DK1963516T3 - Fremgangsmåde til enantioselektiv enzymatisk reduktion af hydroxyketoforbindelser - Google Patents
Fremgangsmåde til enantioselektiv enzymatisk reduktion af hydroxyketoforbindelserInfo
- Publication number
- DK1963516T3 DK1963516T3 DK06819032.1T DK06819032T DK1963516T3 DK 1963516 T3 DK1963516 T3 DK 1963516T3 DK 06819032 T DK06819032 T DK 06819032T DK 1963516 T3 DK1963516 T3 DK 1963516T3
- Authority
- DK
- Denmark
- Prior art keywords
- hydroxy ketone
- alkyl
- general formula
- enzymatic reduction
- enantioselective enzymatic
- Prior art date
Links
- 230000002255 enzymatic effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 102000004316 Oxidoreductases Human genes 0.000 abstract 2
- 108090000854 Oxidoreductases Proteins 0.000 abstract 2
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 abstract 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 abstract 2
- 230000003647 oxidation Effects 0.000 abstract 2
- 238000007254 oxidation reaction Methods 0.000 abstract 2
- 150000003333 secondary alcohols Chemical class 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000002009 diols Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/002—Nitriles (-CN)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0202705A AT503017B1 (de) | 2005-12-19 | 2005-12-19 | Verfahren zur enantioselektiven enzymatischen reduktion von hydroxyketoverbindungen |
| PCT/EP2006/012037 WO2007073875A1 (de) | 2005-12-19 | 2006-12-14 | Verfahren zur enantioselektiven enzymatischen reduktion von hydroxyketoverbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1963516T3 true DK1963516T3 (da) | 2011-06-06 |
Family
ID=37900660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06819032.1T DK1963516T3 (da) | 2005-12-19 | 2006-12-14 | Fremgangsmåde til enantioselektiv enzymatisk reduktion af hydroxyketoforbindelser |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8980592B2 (da) |
| EP (1) | EP1963516B1 (da) |
| JP (1) | JP5328365B2 (da) |
| KR (1) | KR101344605B1 (da) |
| CN (1) | CN101432435A (da) |
| AT (2) | AT503017B1 (da) |
| AU (1) | AU2006331069B2 (da) |
| CA (1) | CA2633583C (da) |
| DE (1) | DE502006008961D1 (da) |
| DK (1) | DK1963516T3 (da) |
| ES (1) | ES2363374T3 (da) |
| PL (1) | PL1963516T3 (da) |
| PT (1) | PT1963516E (da) |
| SI (1) | SI1963516T1 (da) |
| TW (1) | TWI408234B (da) |
| WO (1) | WO2007073875A1 (da) |
| ZA (1) | ZA200805336B (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT504542B1 (de) * | 2006-12-07 | 2008-09-15 | Iep Gmbh | Verfahren zur enantioselektiven enzymatischen reduktion von secodionderivaten |
| TWI601825B (zh) * | 2007-09-27 | 2017-10-11 | Ｉｅｐ有限公司 | 對映異構選擇性酶催化還原中間產物之方法 |
| CN101429514B (zh) * | 2007-11-08 | 2011-06-15 | 陈依军 | 一种双羰基还原酶、其基因及其应用 |
| EP2226386A1 (de) * | 2009-03-05 | 2010-09-08 | IEP GmbH | Verfahren zur stereoselektiven enzymatischen Reduktion von Ketoverbindungen |
| AU2009348523B2 (en) | 2009-06-22 | 2015-02-26 | Sk Biopharmaceuticals Co., Ltd. | Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester |
| US8404461B2 (en) | 2009-10-15 | 2013-03-26 | SK Biopharmaceutical Co. Ltd. | Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester |
| JP2013541942A (ja) * | 2010-10-08 | 2013-11-21 | カディラ ヘルスケア リミティド | 酵素的変換によるシタグリプチンの中間体を生産する方法 |
| CN105441399A (zh) * | 2010-12-16 | 2016-03-30 | 细胞制药有限公司 | 新的7β-羟基类固醇脱氢酶突变体和制备熊去氧胆酸的方法 |
| US9410169B2 (en) * | 2012-06-18 | 2016-08-09 | Laboratorio Chimico Internazionale S.P.A. | Process for producing chiral 1- substituted 2-piperidinols employing oxidoreductases |
| CN102978249A (zh) * | 2012-11-19 | 2013-03-20 | 苏州汉酶生物技术有限公司 | 6-氰基-（3r,5r）-二羟基己酸叔丁酯的生物制备方法 |
| CN103146591B (zh) * | 2013-01-30 | 2014-08-27 | 浙江工业大学 | 生物还原制备他汀侧链6-氰基-(3r,5r)-二羟基己酸叔丁酯及菌株 |
