DK198784A - Pyrimidonderivater - Google Patents

Pyrimidonderivater Download PDF

Info

Publication number: DK198784A
Authority: DK; Denmark
Prior art keywords: pyrimidone; lower alkyl; represents hydrogen; pyrimidone derivatives; represent
Prior art date: 1983-05-05

Application number

DK198784A

Other languages

English (en)

Other versions

DK198784D0 (da

Inventor

Ado Kaiser

Frank Kienzle

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-05-05

Filing date

1984-04-17

Publication date

1984-11-06

1984-04-17 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1984-04-17 Publication of DK198784D0 publication Critical patent/DK198784D0/da

1984-11-06 Publication of DK198784A publication Critical patent/DK198784A/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

Description

12 3 R , R og R betegner hydrogen, lavere al kyl eller lavere alk-oxy, 12 3 eller to nabostillede symboler R , R eller R betegner methylen-dioxy eller ethylendioxy, 4 R betegner hydrogen eller lavere alkyl,

Re betegner eventuelt med R6, R7 og R8 substitueret phenyl, R , R og R betegner chlor, fluor, brom, lavere alkyl eller lavere alkoxy, hvorhos, såfremt R^ betegner hydrogen, og n = 0, mindst én af 1 2 methylengrupperne A og A skal være mono- eller di-laverealky-leret, og fysiologisk tolerable salte deraf hæmmer aggregationen af blodplader og er kredsløbspåvirkende.

Pyrimidonderivaterne fremstilles ud fra tilsvarende chlorerede eller bromerede pyrimidonderivater.

DK198784A 1983-05-05 1984-04-17 Pyrimidonderivater DK198784A (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
CH244283		1983-05-05
CH244283		1983-05-05
CH139284		1984-03-20
CH139284		1984-03-20

Publications (2)

Publication Number	Publication Date
DK198784D0 DK198784D0 (da)	1984-04-17
DK198784A true DK198784A (da)	1984-11-06

Family

ID=25687524

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198784A DK198784A (da)	1983-05-05	1984-04-17	Pyrimidonderivater

Country Status (16)

Country	Link
US (1)	US4581172A (da)
EP (1)	EP0124893A3 (da)
AU (1)	AU2751084A (da)
CA (1)	CA1237429A (da)
CS (1)	CS243486B2 (da)
DK (1)	DK198784A (da)
ES (1)	ES8505369A1 (da)
FI (1)	FI841619A7 (da)
HU (1)	HUT34025A (da)
IL (1)	IL71711A (da)
MC (1)	MC1600A1 (da)
NO (1)	NO841780L (da)
NZ (1)	NZ207981A (da)
PH (1)	PH19219A (da)
PT (1)	PT78549B (da)
ZW (1)	ZW6284A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0134984B1 (en) *	1983-07-16	1988-07-13	Beecham Group Plc	Benzazepine and benzoxazepine derivatives
GB9707251D0 (en) *	1997-04-10	1997-05-28	Smithkline Beecham Plc	Novel method and compounds
ES2208310T3 (es) *	1999-03-31	2004-06-16	Vernalis Limited	Derivados de pirimido(6,1-a) isoquinolin-4-ona.
US7169907B2 (en) *	2002-03-01	2007-01-30	Roche Diagnostics Operations, Inc.	Derivatives, immunogens, and antibodies for detecting ecstasy-class drugs
US7501512B2 (en) *	2003-07-08	2009-03-10	Smithkline Beecham Corporation	Chemical compounds
GB201502260D0 (en)	2015-02-11	2015-04-01	Verona Pharma Plc	Salt of Pyrimido[6,1-A]Isoquinolin-4-one compound
WO2017016960A1 (en) *	2015-07-24	2017-02-02	F. Hoffmann-La Roche Ag	Process for the preparation of (6s)-6-alkyl-10-alkoxy-9-(substituted alkoxy)-2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid analogues
GB201613054D0 (en)	2016-07-28	2016-09-14	Verona Pharma Plc	New compound and process
SI3822272T1 (sl) *	2018-07-13	2025-04-30	Chia Tai Tianqing Pharmaceutical Group Co., Ltd.	Kondenzirana triciklična spojina kot dvojni inhibitor pde3/pde4
EP4643947A3 (en) *	2020-01-15	2025-11-19	Chia Tai Tianqing Pharmaceutical Group Co., Ltd	Crystal of pde3/pde4 dual inhibitor and use thereof
AU2021208129A1 (en) *	2020-01-15	2022-08-18	Chia Tai Tianqing Pharmaceutical Group Co., Ltd.	Pharmaceutical composition of tricyclic PDE3/PDE4 dual inhibitor compound

