DK1978978T3 - Bioforligeligt vævstransplantatmateriale til implantering samt fremgangsmåde til dets fremstilling - Google Patents
Bioforligeligt vævstransplantatmateriale til implantering samt fremgangsmåde til dets fremstilling Download PDFInfo
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- DK1978978T3 DK1978978T3 DK07718044T DK07718044T DK1978978T3 DK 1978978 T3 DK1978978 T3 DK 1978978T3 DK 07718044 T DK07718044 T DK 07718044T DK 07718044 T DK07718044 T DK 07718044T DK 1978978 T3 DK1978978 T3 DK 1978978T3
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- tissue
- solution
- free
- animal tissue
- remove
- Prior art date
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cell Biology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Claims (16)
1. Fremgangsmåde til fremstilling af et absorberbart omformeligt transplantatmateriale, der er antigenfrit og immunologisk indifferent, ved hvilken et dyrisk væv gennemvædes i en blegeopløsning; vaskes i en vaskemiddelopløsning; skylles for at fjerne vaskemiddelopløsningen; konfigureres til en ønsket fysisk form og tykkelse; gennemvædes i en iodophoropløsning; skylles for at fjerne iodophoropløsningen; gennemvædes i en hypertonisk opløsning; og skylles for at fjerne den hypertoniske opløsning; idet fremgangsmåden omfatter: (a) bevægelse af det dyriske væv i en blanding af ætsemiddel og peroxidopløsning for at tilvejebringe et i det væsentlige hårfrit og antigenfrit dyrisk væv; og (b) skylning af det i det væsentlige hårfrie og antigenfrie dyriske væv i vand.
2. Fremgangsmåde ifølge krav 1, ved hvilken det dyriske væv stammer fra en autolog, heterolog eller allogen kilde og er afledt af svine-, okse-, heste-, gnaver- eller menneskevæv.
3. Fremgangsmåde ifølge krav 1 til fremstilling af et absorberbart omformeligt transplantatvævsmateriale, der er hårfrit og immunologisk indifferent, omfattende følgende trin: (a) gennemvædning af et dyrisk væv i en blegeopløsning; (b) vask af det dyriske væv i en vaskemiddelopløsning; (c) skylning af det dyriske væv for at fjerne vaskemiddelopløsningen; (d) konfigurering af det dyriske væv til en ønsket fysisk form og tykkelse; (e) gennemvædning af det dyriske væv i en idophoropløsning; (f) skylning af det dyriske væv for at fjerne iodophoropløsningen; (g) gennemvædning af det dyriske væv i en hypertonisk opløsning; (h) skylning af det dyriske væv for at fjerne den hypertoniske opløsning; (i) bevægelse af det dyriske væv i en blanding af et ætsemiddel og en peroxidopløsning; og (j) skylning af det dyriske væv i vand for at fjerne blandingen af ætsemiddel og peroxidopløsning for at tilvejebringe det hårfrie transplantatvævsmateriale.
4. Fremgangsmåde ifølge krav 3, ved hvilken trinnet til gennemvædning af det dyriske væv i en hypertonisk opløsning endvidere omfatter følgende trin: gennemvædning af det dyriske væv i en række tiltagende hypertoniske opløsninger; og skylning af det dyriske væv efter hver gennemvædning i en hypotonisk opløsning for at fjerne den hypertoniske opløsning.
5. Fremgangsmåde ifølge krav 1 eller 3, ved hvilken blandingen af ætsemiddel og peroxidopløsning omfatter en natriumhydroxidopløsning med en koncentration mellem ca. 0,1 og 5 N og en peroxidopløsning med en koncentration mellem ca. 0,1 og 20 vægt%.
6. Fremgangsmåde ifølge krav 5, ved hvilken blandingen af ætsemiddel og peroxidopløsning omfatter en natriumhydroxidopløsning med en koncentration mellem ca. 0,25 og 3 N og en peroxidopløsning med en koncentration mellem ca. 0,75 og 10 vægt%.
7. Fremgangsmåde ifølge krav 1 eller 3, ved hvilken vævsmaterialet gennemvædes i en saltopløsning efter trin (b) hhv. trin (j).
8. Fremgangsmåde ifølge krav 1 eller 3, ved hvilken vævsmaterialet tværbindes kemisk efter trin (b) hhv. trin (j).
9. Fremgangsmåde til fremstilling af et endotoxinfrit, antigenfrit og immunologisk indifferent implanterbart materiale, der er absorberbart og omformeligt, omfattende de trin at lysere væv under anvendelse af en gradient af osmotisk tryk efterfulgt af fjernelse af resterende immunologiske komponenter ved behandling af vævet med en kaustisk peroxidopløsning efterfulgt af skylning for at fjerne rester til tilvejebringelse af et i det væsentlige hårfrit implanterbart materiale.
10. Fremgangsmåde ifølge krav 9, ved hvilken vævet omfatter hud, arterie, hjerteklap, knogle, pericardium fascia eller dura mater.
11. Fremgangsmåde ifølge krav 9, ved hvilken det implanterbare materiale er kemisk tværbundet.
12. Fremgangsmåde ifølge krav 9, ved hvilken det implanterbare materiale har en tykkelse på ca. 0,02-0,1 inches.
13. Implanterbart materiale opnået ved en fremgangsmåde ifølge krav 1 til 12 omfattende: et i det væsentlige hårfrit, endotoxinfrit og immunologisk indifferent vævsmateriale, der har en tykkelse på ca. 0,02-0,1 inches, og som er bioabsorberbart og omformeligt, idet vævsmaterialet er afledt af hud.