| CN104342410B (zh) * | 2013-07-26 | 2017-04-19 | 南京朗恩生物科技有限公司 | 一种酮还原酶突变体及其制备方法 |
| CN105713884A (zh) * | 2014-12-02 | 2016-06-29 | 安琪酵母股份有限公司 | 生物催化氢化组合物及其合成罗素伐他汀手性中间体方法 |
| US10745263B2 (en) | 2015-05-28 | 2020-08-18 | Sonicu, Llc | Container fill level indication system using a machine learning algorithm |
| US10746586B2 (en) | 2015-05-28 | 2020-08-18 | Sonicu, Llc | Tank-in-tank container fill level indicator |
| CN109913514A (zh) * | 2019-03-12 | 2019-06-21 | 江苏理工学院 | 一种固定化酶流化床连续催化合成ats-7的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5324662A (en) | 1992-05-15 | 1994-06-28 | E. R. Squibb & Sons, Inc. | Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters |
| GB9512837D0 (en) | 1995-06-23 | 1995-08-23 | Zeneca Ltd | reduction of ketone groups |
| AU1551701A (en) * | 1999-12-03 | 2001-06-12 | Kaneka Corporation | Novel carbonyl reductase, gene thereof and method of using the same |
| GB0011120D0 (en) | 2000-05-09 | 2000-06-28 | Avecia Ltd | Process |
| CA2474905A1 (en) * | 2002-03-18 | 2003-09-25 | Ciba Specialty Chemicals Holding Inc. | Alcohol dehydrogenases with high solvent and temperature stability |
| DE10327454A1 (de) | 2003-06-18 | 2005-01-20 | Juelich Enzyme Products Gmbh | Oxidoreduktase aus Pichia capsulata |
| AT413541B (de) * | 2004-05-10 | 2006-03-15 | Iep Gmbh | Verfahren zur herstellung von 2-butanol |
-
2005
- 2005-12-19 AT AT0202705A patent/AT503017B1/de not_active IP Right Cessation
-
2006
- 2006-12-14 ZA ZA200805336A patent/ZA200805336B/xx unknown
- 2006-12-14 AU AU2006331069A patent/AU2006331069B2/en not_active Ceased
- 2006-12-14 WO PCT/EP2006/012037 patent/WO2007073875A1/de not_active Ceased
- 2006-12-14 CA CA2633583A patent/CA2633583C/en active Active
- 2006-12-14 PT PT06819032T patent/PT1963516E/pt unknown
- 2006-12-14 DE DE502006008961T patent/DE502006008961D1/de active Active
- 2006-12-14 AT AT06819032T patent/ATE499447T1/de active
- 2006-12-14 SI SI200631010T patent/SI1963516T1/sl unknown
- 2006-12-14 DK DK06819032.1T patent/DK1963516T3/da active
- 2006-12-14 PL PL06819032T patent/PL1963516T3/pl unknown
- 2006-12-14 CN CNA2006800477546A patent/CN101432435A/zh active Pending
- 2006-12-14 JP JP2008546207A patent/JP5328365B2/ja not_active Expired - Fee Related
- 2006-12-14 EP EP06819032A patent/EP1963516B1/de active Active
- 2006-12-14 KR KR1020087017190A patent/KR101344605B1/ko not_active Expired - Fee Related
- 2006-12-14 ES ES06819032T patent/ES2363374T3/es active Active
- 2006-12-14 US US12/086,704 patent/US8980592B2/en active Active
- 2006-12-18 TW TW095147521A patent/TWI408234B/zh not_active IP Right Cessation
-
2015
- 2015-02-04 US US14/613,863 patent/US9228214B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN101432435A (zh) | 2009-05-13 |
| CA2633583A1 (en) | 2007-07-05 |
| TWI408234B (zh) | 2013-09-11 |
| CA2633583C (en) | 2016-06-21 |
| EP1963516B1 (de) | 2011-02-23 |
| US8980592B2 (en) | 2015-03-17 |
| ES2363374T3 (es) | 2011-08-02 |
| AU2006331069B2 (en) | 2012-04-05 |
| AT503017A4 (de) | 2007-07-15 |
| WO2007073875A1 (de) | 2007-07-05 |
| JP5328365B2 (ja) | 2013-10-30 |
| ATE499447T1 (de) | 2011-03-15 |
| PL1963516T3 (pl) | 2011-07-29 |
| US20090221044A1 (en) | 2009-09-03 |
| US20150152451A1 (en) | 2015-06-04 |
| PT1963516E (pt) | 2011-05-25 |
| KR101344605B1 (ko) | 2013-12-26 |
| DE502006008961D1 (de) | 2011-04-07 |
| US9228214B2 (en) | 2016-01-05 |
| SI1963516T1 (sl) | 2011-06-30 |
| JP2009519722A (ja) | 2009-05-21 |
| KR20080087000A (ko) | 2008-09-29 |
| EP1963516A1 (de) | 2008-09-03 |
| TW200801196A (en) | 2008-01-01 |
| ZA200805336B (en) | 2009-12-30 |
| AU2006331069A1 (en) | 2007-07-05 |
| AT503017B1 (de) | 2007-07-15 |
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