DK195583A - Fremgangsmaade til fremstilling af benzoxazin-2-oner - Google Patents

Fremgangsmaade til fremstilling af benzoxazin-2-oner Download PDF

Info

Publication number: DK195583A
Authority: DK; Denmark
Prior art keywords: group; hydrogen; benzoxazin; oner; preparing
Prior art date: 1982-05-06

Application number

DK195583A

Other languages

English (en)

Other versions

DK195583D0 (da

DK164860C (da

DK164860B (da

Inventor

Berthold Narr

Josef Nickl

Erich Mueller

Josef Roch

Walter Haarmann

Johannes-Maximili Weisenberger

Original Assignee

Thomae Gmbh Dr K

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-05-06

Filing date

1983-05-03

Publication date

1983-11-07

1983-05-03 Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K

1983-05-03 Publication of DK195583D0 publication Critical patent/DK195583D0/da

1983-11-07 Publication of DK195583A publication Critical patent/DK195583A/da

1992-08-31 Publication of DK164860B publication Critical patent/DK164860B/da

1993-01-11 Application granted granted Critical

1993-01-11 Publication of DK164860C publication Critical patent/DK164860C/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)

Description

R4 er hydrogen eller akyl, R5 er hydrogen eller halogen, nitro eller alkyl, og *6 er hydrogen eller halogen eller alkyl fremstilles ved en række fremgangsmåder, der er kendte til fremstilling af analoge forbindelser.

Forbindelserne har værdifulde farmakologiske egenskaber især antithrombotiske virkninger.

DK195583A 1982-05-06 1983-05-03 Analogifremgangsmaade til fremstilling af benzoxazin-2-oner DK164860C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3217012		1982-05-06
DE19823217012 DE3217012A1 (de)	1982-05-06	1982-05-06	Benzoxazin-2-one, deren herstellung und diese verbindungen enthaltende arzneimittel

Publications (4)

Publication Number	Publication Date
DK195583D0 DK195583D0 (da)	1983-05-03
DK195583A true DK195583A (da)	1983-11-07
DK164860B DK164860B (da)	1992-08-31
DK164860C DK164860C (da)	1993-01-11

Family

ID=6162917

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK195583A DK164860C (da)	1982-05-06	1983-05-03	Analogifremgangsmaade til fremstilling af benzoxazin-2-oner

Country Status (25)

Country	Link
US (1)	US4518597A (da)
EP (1)	EP0093922B1 (da)
JP (1)	JPS58203979A (da)
KR (1)	KR900006546B1 (da)
AT (1)	ATE24501T1 (da)
AU (1)	AU563453B2 (da)
CA (1)	CA1204744A (da)
CS (1)	CS236876B2 (da)
DD (1)	DD210453A5 (da)
DE (2)	DE3217012A1 (da)
DK (1)	DK164860C (da)
ES (3)	ES8402585A1 (da)
FI (1)	FI79704C (da)
GB (1)	GB2119382B (da)
GR (1)	GR79255B (da)
HU (1)	HU194842B (da)
IE (1)	IE55481B1 (da)
IL (1)	IL68573A (da)
NO (1)	NO158738C (da)
NZ (1)	NZ204143A (da)
PL (1)	PL139119B1 (da)
PT (1)	PT76627B (da)
SU (1)	SU1138025A3 (da)
YU (1)	YU42854B (da)
ZA (1)	ZA833190B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3439281A1 (de) *	1984-10-26	1986-04-30	Bayer Ag, 5090 Leverkusen	Chromogene 4,4-diaryl-2-oxo-benzo-3,1-oxazine, ihre herstellung und verwendung
US5663169A (en) *	1992-08-07	1997-09-02	Merck & Co., Inc.	Benzoxazinones as inhibitors of HIV reverse transcriptase
IL106507A (en) *	1992-08-07	1997-11-20	Merck & Co Inc	Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type
US5874430A (en) *	1996-10-02	1999-02-23	Dupont Pharmaceuticals Company	4,4-disubstitued-1,4-dihydro-2H-3,1-benzoxazin-2-ones useful as HIV reverse transcriptase inhibitors and intermediates and processes for making the same
US5965729A (en) *	1997-02-05	1999-10-12	Merck & Co., Inc.	Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
US6509334B1 (en) *	1999-05-04	2003-01-21	American Home Products Corporation	Cyclocarbamate derivatives as progesterone receptor modulators
UA73119C2 (en) *	2000-04-19	2005-06-15	American Home Products Corpoir	Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
WO2009089851A1 (en) *	2008-01-17	2009-07-23	Bayer Schering Pharma Aktiengesellschaft	Sulphoximine-substituted quinazoline derivatives as immunomodulators, their preparation and use as medicaments
WO2015120059A1 (en) *	2014-02-04	2015-08-13	Yates Charles Ryan	Inhibitors of paxillin function and related compositions and methods