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ185900A (en) *	1976-12-10	1981-04-24	Hoechst Ag	Pyrimido (6,1-a) isoquinolin-4-ones medicaments intermediate isoquinolines
DE2720085A1 (de) *	1977-05-05	1978-11-16	Hoechst Ag	Pyrimido(6,1-a)isochinolin-2-on- derivate
FI64370C (fi) *	1977-05-05	1983-11-10	Hoechst Ag	Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat
DE2847693A1 (de) *	1978-11-03	1980-05-22	Hoechst Ag	Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
DE3135831A1 (de) *	1981-09-10	1983-04-28	Hoechst Ag, 6230 Frankfurt	9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

1984
- 1984-04-13 CA CA000451949A patent/CA1237429A/en not_active Expired
- 1984-04-13 ZW ZW62/84A patent/ZW6284A1/xx unknown
- 1984-04-17 DK DK198784A patent/DK198784A/da not_active Application Discontinuation
- 1984-04-25 US US06/603,793 patent/US4581172A/en not_active Expired - Fee Related
- 1984-04-25 FI FI841619A patent/FI841619A7/fi not_active Application Discontinuation
- 1984-04-27 NZ NZ207981A patent/NZ207981A/en unknown
- 1984-04-30 AU AU27510/84A patent/AU2751084A/en not_active Abandoned
- 1984-05-01 IL IL71711A patent/IL71711A/xx not_active IP Right Cessation
- 1984-05-02 HU HU841693A patent/HUT34025A/hu unknown
- 1984-05-02 MC MC841703A patent/MC1600A1/fr unknown
- 1984-05-02 CS CS843255A patent/CS243486B2/cs unknown
- 1984-05-04 NO NO841780A patent/NO841780L/no unknown
- 1984-05-04 PH PH30644A patent/PH19219A/en unknown
- 1984-05-04 PT PT78549A patent/PT78549B/pt unknown
- 1984-05-04 EP EP84105052A patent/EP0124893A3/de not_active Withdrawn
- 1984-05-04 ES ES532172A patent/ES8505369A1/es not_active Expired

Also Published As

Publication number	Publication date
HUT34025A (en)	1985-01-28
PT78549A (en)	1984-06-01
EP0124893A2 (de)	1984-11-14
NZ207981A (en)	1987-05-29
DK198784D0 (da)	1984-04-17
EP0124893A3 (de)	1987-11-11
PT78549B (en)	1986-09-15
MC1600A1 (fr)	1985-05-09
NO841780L (no)	1984-11-06
FI841619L (fi)	1984-11-06
FI841619A0 (fi)	1984-04-25
PH19219A (en)	1986-02-12
ES532172A0 (es)	1985-06-01
FI841619A7 (fi)	1984-11-06
CA1237429A (en)	1988-05-31
ES8505369A1 (es)	1985-06-01
AU2751084A (en)	1984-11-08
CS243486B2 (en)	1986-06-12
US4581172A (en)	1986-04-08
IL71711A (en)	1987-08-31
ZW6284A1 (en)	1985-10-30
IL71711A0 (en)	1984-09-30
CS325584A2 (en)	1985-08-15

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Legal Events

Date	Code	Title	Description
1989-12-11	AHB	Application shelved due to non-payment
1999-03-01	AHB	Application shelved due to non-payment