21 JP JP1100330A patent/JPH02138298A/ja active Pending
- 1989-04-21 AU AU33299/89A patent/AU627724B2/en not_active Ceased
- 1989-04-22 CN CN89104408A patent/CN1039441A/zh active Pending

Also Published As

Publication number	Publication date
CN1039441A (zh)	1990-02-07
AU3329989A (en)	1990-02-15
IL89938A0 (en)	1989-12-15
FI891916L (fi)	1989-10-23
NO891662L (no)	1989-10-23
FI891916A0 (fi)	1989-04-21
PT90321B (pt)	1994-08-31
NZ228710A (en)	1992-10-28
JPH02138298A (ja)	1990-05-28
EP0338634A3 (en)	1991-05-29
DE68914316T2 (de)	1994-09-08
EP0338634B1 (en)	1994-04-06
FI891916A7 (fi)	1989-10-23
NO891662D0 (no)	1989-04-21
ATE103931T1 (de)	1994-04-15
DK192189A (da)	1989-10-23
KR900016261A (ko)	1990-11-13
DE68914316D1 (de)	1994-05-11
ES2063113T3 (es)	1995-01-01
PT90321A (pt)	1989-11-10
AU627724B2 (en)	1992-09-03
EP0338634A2 (en)	1989-10-25

Publication	Publication Date	Title
DK192189A (da)	1989-10-23	Polypeptid, fremgangsmaade til inhibering af fibrinogen, fremgangsmaade til rensning af et polypeptid, gen indeholdende rekombinante dna kodende for et polypeptid, vektor, cellekultur og fremgangsmaade til fremstilling af et cysteinrigt polypeptid
DE69738586D1 (de)	2008-04-30	Hohe expressionsrate von proteinen
ATE133681T1 (de)	1996-02-15	Mykobakterielle rekombinanten und peptide
EP0722461A4 (en)	1997-02-26	EXPRESSION OF FUSION POLYPEPTIDES TRANSPORTED OUT OF CYTOPLASM WITHOUT HEAD SEQUENCE
HUT46061A (en)	1988-09-28	Dna sequences encoding hirudin-like protein and process for producing such proteins
PT85977A (en)	1987-11-01	Process for the preparation of human apolipoprotein ai and their variant forms by recombinant dna methods
DK491487A (da)	1988-03-20	Dna-sekvens til ekspressionering af biologisk aktivt faktor xiii og anvendelse af samme
DE69334350D1 (de)	2011-04-21	P- Selectin Ligandenprotein
DE3686579D1 (en)	1992-10-01	Prokaryotisches expressionssystem.
DE69120626D1 (de)	1996-08-08	Polypeptid
NO177570C (no)	1995-10-11	Fremgangsmåte ved fremstilling av peptider med fibronektinbindende egenskaper, mikroorganisme og DNA-sekvens som koder for peptider med fibronektinbindende egenskaper
ZA916171B (en)	1992-04-29	Protein structure of the plant toxin gelonin
DK0425096T3 (da)	1994-05-02	Polypeptider anvendelige til blokering af calciumkanaler
DK203588A (da)	1988-10-16	Fremgangsmaade til fremstilling af proteiner
FI882238A0 (fi)	1988-05-12	Foerbaettringar i samband med organiska foereningar
EP0613946A3 (en)	1995-11-02	Hst-2 mutein, dna coding for the same and preparation thereof.
DE68917520D1 (de)	1994-09-22	Verfahren und Systeme zur Herstellung von HIV-Antigenen.
NZ219611A (en)	1991-01-29	Insecticidal peptide produced by recombinant dna techniques