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3526621A (en) *	1966-08-03	1970-09-01	Farmaceutical Italia Soc	Substituted 3,1-benzoxazin-2-one
US3542774A (en) *	1968-07-05	1970-11-24	Warner Lambert Pharmaceutical	3,4-dihydrobenzoxazinones
CH624395A5 (da) *	1976-01-08	1981-07-31	Ciba Geigy Ag
SU843739A3 (ru) *	1978-02-17	1981-06-30	Карл Томэ Гмбх (Фирма)	Способ получени карбостириловыхили ОКСиНдОлОВыХ пРОизВОдНыХ
US4442111A (en) *	1981-07-25	1984-04-10	Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung	Antithrombotic sulfimino and sulfoximino indolinones-2

1982
- 1982-05-06 DE DE19823217012 patent/DE3217012A1/de not_active Withdrawn
1983
- 1983-04-22 DE DE8383103980T patent/DE3368621D1/de not_active Expired
- 1983-04-22 AT AT83103980T patent/ATE24501T1/de not_active IP Right Cessation
- 1983-04-22 EP EP83103980A patent/EP0093922B1/de not_active Expired
- 1983-04-26 FI FI831412A patent/FI79704C/fi not_active IP Right Cessation
- 1983-04-26 SU SU833583668A patent/SU1138025A3/ru active
- 1983-04-27 YU YU957/83A patent/YU42854B/xx unknown
- 1983-05-02 PT PT76627A patent/PT76627B/pt unknown
- 1983-05-02 DD DD83250508A patent/DD210453A5/de not_active IP Right Cessation
- 1983-05-03 DK DK195583A patent/DK164860C/da not_active IP Right Cessation
- 1983-05-04 GR GR71308A patent/GR79255B/el unknown
- 1983-05-04 KR KR1019830001917A patent/KR900006546B1/ko not_active Expired
- 1983-05-04 HU HU831540A patent/HU194842B/hu not_active IP Right Cessation
- 1983-05-04 CS CS833145A patent/CS236876B2/cs unknown
- 1983-05-04 IL IL68573A patent/IL68573A/xx unknown
- 1983-05-05 AU AU14265/83A patent/AU563453B2/en not_active Ceased
- 1983-05-05 ZA ZA833190A patent/ZA833190B/xx unknown
- 1983-05-05 NO NO831599A patent/NO158738C/no unknown
- 1983-05-05 GB GB08312344A patent/GB2119382B/en not_active Expired
- 1983-05-05 PL PL1983241806A patent/PL139119B1/pl unknown
- 1983-05-05 CA CA000427530A patent/CA1204744A/en not_active Expired
- 1983-05-05 IE IE1032/83A patent/IE55481B1/en not_active IP Right Cessation
- 1983-05-05 ES ES522104A patent/ES8402585A1/es not_active Expired
- 1983-05-05 NZ NZ204143A patent/NZ204143A/en unknown
- 1983-05-06 JP JP58079222A patent/JPS58203979A/ja active Pending
- 1983-10-25 ES ES526724A patent/ES8406454A1/es not_active Expired
- 1983-10-25 ES ES526723A patent/ES8406453A1/es not_active Expired
1984
- 1984-06-06 US US06/617,797 patent/US4518597A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
YU95783A (en)	1985-10-31
NO158738B (no)	1988-07-18
ES526724A0 (es)	1984-07-01
DK195583D0 (da)	1983-05-03
NZ204143A (en)	1986-02-21
SU1138025A3 (ru)	1985-01-30
DD210453A5 (de)	1984-06-13
AU563453B2 (en)	1987-07-09
PT76627A (de)	1983-06-01
NO158738C (no)	1988-11-16
ES8406454A1 (es)	1984-07-01
NO831599L (no)	1983-11-07
CA1204744A (en)	1986-05-20
ZA833190B (en)	1985-01-30
ES526723A0 (es)	1984-07-01
FI831412L (fi)	1983-11-07
ATE24501T1 (de)	1987-01-15
PT76627B (de)	1986-02-26
ES8406453A1 (es)	1984-07-01
KR840004736A (ko)	1984-10-24
EP0093922A2 (de)	1983-11-16
IL68573A0 (en)	1983-09-30
ES522104A0 (es)	1984-02-01
CS236876B2 (en)	1985-05-15
GB2119382A (en)	1983-11-16
PL139119B1 (en)	1986-12-31
EP0093922A3 (en)	1984-01-25
DK164860C (da)	1993-01-11
PL241806A1 (en)	1984-08-13
DE3368621D1 (en)	1987-02-05
DK164860B (da)	1992-08-31
GB2119382B (en)	1985-09-18
KR900006546B1 (ko)	1990-09-13
US4518597A (en)	1985-05-21
IE831032L (en)	1983-11-06
EP0093922B1 (de)	1986-12-30
AU1426583A (en)	1983-11-10
ES8402585A1 (es)	1984-02-01
JPS58203979A (ja)	1983-11-28
IL68573A (en)	1986-10-31
FI79704B (fi)	1989-10-31
IE55481B1 (en)	1990-09-26
FI79704C (fi)	1990-02-12
GB8312344D0 (en)	1983-06-08
YU42854B (en)	1988-12-31
HU194842B (en)	1988-03-28
FI831412A0 (fi)	1983-04-26
GR79255B (da)	1984-10-22
DE3217012A1 (de)	1983-11-10