14. Implanterbart materiale ifølge krav 13, hvor vævsmaterialet er kemisk tværbundet for at forhale bioabsorption eller omformning og for at forøge bestandighed over for enzymatisk nedbrydning.
15. Slynge, net og fyldmateriale omfattende det implanterbare materiale ifølge krav 13.
16. Absorberbart omformeligt transplantatmateriale opnået ved fremgangsmåden ifølge krav 9, hvori vævet omfatter hud.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/333,597 US7670762B2 (en) | 2006-01-17 | 2006-01-17 | Biocompatible tissue graft material for implant and method of making |
| PCT/US2007/060018 WO2007084798A2 (en) | 2006-01-17 | 2007-01-02 | Biocompatible tissue graft material for implant and method of making |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1978978T3 true DK1978978T3 (da) | 2015-04-27 |
Family
ID=38263461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07718044T DK1978978T3 (da) | 2006-01-17 | 2007-01-02 | Bioforligeligt vævstransplantatmateriale til implantering samt fremgangsmåde til dets fremstilling |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7670762B2 (da) |
| EP (1) | EP1978978B1 (da) |
| DK (1) | DK1978978T3 (da) |
| ES (1) | ES2534580T3 (da) |
| WO (1) | WO2007084798A2 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2231061B1 (en) * | 2007-12-07 | 2017-01-25 | C.R.Bard, Inc. | Implantable prosthesis |
| WO2009106642A1 (en) * | 2008-02-29 | 2009-09-03 | Coloplast A/S | Biosynthetic cartilaginous matrix and methods for their production |
| AU2009267181A1 (en) * | 2008-07-01 | 2010-01-07 | Cook Biotech Incorporated | Isolated extracellular matrix material including subserous fascia |
| CN106604697A (zh) * | 2014-08-27 | 2017-04-26 | 阿姆尼斯治疗有限公司 | 包括移植物膜片的可植入装置 |
| CN113758771B (zh) * | 2021-06-25 | 2025-08-29 | 宁波健世科技股份有限公司 | 一种有效控制生物组织材料中细菌内毒素的方法 |
| US20240290222A1 (en) * | 2023-02-28 | 2024-08-29 | Intuitive Surgical Operations, Inc. | Porcine leaf fat membrane used in tissue models for surgical training and associated methods |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3777599A (en) * | 1971-08-23 | 1973-12-11 | Burn Treatment Skin Bank Inc | Process for producing split-thickness animal skin for protecting flayed human tissue |
| YU36755B (en) * | 1971-11-17 | 1984-08-31 | Basf Ag | Process for the elimination of hairs from hides and furs |
| ES421535A1 (es) * | 1973-01-13 | 1976-06-16 | Roehm Gmbh | Procedimiento para la preparacion de pellejos dispuestos para curtir a partir de cuero y pieles de origen animal. |
| DE2906650A1 (de) * | 1979-02-21 | 1980-08-28 | Pfrimmer Pharma | Verfahren zur herstellung von transplantatkonserven |
| US4424208A (en) * | 1982-01-11 | 1984-01-03 | Collagen Corporation | Collagen implant material and method for augmenting soft tissue |
| US4801299A (en) * | 1983-06-10 | 1989-01-31 | University Patents, Inc. | Body implants of extracellular matrix and means and methods of making and using such implants |
| US5108424A (en) * | 1984-01-30 | 1992-04-28 | Meadox Medicals, Inc. | Collagen-impregnated dacron graft |
| US4581148A (en) * | 1984-03-20 | 1986-04-08 | Birko Corporation | Depilating composition and method |
| GB8413319D0 (en) * | 1984-05-24 | 1984-06-27 | Oliver Roy Frederick | Biological material |
| EP0245383A4 (en) * | 1985-11-13 | 1988-06-08 | Domedica Pty Ltd | TREATMENT OF COLLAGEN TISSUE. |
| GB8618374D0 (en) * | 1986-07-28 | 1986-09-03 | Hsc Res Dev Corp | Biological vascular prostheses |
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-
2006
- 2006-01-17 US US11/333,597 patent/US7670762B2/en active Active
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2007
- 2007-01-02 WO PCT/US2007/060018 patent/WO2007084798A2/en not_active Ceased
- 2007-01-02 EP EP07718044.6A patent/EP1978978B1/en active Active
- 2007-01-02 ES ES07718044.6T patent/ES2534580T3/es active Active
- 2007-01-02 DK DK07718044T patent/DK1978978T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007084798A2 (en) | 2007-07-26 |
| EP1978978B1 (en) | 2015-03-11 |
| EP1978978A2 (en) | 2008-10-15 |
| WO2007084798B1 (en) | 2008-07-24 |
| US20070166397A1 (en) | 2007-07-19 |
| HK1123742A1 (en) | 2009-06-26 |
| WO2007084798A3 (en) | 2008-06-05 |
| EP1978978A4 (en) | 2012-01-18 |
| US7670762B2 (en) | 2010-03-02 |
| ES2534580T3 (es) | 2015-04-24 |
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