Legal Events

Date	Code	Title	Description
1994-01-24	PBP	Patent lapsed

Publication	Publication Date	Title
SE8100302L (sv)	1982-04-08	Nya antikoagulerade agmatinderivat jemte sett for deras framstellning
ES534959A0 (es)	1985-04-16	Procedimiento para la preparacion de derivados de oligoglucosido
AU563453B2 (en)	1987-07-09	Substituted 4h-3,1-benzoxazin-2-ones
ES2038166T3 (es)	1993-07-16	Procedimiento para preparar un derivado de indenotiazol.
RO85070B (ro)	1984-09-30	Procedeu pentru prepararea unor derivati de n-fenilcarbamati
MX3464E (es)	1980-12-09	Procedimiento para la preparacion de 4[2-cloro (ometiltio) pirid-3-il]-3,5-dicarbetoxi-2,6-dimetil-1,4-dihidropiridina
ES8400406A1 (es)	1983-11-01	Procedimiento para preparar derivados de indano.
DK47082A (da)	1982-08-06	Fremgangsmaade til fremstilling af bis- og polydisulfider
DK404982A (da)	1983-03-12	Fremgangsmaade til fremstilling af substituerede pyrimid-2-oner eller salte deraf
DK82583D0 (da)	1983-02-23	Furyloxazolyleddikesyrederivater og fremgangsmader til fremstilling deraf
DK0419297T3 (da)	1994-10-31	Hidtil ukendt fremgangsmåde til separation af optiske isomerer af 1,4-dihydropyridinderivater
DK0538291T3 (da)	1995-02-20	Mellemprodukt til fremstilling af deferoxamin
KR840008002A (ko)	1984-12-12	3-아실-2-니트로메틸렌-테트라하이드로-2h-1,3-티아진의 제조방법
DK584077A (da)	1978-07-11	Fremgangsmaade til fremstilling af derivater af apomorphin eller n-substituerede norapomorphiner ved omlejring
ES515201A0 (es)	1983-11-01	"procedimiento para la fabricacion de derivados n- susbtituidos de la tetrahidroisftalimida".
ES530729A0 (es)	1985-10-01	Procedimiento para la obtencion de esteres de acido fosfonico
ES464693A1 (es)	1978-10-01	Procedimiento para la preparacion de 5(fenil sustituido)-oxazolidinonas y sus analogos sulfurados
ES8202824A1 (es)	1982-02-16	Procedimiento para la preparacion de nuevos derivados de pi-razolilpirimidina
ES8603394A1 (es)	1985-12-16	Procedimiento para la obtencion de n-iodopropargil-clorome- tansulfonamidas.
ES455592A1 (es)	1978-02-01	Procedimiento para la preparacion de hidrazinas.
DK35275A (da)	1976-08-01	Fremgangsmade til fremstilling af c1-c7alifatisk hydrokarbylester af en n-/2,6-di(c1-c7alkyl) fenyl/-alfa-aminokarboksylsyre